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CL2018000596A1 - Nuevos compuestos bicíclicos como inhibidores de la atx - Google Patents

Nuevos compuestos bicíclicos como inhibidores de la atx

Info

Publication number
CL2018000596A1
CL2018000596A1 CL2018000596A CL2018000596A CL2018000596A1 CL 2018000596 A1 CL2018000596 A1 CL 2018000596A1 CL 2018000596 A CL2018000596 A CL 2018000596A CL 2018000596 A CL2018000596 A CL 2018000596A CL 2018000596 A1 CL2018000596 A1 CL 2018000596A1
Authority
CL
Chile
Prior art keywords
bicyclic compounds
new bicyclic
atx inhibitors
atx
compounds
Prior art date
Application number
CL2018000596A
Other languages
English (en)
Inventor
Jérôme Hert
Daniel Hunziker
Patrizio Mattei
Markus Rudolph
Giorgio Patrick Di
Petra Schmitz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2018000596A1 publication Critical patent/CL2018000596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS BICICLICOS, INHIBIDORES DE LA AUTOTAXINA (ATX); COMPOSICION FARMACEUTICA QUE LOSCOMPRENDE; PROCESO DE OBTENCION DE DICHOS COMPUESTOS; METODO DE TRATAMIENTO O DE PROFILAXIS DE ESTADOS PATOLOGICOS OCULARES; Y USO PARA EL TRATAMIENTO O PROFILAXIS DE ESTADOS PATOLOGICOS OCULARES.
CL2018000596A 2015-09-24 2018-03-07 Nuevos compuestos bicíclicos como inhibidores de la atx CL2018000596A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186645 2015-09-24

Publications (1)

Publication Number Publication Date
CL2018000596A1 true CL2018000596A1 (es) 2018-08-03

Family

ID=54199041

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018000596A CL2018000596A1 (es) 2015-09-24 2018-03-07 Nuevos compuestos bicíclicos como inhibidores de la atx

Country Status (19)

Country Link
US (2) US20180208602A1 (es)
EP (1) EP3353180B1 (es)
JP (1) JP6846414B2 (es)
KR (1) KR20180054830A (es)
CN (2) CN115124538A (es)
AR (1) AR106101A1 (es)
AU (1) AU2016328535A1 (es)
BR (1) BR112018006024A2 (es)
CA (1) CA2983782A1 (es)
CL (1) CL2018000596A1 (es)
CO (1) CO2017011151A2 (es)
IL (1) IL255570A (es)
MA (1) MA42918A (es)
MX (1) MX2018002217A (es)
PE (1) PE20180461A1 (es)
PH (1) PH12018500408A1 (es)
RU (1) RU2018114289A (es)
TW (1) TW201720824A (es)
WO (1) WO2017050732A1 (es)

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RU2725138C2 (ru) 2015-09-24 2020-06-30 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca)
KR20180054635A (ko) * 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서 이환형 화합물
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JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物
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JOP20190284A1 (ar) 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
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CN116806150A (zh) 2021-01-05 2023-09-26 载度思生命科学有限公司 新的自分泌运动因子抑制剂

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MA42918A (fr) 2018-08-01
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