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CL2016002105A1 - Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3. - Google Patents

Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3.

Info

Publication number
CL2016002105A1
CL2016002105A1 CL2016002105A CL2016002105A CL2016002105A1 CL 2016002105 A1 CL2016002105 A1 CL 2016002105A1 CL 2016002105 A CL2016002105 A CL 2016002105A CL 2016002105 A CL2016002105 A CL 2016002105A CL 2016002105 A1 CL2016002105 A1 CL 2016002105A1
Authority
CL
Chile
Prior art keywords
sample
dll3
melanoma
patient
ligand
Prior art date
Application number
CL2016002105A
Other languages
English (en)
Inventor
Laura Saunders
Samuel Williams
Kathryn Loving
Original Assignee
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Stemcentrx Llc filed Critical Abbvie Stemcentrx Llc
Publication of CL2016002105A1 publication Critical patent/CL2016002105A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Abstract

Se describe un método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende las etapas de: (a) detectar el nivel de expresión de un ligando similar a Delta 3 (DLL3) en una muestra biológica obtenida del paciente que tiene melanoma, donde la detección comprende poner en contacto la muestra biológica con un anticuerpo anti-DLL3 que comprende tres regiones de complementariedad (CDR) de una secuencia de aminoácidos de la región variable de cadena ligera de SEC ID Nº 173 y tres CDR de una secuencia de aminoácidos de la región variable de cadena pesada de la SEC ID Nº 175.
CL2016002105A 2014-02-21 2016-08-19 Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3. CL2016002105A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461942796P 2014-02-21 2014-02-21

Publications (1)

Publication Number Publication Date
CL2016002105A1 true CL2016002105A1 (es) 2017-03-31

Family

ID=53879125

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2016002105A CL2016002105A1 (es) 2014-02-21 2016-08-19 Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3.
CL2018001646A CL2018001646A1 (es) 2014-02-21 2018-06-18 Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma. (divisional solicitud 201602105)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2018001646A CL2018001646A1 (es) 2014-02-21 2018-06-18 Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma. (divisional solicitud 201602105)

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Country Link
US (1) US10308721B2 (es)
EP (1) EP3107576A4 (es)
JP (1) JP2017514143A (es)
KR (1) KR20170008202A (es)
CN (1) CN106550593A (es)
AU (1) AU2015218633A1 (es)
BR (1) BR112016018891A2 (es)
CA (1) CA2939941A1 (es)
CL (2) CL2016002105A1 (es)
CR (1) CR20160437A (es)
DO (1) DOP2016000214A (es)
EA (1) EA201691683A1 (es)
EC (1) ECSP16075472A (es)
GT (1) GT201600168A (es)
IL (1) IL247248A0 (es)
MX (1) MX2016010677A (es)
PE (1) PE20161209A1 (es)
PH (1) PH12016501618A1 (es)
SG (1) SG11201606898TA (es)
WO (1) WO2015127407A1 (es)

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WO2015127407A1 (en) 2015-08-27
MX2016010677A (es) 2017-04-10
DOP2016000214A (es) 2016-11-30
CR20160437A (es) 2017-02-20
AU2015218633A1 (en) 2016-09-01
JP2017514143A (ja) 2017-06-01
BR112016018891A2 (pt) 2017-10-10
PE20161209A1 (es) 2016-11-10
SG11201606898TA (en) 2016-09-29
CL2018001646A1 (es) 2018-10-05
KR20170008202A (ko) 2017-01-23
US10308721B2 (en) 2019-06-04
US20170137533A1 (en) 2017-05-18
EP3107576A1 (en) 2016-12-28
EP3107576A4 (en) 2017-09-06
IL247248A0 (en) 2016-09-29
GT201600168A (es) 2018-12-20
ECSP16075472A (es) 2017-03-31
PH12016501618A1 (en) 2017-02-06
EA201691683A1 (ru) 2017-04-28
CA2939941A1 (en) 2015-08-27

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