CL2015002279A1 - Amidas heterocíclicas como inhibidores de cinasas - Google Patents
Amidas heterocíclicas como inhibidores de cinasasInfo
- Publication number
- CL2015002279A1 CL2015002279A1 CL2015002279A CL2015002279A CL2015002279A1 CL 2015002279 A1 CL2015002279 A1 CL 2015002279A1 CL 2015002279 A CL2015002279 A CL 2015002279A CL 2015002279 A CL2015002279 A CL 2015002279A CL 2015002279 A1 CL2015002279 A1 CL 2015002279A1
- Authority
- CL
- Chile
- Prior art keywords
- kinase inhibitors
- heterocyclic amides
- disorder
- treat
- disease
- Prior art date
Links
- -1 Heterocyclic amides Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
Abstract
COMPUESTOS DERIVADOS DE AMIDAS HETEROCICLICAS, INHIBIDORES DE CINASA RIPI; COPOSICION FARMACEUTICA; METODO PARA TRATAR UNA ENFERMEDAD O TRASTORNO; USO PARA TRATAR UNA ENFERMEDAD O TRASTORNO SELECONADO DE COLITIS ULCEROSA, PSORIASIS, NEFRITIS PIGMENTARIA, PANCREATITIS, ARTRITIS REUMATOIDEA, GOTA, HEPATITIS AUTOINMUNE, ENTRE OTROS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361765664P | 2013-02-15 | 2013-02-15 | |
| US201361790044P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015002279A1 true CL2015002279A1 (es) | 2016-07-08 |
Family
ID=50151350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015002279A CL2015002279A1 (es) | 2013-02-15 | 2015-08-14 | Amidas heterocíclicas como inhibidores de cinasas |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US9556152B2 (es) |
| EP (4) | EP3375780B1 (es) |
| JP (3) | JP6321045B2 (es) |
| KR (2) | KR102228764B1 (es) |
| CN (3) | CN106928203B (es) |
| AU (1) | AU2014217453B2 (es) |
| BR (4) | BR122017002946A2 (es) |
| CA (1) | CA2900695C (es) |
| CL (1) | CL2015002279A1 (es) |
| CR (3) | CR20190511A (es) |
| CY (2) | CY1120320T1 (es) |
| DK (2) | DK2956452T3 (es) |
| DO (3) | DOP2015000196A (es) |
| EA (2) | EA028991B1 (es) |
| ES (3) | ES2672530T3 (es) |
| HR (2) | HRP20180900T1 (es) |
| HU (2) | HUE053215T2 (es) |
| IL (3) | IL240280B (es) |
| LT (2) | LT2956452T (es) |
| MA (1) | MA44820B1 (es) |
| MX (3) | MX360715B (es) |
| MY (2) | MY178552A (es) |
| NZ (1) | NZ628447A (es) |
| PE (1) | PE20151752A1 (es) |
| PH (4) | PH12015501675A1 (es) |
| PL (2) | PL2956452T3 (es) |
| PT (2) | PT2956452T (es) |
| RS (2) | RS61439B1 (es) |
| SG (1) | SG11201505796TA (es) |
| SI (2) | SI3342771T1 (es) |
| SM (2) | SMT202100083T1 (es) |
| TR (1) | TR201808112T4 (es) |
| TW (4) | TWI638815B (es) |
| UA (1) | UA118259C2 (es) |
| UY (1) | UY35330A (es) |
| WO (1) | WO2014125444A1 (es) |
| ZA (1) | ZA201505267B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12281101B2 (en) | 2015-07-02 | 2025-04-22 | Genentech, Inc. | Bicyclic lactams and methods of use thereof |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI638815B (zh) | 2013-02-15 | 2018-10-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類(一) |
| US20170266199A1 (en) * | 2014-08-21 | 2017-09-21 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
| EP3218371B1 (en) * | 2014-11-14 | 2018-09-26 | Boehringer Ingelheim International GmbH | Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (sstr4) agonists |
| JP2017538712A (ja) | 2014-12-11 | 2017-12-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細胞壊死の抑制剤及びそれに関連する方法 |
| KR20170117472A (ko) * | 2015-02-13 | 2017-10-23 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | (S)-5-벤질-N-(5-메틸-4-옥소-2,3,4,5-테트라히드로벤조[b][1,4]옥사제핀-3-일)-4H-1,2,4-트리아졸-3-카르복사미드의 결정질 형태 |
| ES2720577T3 (es) * | 2015-03-02 | 2019-07-23 | Apeiron Biologics Ag | Derivados bicíclicos de tetrahidrotiazepina útiles para el tratamiento de enfermedades neoplásicas y/o infecciosas |
| TWI730959B (zh) | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
| CN107922348A (zh) * | 2015-06-22 | 2018-04-17 | 大日本住友制药株式会社 | 双环杂环酰胺衍生物 |
| KR102667914B1 (ko) | 2015-07-22 | 2024-05-21 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 저해제로서의 벤조다이아제핀 유도체 |
| CA3002542C (en) * | 2015-10-23 | 2023-11-28 | Takeda Pharmaceutical Company Limited | Substituted azepin heterocyclic derivatives and compositions thereof useful as rip1 kinase inhibitor |
| US10709692B2 (en) * | 2015-12-04 | 2020-07-14 | Denali Therapeutics Inc. | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) |
| WO2017109724A1 (en) | 2015-12-21 | 2017-06-29 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| CN108699077B (zh) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | 作为rsv抑制剂的杂环化合物 |
| KR102808827B1 (ko) | 2016-02-05 | 2025-05-19 | 데날리 테라퓨틱스 인크. | 수용체-상호작용 단백질 키나제 1의 억제제 |
| WO2017146128A1 (ja) | 2016-02-26 | 2017-08-31 | 大日本住友製薬株式会社 | イミダゾリルアミド誘導体 |
| WO2018007973A2 (en) | 2016-07-06 | 2018-01-11 | Glaxosmithkline Intellectual Property Development Limited | Process and intermediates for preparing benzoxazepines |
| EP3526219B1 (en) * | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclic pyridone lactams and methods of use thereof |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| TW201831464A (zh) | 2016-11-18 | 2018-09-01 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
| JP6890179B2 (ja) | 2016-12-02 | 2021-06-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二環式アミド化合物及びその使用方法 |
| DK3552017T3 (da) | 2016-12-09 | 2022-05-16 | Denali Therapeutics Inc | Forbindelser, der er anvendelige som ripk1-inhibitorer |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| EP3560494A4 (en) | 2016-12-20 | 2020-08-05 | Sumitomo Dainippon Pharma Co., Ltd. | MEDICINAL PRODUCT TARGETING A CARCINOUS STEM CELL |
| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| NZ756805A (en) | 2017-02-16 | 2025-10-31 | Enanta Pharm Inc | Processes for the preparation of benzodiazepine derivatives |
| US20200062735A1 (en) * | 2017-02-27 | 2020-02-27 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| JOP20190233A1 (ar) * | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
| WO2018192416A1 (en) * | 2017-04-17 | 2018-10-25 | National Institute Of Biological Sciences, Beijing | Treating Male Senescence |
| MY200328A (en) * | 2017-05-17 | 2023-12-20 | Denali Therapeutics Inc | Kinase inhibitors and uses thereof |
| US10752598B2 (en) | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| CA3067944C (en) * | 2017-07-14 | 2023-03-14 | F. Hoffmann-La Roche Ag | Bicyclic ketone compounds and methods of use thereof |
| IL272941B2 (en) | 2017-08-28 | 2023-03-01 | Enanta Pharm Inc | Antiviral agents for viral hepatitis b |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| JP7362600B2 (ja) | 2017-10-11 | 2023-10-17 | エフ. ホフマン-ラ ロシュ アーゲー | Rip1キナーゼ阻害剤として使用するための二環式化合物 |
| CA3078688A1 (en) | 2017-10-31 | 2019-05-09 | F. Hoffmann-La Roche Ag | Bicyclic sulfones and sulfoxides and methods of use thereof |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| WO2019123219A1 (en) | 2017-12-20 | 2019-06-27 | Glaxosmithkline Intellectual Property Development Limited | Crystalline salt form of (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
| JP2021509113A (ja) | 2017-12-29 | 2021-03-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | キナーゼ阻害剤としての複素環式アミド |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| EP3781571B1 (en) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
| CN110407770B (zh) * | 2018-04-27 | 2022-12-30 | 复旦大学 | 3-取代-1,5-苯并氮杂䓬类化合物及其药物用途 |
| RS64736B1 (sr) * | 2018-05-03 | 2023-11-30 | Rigel Pharmaceuticals Inc | Jedinjenja inhibitori rip1 i postupci za njihovo dobijanje i upotrebu |
| BR112020022423A2 (pt) * | 2018-05-03 | 2021-02-02 | Rigel Pharmaceuticals, Inc. | composto, composição farmacêutica, método, método para tratar uma doença em um indivíduo e método para fabricar o composto |
| WO2019224773A1 (en) | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors |
| WO2019224774A1 (en) | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors |
| CN110642874B (zh) * | 2018-06-26 | 2023-03-28 | 中国科学院上海有机化学研究所 | 一类细胞坏死抑制剂及其制备方法和用途 |
| US20210292340A1 (en) * | 2018-06-26 | 2021-09-23 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Cell necrosis inhibitor, preparation method therefor and use thereof |
| HUE052049T2 (hu) * | 2018-07-09 | 2021-04-28 | Fis Fabbrica Italiana Sintetici Spa | Kristályos 2-fluor-3-nitrotoluol és eljárás annak elõállítására |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| CN109134448B (zh) * | 2018-10-16 | 2020-11-27 | 中南大学湘雅医院 | 杂环化合物及其盐、制备方法、用途和药物 |
| CN111138448B (zh) * | 2018-11-02 | 2022-08-02 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2020088194A1 (zh) | 2018-11-02 | 2020-05-07 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| AR119673A1 (es) | 2019-01-11 | 2022-01-05 | Hoffmann La Roche | Compuestos bicíclicos de cetona y métodos para utilizarlos |
| JP7268921B2 (ja) * | 2019-01-25 | 2023-05-08 | 北京賽特明強医薬科技有限公司 | アミド基架橋複素環式化合物、その組成物および応用 |
| KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| CA3139631A1 (en) | 2019-05-17 | 2020-11-26 | Glaxosmithkline Intellectual Property Development Limited | Matrix composition comprising (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
| SG11202113330VA (en) | 2019-05-31 | 2021-12-30 | Medshine Discovery Inc | Bicyclic compound as rip-1 kinase inhibitor and application thereof |
| US12365695B2 (en) * | 2019-08-09 | 2025-07-22 | Bisichem Co., Ltd. | Fused ring heteroaryl compounds as RIPK1 inhibitors |
| JP2022547882A (ja) * | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Nlrp3阻害剤 |
| US11564930B2 (en) | 2019-09-06 | 2023-01-31 | Rigel Pharmaceuticals, Inc. | RIP1 inhibitory compounds and methods for making and using the same |
| US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
| EP4025568B1 (en) * | 2019-09-06 | 2025-05-14 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| US11572367B2 (en) | 2019-10-04 | 2023-02-07 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| IL292536A (en) * | 2019-11-07 | 2022-06-01 | Rigel Pharmaceuticals Inc | Heterocyclic compounds inhibit rip1 |
| AU2020391425A1 (en) * | 2019-11-26 | 2022-06-16 | Board Of Regents, The University Of Texas System | Inhibitors of Receptor Interacting Protein Kinase 1 for the treatment of disease |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| BR112022017099A2 (pt) * | 2020-02-28 | 2022-11-16 | Univ Texas | Composto, composição farmacêutica, método para inibição de ripk1, método para tratamento de uma doença mediada por ripk1 e método para tratamento de lesão no snc |
| AR121717A1 (es) * | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| TW202214617A (zh) | 2020-06-02 | 2022-04-16 | 法商賽諾菲公司 | 作為ripk1抑制劑之異㗁唑啶及其用途 |
| TWI840311B (zh) * | 2020-07-01 | 2024-04-21 | 美商雷傑製藥公司 | Rip1k抑制劑 |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| EP4200281A4 (en) * | 2020-08-18 | 2024-09-25 | Hutchison Medipharma Limited | PYRIMIDINONE COMPOUNDS AND THEIR USES |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CN114716427B (zh) * | 2021-01-07 | 2024-04-26 | 成都贝诺科成生物科技有限公司 | 一种作为rip抑制剂的化合物及其制备方法和用途 |
| WO2022171110A1 (en) * | 2021-02-10 | 2022-08-18 | Zai Lab (Us) Llc | Fused tricyclic compounds as rip1-kinase inhibitors and uses thereof |
| WO2022171111A1 (en) * | 2021-02-10 | 2022-08-18 | Zai Lab (Us) Llc | Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof |
| AR125587A1 (es) * | 2021-03-11 | 2023-08-02 | Rigel Pharmaceuticals Inc | Inhibidores heterocíclicos de la quinasa de rip1 |
| CN113045560B (zh) * | 2021-03-30 | 2022-09-06 | 港科鹏禾生物(苏州)有限公司 | 一种酰胺类衍生物及其制备方法和应用 |
| BR112023020229A2 (pt) | 2021-04-02 | 2023-11-14 | Hoffmann La Roche | Processos para a preparação de um composto bicíclico de cetona quiral, composto de n-amino lactama quiral, composto de sal imidato e composto hidroxicetoéster, composto, ou um sal farmaceuticamente aceitável do mesmo e invenção |
| EP4329766A4 (en) * | 2021-04-27 | 2025-06-11 | Merck Sharp & Dohme LLC | RIPK1 INHIBITORS AND METHODS OF USE |
| CN115246796A (zh) * | 2021-04-27 | 2022-10-28 | 中国科学院上海有机化学研究所 | 一种抑制细胞程序性死亡的化合物及其制备方法 |
| IL308349A (en) | 2021-08-10 | 2024-01-01 | Abbvie Inc | NICOTINAMIDE RIPK1 INHIBITORS |
| CN119528915A (zh) * | 2021-09-14 | 2025-02-28 | 中国科学院上海有机化学研究所 | 抑制细胞程序性死亡的化合物及其制备方法 |
| KR20240099181A (ko) * | 2021-09-17 | 2024-06-28 | 주식회사 비씨켐 | Ripk1 저해제로서 융합된 이종환식 고리 |
| KR20230058292A (ko) * | 2021-10-22 | 2023-05-03 | 보로노이바이오 주식회사 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN113876778B (zh) * | 2021-11-05 | 2023-04-14 | 中日友好医院(中日友好临床医学研究所) | Kw2449在制备改善类风湿性关节炎药物中的应用 |
| WO2023083847A1 (en) | 2021-11-11 | 2023-05-19 | Sanofi | Isoxazolidines as ripk1 inhibitors and use thereof |
| KR20230100646A (ko) * | 2021-12-24 | 2023-07-05 | 제일약품주식회사 | Ripk1 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| WO2023137035A1 (en) | 2022-01-12 | 2023-07-20 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
| EP4495119A4 (en) | 2022-03-16 | 2025-06-25 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | FUSED HETEROCYCLIC COMPOUND, PREPARATION METHOD AND MEDICAL USE THEREOF |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| CN114736197B (zh) * | 2022-06-13 | 2022-09-13 | 南京医工医药技术有限公司 | 咪唑啉酮衍生物及其用途 |
| WO2023240379A1 (zh) * | 2022-06-13 | 2023-12-21 | 南京医工医药技术有限公司 | 咪唑啉酮衍生物及其用途 |
| CN117447460A (zh) * | 2022-07-13 | 2024-01-26 | 南京天印健华医药科技有限公司 | 作为ripk1抑制剂的杂环化合物 |
| WO2024040155A1 (en) | 2022-08-19 | 2024-02-22 | Genzyme Corporation | Isoxazolidines as ripk1 inhibitors and use thereof |
| TW202423921A (zh) * | 2022-08-22 | 2024-06-16 | 美商安塔製藥公司 | 稠合的雜雙環抗病毒劑 |
| CN117645579A (zh) * | 2022-09-02 | 2024-03-05 | 科辉智药生物科技(深圳)有限公司 | 作为ripk1抑制剂的氮杂䓬类稠环化合物及其应用 |
| TW202444357A (zh) * | 2023-01-23 | 2024-11-16 | 美商健臻公司 | 4-(3,3-二氟-2,2-二甲基-丙醯基)-3,5-二氫-2h-吡啶并[3,4-f][1,4]氧氮呯-9-甲腈之藥品調配物 |
| WO2024233547A1 (en) | 2023-05-10 | 2024-11-14 | Genzyme Corporation | Isoxazolidines as ripk1 inhibitors and use thereof |
| WO2024233554A1 (en) | 2023-05-10 | 2024-11-14 | Genzyme Corporation | Isoxazolidines as ripk1 inhibitors and use thereof |
| CN121127467A (zh) | 2023-05-10 | 2025-12-12 | 建新公司 | 作为ripk1抑制剂的异噁唑烷及其用途 |
| WO2025006250A1 (en) * | 2023-06-26 | 2025-01-02 | Eli Lilly And Company | Dosage regimens for the treatment of autoimmune and inflammatory diseases using ly3871801 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5239065B2 (es) | 1971-11-17 | 1977-10-03 | ||
| EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
| US4692522A (en) | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
| US5206234A (en) | 1990-10-22 | 1993-04-27 | Merck & Co., Inc. | Benzolactam analogs as antagonists of cck |
| JP3358069B2 (ja) | 1991-12-24 | 2002-12-16 | 武田薬品工業株式会社 | 三環性複素環類、その製造法及び剤 |
| AU720378B2 (en) | 1995-06-07 | 2000-06-01 | Merck & Co., Inc. | Novel N-(4-oxo-2,3,4,5-tetrahydro-1H-1, 5-benzodiazepin-3yl)-3-amides |
| WO1998041510A1 (en) * | 1997-03-14 | 1998-09-24 | Shionogi & Co., Ltd. | Novel benzolactam derivatives and medicinal compositions comprising the same |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| FR2781483A1 (fr) * | 1998-07-21 | 2000-01-28 | Hoechst Marion Roussel Inc | Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant |
| EP1226139A2 (en) | 1999-07-06 | 2002-07-31 | Vertex Pharmaceuticals Incorporated | Cyclized amide derivatives for treating or preventing neuronal damage |
| CA2391498A1 (en) | 1999-11-18 | 2001-05-25 | Antexpharma, Inc. | Substituted 1-benzazepines and derivatives thereof |
| IL151576A0 (en) | 2000-04-03 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic lactams as inhibitors of a-beta protein production |
| MXPA02009729A (es) | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta. |
| EP1268450A1 (en) | 2000-06-01 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a-beta protein production |
| DE10054279A1 (de) | 2000-11-02 | 2002-05-16 | Apotech Res & Dev Ltd | Verwendung von Liganden von Todesrezeptoren oder RIP zur Auslösung des Caspase-unabhängigen Zelltods und Verbindungen zur Inhibition des Caspase-unabhängigen Zelltods |
| CA2447687A1 (en) | 2001-05-16 | 2002-12-19 | Antexpharma, Inc. | Substituted 1-benzazepines and derivatives thereof |
| US7057046B2 (en) * | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
| EP1620567A1 (en) | 2003-04-15 | 2006-02-01 | Hans-Jürgen Thiesen | Method for diagnosing rheumatoid arthritis or osteoarthritis |
| ATE410161T1 (de) * | 2003-05-02 | 2008-10-15 | Elan Pharm Inc | 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen |
| US20080019909A1 (en) | 2003-09-17 | 2008-01-24 | Francis Ka-Ming Chan | Modulation of Programmed Necrosis |
| EP1640012A1 (de) | 2004-09-24 | 2006-03-29 | Salama, Zoser B. nat.rer.Dr. | Pharmazeutisches Mittel enthaltend Blutbestandteile 10 kDa und deren Verwendung zur Prophylaxe und Behandlung von Defekten des Immunsystems |
| US20060067942A1 (en) | 2004-09-24 | 2006-03-30 | Salama Zoser B | Pharmaceutical agent comprising amino acids, peptides, proteins and/or fractions and fragments thereof and the use of same in the prophylaxis and treatment of immune system deficiency in humans and animals |
| FR2894968B1 (fr) | 2005-12-20 | 2008-02-22 | Trophos Sa | Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation |
| US8324262B2 (en) * | 2005-12-20 | 2012-12-04 | The Brigham And Women's Hospital, Inc. | Tricyclic necrostatin compounds |
| FR2899108B1 (fr) | 2006-03-31 | 2012-02-03 | Trophos | Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur |
| US8007790B2 (en) | 2006-04-03 | 2011-08-30 | Stowers Institute For Medical Research | Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases |
| FR2907783A1 (fr) | 2006-10-30 | 2008-05-02 | Trophos Sa | Nouveaux composes chimiques, leurs procedes de synthese et leur utilisation a titre de medicament, particulierement a titre de medicament cytoprotecteur, neuroprotecteur ou cardioprotecteur |
| WO2008086043A2 (en) | 2007-01-10 | 2008-07-17 | Wyeth | Methods and compositions for assessment and treatment of asthma |
| AU2008219723A1 (en) | 2007-02-28 | 2008-09-04 | Merck Sharp & Dohme Corp. | Substituted benzodiazepinones, benzoxazepinones and benzothiazepinones as sodium channel blockers |
| JP5239065B2 (ja) | 2007-04-20 | 2013-07-17 | 株式会社大一商会 | 遊技機 |
| WO2009023272A1 (en) | 2007-08-15 | 2009-02-19 | President And Fellows Of Harvard College | Heterocyclic inhibitors of necroptosis |
| FR2934596B1 (fr) | 2008-07-30 | 2015-04-10 | Trophos | Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation |
| WO2010075290A1 (en) | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
| US8257921B1 (en) | 2008-12-22 | 2012-09-04 | Schering Corporation | NRIP1 regulation of apolipoprotein A1 |
| EP2381775A4 (en) | 2008-12-23 | 2012-08-15 | Harvard College | INHIBITORS OF NECROPTOSIS OF SMALL MOLECULAR SIZE |
| FR2940650B1 (fr) | 2008-12-29 | 2017-01-27 | Trophos | Nouveaux derives d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant,et procede de preparation |
| US7622106B1 (en) | 2009-03-06 | 2009-11-24 | Board Of Regents, The University Of Texas System | Necrosis assay |
| KR101155506B1 (ko) | 2009-07-08 | 2012-06-15 | 고려대학교 산학협력단 | 활성산소조절 유전자를 이용한 tnf-알파 유도 질병의 치료제 및 예방제의 스크리닝 방법 |
| EP2519260A2 (en) | 2009-12-31 | 2012-11-07 | Deutsches Krebsforschungszentrum | Novel modulators of trail signalling |
| US20130005726A1 (en) | 2010-03-08 | 2013-01-03 | Derek Abbott | Compositions and methods for treating inflammatory disorders |
| US20130137642A1 (en) | 2010-04-23 | 2013-05-30 | Demetrios Vavvas | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
| CN103097340B (zh) | 2010-07-16 | 2018-03-16 | 安吉奥斯医药品有限公司 | 治疗活性组合物及其使用方法 |
| US20120022116A1 (en) | 2010-07-20 | 2012-01-26 | Huayun Deng | Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex |
| WO2012061045A2 (en) | 2010-11-01 | 2012-05-10 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving retinal ganglion cells |
| WO2012125544A2 (en) | 2011-03-11 | 2012-09-20 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
| WO2013013826A1 (en) | 2011-07-27 | 2013-01-31 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Necroptosis inhibitors for the treatment of inflammatory diseases of the gastrointestinal tract |
| WO2013043662A1 (en) | 2011-09-22 | 2013-03-28 | Marv Enterprises Llc | Method for the treatment of multiple sclerosis |
| CN102343102A (zh) | 2011-10-19 | 2012-02-08 | 柳忠辉 | 激活素受体相互作用蛋白2基因在制备药物中的应用 |
| CA2888805C (en) | 2011-10-21 | 2020-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for promoting axon regeneration and nerve function |
| KR101410332B1 (ko) | 2012-02-29 | 2014-06-24 | 코아스템(주) | 중간엽 기질세포 배양용 항산화 조성물 및 이의 용도 |
| ES2446494B1 (es) | 2012-03-28 | 2015-03-16 | Consejo Superior De Investigaciones Científicas (Csic) | Aplicación terapéutica de necrostatina-1 en esteatohepatitis |
| WO2014022102A1 (en) | 2012-08-01 | 2014-02-06 | Amgen Inc. | Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture |
| US10046010B2 (en) | 2012-08-06 | 2018-08-14 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
| CN105074005A (zh) | 2012-12-26 | 2015-11-18 | 皇家飞利浦有限公司 | 使用靶基因表达的线性组合评价细胞信号传导途径活性 |
| WO2014126127A1 (ja) | 2013-02-13 | 2014-08-21 | 国立大学法人北海道大学 | ネクロプトーシス関連疾患の治療用医薬組成物及びその有効成分のスクリーニング方法 |
| TWI638815B (zh) | 2013-02-15 | 2018-10-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類(一) |
| KR20150126882A (ko) | 2013-02-27 | 2015-11-13 | 더 브로드 인스티튜트, 인코퍼레이티드 | T 세포의 균형 유전자 발현, 물질의 조성물 및 이의 사용 방법 |
| EP2968276A4 (en) | 2013-03-15 | 2017-02-15 | President and Fellows of Harvard College | Hybrid necroptosis inhibitors |
| US20170266199A1 (en) | 2014-08-21 | 2017-09-21 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
| KR102808827B1 (ko) | 2016-02-05 | 2025-05-19 | 데날리 테라퓨틱스 인크. | 수용체-상호작용 단백질 키나제 1의 억제제 |
-
2014
- 2014-02-13 TW TW107104622A patent/TWI638815B/zh active
- 2014-02-13 TW TW103104666A patent/TWI637951B/zh active
- 2014-02-13 TW TW107104621A patent/TWI648274B/zh active
- 2014-02-13 TW TW107104619A patent/TWI648273B/zh active
- 2014-02-14 BR BR122017002946A patent/BR122017002946A2/pt not_active Application Discontinuation
- 2014-02-14 PE PE2015001727A patent/PE20151752A1/es not_active Application Discontinuation
- 2014-02-14 SI SI201431772T patent/SI3342771T1/sl unknown
- 2014-02-14 PL PL14705891T patent/PL2956452T3/pl unknown
- 2014-02-14 WO PCT/IB2014/059004 patent/WO2014125444A1/en not_active Ceased
- 2014-02-14 SG SG11201505796TA patent/SG11201505796TA/en unknown
- 2014-02-14 SM SM20210083T patent/SMT202100083T1/it unknown
- 2014-02-14 PL PL18155836T patent/PL3342771T3/pl unknown
- 2014-02-14 ES ES14705891.1T patent/ES2672530T3/es active Active
- 2014-02-14 BR BR122017002949A patent/BR122017002949A2/pt not_active Application Discontinuation
- 2014-02-14 UA UAA201508769A patent/UA118259C2/uk unknown
- 2014-02-14 TR TR2018/08112T patent/TR201808112T4/tr unknown
- 2014-02-14 SI SI201430738T patent/SI2956452T1/en unknown
- 2014-02-14 ES ES18155836T patent/ES2855135T3/es active Active
- 2014-02-14 DK DK14705891.1T patent/DK2956452T3/en active
- 2014-02-14 HU HUE18155836A patent/HUE053215T2/hu unknown
- 2014-02-14 KR KR1020157024819A patent/KR102228764B1/ko not_active Expired - Fee Related
- 2014-02-14 ES ES18152185T patent/ES2814556T3/es active Active
- 2014-02-14 EP EP18152185.7A patent/EP3375780B1/en active Active
- 2014-02-14 RS RS20210156A patent/RS61439B1/sr unknown
- 2014-02-14 CA CA2900695A patent/CA2900695C/en active Active
- 2014-02-14 PT PT147058911T patent/PT2956452T/pt unknown
- 2014-02-14 KR KR1020197004425A patent/KR102267977B1/ko active Active
- 2014-02-14 AU AU2014217453A patent/AU2014217453B2/en active Active
- 2014-02-14 MY MYPI2015702652A patent/MY178552A/en unknown
- 2014-02-14 BR BR122017002951A patent/BR122017002951A2/pt not_active Application Discontinuation
- 2014-02-14 EP EP14705891.1A patent/EP2956452B1/en active Active
- 2014-02-14 RS RS20180698A patent/RS57332B1/sr unknown
- 2014-02-14 CR CR20190511A patent/CR20190511A/es unknown
- 2014-02-14 MY MYPI2020000331A patent/MY195183A/en unknown
- 2014-02-14 CN CN201710029656.XA patent/CN106928203B/zh active Active
- 2014-02-14 MX MX2015010572A patent/MX360715B/es active IP Right Grant
- 2014-02-14 EA EA201591506A patent/EA028991B1/ru not_active IP Right Cessation
- 2014-02-14 DK DK18155836.2T patent/DK3342771T3/da active
- 2014-02-14 MX MX2018008311A patent/MX373866B/es unknown
- 2014-02-14 JP JP2015557554A patent/JP6321045B2/ja not_active Expired - Fee Related
- 2014-02-14 HR HRP20180900TT patent/HRP20180900T1/hr unknown
- 2014-02-14 LT LTEP14705891.1T patent/LT2956452T/lt unknown
- 2014-02-14 SM SM20180289T patent/SMT201800289T1/it unknown
- 2014-02-14 PT PT181558362T patent/PT3342771T/pt unknown
- 2014-02-14 EP EP19154374.3A patent/EP3508484B1/en active Active
- 2014-02-14 MA MA44820A patent/MA44820B1/fr unknown
- 2014-02-14 NZ NZ628447A patent/NZ628447A/en unknown
- 2014-02-14 EA EA201792039A patent/EA031971B1/ru not_active IP Right Cessation
- 2014-02-14 UY UY0001035330A patent/UY35330A/es not_active Application Discontinuation
- 2014-02-14 MX MX2018008312A patent/MX373867B/es unknown
- 2014-02-14 CN CN201480021120.8A patent/CN105121432B/zh active Active
- 2014-02-14 US US14/763,183 patent/US9556152B2/en active Active
- 2014-02-14 HU HUE14705891A patent/HUE037763T2/hu unknown
- 2014-02-14 LT LTEP18155836.2T patent/LT3342771T/lt unknown
- 2014-02-14 EP EP18155836.2A patent/EP3342771B1/en active Active
- 2014-02-14 CR CR20190512A patent/CR20190512A/es unknown
- 2014-02-14 BR BR112015019627-6A patent/BR112015019627B1/pt active IP Right Grant
- 2014-02-14 CN CN201810758606.XA patent/CN108774214B/zh active Active
-
2015
- 2015-07-21 ZA ZA2015/05267A patent/ZA201505267B/en unknown
- 2015-07-28 PH PH12015501675A patent/PH12015501675A1/en unknown
- 2015-07-30 IL IL240280A patent/IL240280B/en active IP Right Grant
- 2015-08-14 CR CR20150420A patent/CR20150420A/es unknown
- 2015-08-14 DO DO2015000196A patent/DOP2015000196A/es unknown
- 2015-08-14 CL CL2015002279A patent/CL2015002279A1/es unknown
-
2016
- 2016-09-21 US US15/271,581 patent/US9624202B2/en active Active
-
2017
- 2017-03-15 US US15/459,141 patent/US10292987B2/en active Active
- 2017-12-08 US US15/835,747 patent/US20180098998A1/en not_active Abandoned
- 2017-12-22 IL IL256500A patent/IL256500B/en active IP Right Grant
- 2017-12-22 IL IL256502A patent/IL256502B/en active IP Right Grant
-
2018
- 2018-02-15 PH PH12018500342A patent/PH12018500342A1/en unknown
- 2018-02-15 PH PH12018500341A patent/PH12018500341A1/en unknown
- 2018-02-15 PH PH12018500343A patent/PH12018500343A1/en unknown
- 2018-03-12 JP JP2018044611A patent/JP6352571B1/ja active Active
- 2018-04-04 DO DO2018000088A patent/DOP2018000088A/es unknown
- 2018-04-04 DO DO2018000089A patent/DOP2018000089A/es unknown
- 2018-06-04 JP JP2018107215A patent/JP2018150372A/ja active Pending
- 2018-06-08 CY CY20181100604T patent/CY1120320T1/el unknown
-
2019
- 2019-03-12 US US16/299,254 patent/US10933070B2/en active Active
- 2019-05-10 US US16/408,718 patent/US10940154B2/en active Active
-
2021
- 2021-02-12 HR HRP20210252TT patent/HRP20210252T1/hr unknown
- 2021-02-12 CY CY20211100121T patent/CY1123915T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12281101B2 (en) | 2015-07-02 | 2025-04-22 | Genentech, Inc. | Bicyclic lactams and methods of use thereof |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2015002279A1 (es) | Amidas heterocíclicas como inhibidores de cinasas | |
| CL2018000649A1 (es) | Nuevos compuestos bicíclicos como inhibidores duales de atx / ca | |
| EA201692105A1 (ru) | Новые пиразолопиримидиновые производные и их применение в качестве ингибиторов malt1 | |
| HRP20181679T1 (hr) | Amidni spojevi za liječenje hiv | |
| CL2016001706A1 (es) | Compuestos de nicotinamida sustituida con heteroarilo | |
| MX2016000143A (es) | Compuestos triciclicos fusionados de urea como inhibidores de raf quinasa y/o dimero de raf quinasa. | |
| CL2015003089A1 (es) | Heterociclos biciclicos como inhibidores de fgfr. | |
| CL2015001268A1 (es) | Compuestos derivados de pirrolopirimidina, como inhibidores de quinasas; composicion farmaceutica que los comprende, util para el tratamiento de una enfermedad o condicion autoinmune tal como artritis reumatoide o lupus, y para el tratamiento de una enfermedad o condicion heteroinmune o inflamatoria. | |
| CL2015003355A1 (es) | Derivados del bipirazol como inhibidores jak | |
| MX378288B (es) | Inhibidores de pirimidina del fgfr4. | |
| CL2015000094A1 (es) | Compuestos derivados de imidazotriazincarbonitrilos, inhibidores de la proteina cinasa; composicion farmaceutica que los comprende; y su uso para tratar el cancer, psoriasis y artritis reumatoide. | |
| LT3371190T (lt) | Heterocikliniai junginiai, kaip pi3k-gama inhibitoriai | |
| MX375102B (es) | Compuestos de ciclopropilamina como inhibidores de histona demetilasa | |
| CL2015001377A1 (es) | Inhbibidores de bmi-1 primidinas sustituidas inversas | |
| DK3145420T3 (da) | Intraoperativ fremgangsmåde til tracking | |
| UY35274A (es) | Compuestos y métodos para tratar infecciones bacterianas | |
| EA201600124A1 (ru) | Новые индолизиновые соединения, способ их получения и фармацевтические композиции, содержащие их | |
| ME03004B (me) | Postupak za proizvodnju stabilnog, injektabilnog rastvora noradrenalina niske koncentracije | |
| CL2016001218A1 (es) | Tienopirimidinas como inhibidores mknk1 y mknk2 | |
| LT3552017T (lt) | Junginiai, naudotini kaip ripk1 inhibitoriai | |
| HRP20190527T1 (hr) | Sinteza kopanlisiba i njegove dihidrokloridne soli | |
| EA201890828A1 (ru) | Оптимизированная таблетка с высокой дозой активного соединения, содержащая месалазин | |
| CO2017005732A2 (es) | Compuestos de dihidropirimidin-2-ona y sus usos médicos | |
| EP2970247A4 (en) | SALTS, COCKRISTALS AND POLYMORPHES OF AN ANSWERING CONNECTION | |
| MX377905B (es) | Rutas semi-sinteticas para compuestos organicos. |