CN105168807A - Traditional Chinese medicine composition for treating porcine reproductive and respiratory syndrome and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating pig blue-ear disease and a preparation method of the traditional Chinese medicine composition. Belonging to the field of veterinary medicine, the composition is mainly composed of the following raw materials in parts by weight: 10-25 parts of gorgon, 8-10 parts of forsythia, 5-9 parts of berberine, 7-13 parts of bupleurum, and 10-20 parts of roasted licorice , 9-16 parts of Radix Paeoniae Alba, 6-10 parts of garlic, 20-30 parts of plant polysaccharides, said plant polysaccharides are mixed by aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides according to the mass ratio of 8-15:7-10:5-8 be made of. The medicine of the present invention has the functions of clearing away heat and purging fire, reducing inflammation, and antibacterial. The addition of plant polysaccharides can effectively improve the immunity of pigs and reduce the incidence of PRRS. The present invention can add vitamin C to promote growth and prevent and control diseases. The preparation method of the composition is simple, safe and reliable, free from pollution and residue, and easy to popularize.

Description

Traditional Chinese medicine composition for treating pig blue-ear disease and preparation method thereof

technical field

The invention belongs to the field of veterinary medicine, in particular to a traditional Chinese medicine composition for treating pig blue-ear disease and a preparation method of the traditional Chinese medicine composition.

Background technique

Porcine Reproductive and Respiratory Syndrome, also known as PRRS, is a porcine respiratory and reproductive disorder caused by a virus. It is a major infectious disease in the pig industry worldwide, with high mortality and high infection rate. The rate has brought serious economic loss to the pig farm. Pigs are the only host of porcine PRRS. Pigs of all ages, breeds and feeding conditions can be infected, but the susceptibility of pigs of different ages is different. The symptoms of infection in growing pigs and finishing pigs are relatively mild , while pregnant sows and piglets within 1 month of age are the most susceptible, the symptoms are more serious, and the mortality rate of suckling pigs can reach 80% to 100%. Sick pigs and infected pigs are important sources of infection for this disease. The main routes of transmission are contact infection, airborne transmission and semen transmission, and can also be transmitted vertically through the placenta. Pigs suffering from PRRS mainly show a decline in the production performance of the pig herd, slow growth, and a decline in the reproductive performance of the sow herd. Herd immune function declines, and it is easy to be infected with other bacterial and viral diseases secondary to it. The incidence of respiratory diseases (such as mycoplasma infection, infectious pleuropneumonia, streptococcal disease, eperythrozoonosis) in pigs has increased. The pathogenesis of porcine PRRS mainly lies in the destruction of the immune function of pigs, leading to infection. Therefore, the effective way of treatment should start with improving the immune function of the body against virus-infected cells.

At present, there are many ways to prevent and treat pig PRRS, mainly using western medicine, vaccination, and Chinese herbal medicine to prevent and treat it. Among them, the widespread use of western medicine has brought great safety hazards to pork products, and drug residues have become one of the main factors affecting the safety of pork products. The early effect of vaccination is better, but multiple vaccinations are required, the operation is troublesome, the cost is high, and it is easy to cause stress response; moreover, the clinical use of vaccination is controversial and cannot be promoted on a large scale. Chinese herbal medicine feed additive is the current research direction. However, most of the current Chinese herbal medicine feed additives have unsatisfactory drug effects, slow treatment, long course of treatment, and low cure rate. Therefore, improving the curative effect of Chinese herbal medicine feed additives for the treatment of pig PRRS is still a big problem in this field.

Contents of the invention

In order to solve the problem of poor curative effect of Chinese herbal medicine additives for treating pig blue-ear disease in the prior art, the invention provides a traditional Chinese medicine composition for treating pig blue-ear disease and a preparation method thereof. The composition is applied by feeding In the prevention and control of pig PRRS, it can achieve the dual effects of preventing and controlling PRRS and enhancing immunity, and reducing the incidence of pig PRRS.

In order to achieve the above object, the present invention is achieved in the following way: a traditional Chinese medicine composition for treating pig blue ear disease, the composition is mainly composed of the following raw materials in parts by weight: 10-25 parts of Gorgon fruit, 8-10 parts of forsythia, 5-9 parts of coptis, 7-13 parts of Bupleurum, 10-20 parts of roasted licorice, 9-16 parts of white peony, 6-10 parts of garlic, 20-30 parts of plant polysaccharides, the plant polysaccharides are composed of aloe polysaccharides, astragalus The polysaccharide and Codonopsis polysaccharide are prepared by mixing according to the mass ratio of 8-15:7-10:5-8;

The aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides adopt the following extraction methods respectively: clean the raw materials, after crushing, extracting and concentrating, add a mixture of citric acid and ethanol to the concentrated solution, concentrate, citric acid and Add ethanol according to the volume ratio of 2:1:1; after mixing, carry out microwave extraction, microwave irradiation time 30s~50s, microwave power 700W, filter, decolorize with activated carbon, and concentrate to obtain the product.

The dosage of the pharmaceutical components of the present invention is obtained by the inventor through a lot of exploration. Each component has a good curative effect in the following parts by weight, 15 parts of Gorgon fruit, 9.5 parts of forsythia, 7.5 parts of Coptidis rhizome, 10 parts of Bupleurum, 12 parts of roasted licorice, 10.5 parts of white peony, 6.5 parts of garlic, and 28 parts of plant polysaccharides.

Preferably, the plant polysaccharide is prepared by mixing aloe polysaccharide, astragalus polysaccharide and Codonopsis polysaccharide in a mass ratio of 13:8:7.

Each component of the medicine of the present invention can also be: 10-25 parts of Gorgon fruit, 8-10 parts of Forsythia, 5-9 parts of Coptis chinensis, 7-13 parts of Bupleurum, 10-20 parts of roasted licorice, 9-16 parts of Radix Paeoniae Alba, 6-10 parts of garlic, 20-35 parts of plant polysaccharides, 3-9 parts of vitamin C.

More preferably, it is 15 parts of Gorgon fruit, 9.5 parts of forsythia, 7.5 parts of coptis, 10 parts of Bupleurum, 12 parts of roasted licorice, 10.5 parts of white peony, 6.5 parts of garlic, 28 parts of plant polysaccharides, and 7.5 parts of vitamin C.

The medicine of the present invention selects Gorgon fruit, Bupleurum chinensis, roasted licorice, white peony root, garlic, forsythia, coptis and plant polysaccharides and vitamin C to combine, and the combination of these medicines makes the efficacy of each medicine produce a synergistic effect, so that it can effectively treat pig blue-ear disease . Among them, Coptis chinensis is mostly used for damp-heat accumulation, gastrointestinal damp-heat, vomiting, diarrhea and other diseases, for febrile disease with high fever, thirst and irritability, blood heat rash, and heat-toxin sores, etc. Its main component, berberine, fights bacterial toxins, Reduce the coagulase and hemolysin titer of Staphylococcus aureus, and reduce the virulence of E. coli. It can be used in conjunction with saikosaponin to significantly relieve fever caused by typhoid, paratyphoid vaccine, E. coli liquid, fermented milk, yeast, etc. Thermal effect; and can lower the normal body temperature of animals. At the same time, saikosaponin has the effect of promoting immune function, improving virus-specific antibody titer, increasing lymphocyte nuclear transfer rate, and improving skin delayed allergic reaction. Roasted licorice contains glycyrrhizin, glycyrrhetinic acid, licorice polysaccharide and other chemical components, which have anti-inflammatory and anti-allergic effects, can regulate the body's immune function, anti-tumor and analgesic effects. Paeoniflorin contained in white peony has antibacterial, antipyretic, anti-inflammatory, increase coronary artery flow, improve myocardial nutritional blood flow, dilate blood vessels, resist acute myocardial ischemia, inhibit platelet aggregation, sedative, analgesic, antispasmodic, anti-ulcer , Regulate blood sugar. High-purity aloe polysaccharides, astragalus polysaccharides, and Codonopsis polysaccharides are obtained through microwave extraction. After mixing, they are added to traditional Chinese medicine components. The role of oxygen free radicals, especially aloe polysaccharides and Codonopsis polysaccharides can regulate the body's immunity.

In order to achieve a better curative effect, the present invention also selects Gorgon fruit, garlic and forsythia for combination, because Gorgon fruit is flat in nature, sweet and astringent in taste. It has the functions of invigorating the spleen and stopping diarrhea, dispelling dampness and stopping belt. It is rich in carbohydrates and very little in fat, so it is very easy to be absorbed. Garlic has the functions of detoxifying and killing insects, reducing swelling and pain, relieving diarrhea and dysentery, curing lungs, expelling parasites, and warming the spleen and stomach; Control warm-heat, erysipelas, macule, carbuncle sore swollen poison etc. effect. In order to obtain the best effect, the present invention also adds vitamin C on the basis of the above drugs, which can participate in the immune response of the matrix.

The present invention also claims the preparation method of the above-mentioned Chinese medicine composition for the treatment of pig PRRS, comprising the following steps:

(1) Weigh 10-25 parts of Gorgon, 7-13 parts of Bupleurum, 10-20 parts of Radix Glycyrrhizae, 9-16 parts of Paeoniae Alba, 6-10 parts of garlic, 8-10 parts of Forsythia and 5-9 parts of Coptidis , remove impurities and dry in the sun;

(2) Soak Gorgon fruit, bupleurum, roasted licorice, white peony root, and garlic in water for 15-45 minutes. It is advisable to add water to cover the surface of the medicine. Decoct at 90-100°C for 2-4 hours before filtering the medicine liquid , then decocted the filtrate at 40-50°C for 1-1.5 hours, and centrifuged to obtain liquid medicine I;

(3) Grind Forsythia and Coptis chinensis and add 8 to 10 times the volume of water to cook at 90 to 100°C for 1 to 3 hours, then use 90% to 95% ethanol to reflux to extract, recover the ethanol, and filter the extract , to obtain liquid medicine II for use;

(4) Mix the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio of 8-15:7-10:5-8 to obtain plant polysaccharides;

(5) Mix liquid medicine I and liquid medicine II, add 20-35 parts of plant polysaccharides and 3-9 parts of vitamin C, stir well, cook at 50-60°C for 0.5-1 hour, dry at 45-50°C, and It is pulverized into powder to obtain a traditional Chinese medicine composition.

The traditional Chinese medicine composition for treating pig PRRS described in the present invention can be made into any pharmaceutically acceptable dosage form, such as spray, granule or decoction.

The medicine of the present invention can be prepared into any conventional oral preparation by adopting conventional methods of traditional Chinese medicine preparations. For example, the crude drug can be ground into powder and mixed uniformly to make a powder for infusion. The raw material can be decocted in water, and then the decoction can be concentrated. Microwave extraction is carried out, and forsythia and berberine are subjected to ethanol extraction.

The composition of the present invention can be prepared into any commonly used dosage form, such as spray, granule or decoction, by adding various conventional auxiliary materials required for preparing different dosage forms, such as lubricants, binders, etc., by conventional Chinese medicine preparation methods.

The beneficial effects of the present invention are: the medicine of the present invention has the functions of clearing away heat and purging fire, reducing inflammation, and antibacterial. Adding plant polysaccharides can effectively provide pig immunity and reduce the incidence of PRRS. It has the advantages of disease control and the like, and the preparation method of the composition is simple, safe, reliable, pollution-free, residue-free, and easy to popularize.

Detailed ways

The preparation method and beneficial effect of the medicine of the present invention are further illustrated by the following examples.

Aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides all use the following extraction methods: clean the raw materials, after crushing, extracting and concentrating, add a mixture of citric acid and ethanol to the concentrated solution, concentrate, citric acid and ethanol according to 2 : Add at a volume ratio of 1:1; after mixing, carry out microwave extraction, microwave irradiation time 30s~50s, microwave power 700W, filter, decolorize with activated carbon, and concentrate to obtain the product.

Example 1

15 grams of Gorgon fruit, 9.5 grams of forsythia, 7.5 grams of coptis, 10 grams of Bupleurum, 12 grams of roasted licorice, 10.5 grams of white peony, 6.5 grams of garlic, 28 grams of plant polysaccharides and 7 grams of vitamin C.

28 grams of plant polysaccharides are prepared by mixing 13 grams of aloe polysaccharides, 8 grams of astragalus polysaccharides and 7 grams of Codonopsis polysaccharides.

(1) Weigh an appropriate amount of Euryale Gorgon, Bupleurum, Radix Glycyrrhiza, Radix Paeoniae Alba, Garlic, Forsythia, Coptis Rhizoma, remove impurities, and dry in the sun;

(2) Soak Gorgon fruit, Bupleurum, Radix Glycyrrhizae, Paeoniae Alba, and garlic in water for 15-45 minutes. decoct the filtrate for 1.5 hours at ℃, and centrifuge to obtain the medicinal solution Ⅰ;

(3) Grind Forsythia and Coptis Rhizoma and add 10 times the volume of water to cook at 100°C for 1 hour, then reflux extraction with 95% ethanol, recover the ethanol, filter the extract, and obtain liquid II for use;

(4) mixing the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio to obtain plant polysaccharides;

(5) Mix medicinal solution I and medicinal solution II, add plant polysaccharide and vitamin C, stir evenly, cook at 60°C for 1 hour, dry at 50°C, pulverize it into powder, and obtain a traditional Chinese medicine composition.

The obtained traditional Chinese medicine composition is added into deionized water to dissolve, and the spray can be obtained by packing in an aerosol bottle.

Example 2

10 grams of Gorgon, 10 grams of Forsythia, 9 grams of Coptis chinensis, 7 grams of Bupleurum, 20 grams of roasted licorice, 9 grams of white peony, 6 grams of garlic, 20 grams of plant polysaccharides and 3 grams of vitamin C.

20 grams of plant polysaccharides are prepared by mixing 8 grams of aloe polysaccharides, 7 grams of astragalus polysaccharides and 5 grams of Codonopsis polysaccharides.

(1) Weigh an appropriate amount of Euryale Gorgon, Bupleurum, Radix Glycyrrhiza, Radix Paeoniae Alba, Garlic, Forsythia, Coptis Rhizoma, remove impurities, and dry in the sun;

(2) Soak Gorgon fruit, bupleurum, roasted licorice, white peony root, and garlic in water for 15-45 minutes. Decoct the filtrate for 1 hour, and centrifuge to obtain medicinal solution Ⅰ;

(3) Grind Forsythia and Coptis Rhizoma and add 8 times the volume of water to cook at 90°C for 2 hours, then reflux extraction with 95% ethanol, recover the ethanol, filter the extract, and obtain liquid II for use;

(4) mixing the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio to obtain plant polysaccharides;

(5) Mix liquid medicine I and liquid medicine II, add plant polysaccharide and vitamin C, stir evenly, cook at 55°C for 1 hour, dry at 45°C, pulverize it into powder, and obtain a traditional Chinese medicine composition.

The obtained traditional Chinese medicine composition is pulverized into fine powder, ethanol is added as a binder, starch is added as a filler, and the powder is pressed into granules.

Example 3

Gorgon fruit 25 grams, forsythia 9.5 grams, coptis 5 grams, Bupleurum 12 grams, licorice 10.5 grams, white peony root 15 grams, garlic 9 grams, plant polysaccharides 30 grams and vitamin C 9 grams.

30 grams of plant polysaccharides are prepared by mixing 12 grams of aloe polysaccharides, 10 grams of astragalus polysaccharides and 8 grams of Codonopsis polysaccharides.

(1) Weigh an appropriate amount of Euryale Gorgon, Bupleurum, Radix Glycyrrhiza, Radix Paeoniae Alba, Garlic, Forsythia, Coptis Rhizoma, remove impurities, and dry in the sun;

(2) Soak Gorgon fruit, bupleurum, roasted licorice, white peony root, and garlic in water for 15-45 minutes. Decoct the filtrate for 1.5 hours, and centrifuge to obtain medicinal solution I;

(3) Grinding Forsythia and Coptis Rhizoma and adding 10 times the volume of water to boil at 100°C for 2 hours, then reflux extraction with 90% ethanol at a mass concentration, recover the ethanol, filter the extract, and obtain liquid II for use;

(4) mixing the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio to obtain plant polysaccharides;

(5) Mix medicinal liquid I and medicinal liquid II, add plant polysaccharides and vitamin C, stir evenly, boil at 50°C for 0.5-1 hour, dry at 45°C, pulverize it into powder to obtain a traditional Chinese medicine composition.

The obtained traditional Chinese medicine composition is added into deionized water, dissolved and boiled to make a decoction.

Example 4

20 grams of Gorgon, 8 grams of Forsythia, 8.5 grams of Coptidis, 13 grams of Bupleurum, 10 grams of Zhigancao, 16 grams of white peony, 10 grams of garlic and 26 grams of plant polysaccharides.

33 grams of plant polysaccharides are prepared by mixing 15 grams of aloe polysaccharides, 10 grams of astragalus polysaccharides and 8 grams of Codonopsis polysaccharides.

(1) Weigh an appropriate amount of Euryale Gorgon, Bupleurum, Radix Glycyrrhiza, Radix Paeoniae Alba, Garlic, Forsythia, Coptis Rhizoma, remove impurities, and dry in the sun;

(2) Soak Gorgon fruit, bupleurum, roasted licorice, white peony root, and garlic in water for 15-45 minutes. Decoct the filtrate for 1.5 hours, and centrifuge to obtain medicinal solution I;

(3) Grind Forsythia and Coptis Rhizoma and add 10 times the volume of water to cook at 100°C for 3 hours, then reflux extraction with 90% ethanol, recover the ethanol, filter the extract, and obtain liquid II for use;

(4) mixing the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio to obtain plant polysaccharides;

(5) Mix medicinal solution I and medicinal solution II, add plant polysaccharide and vitamin C, stir evenly, boil at 60°C for 1 hour, dry at 45°C, and pulverize it into powder to obtain a traditional Chinese medicine composition.

The obtained traditional Chinese medicine composition is added into deionized water to dissolve, cooled to room temperature, and packaged in an aerosol bottle to obtain a spray.

Test example 1:

1. Experimental grouping: select 100 piglets and adult pigs suffering from PRRS respectively, 200 in total, both male and female, and divide them into piglet group and adult pig group, and divide the two groups into four groups at random, with 50 pigs in each group. Two groups are used as control groups, one group is a blank group using equal quality water, one group is a treatment comparison group using antibiotics, and the other two groups are treatment groups using different dosage forms of the traditional Chinese medicine composition of the present invention.

2. Diagnostic criteria:

Body temperature above 40°C, dyspnea, sometimes abdominal breathing, loss of appetite or loss of appetite, diarrhea, loner, alone or huddled together, rough coat, muscle tremors, unsteady walking, ataxia, extremities Abduction, paralysis of hindquarters, progressive emaciation, eyelid edema. Some piglets have very itchy mouth and nose. It is common for the nose plate and mouth to rub against the wall in the pen, and the nose has batter-like or watery secretions.

3. Treatment method:

The spray is used 3-5 times a day, 10-30ml each time, for 14 consecutive days. The granules and decoctions were mixed into the feed, fed according to the conventional method, each mixing amount was 0.1-0.2% of the total mass of the feed, used continuously for 14 days, and the treatment was observed on the 15th day.

4. Evaluation criteria for curative effect:

Significantly effective: pigs have normal body temperature, no diarrhea, normal breathing, no edema, normal spirit and appetite;

Improvement: The body temperature of the pig is normal, without diarrhea, with slight respiratory symptoms, and the spirit and appetite are normal;

Invalid: Cannot reach the improvement standard or die.

5. Treatment results

Table 1 Therapeutic effect of traditional Chinese medicine composition on pig PRRS

group Dose g/kg invalid head count survival rate cure rate control group equal amount of water 46 8% 0 antibiotic group 10 41 17% 13% Chinese medicine spray group 16.5 12 76% 64%

Chinese medicine granules 15 9 82% 74%

Note: ***P<0.01 compared with the control group.

Test example 2

The traditional Chinese medicine composition prepared by the present invention is subjected to clinical trials.

Clinical trial one:

37 1-month-old piglets in a pig farm in Dalian were suspected to be sick, and symptoms of fever, diarrhea, and dyspnea occurred, accompanied by lack of energy and loss of appetite. The traditional Chinese medicine spray prepared by the present invention was used for treatment. 30ml each time, half a month is a course of treatment, two courses of treatment are used continuously, as shown in Table 2, it is the curative effect observation situation after the treatment of the traditional Chinese medicine spray group.

Table 2

Clinical trial two:

60 adult pigs in a pig farm in Dalian were suspected to be sick, and symptoms of fever, diarrhea, and dyspnea occurred, accompanied by lack of energy and loss of appetite. The traditional Chinese medicine granules prepared by the present invention were treated and fed according to conventional methods. The amount mixed each time was 0.1% of the total mass of the feed, as shown in Table 3, is the curative effect observation situation of the Chinese medicine granule group after treatment.

table 3

Clinical Trial Three:

42 1-month-old piglets in a pig farm in Dalian were suspected to be sick, and symptoms of fever, diarrhea, and dyspnea were accompanied by lack of energy and loss of appetite. The mixing amount is 0.2% of the total mass of the feed, as shown in Table 4, which is the curative effect observation situation of the Chinese medicine decoction group after treatment.

Table 4

Piglets taking the decoction of the present invention have obvious curing effect on PRRS, and the effective rate can reach 90.5%, and it is found that the traditional Chinese medicine can promote the growth of piglets.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone familiar with the technical field within the technical scope disclosed in the present invention, according to the technical solution of the present invention Any equivalent replacement or change of the inventive concepts thereof shall fall within the protection scope of the present invention.

Claims (6)

1. A traditional Chinese medicine composition for the treatment of pig blue-ear disease, characterized in that the composition is mainly composed of the following raw materials in parts by weight: 10-25 parts of Gorgon fruit, 8-10 parts of forsythia, 5-9 parts of Coptis chinensis, 7-13 parts of bupleurum, 10-20 parts of roasted licorice, 9-16 parts of white peony, 6-10 parts of garlic, 20-35 parts of plant polysaccharides, the plant polysaccharides are composed of aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides according to the quality Prepared by mixing 8-15:7-10:5-8; The aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides adopt the following extraction methods respectively: clean the raw materials, after crushing, extracting and concentrating, add a mixture of citric acid and ethanol to the concentrated solution, concentrate, citric acid and Add ethanol according to the volume ratio of 2:1:1; after mixing, carry out microwave extraction, microwave irradiation time 30s~50s, microwave power 700W, filter, decolorize with activated carbon, and concentrate to obtain the product. 2. The traditional Chinese medicine composition for treating pig blue-ear disease according to claim 1, characterized in that, the dosage of each raw material in the composition is: 15 parts of Gorgon fruit, 9.5 parts of Forsythia, 7.5 parts of Coptidis root, 10 parts of Bupleurum 12 parts of roasted licorice, 10.5 parts of white peony, 6.5 parts of garlic, and 28 parts of plant polysaccharides. 3. The traditional Chinese medicine composition for treating pig blue-ear disease according to claim 1, wherein the plant polysaccharide is prepared by mixing aloe polysaccharide, astragalus polysaccharide and Codonopsis polysaccharide in a mass ratio of 13:8:7. 4. The traditional Chinese medicine composition for treating porcine blue-ear disease according to claim 1, characterized in that there are 3 to 9 parts of vitamin C in the crude drug. 5. the preparation method of a kind of Chinese medicine composition for the treatment of porcine blue-ear disease as claimed in claim 1, is characterized in that, comprises the following steps: (1) Weigh 10-25 parts of Gorgon, 7-13 parts of Bupleurum, 10-20 parts of Radix Glycyrrhizae, 9-16 parts of Paeoniae Alba, 6-10 parts of garlic, 8-10 parts of Forsythia and 5-9 parts of Coptidis , remove impurities and dry in the sun; (2) Soak Gorgon fruit, bupleurum, roasted licorice, white peony root, and garlic in water for 15-45 minutes. It is advisable to add water to cover the surface of the medicine. Decoct at 90-100°C for 2-4 hours before filtering the medicine liquid , then decocted the filtrate at 40-50°C for 1-1.5 hours, and centrifuged to obtain liquid medicine I; (3) Grind Forsythia and Coptis chinensis and add 8 to 10 times the volume of water to cook at 90 to 100°C for 1 to 3 hours, then use 90% to 95% ethanol to reflux to extract, recover the ethanol, and filter the extract , to obtain liquid medicine II for use; (4) Mix the extracted aloe polysaccharides, astragalus polysaccharides and Codonopsis polysaccharides evenly according to the ratio of 8-15:7-10:5-8 to obtain plant polysaccharides; (5) Mix liquid medicine I and liquid medicine II, add 20-35 parts of plant polysaccharides and 3-9 parts of vitamin C, stir well, cook at 50-60°C for 0.5-1 hour, dry at 45-50°C, and It is pulverized into powder to obtain a traditional Chinese medicine composition. 6. The preparation method of the Chinese medicine composition for the treatment of pig PRRS according to claim 1, characterized in that it can be made into any pharmaceutically acceptable dosage form, such as spray, granule or decoction.