[go: up one dir, main page]

CL2018002467A1 - El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint - Google Patents

El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint

Info

Publication number
CL2018002467A1
CL2018002467A1 CL2018002467A CL2018002467A CL2018002467A1 CL 2018002467 A1 CL2018002467 A1 CL 2018002467A1 CL 2018002467 A CL2018002467 A CL 2018002467A CL 2018002467 A CL2018002467 A CL 2018002467A CL 2018002467 A1 CL2018002467 A1 CL 2018002467A1
Authority
CL
Chile
Prior art keywords
potentiate
glucocorticoid receptor
receptor modulators
checkpoint inhibitors
checkpoint inhibitor
Prior art date
Application number
CL2018002467A
Other languages
English (en)
Inventor
Hazel Hunt
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of CL2018002467A1 publication Critical patent/CL2018002467A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN PROPORCIONA UN MÉTODO QUE COMBINA UN INHIBIDOR DE CHECKPOINT Y UN MODULADOR DEL RECEPTOR DE GLUCOCORTICOIDES PARA TRATAR CÁNCER, POR EJEMPLO, UN CÁNCER SENSIBLE A UN INHIBIDOR DE CHECKPOINT.
CL2018002467A 2016-03-01 2018-08-29 El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint CL2018002467A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662302106P 2016-03-01 2016-03-01
US201662320276P 2016-04-08 2016-04-08

Publications (1)

Publication Number Publication Date
CL2018002467A1 true CL2018002467A1 (es) 2018-11-23

Family

ID=59744340

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018002467A CL2018002467A1 (es) 2016-03-01 2018-08-29 El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint

Country Status (14)

Country Link
US (3) US10980797B2 (es)
EP (1) EP3423453A4 (es)
JP (4) JP6847120B2 (es)
KR (1) KR102845317B1 (es)
CN (1) CN109071537B (es)
AU (1) AU2017228329B2 (es)
CA (1) CA3015218A1 (es)
CL (1) CL2018002467A1 (es)
IL (2) IL297201A (es)
MX (1) MX390517B (es)
PH (1) PH12018501848B1 (es)
SG (1) SG11201807421TA (es)
WO (1) WO2017151613A1 (es)
ZA (1) ZA201805787B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684612B2 (en) 2019-02-22 2023-06-27 Corcept Therapeutics Incorporated Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
US12433882B2 (en) 2022-10-28 2025-10-07 Corcept Therapeutics Incorporated Treatments for amyotrophic lateral sclerosis using dazucorilant

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US10980797B2 (en) 2016-03-01 2021-04-20 Corcept Therapeutics Incorporated Use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
US9943505B2 (en) * 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer
MX2019011543A (es) 2017-03-31 2019-12-16 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical.
ES3043682T3 (en) 2017-06-20 2025-11-25 Corcept Therapeutics Inc Treatment of neuroepithelial tumors using selective glucocorticoid receptor modulators
KR102294721B1 (ko) 2018-09-28 2021-08-31 경북대학교 산학협력단 티아민 유도체를 포함하는 고코르티솔증 예방 또는 치료용 조성물
MX2021005438A (es) * 2018-11-09 2021-06-15 Corcept Therapeutics Inc Metodos para reducir el tama?o de tumores hipofisarios.
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
MX2021007322A (es) 2018-12-19 2021-07-07 Corcept Therapeutics Inc Formulaciones farmaceuticas que contienen relacorilant, un compuesto de azadecalina fusionado con heteroaril-cetona.
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
KR102845522B1 (ko) * 2019-10-16 2025-08-12 코어셉트 쎄라퓨틱스 인코포레이티드 선택적 글루코코르티코이드 수용체 길항제로 암 환자의 호중구 대 림프구 비율을 정상화시키는 방법
BR112022015011A2 (pt) * 2020-01-29 2022-09-20 Corcept Therapeutics Inc Método para tratar um sujeito que sofre de tumor de carcinoma adrenocortical e tendo excesso de cortisol, e, composição farmacêutica para tratar carcinoma adrenocortical
NZ791259A (en) * 2020-02-10 2025-09-26 Corcept Therapeutics Inc Methods of stimulating an anti-tumor response using a selective glucocorticoid receptor modulator
WO2021242916A1 (en) * 2020-05-27 2021-12-02 Corcept Therapeutics Incorporated Concomitant administration of glucocorticoid receptor modulator relacorilant and cyp2c9 substrates
EP4157275A4 (en) * 2020-05-27 2024-06-05 Corcept Therapeutics Incorporated Concomitant administration of glucocorticoid receptor modulator relacorilant and cyp2c8 substrates
WO2022134033A1 (en) * 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CN118891062A (zh) * 2021-12-03 2024-11-01 得克萨斯大学体系董事会 用米非司酮阻断糖皮质激素受体使胰腺癌对免疫疗法敏感
AU2023355849A1 (en) 2022-10-06 2025-04-03 Corcept Therapeutics Incorporated Formulations of glucocorticoid receptor modulators

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1761497E (pt) 2004-01-09 2008-09-25 Corcept Therapeutics Inc Azadecalinas moduladoras do receptor de glucocorticóides
ATE407934T1 (de) 2004-03-09 2008-09-15 Corcept Therapeutics Inc Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren
DK2429529T3 (en) 2009-05-12 2015-03-09 Corcept Therapeutics Inc The solid forms and process for preparing
US8710035B2 (en) 2010-03-24 2014-04-29 The University Of Chicago Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
KR20140015472A (ko) 2011-03-15 2014-02-06 애브비 인코포레이티드 핵 호르몬 수용체 조절제
WO2013039916A1 (en) * 2011-09-12 2013-03-21 The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Compositions for and methods of treatment and enhanced detection of non-pituitary tumors
RU2672874C2 (ru) * 2011-10-04 2018-11-20 Инвайвис Фармасьютикалз Инк. Способы и системы для выявления и лечения опухолей, восприимчивых к антипрогестинам
US20150118244A1 (en) 2012-05-10 2015-04-30 Bristol-Myers Squibb Company Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
EP4434584A3 (en) 2012-05-25 2024-11-20 Corcept Therapeutics Incorporated Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
RS57520B1 (sr) * 2012-09-07 2018-10-31 Regeneron Pharma Postupci za lečenje atopijskog dermatitisa primenom antagonista il-4r
TWI697334B (zh) * 2013-06-04 2020-07-01 美商再生元醫藥公司 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
CN105848680A (zh) 2013-10-25 2016-08-10 药品循环有限责任公司 使用布鲁顿酪氨酸激酶抑制剂和免疫疗法的治疗
WO2015070060A1 (en) * 2013-11-11 2015-05-14 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2015077414A1 (en) 2013-11-20 2015-05-28 Dana-Farber Cancer Institute, Inc. Kynurenine pathway biomarkers predictive of anti-immune checkpoint inhibitor response
DK3848027T3 (da) 2013-11-25 2023-05-01 Corcept Therapeutics Inc Octahydro-kondenserede azadecalinglucocorticoidreceptormodulatorer
AU2014368898B2 (en) * 2013-12-20 2020-06-11 Dana-Farber Cancer Institute, Inc. Combination therapy with neoantigen vaccine
ES2698998T3 (es) * 2013-12-24 2019-02-06 Bristol Myers Squibb Co Compuestos tricíclicos como agentes antineoplásicos
EP3149481B1 (en) 2014-05-30 2019-01-09 Ventana Medical Systems, Inc. Multiplex assay for improved scoring of tumor tissues stained for pd-l1
MX2021001096A (es) 2015-01-30 2023-01-17 Oncoceutics Inc 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia.
US20180064679A1 (en) * 2015-03-05 2018-03-08 Abraxis Bioscience, Llc Method for treating cancer based on level of glucocorticoid receptor
US10980797B2 (en) 2016-03-01 2021-04-20 Corcept Therapeutics Incorporated Use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
CA3060416A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684612B2 (en) 2019-02-22 2023-06-27 Corcept Therapeutics Incorporated Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
US12097192B2 (en) 2019-02-22 2024-09-24 Corcept Therapeutics Incorpoarted Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
US12433882B2 (en) 2022-10-28 2025-10-07 Corcept Therapeutics Incorporated Treatments for amyotrophic lateral sclerosis using dazucorilant

Also Published As

Publication number Publication date
ZA201805787B (en) 2020-05-27
PH12018501848B1 (en) 2024-02-23
US20190083486A1 (en) 2019-03-21
US10980797B2 (en) 2021-04-20
EP3423453A1 (en) 2019-01-09
AU2017228329B2 (en) 2021-03-11
IL261502B2 (en) 2023-03-01
KR102845317B1 (ko) 2025-08-13
AU2017228329A1 (en) 2018-09-06
US20250073224A1 (en) 2025-03-06
JP2023060061A (ja) 2023-04-27
SG11201807421TA (en) 2018-09-27
NZ745540A (en) 2025-03-28
EP3423453A4 (en) 2019-11-06
IL297201A (en) 2022-12-01
JP2025028214A (ja) 2025-02-28
WO2017151613A1 (en) 2017-09-08
IL261502A (en) 2018-10-31
PH12018501848A1 (en) 2019-01-28
CA3015218A1 (en) 2017-09-08
US12171760B2 (en) 2024-12-24
US20210205294A1 (en) 2021-07-08
KR20180116372A (ko) 2018-10-24
CN109071537B (zh) 2024-07-05
IL261502B (en) 2022-11-01
MX390517B (es) 2025-03-20
JP2019023228A (ja) 2019-02-14
JP6847120B2 (ja) 2021-03-24
JP2019507159A (ja) 2019-03-14
BR112018067330A2 (pt) 2019-01-22
MX2018010564A (es) 2018-11-09
CN109071537A (zh) 2018-12-21

Similar Documents

Publication Publication Date Title
CL2018002467A1 (es) El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint
CL2019002314A1 (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr).
MX2023004593A (es) Inhibidores de tirosina cinasa 2 (tyk2) y usos de los mismos.
MX2018013593A (es) Terapias combinadas de inhibidores de hdac e inhibidores de pd-l1.
CL2019002108A1 (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr).
CO2019001212A2 (es) Composiciones y métodos de inhibición del masp-3 para el tratamiento de diversas enfermedades y trastornos
CL2019002112A1 (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr).
CO2018013298A2 (es) Anticuerpos anti-gitr y sus usos.
MX381046B (es) Anticuerpos anti-csf1r e inhibidores de pd-1/pd-l1, y usos de los mismos para el tratamiento de cáncer remisión a las solicitudes relacionadas.
CR20150664A (es) Moduladores de los receptores de estrógeno y sus usos
CL2018000687A1 (es) Nuevos compuestos bicíclicos como inhibidores de atx.
BR112018013995A2 (pt) terapia de combinação de vírus oncolítico e inibidor de ponto de verificação
MX2018005528A (es) Inhibidores de ret.
ECSP17023281A (es) Inhibidores de mk2 y sus usos
MX2017005555A (es) Inhibidores del bromodominio.
CL2016000400A1 (es) Moduladores del receptor p2x3 y p2x2/3 de diaminopiridina para el tratamiento de la tos aguda, sub-aguda o crónica.
CL2015003200A1 (es) Potenciador de inhibidores del homólogo de zeste
CR20160500A (es) Anticuerpos anti-ox40 y métodos de uso
BR112017024555A2 (pt) moduladores de ccr2
MX2017016041A (es) Metodos para usar activadores de piruvato cinasa.
CL2018001252A1 (es) Métodos para tratar esclerosis múltiple usando compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton
BR112019004123A2 (pt) sistemas e métodos para atuar dispositivos hidraulicamente atuados
CL2015002113A1 (es) Compuestos de azetidinloxifenilpirrolidina
CO2017002356A2 (es) Métodos para tratar la depresión usando moduladores de nmda
MX2017014128A (es) 2-tiopirimidinonas.