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CL2018000263A1 - Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3. - Google Patents

Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3.

Info

Publication number
CL2018000263A1
CL2018000263A1 CL2018000263A CL2018000263A CL2018000263A1 CL 2018000263 A1 CL2018000263 A1 CL 2018000263A1 CL 2018000263 A CL2018000263 A CL 2018000263A CL 2018000263 A CL2018000263 A CL 2018000263A CL 2018000263 A1 CL2018000263 A1 CL 2018000263A1
Authority
CL
Chile
Prior art keywords
egfrviii
antibody construction
bind
polinucleotide
bispecific antibody
Prior art date
Application number
CL2018000263A
Other languages
English (en)
Inventor
Tobias Raum
Peter Kufer
Doris Rau
Markus Muenz
Ines Herrmann
Patrick Hoffmann
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of CL2018000263A1 publication Critical patent/CL2018000263A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LLA PRESENTE INVENCIÓN SE REFIERE A UN CONSTRUCTO DE ANTICUERPO BIESPECÍFICO QUE COMPRENDE UN PRIMER DOMINIO DE UNIÓN QUE SE UNE A EGFRVIII HUMANO EN LA SUPERFICIE DE UNA CÉLULA DIANA Y UN SEGUNDO DOMINIO DE UNIÓN QUE SE UNE A CD3 HUMANO EN LA SUPERFICIE DE UNA CÉLULA T. ADEMÁS, LA INVENCIÓN PROVEE UN POLINUCLEÓTIDO QUE CODIFICA EL CONSTRUCTO DE ANTICUERPO, UN VECTOR QUE COMPRENDE DICHO POLINUCLEÓTIDO Y UNA CÉLULA HOSPEDANTE TRANSFORMADA O TRANSFECTADA CON DICHO POLINUCLEÓTIDO O VECTOR. ADICIONALMENTE, LA INVENCIÓN PROVEE UN PROCEDIMIENTO PARA LA PRODUCCIÓN DEL CONSTRUCTO DE ANTICUERPO DE LA INVENCIÓN, UN USO MÉDICO DE DICHO CONSTRUCTO DE ANTICUERPO Y UN KIT QUE COMPRENDE DICHO CONSTRUCTO DE ANTICUERPO.
CL2018000263A 2015-07-31 2018-01-30 Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3. CL2018000263A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199945P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03

Publications (1)

Publication Number Publication Date
CL2018000263A1 true CL2018000263A1 (es) 2018-10-05

Family

ID=56800255

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018000263A CL2018000263A1 (es) 2015-07-31 2018-01-30 Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3.

Country Status (30)

Country Link
US (3) US10519241B2 (es)
EP (2) EP3912999A1 (es)
JP (1) JP6986008B2 (es)
KR (1) KR102735615B1 (es)
CN (1) CN107922495B (es)
AU (2) AU2016302683B2 (es)
CA (1) CA2991278C (es)
CL (1) CL2018000263A1 (es)
CO (1) CO2018000887A2 (es)
CR (1) CR20180065A (es)
CY (1) CY1124384T1 (es)
DK (1) DK3328892T3 (es)
ES (1) ES2876348T3 (es)
HU (1) HUE054384T2 (es)
IL (1) IL256872B2 (es)
JO (1) JO3788B1 (es)
LT (1) LT3328892T (es)
MX (1) MX2018001161A (es)
MY (1) MY185953A (es)
PE (1) PE20181013A1 (es)
PH (1) PH12018500156B1 (es)
PL (1) PL3328892T3 (es)
PT (1) PT3328892T (es)
SG (1) SG10202109625YA (es)
SI (1) SI3328892T1 (es)
TN (1) TN2017000548A1 (es)
TW (1) TWI744242B (es)
UA (1) UA124417C2 (es)
WO (1) WO2017021370A1 (es)
ZA (1) ZA201708306B (es)

Cited By (5)

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US11434302B2 (en) 2016-02-03 2022-09-06 Amgen Research (Munich) Gmbh Bispecific T cell engaging antibody constructs
US11447567B2 (en) 2015-07-31 2022-09-20 Amgen Research (Munich) Gmbh Antibody constructs for FLT3 and CD3
US11672858B2 (en) 2018-12-21 2023-06-13 Hoffmann-La Roche Inc. Bispecific antibody molecules binding to CD3 and TYRP-1
US11884720B2 (en) 2015-07-31 2024-01-30 Amgen Research (Munich) Gmbh Antibody constructs for MSLN and CD3
US12428491B2 (en) 2016-02-03 2025-09-30 Amgen Research (Munich) Gmbh PSMA and CD3 bispecific T cell engaging antibody constructs

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KR101837053B1 (ko) * 2008-10-01 2018-03-12 암젠 리서치 (뮌헨) 게엠베하 종간 특이적 ＰＳＣＡｘＣＤ３, ＣＤ19ｘＣＤ3, ｃ-ＭＥＴｘＣＤ3, 엔도시알린ｘＣＤ3, ＥｐＣＡＭｘＣＤ3, ＩＧＦ-1ＲｘＣＤ3 또는 ＦＡＰαｘＣＤ3 이중특이적 단일쇄 항체
AU2009299794B2 (en) 2008-10-01 2015-08-13 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
JO3519B1 (ar) 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
AR101936A1 (es) 2014-07-31 2017-01-25 Amgen Res Munich Gmbh Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
TWI793062B (zh) * 2015-07-31 2023-02-21 德商安美基研究（慕尼黑）公司 Ｄｌｌ３及ｃｄ３抗體構築體
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AU2019247830B2 (en) * 2018-04-06 2026-02-19 The Regents Of The University Of California Trans-antigen targeting in heterogeneous cancers and methods of use thereof
UY38326A (es) * 2018-08-03 2020-01-31 Amgen Inc Constructos de anticuerpos para cldn18.2 y cd3
MY207205A (en) * 2018-12-07 2025-02-06 Shanghai hengrui pharmaceutical co ltd Cd3 antibody and pharmaceutical use thereof
JP7090780B2 (ja) * 2018-12-21 2022-06-24 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｃｄ３に結合する抗体
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EP4055061A4 (en) * 2019-11-07 2023-12-20 Amgen Inc. Dosage regimen for anti-egfrviii agents
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
AU2021340708A1 (en) * 2020-09-11 2023-04-13 Amgen Inc. Materials and methods to reduce protein aggregation
JP2023550148A (ja) 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法
AU2022365116A1 (en) * 2021-10-15 2024-05-02 Amgen Inc. Activatable polypeptide complex
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TWI790206B (zh) 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
TWI781108B (zh) 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
HUE063020T2 (hu) 2016-09-23 2023-12-28 Regeneron Pharma Bispecifikus anti-MUC16-CD3 antitestek és anti-MUC16 gyógyszerkonjugátumok
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US11447567B2 (en) 2015-07-31 2022-09-20 Amgen Research (Munich) Gmbh Antibody constructs for FLT3 and CD3
US11884720B2 (en) 2015-07-31 2024-01-30 Amgen Research (Munich) Gmbh Antibody constructs for MSLN and CD3
US11434302B2 (en) 2016-02-03 2022-09-06 Amgen Research (Munich) Gmbh Bispecific T cell engaging antibody constructs
US12428491B2 (en) 2016-02-03 2025-09-30 Amgen Research (Munich) Gmbh PSMA and CD3 bispecific T cell engaging antibody constructs
US11672858B2 (en) 2018-12-21 2023-06-13 Hoffmann-La Roche Inc. Bispecific antibody molecules binding to CD3 and TYRP-1
US12473373B2 (en) 2018-12-21 2025-11-18 Hoffmann-La Roche Inc. Bispecific antibody molecules binding to CD3 and EGFRvIII

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