CN104771158B - Action potential recorder and closed loop pain suppression system - Google Patents
Action potential recorder and closed loop pain suppression system Download PDFInfo
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- CN104771158B CN104771158B CN201510160386.7A CN201510160386A CN104771158B CN 104771158 B CN104771158 B CN 104771158B CN 201510160386 A CN201510160386 A CN 201510160386A CN 104771158 B CN104771158 B CN 104771158B
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- 208000002193 Pain Diseases 0.000 title claims abstract description 110
- 230000036982 action potential Effects 0.000 title claims abstract description 50
- 230000001629 suppression Effects 0.000 title claims abstract description 30
- 238000006243 chemical reaction Methods 0.000 claims abstract description 26
- 238000012545 processing Methods 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 9
- 230000003044 adaptive effect Effects 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 9
- 238000004088 simulation Methods 0.000 claims description 8
- 230000003321 amplification Effects 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 238000010248 power generation Methods 0.000 claims 1
- 230000005611 electricity Effects 0.000 description 9
- 239000000523 sample Substances 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 230000009466 transformation Effects 0.000 description 4
- 230000007383 nerve stimulation Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002509 periaqueductal gray Anatomy 0.000 description 2
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
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Abstract
A kind of action potential recorder and closed loop pain suppression system, the action potential recorder include the first amplifying circuit, frequency selection circuit, analog to digital conversion circuit, first control circuit and the first wireless transceiver circuit.First amplifying circuit is suitable to be amplified pain signal processing to obtain amplified signal；Frequency selection circuit is suitable to carry out the amplified signal frequency-selecting processing to obtain frequency-selecting signal；Analog to digital conversion circuit is suitable to the frequency-selecting signal is carried out analog-to-digital conversion process to obtain digital sampled signal；First control circuit is suitable to be communicated with the first wireless transceiver circuit；First wireless transceiver circuit is suitable to be communicated with master control instrument.Action potential recorder and closed loop pain suppression system that the present invention is provided, by setting frequency selection circuit, improve the accuracy that action potential recorder gathers pain signal, do not allow useful pain signal to be lost.
Description
Technical field
The present invention relates to medical treatment device technical field, more particularly to a kind of action potential recorder and closed loop pain suppress system
System.
Background technology
Chronic ache is considered as a serious public health problem always, and it drastically influence the personal lifestyle of patient
Quality.Prolonged chronic ache can cause the blood pressure and blood glucose rise of patient, digestion power and blood circulation ability to decline.No
Only in this way, it, which also results in patient, produces psychological various problems, such as frightened, dejected, self-closing, anxiety, insomnia, even
Introgression.From the NULL as shown by data from North America, West Europe, New Zealand and Australia, chronic ache is puzzlement
One of most common illness of adult.Treat chronic ache generally use chemical method, but most of chronic pain patients due to
Economic problems or side effect puzzlement, are not sufficiently succoured and are treated.
Nerve stimulation it is verified that chronic ache can be alleviated,《Wireless closed-loop town pain system based on nerve stimulation
Research》A kind of closed loop is disclosed in (left side is super, Chinese Ph.D. Dissertation's full-text database, the Central China University of Science and Technology, 2013)
Pain suppression system, the structural representation of the closed loop pain suppression system as shown in figure 1, including action potential recorder 11,
Pain suppressor 12, master control instrument 13 and host computer 14.
The action potential recorder 11 includes the first amplifying circuit 111, analog to digital conversion circuit 112, first control circuit
113 and wireless transmission circuit 114.First amplifying circuit 111 is connected by electrode with the spinal cord 101 of rat 10, is suitable to
To probe in detecting to pain signal be amplified processing to obtain amplified signal；Analog-digital conversion circuit as described 112 is suitable to institute
Amplified signal is stated to carry out analog-to-digital conversion process to obtain digital sampled signal；The first control circuit 113 is suitable to the number
Word sampled signal is sent to the wireless transmission circuit 114；The wireless transmission circuit 114 is suitable to institute with communication
Digital sampled signal is stated to send to the master control instrument 13.
The master control instrument 13 includes wireless transceiver circuit 131 and second control circuit 132.The wireless transceiver circuit 131
Suitable for receiving the digital sampled signal, and digital stimulus signal is sent to the pain suppressor with communication
12；The second control circuit 132 is suitable to send the digital sampled signal to the host computer 14 by USB interface, and
The digital stimulus signal that the host computer 14 is produced is received by USB interface.
The host computer 14 is suitable to the storage digital sampled signal and supplies off-line analysis, and based on LabVIEW (National
Instruments Corporation) the real-time display waveforms of GUI.Meanwhile, the host computer 14 is integrated with special algorithm, can
To adjust neural stimulation parameter, the varying strength of triggering nerve stimulation is automatically provided according to the digital sampled signal of varying strength
Digital stimulus signal.
The pain suppressor 12 include wireless receiving circuit the 121, the 3rd control circuit 122, D/A converting circuit 123 with
And second amplifying circuit 124.The wireless receiving circuit 121 is suitable to receive the digital stimulus signal；The 3rd control electricity
Road 122 is suitable to send the digital stimulus signal to the D/A converting circuit 123；The D/A converting circuit 123 is suitable to
The digital stimulus signal is carried out digital-to-analogue conversion processing to obtain simulation stimulus signal；Second amplifying circuit 124 is suitable to
Processing is amplified to the simulation stimulus signal and suppresses electric current to obtain pain, the pain suppresses electric current to be stimulated by probe
PAG (periaqueductal gray, periaqueductal gray) 102 regions of rat 10.
Closed loop pain suppression system shown in Fig. 1, can in real time record, show Neural spike train information, and will recorded
Information automatically processed by algorithm after it is synchronous judge whether outside stimulus possesses nocuity, then closed loop feedback triggering electricity is pierced
Energizing signal, targetedly carries out pain suppression.However, because the pain signal between different treatment individuals differs greatly, and
And the pain signal between the same individual different parts for the treatment of also has larger difference, is pressed down using the closed loop pain shown in Fig. 1
The pain signal that the accuracy of system acquisition pain signal processed is low, useful is easy to lose.
The content of the invention
It is to be solved by this invention be existing closed loop pain suppression system collection pain signal accuracy is low, useful pain
The problem of pain signal is easy to lose.
To solve the above problems, the present invention provides a kind of action potential recorder, including the first amplifying circuit, frequency-selecting electricity
Road, analog to digital conversion circuit, first control circuit and the first wireless transceiver circuit；
First amplifying circuit is suitable to be amplified pain signal processing to obtain amplified signal；
The frequency selection circuit is suitable to carry out the amplified signal frequency-selecting processing to obtain frequency-selecting signal；
Analog-digital conversion circuit as described is suitable to the frequency-selecting signal is carried out analog-to-digital conversion process to obtain digital sampled signal；
The first control circuit is suitable to be communicated with first wireless transceiver circuit；
First wireless transceiver circuit is suitable to be communicated with master control instrument.
Optionally, first amplifying circuit is program control differential amplifier circuit, and the first control circuit is further adapted for institute
State program control differential amplifier circuit and multiplication factor control data is provided.
Optionally, the frequency selection circuit includes switchable capacitive module, variable resistor module and operational amplifier；
The switchable capacitive module be suitable under the control of variable capacitance control data provide capacitance is adjustable can power transformation
Hold；
The variable resistor module be suitable under the control of variable resistor control data provide resistance value is adjustable can power transformation
Resistance；
The operational amplifier is suitable to filter the amplified signal according to the variable capacitance and the variable resistor
Ripple handles to obtain the frequency-selecting signal；
The first control circuit is also adapted to provide the variable capacitance control data and the variable resistor control data.
Optionally, the frequency selection circuit is further adapted for carrying out the frequency of the frequency-selecting signal calibration process, first control
Circuit processed is further adapted for providing frequency-selecting calibration signal to the frequency selection circuit.
Optionally, the action potential recorder also include adaptive amplifying circuit, the frequency selection circuit by it is described from
Adapt to amplifying circuit connection analog-digital conversion circuit as described；
The adaptive amplifying circuit is suitable to the amplitude for automatically adjusting the frequency-selecting signal.
Based on above-mentioned action potential recorder, the present invention also provides a kind of closed loop pain suppression system, including pain suppresses
Device, master control instrument, host computer and above-mentioned action potential recorder.
Optionally, the first control circuit also includes computing circuit；
The computing circuit is suitable to carry out computing to obtain digital stimulus signal according to the digital sampled signal；
The host computer, which is suitable to stimulate the numeral by the first wireless transceiver circuit described in the master control instrument control system, to be believed
Number wirelessly send to the pain suppressor.
Optionally, the host computer is hyper terminal.
Optionally, the master control instrument includes the second wireless transceiver circuit and second control circuit；
Second wireless transceiver circuit is suitable to be communicated with the action potential recorder and the pain suppressor；
The second control circuit is suitable to be communicated with second wireless transceiver circuit and the host computer.
Optionally, the pain suppressor include the 3rd wireless transceiver circuit, the 3rd control circuit, D/A converting circuit with
And second amplifying circuit；
3rd wireless transceiver circuit is suitable to be communicated with the action potential recorder and the master control instrument；
The 3rd control circuit is suitable to be communicated with the 3rd wireless transceiver circuit；
The D/A converting circuit is suitable to carry out digital-to-analogue conversion to the digital stimulus signal of the 3rd control circuit output
Handle to obtain simulation stimulus signal；
Second amplifying circuit is suitable to be amplified processing to the simulation stimulus signal to obtain pain suppression electric current.
Compared with prior art, the present invention has advantages below：
Action potential recorder and closed loop pain suppression system that technical solution of the present invention is provided, by the action electricity
Frequency selection circuit is set in the recorder of position, user can set different frequency collection scopes according to the actual requirements, so that useful
Pain signal be located in the range of the frequency collection of setting, thus improve action potential recorder collection pain signal
Accuracy, is unlikely to allow useful pain signal to lose.Further, technical solution of the present invention provide action potential recorder and
Closed loop pain suppression system is simple and practical, alleviates the burden of user.
In the alternative of the present invention, processing is amplified to pain signal using program control differential amplifier circuit.By adjusting
The multiplication factor control data of the whole program control differential amplifier circuit, can carry out putting for different multiples to different pain signals
Greatly, the dynamic range of the action potential recorder can not only be improved, making an uproar for the action potential recorder can also be adjusted
Sonic system number.
In the alternative of the present invention, the frequency selection circuit is further adapted for calibrating its own reference for being operated in user's setting
In frequency range, the accuracy that the action potential recorder gathers signal is further increased.
In the alternative of the present invention, the action potential recorder also includes being connected to the frequency selection circuit and modulus turns
The adaptive amplifying circuit changed between circuit.The adaptive amplifying circuit can be according to the amplitude size of frequency-selecting signal, automatically
The amplitude of the frequency-selecting signal is adjusted, controls the amplitude of the frequency-selecting signal in reference value set in advance in dynamic range
Interior, so as to improve the dynamic range and stability of system, increase system receives the amplitude range of signal, makes the practicality of system more
By force.
In the alternative of the present invention, the first control circuit of the action potential recorder also includes computing circuit, institute
Digital stimulus signal can be directly obtained according to digital sampled signal progress computing by stating computing circuit.By the control of host computer,
The action potential recorder directly can carry out radio communication with pain suppressor, and the numeral obtained by the action potential instrument is believed
Number directly control the pain suppressor to produce pain and suppress electric current, so as to mitigate the control burden of the host computer.
In the alternative of the present invention, the host computer is that cloud computing stores center and based on movable equipments such as mobile phones
Synchrodata hyper terminal.The hyper terminal can record the wireless signal that the action potential recorder is sent at any time,
And the action potential recorder can be terminated at any time transmit signals to the pain suppressor.
Brief description of the drawings
Fig. 1 is a kind of structural representation of existing closed loop pain suppression system；
Fig. 2 is the structural representation of the closed loop pain suppression system of the embodiment of the present invention；
Fig. 3 is the structural representation of the first amplifying circuit of the embodiment of the present invention；
Fig. 4 is the structural representation of the frequency selection circuit of the embodiment of the present invention；
Fig. 5 is another structural representation of the action potential recorder of the embodiment of the present invention.
Embodiment
Just as described in the background art, the standard of pain signal is gathered using the closed loop pain suppression system shown in Fig. 1
True low, the useful pain signal of property is easy to lose.By study find, difference treatment individual between pain signal amplitudes and
There is larger difference in frequency, there is also larger difference for the amplitude and frequency of the pain signal between the individual different parts of same treatment
It is different.However, the frequency collection scope of the closed loop pain suppression system shown in Fig. 1 is changeless, same system can only be received
The pain signal of fixed frequency scope, thus low, the useful pain signal of accuracy of collection pain signal is easy to lose.This hair
Bright technical scheme provides a kind of action potential recorder and closed loop pain suppression system, by the action potential recorder
Frequency selection circuit is set, useful pain signal can be made to be located in the range of the frequency collection of setting, to improve the action potential
Recorder gathers the accuracy of pain signal, does not allow useful pain signal to be lost.
The present invention will now be described in further detail with reference to the accompanying drawings and the accompanying drawings, but embodiments of the present invention
Not limited to this.
Fig. 2 is the structural representation of the closed loop pain suppression system of the embodiment of the present invention, the closed loop pain suppression system
Including action potential recorder 21, pain suppressor 22, master control instrument 23 and host computer 24.Wherein, the action potential record
Instrument 21 is suitable to that digital sampled signal will be converted to from the pain signal of the collection for the treatment of individual 20；The master control instrument 23 is by the numeral
Sampled signal is sent to the host computer 24, and the digital stimulus signal received from the host computer 24 is sent to the pain
Suppressor 22；The host computer 24 is suitable to store the digital sampled signal, in real time the corresponding waveform of display pain signal, and will
The digital sampled signal is substituted into be calculated to obtain the digital stimulus signal in specific algorithm；The pain suppressor
22 are suitable to the digital stimulus signal being converted to pain suppression electric current, stimulate the treatment individual 20.
Specifically, the action potential recorder 21 includes the first amplifying circuit 211, frequency selection circuit 212, analog-to-digital conversion electricity
Road 213, the wireless transceiver circuit 215 of first control circuit 214 and first.
First amplifying circuit 211 is suitable to be amplified the pain signal processing to obtain amplified signal.When controlling
When pain symptom occurs in treatment individual 20, the neuron of spinal cord 201 of the treatment individual 20 can be discharged, the telecommunications produced of discharging
Number be the pain signal.Pain signal is by being implanted into the probe treated in individual 20 body and be connected with the spinal cord 201
Obtain, and be transferred to by the probe input of first amplifying circuit 211.The electric signal produced due to Neural spike train
It is very faint, thus need described first amplifying circuit, 211 pairs of pain signals to be amplified processing.It should be noted that
The treatment individual 20 can be human body, or animal body, the present embodiment is not construed as limiting to this.
With reference to Fig. 3, first amplifying circuit 211 of the present embodiment is program control differential amplifier circuit 30, the program control difference
Dynamic amplifying circuit 30 includes first input end i31, the second input i32, output end o31 and control end c31.The program control difference
The first input end i31 of dynamic amplifying circuit 30 and the second input i32 of the program control differential amplifier circuit 30 are suitable to input institute
The differential signal of pain signal is stated, the control end c31 of the program control differential amplifier circuit 30 is suitable to input multiplication factor control number
According to the output end o31 of the program control differential amplifier circuit 30 is suitable to export the amplified signal.
The multiplication factor control data is provided by the first control circuit 214.Specifically, user is by described
The corresponding waveform of the pain signal can be observed in position machine 24, the signal intensity of the pain signal is known, so that by described
Host computer 24 sets the multiplication factor of the program control differential amplifier circuit 30；The host computer 24 is by the master control instrument 23 by institute
Multiplication factor is stated to send to the first control circuit 214；The first control circuit 214 is according to program to the multiplication factor
Carry out processing and obtain the multiplication factor control data, and the multiplication factor control data is provided to described program control differential put
The control end c31 of big circuit 30.Those skilled in the art know how to set the multiplication factor, also know first control
How circuit 214 is handled the multiplication factor, will not be repeated here.
The program control differential amplifier circuit 30 can realize 2~21 times of multiplication factor regulation and 100dB common mode inhibition
Than, and the power consumption of whole circuit is low, input impedance is very big, thus with very strong access capability.Also, the program control difference
Dynamic amplifying circuit 30 is in the action potential recorder 21 foremost, can carry out different multiples to different pain signals
Amplification, the dynamic range of the action potential recorder 21 can not only be improved, action potential record can also be adjusted
The noise coefficient of instrument 21.
The frequency selection circuit 212 is suitable to carry out the amplified signal frequency-selecting processing to obtain frequency-selecting signal, and itself is
The adjustable bandpass filter of one frequency range, after the amplified signal is by the frequency selection circuit 212, useful pain signal quilt
Retain.Fig. 4 is the structural representation of the frequency selection circuit 212 of the embodiment of the present invention, and the frequency selection circuit 212 includes can power transformation
Molar block 40, variable resistor module 41 and operational amplifier 42.The switchable capacitive module 40 includes control end c41, described
Variable resistor module 41 includes control end c42, and the operational amplifier 42 includes input i41 and output end o41.
Specifically, the control end c41 of the switchable capacitive module 40 is suitable to receive variable capacitance control data, and described
Under the control of variable capacitance control data the adjustable variable capacitance of capacitance is provided to the operational amplifier 42.It is described can power transformation
The control end c42 for hindering module 41 is suitable to receive variable resistor control data, and under the control of the variable resistor control data
The adjustable variable resistor of resistance value is provided to the operational amplifier 42.The input i41 of the operational amplifier 42 is suitable to defeated
Enter the amplified signal, and be filtered processing to the amplified signal to obtain according to the variable capacitance and the variable resistor
The frequency-selecting signal is obtained, the frequency-selecting signal is exported by the output end o41 of the operational amplifier 42.
Generation with the multiplication factor control data is similar, the variable capacitance control data and the variable resistor control
Data processed are also provided by the first control circuit 214.Specifically, user sets required frequency by the host computer 24
Acquisition range；The host computer 24 calculates corresponding resistance parameter according to the frequency collection scope and active filter algorithm
And capacitance parameter, and sent the resistance parameter and the capacitance parameter to the described first control electricity by the master control instrument 23
Road 214；The first control circuit 214 is handled the capacitance parameter and the resistance parameter according to program, obtains institute
State variable capacitance control data and the variable resistor control data, and by the variable capacitance control data send to it is described can
Become the control end c41 of capacitance module 40, the variable resistor control data is sent to the control of the variable resistor module 41
Hold c42.
In the present embodiment, the frequency selection circuit 212 is further adapted for carrying out calibration process, institute to the frequency of the frequency-selecting signal
First control circuit 214 is stated to be further adapted for providing frequency-selecting calibration signal to the frequency selection circuit 212.Further, the operation amplifier
Device 42 also includes control end c43, and the control end c43 of the operational amplifier 42 is suitable to receive the frequency-selecting calibration signal.Below
Describe the operation principle of the frequency selection circuit 212 in detail：
First, user sets required frequency collection scope by the host computer 24；The host computer 24 is according to institute
State frequency collection scope and active filter algorithm calculates corresponding resistance parameter and capacitance parameter, and pass through the master control instrument
23 send the resistance parameter and the capacitance parameter to the first control circuit 214；The first control circuit 214 is pressed
The capacitance parameter and the resistance parameter are handled according to program, the variable capacitance control data is obtained and described variable
Resistance control data, and the variable capacitance control data and the variable resistor control data are sent to the frequency selection circuit
212；The frequency selection circuit 212 exports institute under the control of the variable capacitance control data and the variable resistor control data
State frequency-selecting signal；The frequency-selecting signal turns into the digital sampled signal by subsequent treatment, and the digital sampled signal is passed
Transport to the host computer 24；The host computer 24 is received after the digital sampled signal, sends frequency-selecting calibration command, the choosing
Frequency calibration command is sent to the first control circuit 214 by the master control instrument 23；The first control circuit 214 is according to journey
Frequency-selecting calibration command described in ordered pair carries out processing and obtains the frequency-selecting calibration signal, and the frequency-selecting calibration signal is sent to institute
State frequency selection circuit 212；The frequency selection circuit 212 carries out school under the control of the frequency-selecting calibration signal to its own working frequency
Standard, produces the frequency-selecting signal after calibration；Digital sample of the frequency-selecting signal after subsequent treatment turns into calibration after the calibration
Signal, the digital sampled signal after the calibration is transferred to the host computer 24；After described 24 pairs of calibrations of host computer
The accuracy of digital sampled signal is judged, if the frequency that the frequency of the digital sampled signal after the calibration is set in user
In rate acquisition range, then the host computer 24 enters the state that normally receives, it is on the contrary then need to recalculate corresponding resistance parameter with
Capacitance parameter, repeats said process.
With continued reference to Fig. 2, analog-digital conversion circuit as described 213 is suitable to the frequency-selecting signal is carried out analog-to-digital conversion process to obtain
Obtain the digital sampled signal.In the present embodiment, analog-digital conversion circuit as described 213 is using with automatic low-power consumption burst mode
Analog-digital converter, analog-digital conversion circuit as described 213 can be automatically placed in the off-position of low-power consumption.In order to improve sampling essence
Degree, user can also voluntarily adjust the sample rate of analog-digital conversion circuit as described 213 by the host computer 24.
The first control circuit 214 is suitable to carry out with first wireless transceiver circuit 215 by synchronous serial interface
Communication, and the data of its own reception are handled.In the present embodiment, the first control circuit 214 is by the numeral
Sampled signal is sent to first wireless transceiver circuit 215, and from first wireless transceiver circuit 215 receive data and from
Reason, for example, being handled the multiplication factor to obtain the multiplication factor control data, at the capacitance parameter
Reason is handled the resistance parameter to obtain the variable resistor control number to obtain the variable capacitance control data
According to being handled the frequency-selecting calibration command to obtain the frequency-selecting calibration signal.
First wireless transceiver circuit 215 is suitable to be communicated with the master control instrument 23 by wireless transmission method, complete
Reception and sending function into data.Specifically, first wireless transceiver circuit 215 is suitable to send out the digital sampled signal
The master control instrument 23 is delivered to, and the data that the host computer 24 is sent are received from the master control instrument 23, as described multiplication factor, institute
State capacitance parameter, the resistance parameter and the frequency-selecting calibration command.First wireless transceiver circuit 215 is operated in the world
General purpose I SM frequency ranges, mainly including frequency generator, power amplifier and modem.First wireless transceiver circuit
215 wireless transmission rate has 125 selectable working channels up to 2Mbps, while during switching between each channel
Between it is very short.First wireless transceiver circuit 215 in a receive mode when, it has a very high receiving sensitivity, it is minimum it is reachable-
85dB；When first wireless transceiver circuit 215 is in sending mode, its power output is adjustable, and power output is most
High reachable 3dB.
The master control instrument 23 includes the second wireless transceiver circuit 231 and second control circuit 232.
Second wireless transceiver circuit 231 is suitable to by wireless transmission method and the action potential recorder 21 and institute
Pain suppressor 22 is stated to be communicated.Specifically, second wireless transceiver circuit 231 is suitable to from first wireless receiving and dispatching electricity
Road 215 receives the digital sampled signal, by the multiplication factor, the capacitance parameter, the resistance parameter and the choosing
Frequency calibration command is sent to first wireless transceiver circuit 215, and the digital stimulus signal is sent to the pain and suppressed
Device 22.The performance of second wireless transceiver circuit 231 is similar with the performance of first wireless transceiver circuit 215, herein not
Repeat again.
The second control circuit 232 is suitable to carry out with second wireless transceiver circuit 231 by synchronous serial interface
Communication, is communicated by USB interface and the host computer 24.Specifically, the second control circuit 232 will be from described second
The digital sampled signal that wireless transceiver circuit 231 is received is transmitted to the host computer 24, will be received from the host computer 24
The digital stimulus signal, the multiplication factor, the capacitance parameter, the resistance parameter and the frequency-selecting calibration command
Send to second wireless transceiver circuit 231.
The host computer 24 is suitable to the storage digital sampled signal and supplies off-line analysis, and the GUI based on LabVIEW is real-time
Display waveform, and receive the multiplication factor and the frequency collection scope of user's input.Meanwhile, the host computer 24 collects
Into special algorithm, such as enhanced pain signal recognizer, according to the digital sampled signal can calculate acquisition
Digital stimulus signal, and the intensity of the digital stimulus signal follows the Strength Changes of the digital sampled signal.
The pain suppressor 22 includes the 3rd wireless transceiver circuit the 221, the 3rd control circuit 222, D/A converting circuit
223 and second amplifying circuit 224.
3rd wireless transceiver circuit 221 is suitable to be communicated with the master control instrument 23 by wireless transmission method, i.e.,
The digital stimulus signal is received from second wireless transceiver circuit 231.The performance of 3rd wireless transceiver circuit 221 with
The performance of first wireless transceiver circuit 215 is similar, will not be repeated here.The 3rd control circuit 222 is suitable to by same
Step serial line interface is communicated with the 3rd wireless transceiver circuit 221, by what is received from the 3rd wireless transceiver circuit 221
The digital stimulus signal is sent to the D/A converting circuit 223.The D/A converting circuit 223 is suitable to pierce the numeral
Energizing signal carries out digital-to-analogue conversion processing to obtain simulation stimulus signal, and similar with analog-digital conversion circuit as described 213, user also may be used
Voluntarily to adjust the resolution ratio of the D/A converting circuit 223 by the host computer 24.Second amplifying circuit 224 is suitable to
Processing is amplified to the simulation stimulus signal and suppresses electric current to obtain pain, the pain suppresses electric current to be stimulated by probe
The regions of PAG 202 of the treatment individual 20.In the present embodiment, it is -20mA~20mA, electric current step that the pain, which suppresses electric current,
Enter for 0.25mA.
The closed loop pain suppression system that the present embodiment is provided, by setting the choosing in the action potential recorder 21
Frequency circuit 212, user can set different frequency collection scopes according to the actual requirements, so that useful pain signal is located at
In the range of the frequency collection of setting, thus the accuracy that the action potential recorder 21 gathers pain signal is improved, it is unlikely
Lost in allowing useful pain signal.
The embodiment of the present invention also provides another closed loop pain suppression system, the structure of the closed loop pain suppression system and
Function embodiment corresponding with Fig. 2 is similar, and difference is：The first control circuit 214 also includes computing circuit.The computing
Circuit can be using the integrated special algorithm of the host computer 24, such as enhanced pain signal recognizer, according to the number
Word sampled signal carries out computing to obtain digital stimulus signal.User can set the action electricity by the host computer 24
Position recorder 21 and the pain suppressor 22 are communicated, i.e., described host computer 24 controls described the by the master control instrument 23
One wireless transceiver circuit 215 is communicated with the 3rd wireless transceiver circuit 221, and the numeral that the computing circuit is obtained is pierced
Energizing signal is sent to the pain suppressor 22, and the data signal obtained by the computing circuit directly controls the pain to suppress
Device 22 produces pain and suppresses electric current, so as to mitigate the control burden of the host computer 24.
In the present embodiment, the host computer 24 can store center and based on movable equipments such as mobile phones for cloud computing
Synchrodata hyper terminal.The hyper terminal can record the numeral that the action potential recorder 21 is obtained at any time
Sampled signal, it is possible to terminate the action potential recorder 21 at any time and send digital stimulus signal to the pain suppressor
22。
Fig. 5 is the structural representation of another action potential recorder provided in an embodiment of the present invention, the action potential
Recorder includes the first amplifying circuit 511, frequency selection circuit 512, analog to digital conversion circuit 513, first control circuit 514, the first nothing
Line transmission circuit 515 and adaptive amplifying circuit 516.First amplifying circuit 511, the frequency selection circuit 512, the mould
The 26S Proteasome Structure and Function and Fig. 2 of number change-over circuit 513, the first control circuit 514 and first wireless transceiver circuit 515
Corresponding circuit is similar, and difference is：The frequency selection circuit 512 connects the modulus by the adaptive amplifying circuit 516
Change-over circuit 513, the adaptive amplifying circuit 516 is suitable to automatically adjust the frequency-selecting signal that the frequency selection circuit 512 is produced
Amplitude.
In the present embodiment, the adaptive amplifying circuit 516 is the circuit that output amplitude is controlled with software, whole electricity
Road has 60dB dynamic range, and multiplication factor is 30dB, and attenuator is 30dB；In the adaptive dynamic of amplifying circuit 516
In the range of, the P-to-P voltage of the adaptive output signal of amplifying circuit 516 is 1.2V.Pass through the adaptive amplifying circuit
516 can improve the dynamic range of system, and increase system receives the amplitude range of signal, while also advantageously improving the stabilization of system
Property.
It is described above, be only presently preferred embodiments of the present invention, any formal limitation not done to the present invention, it is every according to
According to the present invention technical spirit above example is made any simple modification, equivalent variations, each fall within the present invention protection
Within the scope of.
Claims (8)
1. a kind of action potential recorder, it is characterised in that including the first amplifying circuit, frequency selection circuit, analog to digital conversion circuit,
One control circuit and the first wireless transceiver circuit；
First amplifying circuit is suitable to be amplified pain signal processing to obtain amplified signal；
The frequency selection circuit is suitable to carry out the amplified signal frequency-selecting processing to obtain frequency-selecting signal；
Analog-digital conversion circuit as described is suitable to the frequency-selecting signal is carried out analog-to-digital conversion process to obtain digital sampled signal；
The first control circuit is suitable to be communicated with first wireless transceiver circuit；
First wireless transceiver circuit is suitable to be communicated with master control instrument；
The frequency selection circuit includes switchable capacitive module, variable resistor module and operational amplifier；
The switchable capacitive module is suitable under the control of variable capacitance control data provide the adjustable variable capacitance of capacitance；
The variable resistor module is suitable under the control of variable resistor control data provide the adjustable variable resistor of resistance value；
The operational amplifier is suitable to be filtered place to the amplified signal according to the variable capacitance and the variable resistor
Manage to obtain the frequency-selecting signal；
The first control circuit is also adapted to provide the variable capacitance control data and the variable resistor control data；
The frequency selection circuit is further adapted for carrying out calibration process to the frequency of the frequency-selecting signal, and the first control circuit is further adapted for
Frequency-selecting calibration signal is provided to the frequency selection circuit；
When carrying out frequency calibration, the frequency collection scope and active filter algorithm that host computer is set according to user calculate phase
The resistance parameter and capacitance parameter answered simultaneously are sent to the first control circuit by master control instrument, and the first control circuit is to institute
State capacitance parameter and the resistance parameter carries out processing and obtains the variable capacitance control data and variable resistor control number
According to and send to the frequency selection circuit, the frequency selection circuit is in the variable capacitance control data and variable resistor control number
According to control under export the frequency-selecting signal, the frequency-selecting signal is transferred to by the first control circuit and master control instrument
Position machine, host computer sends frequency-selecting calibration command, and the frequency-selecting calibration command is sent to the first control circuit by master control instrument,
The first control circuit carries out processing to the frequency-selecting calibration command and obtains the frequency-selecting calibration signal and by the frequency-selecting school
Calibration signal is sent to the frequency selection circuit, and the frequency selection circuit is under the control of the frequency-selecting calibration signal to its own work frequency
Rate carries out the frequency-selecting signal after being calibrated, and numeral of the frequency-selecting signal after being treated as calibration after the calibration is adopted
Sample signal is simultaneously transferred to host computer, if the frequency collection that the frequency of the digital sampled signal after the calibration is set in user
In the range of, then host computer, which enters, normally receives state, on the contrary then recalculate corresponding resistance parameter and capacitance parameter.
2. action potential recorder according to claim 1, it is characterised in that first amplifying circuit is program control differential
Amplifying circuit, the first control circuit is further adapted for providing multiplication factor control data to the program control differential amplifier circuit.
3. the action potential recorder according to any one of claim 1 and 2, it is characterised in that also including adaptive amplification
Circuit, the frequency selection circuit connects analog-digital conversion circuit as described by the adaptive amplifying circuit；
The adaptive amplifying circuit is suitable to the amplitude for automatically adjusting the frequency-selecting signal.
4. a kind of closed loop pain suppression system, it is characterised in that will including pain suppressor, master control instrument, host computer and right
Seek the action potential recorder described in 1 to 3 any one.
5. closed loop pain suppression system according to claim 4, it is characterised in that the first control circuit also includes fortune
Calculate circuit；
The computing circuit is suitable to carry out computing to obtain digital stimulus signal according to the digital sampled signal；
The host computer be suitable to by the first wireless transceiver circuit described in the master control instrument control system by the digital stimulus signal with
It is sent wirelessly to the pain suppressor.
6. closed loop pain suppression system according to claim 5, it is characterised in that the host computer is hyper terminal.
7. closed loop pain suppression system according to claim 6, it is characterised in that the master control instrument includes the second wireless receipts
Power Generation Road and second control circuit；
Second wireless transceiver circuit is suitable to be communicated with the action potential recorder and the pain suppressor；
The second control circuit is suitable to be communicated with second wireless transceiver circuit and the host computer.
8. closed loop pain suppression system according to claim 4, it is characterised in that the pain suppressor includes the 3rd nothing
Line transmission circuit, the 3rd control circuit, D/A converting circuit and the second amplifying circuit；
3rd wireless transceiver circuit is suitable to be communicated with the action potential recorder and the master control instrument；
The 3rd control circuit is suitable to be communicated with the 3rd wireless transceiver circuit；
The D/A converting circuit is suitable to carry out digital-to-analogue conversion processing to the digital stimulus signal of the 3rd control circuit output
To obtain simulation stimulus signal；
Second amplifying circuit is suitable to be amplified processing to the simulation stimulus signal to obtain pain suppression electric current.
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| CN106308738B (en) * | 2016-08-30 | 2018-02-16 | 湖州美科沃华医疗技术有限公司 | A kind of device and method for glaucoma detection |
| CN107374611A (en) * | 2017-09-08 | 2017-11-24 | 四川新源生物电子科技有限公司 | A kind of bio signal processing unit |
| CN112023265B (en) * | 2020-09-28 | 2022-01-07 | 杭州神络医疗科技有限公司 | Electrical stimulation device |
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| CN204500672U (en) * | 2015-04-07 | 2015-07-29 | 四川新源生物电子科技有限公司 | Action potential monitor and closed loop pain suppress system |
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