CN104107815A - Cleaning device of sampling needle, cleaning method of sampling needle and sample analyzing device - Google Patents

Abstract

A cleaning device for a sampling needle, comprising a cleaning pool, the cleaning pool is provided with a main channel into which the sampling needle can be inserted and a spray hole provided with a liquid outlet, and the liquid outlet is connected to the main channel for Clean the outer wall of the sampling needle tip passing through the liquid outlet of the spray hole and the outer wall of the sampling needle body that needs to be cleaned. The outer wall of the sampling needle is sprayed twice to clean the outer wall of the sampling needle by setting the main channel and the spray hole. During the first spray, the water sprayed from the spray hole directly washes the outer wall of the needle tip of the sampling needle at a close distance, and can remove residues on the outer wall of the needle tip. Most of the samples or reagents are washed away, and the cleaning liquid output by the second spray through the spray hole cleans the outer wall of the sampling needle body and the outer wall of the sampling needle, so that when the cleaning height range of the outer wall of the sampling needle is large, the sampling needle The outer wall of the needle tip can be effectively cleaned, reducing the probability of contamination carried by the needle tip of the sampling needle. The invention also provides a cleaning method for the sampling needle.

Description

Sampling needle cleaning device, method and sample analysis device

technical field

The invention relates to the technical field of medical devices, in particular to a sampling needle cleaning device, method and sample analysis device.

Background technique

In immunoassay instruments, sampling needles are used for precise sampling of samples or reagents. After sampling begins or ends, the inner and outer walls of the sampling needles are generally cleaned to avoid carryover between samples or reagents.

Generally, the sample or reagent is placed in a container with a protective film, and the sampling needle must pass through the protective film to complete the sampling. During the sampling process, in addition to the tip of the sampling needle submerged below the liquid surface will touch the sample or reagent, the outer wall above the tip of the sampling needle will also be polluted due to contact with the protective film. Therefore, when cleaning the outer wall of the sampling needle, it is necessary to clean the outer wall of the tip of the sampling needle and the outer wall at a certain height above the tip of the sampling needle. The traditional method is to clean the outer wall of the sampling needle by spraying or in a reservoir with a certain depth, so as to complete the cleaning of the outer wall of the sampling needle within a relatively large height range.

The disadvantage of the cleaning of the above-mentioned sampling needles is that due to the large height range of the outer wall of the sampling needle that needs to be cleaned, it is difficult to effectively clean the outer wall of the needle tip with the most serious pollution on the outer wall of the sampling needle, resulting in a large carryover of the outer wall of the needle tip.

Contents of the invention

Based on this, it is necessary to provide a sampling needle cleaning device, method and sample analysis device to solve the problem that the outer wall of the sampling needle tip cannot be effectively cleaned when the cleaning height range of the outer wall of the sampling needle is large.

A cleaning device for a sampling needle, comprising a cleaning pool, the cleaning pool is provided with a main flow channel into which the sampling needle can be inserted and a spray hole provided with a liquid outlet, and the liquid outlet is connected to the main flow channel for Clean the outer wall of the sampling needle tip passing through the liquid outlet of the spray hole and the outer wall of the sampling needle body to be cleaned.

In one of the embodiments, the main channel is a cylindrical main channel, and the cleaning tank is also provided with a conical constricted flow channel, and the conical constricted flow channel is extended at the outlet end of the main channel, and the The area of the port at one end of the tapered constricted flow channel away from the outlet end of the main flow channel is smaller than the area of the port at the other end.

In one embodiment, the tapered constricted flow channel is a tapered constricted flow channel having the same shrinkage ratio as that of the needle tip of the sampling needle.

In one of the embodiments, the spray hole is an annular spray hole with a liquid outlet arranged around the main channel.

In one embodiment, the spray hole and the main channel are not parallel to each other, the spray hole includes a liquid inlet, and the liquid inlet is higher than the liquid outlet.

In one of the embodiments, the cleaning tank is further provided with a waste liquid flow channel, and the output end of the tapered constricted flow channel is connected to the waste liquid flow channel.

In one of the embodiments, a negative pressure waste liquid system is also included, and the negative pressure waste liquid system is connected with the waste liquid flow channel.

A method for cleaning a sampling needle, comprising the following steps:

Insert the sampling needle into the main channel so that the needle tip of the sampling needle is located at the liquid outlet of the spray hole, and the cleaning liquid output through the spray hole cleans the outer wall of the needle tip of the sampling needle;

Push the sampling needle to move toward the outlet end of the main channel, so that the outer wall of the sampling needle body and the outer wall of the sampling needle tip pass through the liquid outlet of the spray hole, and the cleaning liquid output through the spray hole cleans the cleaning liquid of the sampling needle body. The outer wall and the outer wall of the sampling needle tip.

In one of the embodiments, in the step of cleaning the outer wall of the sampling needle body and the outer wall of the sampling needle tip, the sampling needle tip is located in the conical constricted flow channel, and the bottom of the sampling needle tip and the conical constricted flow channel output Flat ends.

In one of the embodiments, it also includes the step of cleaning the inner wall of the sampling needle at the same time.

In one of the embodiments, the waste liquid generated by cleaning the sampling needle is collected through the waste liquid flow channel.

In one of the embodiments, the waste liquid collected by the waste liquid channel is sucked through the negative pressure waste liquid system.

A sample analysis device, comprising the cleaning device for the above-mentioned sampling needle.

The cleaning device, method, and sample analysis device for the above-mentioned sampling needle are provided with a main flow channel and a spray hole to spray and clean the outer wall of the sampling needle twice, and the cleaning liquid output through the spray hole for the first time is sprayed on the sampling needle. Clean the outer wall of the needle tip with the most serious outer wall pollution. At this time, the outer wall of the needle tip of the sampling needle is close to the spray hole, and the cleaning liquid sprayed from the spray hole directly washes the outer wall of the needle tip of the sampling needle at close range, which can remove most of the samples remaining on the outer wall of the needle tip or The reagent is washed away, and the cleaning solution output by the second spray through the spray hole cleans the outer wall of the sampling needle body and the outer wall of the sampling needle tip, and the sample or reagent remaining on the outer wall of the sampling needle body contacts the protective film. At the same time, the sample or reagent remaining on the outer wall of the sampling needle tip is further cleaned, so that when the cleaning height range of the outer wall of the sampling needle is large, the outer wall of the sampling needle tip can be effectively cleaned, reducing the probability of carryover contamination of the sampling needle tip.

Description of drawings

Fig. 1 is a diagram of the use state of the cleaning device of the sampling needle;

Fig. 2 is another usage status diagram of the cleaning device of the sampling needle;

Fig. 3 is a flow chart of the cleaning method of the sampling needle.

Detailed ways

Referring to FIG. 1 and FIG. 2 , the sampling needle cleaning device 100 includes a cleaning pool 110 , and the cleaning pool 110 is provided with a main channel 120 for inserting the sampling needle 200 and a spray hole 130 with a liquid outlet 134 . The liquid outlet 134 can output cleaning liquid, and can also output cleaning water. In the embodiment of the body, the liquid outlet 134 outputs cleaning liquid. The sampling needle 200 includes a sampling needle tip 220 and a sampling needle body 210 . The liquid outlet 134 communicates with the main channel 120 for cleaning the outer wall of the sampling needle tip 220 passing through the liquid outlet 134 of the spray hole 130 and the outer wall of the sampling needle body 210 to be cleaned.

The length of the main channel 120 is enough to accommodate the length of the contaminated sampling needle 200, so the length of the main channel 120 can generally be set to be shorter than the length of the sampling needle 200, and the length of the main channel 120 can be reasonably set according to different requirements. The size of the internal end surface of the main channel 120 is enough to allow the insertion of the sampling needle 200 without causing damage to the sampling needle 200. Generally, it is set to be larger than the size of the end surface of the sampling needle 200, and different settings can be made according to actual needs.

In this embodiment, the main channel 120 adopts a cylindrical main channel 120 , and adopts a straight cylindrical main channel 120 . When the sampling needle 200 is inserted into the main channel 120 for cleaning, the outer wall of the sampling needle 200 will contact the cleaning liquid in a large area, which will cause hanging liquid on the outer wall of the sampling needle 200 and dilute the sample, resulting in inaccurate test results. Since the shape of the general sampling needle 200 is also cylindrical, adopting the setting of the cylindrical main channel 120 is adapted to the external dimensions of the sampling needle 200, which can reduce the hanging liquid on the outer wall of the sampling needle 200 and improve the accuracy of the test results. Spend. In other embodiments, other shapes of the main channel 120 into which the sampling needle 200 can be inserted may also be used.

In this embodiment, the cleaning pool 110 is also provided with a tapered constricted flow channel 140 extending from the outlet end 124 of the main channel 120, and the conical constricted flow channel 140 is far away from The port area of one end of the outlet end 124 of the main channel 120 is smaller than the area of the other end port. When cleaning the outer wall of the sampling needle 200, the hanging liquid generated by contacting the cleaning liquid is particularly likely to gather at the transition site of the sampling needle tip 220 where the size of the outer wall of the sampling needle 200 suddenly shrinks. In this embodiment, since the tapered constricted flow channel 140 adopts a structure adapted to the external dimensions of the sampling needle tip 220, when the sampling needle tip 220 enters the conical constricted flow channel 140, the contraction of the conical constricted flow channel 140 The impact of sudden expansion of the actual cleaning channel of the sampling needle tip 220 caused by the shrinkage of the sampling needle tip 220 is compensated, which can effectively reduce the hanging liquid of the sampling needle tip 220 and improve the accuracy of the test results.

The spray hole 130 communicates with the main channel 120 through the liquid outlet 134 , so that the cleaning liquid output through the spray hole 130 can clean the sampling needle 200 . Generally, the liquid outlet 134 of the spray hole 130 is close to the inlet end 122 of the main flow channel 120, so that the cleaning liquid output through the spray hole 130 can clean the outer wall of the polluted sampling needle 200, that is, from the liquid outlet 134 of the spray hole 130 to the main flow. The height of the outlet end 124 of the channel 120 can accommodate the height of the outer wall of the contaminated sampling needle 200, and the specific position can be set according to actual needs.

There may be more than two spray holes 130, and the liquid outlets 134 may be located on the same plane. When there are two spray holes 130 , the liquid outlets 134 of the spray holes 130 can be arranged symmetrically on both sides of the main flow channel 120 to more evenly spray and flush the outer wall of the sampling needle 200 . The spray hole 130 can also be one, at this moment, the spray hole 130 can be the annular spray hole 130 that the liquid outlet 134 surrounds the described main channel 120, so that the cleaning that can be output through the spray hole 130 liquid outlet 134 The liquid evenly washes the circumferential position of the outer wall of the sampling needle 200, and cleans the residual sample or reagent on the outer wall of the sampling needle 200, and the cleaning is more comprehensive.

The spray holes 130 may be arranged parallel to the main flow channel 120 or not parallel to the main flow channel 120 . In this embodiment, the spray hole 130 includes a liquid inlet 132, the spray hole 130 and the main channel 120 are not parallel to each other, and one end of the liquid inlet 132 of the spray hole 130 is higher than the liquid outlet of the spray hole 130. 134, so that when the cleaning liquid used to clean the outer wall of the sampling needle 200 is output from one end of the liquid inlet 132 to the liquid outlet 134, it can use its own gravity to generate an impact force to flush the outer wall of the sampling needle 200. With the help of external force, the cost is saved, and the height difference between the liquid inlet 132 and the liquid outlet 134 can be reasonably set according to the flushing intensity required by the actual sampling needle 200, which is convenient and practical.

The cleaning device 100 of the above-mentioned sampling needle 200 is provided with a main channel 120 for inserting the sampling needle 200 in the cleaning tank 110, and a spray hole 130 communicated with the main channel 120, and the liquid outlet 134 of the spray hole 130 is close to The setting of the inlet end 122 of the main channel 120 can spray and clean the outer wall of the sampling needle tip 220. When the sampling needle 200 is further extended, it can spray the outer wall of the sampling needle body 210 to be cleaned and at the same time spray the outer wall of the sampling needle tip 220. Clean up.

When cleaning the sampling needle 200, the needle tip 220 of the sampling needle with the most serious contamination on the outer wall of the sampling needle 200 is first inserted into the spray hole 130, so that the needle tip 220 of the sampling needle is aligned with the liquid outlet 134 of the spray hole 130, and the sampling The part of the needle tip 220 can be cleaned by the cleaning liquid output from the spray hole 130 . In this way, the first spraying can directly wash the outer wall of the most polluted sampling needle tip 220 through the cleaning liquid output from the spray hole 130, and wash away most of the samples or reagents remaining on the outer wall of the sampling needle tip 220 to ensure Sufficient cleaning of the needle tip 220 of the sampling needle.

Then, the sampling needle 200 can be pushed to continue to move toward the outlet end 124 of the main channel 120, so that the parts to be cleaned on the outer wall of the sampling needle body 210 and the outer wall of the sampling needle tip 220 pass through the outlet 134 of the spray hole 130, thereby spraying the hole The cleaning liquid output by the outlet water at 130 can spray and clean the parts that need to be cleaned on the outer wall of the sampling needle body 210 and the outer wall of the sampling needle tip 220. Clean the samples or reagents, and further clean the outer wall of the sampling needle tip 220, so as to achieve the purpose of effectively cleaning the outer wall of the sampling needle tip 220 when the cleaning height range of the outer wall of the sampling needle 200 is large, reducing the Carryover probability of the sampling needle tip 220 .

It can be understood that when the sampling needle 200 is inserted into the cleaning pool 110 for cleaning, the cleaning device 100 for the sampling needle 200 is not limited to only cleaning the sampling needle 200 twice, and the outer wall of the sampling needle 200 can be cleaned according to actual needs. For example, when the outer wall to be cleaned by pushing the sampling needle body 210 and the outer wall of the sampling needle tip 220 pass through the spray hole 130 liquid outlet 134, the injection valve of the cleaning solution can be opened to clean the outer wall of the sampling needle 200. Cleaning, in the process of cleaning the outer wall of the sampling needle 200, the drain valve can be opened and closed multiple times, so that the cleaning fluid can be replaced multiple times, and the outer wall of the sampling needle can be cleaned multiple times, or the drain valve is always open, or the liquid injection valve Both the drain valve and the drain valve can be opened and closed multiple times, etc., to achieve the purpose of cleaning the outer wall of the sampling needle 200 clean.

In this embodiment, the cleaning pool 110 is further provided with a waste liquid channel 150 , and the output end of the tapered constricted channel 140 is connected to the waste liquid channel 150 . The waste liquid flow channel 150 can collect the waste liquid generated by cleaning the sampling needle 200, and perform waste liquid treatment in a unified manner. Of course, it is also possible to directly connect the output end of the tapered constricted channel 140 to the waste liquid discharge pipe to discharge the waste liquid, or to process the waste liquid in other ways.

In this embodiment, the cleaning device 100 of the sampling needle 200 further includes a negative pressure waste liquid system, and the negative pressure waste liquid system is connected to the waste liquid flow channel 150 . The pressure in the negative pressure waste liquid system is lower than normal pressure, such as a vacuum waste liquid system. By setting the negative pressure waste liquid system, the waste liquid flowing into the waste liquid flow channel 150 can be sucked clean in time. When cleaning the outer wall of the sampling needle 200, the inner wall of the sampling needle 200 can also be continuously cleaned at the same time, and the waste liquid generated by cleaning the inner wall of the sampling needle 200 can also be sucked away at the same time. During the whole process of cleaning the sampling needle 200, the negative pressure waste liquid system can always keep sucking the waste liquid in the cleaning pool 110, and discharge the waste liquid in time.

Since the sampling needle tip 220 is located in the tapered constricted flow channel 140 with the same shrinkage ratio as the sampling needle tip 220, after the spraying and flushing of the outer wall of the sampling needle 200 is completed, the vacuum formed between the sampling needle 200 and the cleaning pool 110 The flow path of the suction is actually close to uniform, so that the outer wall of the sampling needle tip 220 and the outer wall of the sampling needle body 210 maintain the same negative pressure suction speed, which further effectively reduces the hanging liquid of the sampling needle tip 220 and improves the accuracy of the test results .

It can be understood that the negative pressure waste liquid system may not be provided, or the waste liquid in the waste liquid flow channel 150 may be sucked clean by other means, which does not affect the purpose of cleaning the outer wall of the sampling needle 200 .

A sample analysis device includes the cleaning device 100 for a sampling needle described above. In the process of analyzing the samples, the sampling needle 200 needs to be cleaned. Since the outer wall of the sampling needle tip 220 and the outer wall of the sampling needle body 210 can be effectively cleaned, it is possible to avoid carryover between samples during the test. Contamination, at the same time, when the cleaning device 100 for the sampling needle is used for cleaning, it can effectively reduce the liquid hanging on the tip of the sampling needle and improve the accuracy of the sample analysis and test results.

Please refer to Figure 3, a cleaning method for a sampling needle, comprising the following steps:

Step S110 , inserting the sampling needle into the main channel so that the needle tip of the sampling needle is located at the liquid outlet of the spray hole, and the cleaning liquid output through the spray hole cleans the outer wall of the needle tip of the sampling needle. In this step, the cleaning liquid output from the spray hole directly cleans the outer wall of the needle tip with the most serious pollution on the outer wall of the sampling needle. At this time, the outer wall of the needle tip of the sampling needle is close to the spray hole, and the water sprayed from the spray hole directly rinses and samples at close range. The outer wall of the needle tip can wash away most of the samples or reagents remaining on the outer wall of the needle tip.

Step S120, pushing the sampling needle to move toward the outlet end of the main channel, so that the outer wall of the sampling needle body and the outer wall of the sampling needle tip to be cleaned pass through the liquid outlet of the spray hole, and the cleaning liquid output through the spray hole cleans the area of the sampling needle body. The outer wall to be cleaned and the outer wall of the needle tip of the sampling needle. In this step, the cleaning liquid output through the spray hole cleans the outer wall of the sampling needle body and the outer wall of the sampling needle, and washes away the sample or reagent left by the outer wall of the sampling needle body in contact with the protective film, and further Thoroughly clean the sample or reagent remaining on the outer wall of the needle tip of the sampling needle.

As shown by the arrow in Figure 1, in steps S110 and S120, during the process of pushing the sampling needle to move from the inlet end to the outlet end of the main channel, the moving direction of the sampling needle is generally perpendicular to the end surface of the main channel, that is, the sampling needle is The movement parallel to the axial direction of the main channel prevents the sampling needle from colliding with the wall of the main channel, and also improves the cleaning efficiency of the sampling needle.

It can be understood that when the outer wall of the sampling needle is cleaned by the above-mentioned cleaning method of the sampling needle, more than two cleanings can be performed, except that the outer wall of the needle tip of the sampling needle can be sprayed and rinsed close to the liquid outlet of the spray hole, and other residual samples or When the outer wall of the sampling needle body with a lot of reagents needs to be sprayed and rinsed at a short distance, a certain part of the sampling needle body can be directly close to the liquid outlet of the spray hole for sufficient cleaning.

In this embodiment, in step S120, that is, in the step of cleaning the outer wall of the sampling needle body and the outer wall of the sampling needle tip, the sampling needle tip is located in the tapered constricted flow channel, and the bottom of the sampling needle tip is in contact with the tapered The output end of the constricted runner is flush. In this way, when the needle tip of the sampling needle enters the tapered constricted flow channel, the contraction of the conical constricted flow channel compensates for the impact of the sudden expansion of the actual cleaning flow channel at the needle tip due to the shrinkage of the outer dimension of the needle tip of the sampling needle, which can be effectively reduced. The liquid on the tip of the needle improves the accuracy of the test results.

Of course, when cleaning the outer wall of the sampling needle, a step of washing the inner wall of the sampling needle may also be included, thereby saving time and cost.

In this embodiment, the waste liquid generated by cleaning the sampling needle is collected through the waste liquid flow channel. While cleaning the sampling needle, the waste liquid generated by cleaning the outer wall of the sampling needle and cleaning the inner wall of the sampling needle can directly flow into the waste liquid flow channel for uniform waste liquid treatment.

In this embodiment, the waste liquid collected in the waste liquid channel is sucked through the negative pressure waste liquid system. During the whole process of cleaning the sampling needle, the negative pressure waste liquid system can always maintain the suction of the waste liquid in the cleaning pool, and suck the waste liquid in time.

It can be understood that if the waste liquid flow channel and the negative pressure waste liquid system are not provided, it will not affect the purpose of cleaning the outer wall of the sampling needle tip when the cleaning range of the outer wall of the sampling needle is relatively large.

The cleaning method of the sampling needle mentioned above is to spray and clean the outer wall of the sampling needle more than twice. When the cleaning height range of the outer wall of the sampling needle is large, the outer wall of the sampling needle tip can be effectively cleaned, reducing the probability of carryover contamination of the sampling needle tip.

The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (13)

1. the cleaning device of a sampling needle, it is characterized in that, comprise service sink, described service sink offers the sprue that can insert for sampling needle and the spray apertures that is provided with liquid outlet, and described liquid outlet is communicated in described sprue for cleaning through the sampling needle needle point outer wall at spray apertures liquid outlet place and the outer wall of the required cleaning of sampling needle body.

2. the cleaning device of sampling needle according to claim 1, it is characterized in that, described sprue is bar shape sprue, described service sink also offers taper contracted channel, described taper contracted channel is located at the described sprue port of export, and described taper contracted channel is less than other end port area away from one end port area of the described sprue port of export.

3. the cleaning device of sampling needle according to claim 2, is characterized in that, described taper contracted channel is the taper contracted channel identical with sampling needle needle point shrinkage rates.

4. according to the cleaning device of the sampling needle described in claims 1 to 3 any one, it is characterized in that, described spray apertures is the ring-type spray apertures that liquid outlet arranges around described sprue.

5. the cleaning device of sampling needle according to claim 4, is characterized in that, described spray apertures and described sprue are not parallel to each other, and described spray apertures comprises inlet, and described inlet is higher than described liquid outlet.

6. according to the cleaning device of the sampling needle described in claims 1 to 3 any one, it is characterized in that, described service sink also offers waste liquid runner, and described taper contracted channel output is communicated in described waste liquid runner.

7. the cleaning device of sampling needle according to claim 6, is characterized in that, also comprises negative pressure liquid waste system, and described negative pressure liquid waste system is connected with described waste liquid runner.

8. a cleaning method for sampling needle, is characterized in that, comprises the following steps:

Sampling needle is inserted to sprue, make sampling needle needle point be positioned at spray apertures liquid outlet place, the cleaning fluid of exporting by spray apertures cleans sampling needle needle point outer wall;

Promoting sampling needle moves to the sprue port of export, make outer wall and the sampling needle needle point outer wall of the required cleaning of sampling needle body all pass through spray apertures liquid outlet place, the cleaning fluid of exporting by spray apertures cleans outer wall and the sampling needle needle point outer wall of the required cleaning of sampling needle body.

9. the cleaning method of sampling needle according to claim 8, it is characterized in that, in the outer wall of the required cleaning of described cleaning sampling needle body and the step of sampling needle needle point outer wall, sampling needle needle point is arranged in taper contracted channel, and sampling needle needle point bottom is concordant with taper contracted channel output.

10. the cleaning method of sampling needle according to claim 8, is characterized in that, also comprises the step of simultaneously cleaning sampling needle inwall.

The cleaning method of the sampling needle described in 11. according to Claim 8 to 10 any one, is characterized in that, is collected and is cleaned the waste liquid that sampling needle produces by waste liquid runner.

The cleaning method of 12. sampling needles according to claim 11, is characterized in that, by the collected waste liquid of negative pressure liquid waste system suction waste liquid runner.

13. 1 kinds of device for analyzing samples, is characterized in that, comprise the cleaning device of the sampling needle as described in claim 1 to 7 any one.