CN104436164A - Foot powder containing biologic peptide composition, as well as preparation thereof - Google Patents
Foot powder containing biologic peptide composition, as well as preparation thereof Download PDFInfo
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- 239000000843 powder Substances 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 24
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims abstract description 17
- 239000001095 magnesium carbonate Substances 0.000 claims abstract description 17
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims abstract description 17
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 12
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 12
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- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 12
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 12
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 abstract description 6
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- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
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- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
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- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
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- HCQPHKMLKXOJSR-IRCPFGJUSA-N cecropin-a Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C1=CC=CC=C1 HCQPHKMLKXOJSR-IRCPFGJUSA-N 0.000 description 1
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
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- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses foot powder containing a biologic peptide composition, as well as preparation thereof. The foot powder containing the biologic peptide composition is prepared from the following components in parts by weight: 30-40 parts of starch component, 0.05-5 parts of biologic peptide composition, 0.03-0.5 part of menthol, 20-30 parts of kaolin, 0.03-3 parts of salicylic acid and the balance of magnesium carbonate. The foot powder containing the biologic peptide composition adopts the biologic peptide composition as the antibacterial component, and the growth of foot pathogenic bacteria can be effectively inhibited by utilizing the broad-spectrum antibacterial characteristic of the biologic peptide; in addition, the hidden safety hazard during use of talcum powder foot powder can be avoided by replacing talcum powder with safe and reliable components,namelycorn starch and denatured starch. The foot powder is safe and reliable, convenient to use and sweat-absorbing, maintains the comfortable and cool feet and has good efficacy of antibacterial characteristic and the like, the demand on daily foot care of people can be met, and the foot powder can also serve as daily foot health products of common people.
Description
Technical field
The present invention relates to article of everyday use, be specifically related to a kind of foot-powder containing biological peptide combinations, also relate to the preparation method of this foot-powder.
Background technology
Tinea pedis is common foot dermatosis, is caused by pathogenic fungus, has infectiousness, and in China, the sickness rate of tinea pedis is quite high.Research shows: do not have sebaceous gland between the vola of people and toe, thus lacks the fatty acid suppressing skin filamentous fungi, and physiological defense function is poor, and the sweat gland of skin at these positions is very abundant, perspire many, poor, the locally damp warm of air circulation, is conducive to the growth of filamentous fungi in addition.In addition, vola area skin horny layer is thicker, and the keratin in horny layer is the abundant nutrition material of fungus, is conducive to the growth of fungus.In general, gravid woman, overweight people, diabetics is the group of people at high risk of tinea pedis, and the morbidity of tinea pedis is also relevant with living habit simultaneously.Some people does not note the situation of foot sanitation and hygiene and footgear, good grows place for fungus provides.The tinea pedis medicine of existing market is many containing chemicals, and its antibacterial components is generally antibiotic or hormones, and life-time service exists side effect, easily cause the problems such as the drug resistance of fungus, and for tinea pedis Susceptible population, daily foodcare and health care seem particularly important therefore
The class produced through induction in the former finger insect bodies of biological peptide has the basic polypeptide material of antibacterial activity, and molecular weight, about 2000 ~ 7000, is made up of 20 ~ 60 amino acid residues.At first, people are when studying the immunologic mechanism of North America giant silkworm, and find that its diapause pupae is after environmental stimuli induction, create the peptide material with bacteriostasis in its hemolymph, this kind of antibacterial polypeptide is named as cecropin (Cecropins).Afterwards, from other insecticides and amphibian animal, mammal, be also separated to the antibacterial polypeptide that structure is similar, and had the structure of more than 70 kind of antibacterial polypeptide determined.Between the several years after 1980, people in succession find and are separated the polypeptide obtaining and have antibacterial activity from antibacterial, fungus, amphibian, insecticide, higher plant, mammal and even the mankind.Active polypeptide majority has the features such as strong basicity, heat stability and broad-spectrum antiseptic, and is considered to have broad application prospects.
At present, foot-powder on market is mainly with foot bath salt, the foot bath series products such as lavipeditum powder are main, and the function that the foot-powder of other types generally also just has absorbing sweat, keeps foot dry and comfortable, not containing antibacterial components, function singleness, the growth of foot harmful fungoid cannot be suppressed, the daily foodcare of tinea pedis patient is had little effect, and there is in foot-powder the Pulvis Talci of ability of sweat absorption, research shows the harm certain to human body, and therefore we should avoid using containing talcous foot-powder as far as possible.
Prior art is compared, foot-powder containing biological peptide combinations of the present invention has the following advantages: adopt biological peptide combinations as antibacterial components, biological peptide is utilized to have the characteristic of broad spectrum antibacterial, effectively can suppress the growth of foot pathogenic bacterium, simultaneously, the present invention also adopts safe and reliable component (corn starch and modified starch) to substitute Pulvis Talci, avoids the potential safety hazard using Pulvis Talci foot-powder to bring.Foot-powder of the present invention is safe and reliable, easy to use, and energy absorbing sweat, resists and chap, and keeps foot pleasant and has the effects such as good antibacterial characteristics, can meet the demand of the daily foodcare of people, also can be used as the daily foot health article of general personage.
Summary of the invention
The first object of the present invention is to provide a kind of foot-powder containing biological peptide combinations, and it can effectively suppress foot pathogenic bacterium and avoid the harm of Pulvis Talci to human body.
Foot-powder containing biological peptide combinations of the present invention, is prepared from by following each component by weight:
Foot-powder containing biological peptide combinations of the present invention, wherein, described starch based component is modified starch and/or corn starch.
Modified starch used in the present invention is one or more in existing known any modified starch (as modified corn starch, modified potato starch, cassava modified starch, rice modified starch, Semen Tritici aestivi modified starch), when for multiple combination, concrete proportioning can be limited as required.
Foot-powder containing biological peptide combinations of the present invention, wherein, described biological peptide is combined as Xenopus laevis element, cecropin, at least two kinds in alexin and bacteriocin.
Institute of the present invention, the foot-powder containing biological peptide combinations stated, described biological peptide combination is preferably cecropin and alexinic mixture.
Xenopus laevis element of the present invention, cecropin, alexin and bacteriocin are known substance, obtain or buied by commercially available by existing technology.Xenopus laevis element can select Xenopus laevis element 2 etc., and cecropin can select cecropin A etc., and alexin can select α-alexin, beta-alexin and θ-alexin etc., and bacteriocin can select colicin, nisin and pyo etc.
As preferred scheme, the foot-powder containing biological peptide combinations of the present invention, is prepared from by following each component by weight:
Described biological peptide combinations is weight ratio is the cecropin of 1:1-3 and alexinic mixture.
As preferred scheme, the foot-powder containing biological peptide combinations of the present invention, is prepared from by following each component by weight:
Another object of the present invention is to provide the preparation method of the described foot-powder containing biological peptide combinations, comprises following steps:
(1) mixing by the magnesium carbonate of the starch based component of proportional quantity, menthol, Kaolin, salicylic acid and 20-80% (w/w) proportional quantity;
(2) add biological peptide combinations and the residue magnesium carbonate of proportional quantity in mixture step (1) obtained, stir postlyophilization;
(3) dried for step (2) mixture grinding is sieved, obtain the foot-powder containing biological peptide combinations.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: a kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, each component following by weight is prepared from: corn starch 35g, cecropin 0.1g, alexin 0.25g, menthol 0.05g, Kaolin 25g, and salicylic acid 0.1g, magnesium carbonate adds to 100g.
Containing the preparation method of the foot-powder of biological peptide combinations described in the present embodiment, comprise following steps:
(1) mixing by the magnesium carbonate of corn starch, menthol, Kaolin, salicylic acid and 50% (w/w);
(2) add cecropin, alexin and residue magnesium carbonate in mixture step (1) obtained, stir postlyophilization;
(3) dried for step (2) mixture grinding is sieved, obtain the foot-powder containing biological peptide combinations.
Embodiment 2: a kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, each component following by weight is prepared from: corn starch 32g, cecropin 0.05g, alexin 0.05g, menthol 0.04g, Kaolin 23g, and salicylic acid 0.05g, magnesium carbonate adds to 100g.
The preparation method of biological peptide combinations foot-powder is contained with embodiment 1 described in the present embodiment.
Embodiment 3: a kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, each component following by weight is prepared from: corn starch 38g, cecropin 0.125g, alexin 0.375g, menthol 0.06g, Kaolin 27g, and salicylic acid 0.15g, magnesium carbonate adds to 100g.
The preparation method of the foot-powder of biological peptide combinations is contained with embodiment 1 described in the present embodiment.Embodiment 4: a kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, each component following by weight is prepared from: modified starch 30g, cecropin 0.05g, menthol 0.03g, Kaolin 20g, and salicylic acid 0.03g, magnesium carbonate adds to 100g.
Containing the preparation method of the foot-powder of biological peptide combinations described in the present embodiment, comprise the following steps:
(1) magnesium carbonate of modified starch, menthol, Kaolin, salicylic acid and 20% (w/w) is mixed;
(2) add cecropin and residue magnesium carbonate in mixture step (1) obtained, stir postlyophilization;
(3) dried for step (2) mixture grinding is sieved, obtain the foot-powder containing biological peptide combinations.
Embodiment 5: a kind of foot-powder containing biological peptide combinations
Containing biological peptide combinations foot-powder described in the present embodiment, each component following by weight is prepared from: corn starch 40g, and Xenopus laevis element 0.09g, alexin 0.10g, bacteriocin 0.15g, menthol 0.05g, Kaolin 30g, salicylic acid 0.1g, magnesium carbonate adds to 100g.
Containing the preparation method of the foot-powder of biological peptide combinations described in the present embodiment, comprise the following steps:
(1) corn starch, menthol, Kaolin, salicylic acid and 80% (w/w) magnesium carbonate are mixed;
(2) add Xenopus laevis element, alexin, bacteriocin and residue magnesium carbonate in mixture step (1) obtained, stir postlyophilization;
(3) dried for step (2) mixture grinding is sieved, both must containing the foot-powder of biological peptide combinations.
Embodiment 6: a kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, each component following by weight is prepared from: corn starch 30g, modified starch 5g, Xenopus laevis element 1g, cecropin 1g, alexin 1g, bacteriocin 2g, menthol 0.5g, Kaolin 25g, salicylic acid 3g, magnesium carbonate adds to 100g.
The preparation method of the foot-powder of biological peptide combinations is contained with embodiment 5 described in the present embodiment.
For verifying the excellent properties of foot-powder of the present invention further, inventor expands the test of a large amount of Performance Detection further to it, and length limit, and only exemplifies the part test of part most cogency herein.
Experimental example 1: In Vitro Anti fungus is tested
1, laboratory sample
Sample 1-5 is the foot-powder of embodiment 1-5, and reference substance 1-3 is composition and the preparation method of reference example 3, wherein:
Reference substance 1: be to delete cecropin with the difference of embodiment 3, adjustment alexin is 0.5g, all the other components and weight constant;
Reference substance 2: be to delete alexin with the difference of embodiment 3, adjustment cecropin is 0.5g, all the other components and weight constant;
Reference substance 3: be to delete cecropin and alexin with the difference of embodiment 3, uses active component (Cortex Phellodendri, Herba Pogostemonis, Radix Vladimiriae, Ramulus Cinnamomi and the Radix Stemonae) 0.5g altogether in CN102652717, all the other components and weight constant.
2, experimental technique
(1) sample 1-5 and reference substance 1-3 is configured to deionized water the solution that concentration is 1mg/mL respectively;
(2) Candida albicans cultivates the second filial generation fresh cultured thing of 24h with 20-25 DEG C, dilutes with sodium chloride injection; Acrothesium floccosum, ulotrichy pityrosporion ovale, trichophyton gypseum and trichophyton all cultivate the slant culture of 7 days with 20-25 DEG C, with sodium chloride injection, culture is washed down, jolting, filtration, microscopy meter spore count, dilution, make bacterium liquid ultimate density be 1 × 10
5cFU/mL, adopts test tube doubling dilution to measure minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
3, experimental result
The experiment of In Vitro Anti fungus records minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), in table 1.
Table 1: minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) (μ g/mL)
Known according to table 1, compared with reference substance 1-3, sample 1-5 shows significant fungistatic effect, and wherein sample 1-3 is more outstanding, best with sample 1.
Foot-powder of the present invention has significantly antibacterial and bactericidal action to the susceptible fungus of foot, uses little amount can reach antibacterial and the effect of sterilization, with the foot-powder of embodiment 1 for the best.
Experimental example 2: In Vitro Bacteriostasis stability test
1, test specimen: identical with experimental example 1.
2, test method
Sample 1-5 and reference substance 1-3 is mixed with deionized water the solution that concentration is 1mg/mL respectively;
Trichophyton, acrothesium floccosum and trichophyton gypseum potato dextrose agar solid medium are activated.3 strains picking 1 single bacterium colony respectively, respectively with after 10mL Sterile Saline grinding 15min, measures containing after bacterium number with the method for plate culture count, regulates bacteria suspension to count to 1 × 10 containing bacterium
5~ 1 × 10
6cfu/mL, for subsequent use;
Diluted 3 kinds of bacterium liquid are respectively got 100 μ L, joins in potato dextrose agar solid medium, smear evenly.Then in each flat board, add 4 filter papers (diameter 5mm), and filter paper is flattened.4 filter paper wherein on each flat board are respectively containing testing sample, blank, amphotericin (positive control), Sterile Saline (negative control).The consumption of testing sample is 10 μ L, establishes 3 repetitions to each strain.Each testing sample is carried out aforesaid operations to 3 kinds successively for examination bacterium, and carries out separator.After testing sample is fully absorbed by filter paper, overturn by culture dish and put into 28 DEG C for microbiological incubator, within 7 days, observing afterwards and determination experiment result, the experimental result of each testing sample gets 3 meansigma methodss repeated.
Detection time is 0 month, 3 months, 6 months, 12 months, and preservation condition is: with vial sealing, and indoor shady and cool place is conventional places, and is not placed in direct projection under sunlight.
3, In Vitro Bacteriostasis stability test result
3.1 Bactericidal test criterions:
Antibacterial circle diameter is greater than 20mm: extremely quick; 15 ~ 20mm: Gao Min; 10 ~ 15mm: in quick; 7 ~ 10mm: hypoallergenic; Be less than 7mm: insensitive.
3.2,0 month average inhibition zone of extracorporeal bacteria inhibitor test, in table 2.
Table 2:0 average inhibition zone of month extracorporeal bacteria inhibitor test (mm)
Known according to table 2, compared with reference substance 1-3, the fungistatic effect of sample 1-5 is remarkable, is extremely quick to three strains.The inhibition of sample 1-3 is given prominence to, best with sample 1.
3.3,6 months average inhibition zones of extracorporeal bacteria inhibitor test, in table 3.
Table 3:6 average inhibition zone of month extracorporeal bacteria inhibitor test (mm)
Known according to table 3, compared with reference substance 1-3, the fungistatic effect of sample 1-5 is good, and part is extremely quick to three strains, and all the other are Gao Min.The inhibition of sample 1-3 is given prominence to, best with sample 1.
3.4,12 months average inhibition zones of extracorporeal bacteria inhibitor test, in table 4.
Table 4:12 average inhibition zone of month extracorporeal bacteria inhibitor test (mm)
Known according to table 4, compared with reference substance 1-3, sample 1-5 has certain fungistatic effect, and part is extremely quick to three strains, and all the other are Gao Min.The inhibition of sample 1-3 is given prominence to, best with sample 1.
3.5,18 months average inhibition zones of extracorporeal bacteria inhibitor test, in table 5.
Table 5:18 average inhibition zone of month extracorporeal bacteria inhibitor test (mm)
Known according to table 5, compared with reference substance 1-3, sample 1-5 has certain fungistatic effect, and the inhibition of sample 1-3 is given prominence to, best with sample 1, is extremely quick to 3 strains.
To sum up analyze known, foot-powder of the present invention is remarkable to the fungistatic effect of 3 strains, and wherein the foot-powder of embodiment 1 is best at the fungistatic effect of 0-18 month, and stable.
Experimental example 3: clinical trial
1, clinical data
Select 198 tinea pedis and dermatitis patients, each 99 of men and women, the mean age is 29 years old, max age 75 years old, minimal ages 22 years old.Be divided into 9 experimental grouies at random.
2, test specimen: with experimental example 1.
2, Therapeutic Method
Each experimental group uses a kind of different testing sample, soaking therapy.Soak 1 every day, be dissolved in 37 ~ 40 DEG C of water with 5g testing sample, soak half an hour, two weeks is a course for the treatment of at every turn at every turn.
3, therapeutic outcome
3.1, standard is treated:
Clinical recovery: skin lesion place Mycology examination is negative, skin lesion disappears;
Effective: skin lesion place Fungus examination is turned out cloudy, and skin lesion disappears 80%;
Effective: skin lesion place Fungus examination is turned out cloudy, and skin lesion disappears 60%;
Invalid: skin lesion place Fungus examination is positive, skin lesion disappear less than 30% or counter see increase.The treatment various skin lesion situation of fore-and-aft observing record and untoward reaction, if any burning sensation, pruritus, redness etc., should discontinue medication in coating position.
3.2, therapeutic outcome, in table 6.
Table 6: clinical treatment outcome (%)
Known according to table 6, compared with reference substance 1-3, the clinical therapeutic efficacy of sample 1-5 is remarkable, and sample 1-3 is more outstanding, best with sample 1.Foot-powder of the present invention is treated, and embodiment 1 is best.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1., containing a foot-powder for biological peptide combinations, it is characterized in that: be prepared from by following each component by weight:
2. the foot-powder containing biological peptide combinations according to claim 1, is characterized in that: described starch based component is modified starch and/or corn starch.
3. the foot-powder containing biological peptide combinations according to claim 1, is characterized in that: described biological peptide is combined as Xenopus laevis element, cecropin, at least two kinds in alexin and bacteriocin.
4. the foot-powder containing biological peptide combinations according to claim 3, is characterized in that: described biological peptide is combined as cecropin and alexinic mixture.
5. the foot-powder containing biological peptide combinations according to any one of claim 1 to 4, is characterized in that, be prepared from by following each component by weight:
Described biological peptide combinations is weight ratio is the cecropin of 1:1-3 and alexinic mixture.
6. the foot-powder containing biological peptide combinations according to claim 5, is characterized in that, be prepared from by following each component by weight:
7. the preparation method of the foot-powder containing biological peptide combinations according to any one of claim 1 to 6, is characterized in that, comprise following steps:
(1) by the starch based component of proportional quantity, menthol, Kaolin, salicylic acid and 20-80% proportional quantity magnesium carbonate mix;
(2) add biological peptide combinations and the residue magnesium carbonate of proportional quantity in mixture step (1) obtained, stir postlyophilization;
(3) dried for step (2) mixture grinding is sieved, obtain containing biological peptide combinations foot-powder.
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| CN106619519A (en) * | 2016-12-24 | 2017-05-10 | 叶宗瑞 | Bacteriostatic foot powder and preparation method thereof |
| CN106726957A (en) * | 2016-12-23 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of deodorant antibacterial foot-powder and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106726957A (en) * | 2016-12-23 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of deodorant antibacterial foot-powder and preparation method thereof |
| CN106619519A (en) * | 2016-12-24 | 2017-05-10 | 叶宗瑞 | Bacteriostatic foot powder and preparation method thereof |
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