CL2014002048A1 - Compuestos derivados de 4-(benzoimidazol-2-il)-tiazol y derivados aza relacionados; composicion farmaceutica; y uso en la prevencion y el tratamiento de trastornos autoinmunes, inflamatorios, enfermedades infecciosas, entre otras. - Google Patents
Compuestos derivados de 4-(benzoimidazol-2-il)-tiazol y derivados aza relacionados; composicion farmaceutica; y uso en la prevencion y el tratamiento de trastornos autoinmunes, inflamatorios, enfermedades infecciosas, entre otras.Info
- Publication number
- CL2014002048A1 CL2014002048A1 CL2014002048A CL2014002048A CL2014002048A1 CL 2014002048 A1 CL2014002048 A1 CL 2014002048A1 CL 2014002048 A CL2014002048 A CL 2014002048A CL 2014002048 A CL2014002048 A CL 2014002048A CL 2014002048 A1 CL2014002048 A1 CL 2014002048A1
- Authority
- CL
- Chile
- Prior art keywords
- benzoimidazol
- thiazole
- autoimmune
- inflammatory
- prevention
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2012/050489 | 2012-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002048A1 true CL2014002048A1 (es) | 2014-11-14 |
Family
ID=48014121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014002048A CL2014002048A1 (es) | 2012-02-02 | 2014-07-31 | Compuestos derivados de 4-(benzoimidazol-2-il)-tiazol y derivados aza relacionados; composicion farmaceutica; y uso en la prevencion y el tratamiento de trastornos autoinmunes, inflamatorios, enfermedades infecciosas, entre otras. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9266876B2 (es) |
| EP (1) | EP2809668B1 (es) |
| JP (1) | JP6073931B2 (es) |
| KR (1) | KR101800607B1 (es) |
| CN (1) | CN104093715B (es) |
| AU (1) | AU2013216354B2 (es) |
| BR (1) | BR112014018714A8 (es) |
| CA (1) | CA2861020C (es) |
| CL (1) | CL2014002048A1 (es) |
| EA (1) | EA027595B1 (es) |
| ES (1) | ES2632237T3 (es) |
| IL (1) | IL233872A (es) |
| MX (1) | MX352181B (es) |
| MY (1) | MY170524A (es) |
| NZ (1) | NZ629795A (es) |
| PH (1) | PH12014501540A1 (es) |
| PL (1) | PL2809668T3 (es) |
| SG (1) | SG11201404144PA (es) |
| UA (1) | UA113638C2 (es) |
| WO (1) | WO2013114332A1 (es) |
Families Citing this family (11)
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| EP3024832B1 (en) | 2013-07-22 | 2018-03-28 | Idorsia Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
| EP3091984B1 (en) | 2014-01-09 | 2020-04-22 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Substituted benzoxazine and related compounds |
| AR099789A1 (es) * | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| AR103399A1 (es) * | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| MA41337A (fr) * | 2015-01-15 | 2017-11-22 | Idorsia Pharmaceuticals Ltd | Dérivés de l'hydroxyalkyl pipérazine utilisés comme modulateurs du récepteur cxcr3 |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2018011265A1 (en) | 2016-07-13 | 2018-01-18 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
| FR3067028B1 (fr) | 2017-06-06 | 2019-07-12 | Adpuerivitam | Modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central |
| MX2023001758A (es) * | 2020-08-11 | 2023-04-11 | Univ Michigan State | Potenciadores de proteasoma y usos de los mismos. |
| CA3195127A1 (en) * | 2020-10-16 | 2022-05-05 | John K. Walker | Rev-erb agonists |
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| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
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| US20120122928A1 (en) | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
| US8759527B2 (en) | 2010-08-25 | 2014-06-24 | Bayer Cropscience Ag | Heteroarylpiperidine and -piperazine derivatives as fungicides |
| CN107033139B (zh) | 2010-10-27 | 2019-11-19 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
| US8748431B2 (en) | 2010-11-25 | 2014-06-10 | Syngenta Participations Ag | Microbicidal heterocycles |
| BR112013015166A2 (pt) | 2010-12-17 | 2016-07-12 | Du Pont | composto selecionado a partir de fórmula 1, composição fungicida e método para controlar doenças de plantas |
| MX352307B (es) | 2011-02-01 | 2017-11-17 | Bayer Ip Gmbh | Derivados de heteroarilpiperidina y -piperazina como fungicidas. |
| EP2673272A1 (en) | 2011-02-10 | 2013-12-18 | Syngenta Participations AG | Microbiocidal pyrazole derivatives |
| US8748432B2 (en) | 2011-02-10 | 2014-06-10 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN103827112A (zh) | 2011-09-15 | 2014-05-28 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的哌啶吡唑 |
| BR112014009037A2 (pt) | 2011-10-18 | 2017-05-09 | Syngenta Participations Ag | derivados pirazol microbicidas |
| BR112014009086A2 (pt) | 2011-10-18 | 2017-05-09 | Syngenta Participations Ag | derivados pirazol microbicidas |
| US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US20150031541A1 (en) | 2012-03-02 | 2015-01-29 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| IN2012DE00620A (es) | 2012-03-02 | 2015-08-21 | Syngenta Participations Ag | |
| WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
| WO2014075873A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| WO2014075874A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
-
2013
- 2013-02-01 JP JP2014555374A patent/JP6073931B2/ja not_active Expired - Fee Related
- 2013-02-01 KR KR1020147024508A patent/KR101800607B1/ko not_active Expired - Fee Related
- 2013-02-01 CN CN201380007926.7A patent/CN104093715B/zh not_active Expired - Fee Related
- 2013-02-01 WO PCT/IB2013/050870 patent/WO2013114332A1/en not_active Ceased
- 2013-02-01 EA EA201400854A patent/EA027595B1/ru not_active IP Right Cessation
- 2013-02-01 MX MX2014009355A patent/MX352181B/es active IP Right Grant
- 2013-02-01 CA CA2861020A patent/CA2861020C/en active Active
- 2013-02-01 ES ES13712913.6T patent/ES2632237T3/es active Active
- 2013-02-01 US US14/376,307 patent/US9266876B2/en active Active
- 2013-02-01 NZ NZ629795A patent/NZ629795A/en not_active IP Right Cessation
- 2013-02-01 UA UAA201409420A patent/UA113638C2/uk unknown
- 2013-02-01 AU AU2013216354A patent/AU2013216354B2/en not_active Ceased
- 2013-02-01 PL PL13712913T patent/PL2809668T3/pl unknown
- 2013-02-01 MY MYPI2014702122A patent/MY170524A/en unknown
- 2013-02-01 EP EP13712913.6A patent/EP2809668B1/en active Active
- 2013-02-01 BR BR112014018714A patent/BR112014018714A8/pt not_active IP Right Cessation
- 2013-02-01 SG SG11201404144PA patent/SG11201404144PA/en unknown
-
2014
- 2014-07-03 PH PH12014501540A patent/PH12014501540A1/en unknown
- 2014-07-30 IL IL233872A patent/IL233872A/en not_active IP Right Cessation
- 2014-07-31 CL CL2014002048A patent/CL2014002048A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2809668A1 (en) | 2014-12-10 |
| AU2013216354A1 (en) | 2014-09-25 |
| KR20140120364A (ko) | 2014-10-13 |
| WO2013114332A1 (en) | 2013-08-08 |
| KR101800607B1 (ko) | 2017-11-23 |
| SG11201404144PA (en) | 2014-10-30 |
| NZ629795A (en) | 2016-06-24 |
| PH12014501540B1 (en) | 2014-09-22 |
| JP6073931B2 (ja) | 2017-02-01 |
| CA2861020A1 (en) | 2013-08-08 |
| UA113638C2 (xx) | 2017-02-27 |
| US9266876B2 (en) | 2016-02-23 |
| ES2632237T3 (es) | 2017-09-12 |
| HK1203939A1 (en) | 2015-11-06 |
| PH12014501540A1 (en) | 2014-09-22 |
| IL233872A (en) | 2017-05-29 |
| CA2861020C (en) | 2018-07-17 |
| US20140371204A1 (en) | 2014-12-18 |
| JP2015506957A (ja) | 2015-03-05 |
| BR112014018714A8 (pt) | 2017-12-26 |
| BR112014018714A2 (es) | 2017-06-20 |
| EP2809668B1 (en) | 2017-04-12 |
| MX352181B (es) | 2017-11-13 |
| PL2809668T3 (pl) | 2018-02-28 |
| AU2013216354B2 (en) | 2017-08-31 |
| CN104093715B (zh) | 2017-04-26 |
| MX2014009355A (es) | 2014-09-01 |
| MY170524A (en) | 2019-08-09 |
| EA201400854A1 (ru) | 2015-04-30 |
| EA027595B1 (ru) | 2017-08-31 |
| CN104093715A (zh) | 2014-10-08 |
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