[go: up one dir, main page]

CL2013003143A1 - Uso de compuestos derivados de fenilaminopirimidinilo, un enantiomero o una sal farmaceuticamente aceptable del mismo para reducir la viabilidad de celulas de mieloma multiple en un estado de celulas no erspondedoras a il-6 y/o que tienen un fenotipo cd45-. - Google Patents

Uso de compuestos derivados de fenilaminopirimidinilo, un enantiomero o una sal farmaceuticamente aceptable del mismo para reducir la viabilidad de celulas de mieloma multiple en un estado de celulas no erspondedoras a il-6 y/o que tienen un fenotipo cd45-.

Info

Publication number
CL2013003143A1
CL2013003143A1 CL2013003143A CL2013003143A CL2013003143A1 CL 2013003143 A1 CL2013003143 A1 CL 2013003143A1 CL 2013003143 A CL2013003143 A CL 2013003143A CL 2013003143 A CL2013003143 A CL 2013003143A CL 2013003143 A1 CL2013003143 A1 CL 2013003143A1
Authority
CL
Chile
Prior art keywords
phenylaminopyrimidinyl
enantiomer
phenotype
viability
cells
Prior art date
Application number
CL2013003143A
Other languages
English (en)
Inventor
Christopher John Burns
Andrew Spencer
Katherine Anne Monaghan
Original Assignee
Ym Biosciences Australia Pty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47107683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013003143(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ym Biosciences Australia Pty filed Critical Ym Biosciences Australia Pty
Publication of CL2013003143A1 publication Critical patent/CL2013003143A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CL2013003143A 2011-05-02 2013-10-30 Uso de compuestos derivados de fenilaminopirimidinilo, un enantiomero o una sal farmaceuticamente aceptable del mismo para reducir la viabilidad de celulas de mieloma multiple en un estado de celulas no erspondedoras a il-6 y/o que tienen un fenotipo cd45-. CL2013003143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161481425P 2011-05-02 2011-05-02

Publications (1)

Publication Number Publication Date
CL2013003143A1 true CL2013003143A1 (es) 2014-07-04

Family

ID=47107683

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003143A CL2013003143A1 (es) 2011-05-02 2013-10-30 Uso de compuestos derivados de fenilaminopirimidinilo, un enantiomero o una sal farmaceuticamente aceptable del mismo para reducir la viabilidad de celulas de mieloma multiple en un estado de celulas no erspondedoras a il-6 y/o que tienen un fenotipo cd45-.

Country Status (21)

Country Link
US (1) US20140171433A1 (es)
EP (1) EP2704722A4 (es)
JP (1) JP2014514337A (es)
KR (1) KR20140081757A (es)
CN (1) CN103533939A (es)
AP (1) AP2013007281A0 (es)
AU (1) AU2012250491A1 (es)
BR (1) BR112013028420A2 (es)
CA (1) CA2834414A1 (es)
CL (1) CL2013003143A1 (es)
CO (1) CO6900134A2 (es)
EA (1) EA201391591A1 (es)
IL (1) IL228981A0 (es)
MA (1) MA35129B1 (es)
MD (1) MD20130089A2 (es)
MX (1) MX2013012785A (es)
PE (1) PE20140750A1 (es)
PH (1) PH12013502144A1 (es)
SG (1) SG194212A1 (es)
WO (1) WO2012149602A1 (es)
ZA (1) ZA201308918B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101737753B1 (ko) 2007-03-12 2017-05-18 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도
US8809359B2 (en) 2012-06-29 2014-08-19 Ym Biosciences Australia Pty Ltd Phenyl amino pyrimidine bicyclic compounds and uses thereof
EP3148545B1 (en) 2014-05-28 2023-03-15 Onco Tracker, Inc. Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids
TW202134236A (zh) * 2014-06-12 2021-09-16 美商西爾拉癌症醫學公司 N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺
EP3171892B1 (en) 2014-07-22 2021-11-24 Apollomics Inc. Anti-pd-1 antibodies
SG10201901057UA (en) 2014-08-05 2019-03-28 Cb Therapeutics Inc Anti-pd-l1 antibodies
CN106316963B (zh) * 2015-06-26 2021-06-08 苏州泽璟生物制药股份有限公司 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物
CN105837515B (zh) * 2016-04-06 2018-08-03 中国药科大学 一种JAK抑制剂Momelotinib的制备方法
CN106075046A (zh) * 2016-07-31 2016-11-09 孙书芳 一种治疗肝肾阴虚型多发性骨髓瘤的中药
US10487321B2 (en) * 2016-09-29 2019-11-26 PZM Diagnostics, LLC Method of extraction of genomic DNA for molecular diagnostics and application
WO2019055930A1 (en) * 2017-09-15 2019-03-21 University Of Iowa Research Foundation METHODS OF IDENTIFYING MYELOMA TUMOR INITIATOR CELLS AND TARGETED THERAPY
CN109045040A (zh) * 2018-03-12 2018-12-21 首都医科大学附属北京天坛医院 Cyt387用于制备治疗神经胶质瘤的药物的应用
CN111100076A (zh) * 2019-12-30 2020-05-05 武汉九州钰民医药科技有限公司 Jak抑制剂莫美洛替尼的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1750697A4 (en) * 2004-05-05 2009-08-26 Celgene Corp METHODS AND COMPOSITIONS USING CYTOKINE INHIBITION DRUGS FOR THE TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES
JP2010510971A (ja) * 2006-11-27 2010-04-08 アレス トレーディング ソシエテ アノニム 多発性骨髄腫の治療
KR101737753B1 (ko) * 2007-03-12 2017-05-18 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도

Also Published As

Publication number Publication date
PE20140750A1 (es) 2014-07-06
EA201391591A1 (ru) 2014-12-30
SG194212A1 (en) 2013-11-29
WO2012149602A1 (en) 2012-11-08
MD20130089A2 (ro) 2014-05-31
EP2704722A4 (en) 2014-11-05
KR20140081757A (ko) 2014-07-01
PH12013502144A1 (en) 2017-10-25
MA35129B1 (fr) 2014-05-02
AP2013007281A0 (en) 2013-11-30
IL228981A0 (en) 2013-12-31
US20140171433A1 (en) 2014-06-19
MX2013012785A (es) 2014-05-28
JP2014514337A (ja) 2014-06-19
AU2012250491A1 (en) 2013-05-02
CA2834414A1 (en) 2012-11-08
ZA201308918B (en) 2014-08-27
CO6900134A2 (es) 2014-03-20
BR112013028420A2 (pt) 2017-01-24
EP2704722A1 (en) 2014-03-12
CN103533939A (zh) 2014-01-22

Similar Documents

Publication Publication Date Title
CL2013003143A1 (es) Uso de compuestos derivados de fenilaminopirimidinilo, un enantiomero o una sal farmaceuticamente aceptable del mismo para reducir la viabilidad de celulas de mieloma multiple en un estado de celulas no erspondedoras a il-6 y/o que tienen un fenotipo cd45-.
LUC00083I2 (en) Bictegravir or a pharmaceutically acceptable salt thereof, in particular bictegravir sodium
CL2014002757A1 (es) Compuestos derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1, composicion farmaceutica; y uso en el tratamiento del cancer.
BR112013023681A2 (pt) compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos
LT2768942T (lt) Pristatymas į ląstelės vidų
DK2877574T3 (da) Alpha (1,2)-fucosyltransferaser egnet til anvendelse i fremstillingen af fucosylerede oligosaccharider
BR112015003376A2 (pt) composto ou sal farmaceuticamente aceitável do mesmo , composição farmacêutica e usos de quantidade eficiente
DK3091029T3 (da) Anti-IL13-antistofformuleringer
HUE036755T2 (hu) Antimikrobiális vegyületek, valamint ezek elõállítása és alkalmazása
CL2015001752A1 (es) Compuestos derivados de pirazolo-piramidina, inhibidores selectivos de actividad fosfatidil-inositol-4-kinasa iii beta (pi4kiiib); composicion farmaceutica; y su uso para el tratamiento o prevencion de un trastorno inflamatorio, autoinmune u oncologico, una enfermedad viral o malaria o rechazo a trasplante de organos o celulas
BR112013019327A2 (pt) composto, e, composição.
CL2014001861A1 (es) Compuestos derivados de bencil sulfonamida, inhibidores de mogat-2; compuesto cristalino; composicion farmaceutica; y su uso en el tratamiento de la hipertrigliceridemia.
JP2013541099A5 (es)
BR112015007749A2 (pt) métodos para tratamento de hipertensão , de hipercaliemia , e de doença renal crônica.
CL2014001290A1 (es) Proceso para la recuperacion de betaina de melazas; producto de melaza de remolacha; y su uso.
HRP20181286T1 (hr) 2,4 supstituirani pirimidindiamini za uporabu kod diskoidnog lupusa
BR112014032501A2 (pt) composto, e, composição farmacêutica.
BR112014001425A2 (pt) forma de dosagem farmacêutica, composição farmacêutica, e, composto (i) ou sal farmaceuticamente aceitável do mesmo
DK2748147T3 (da) Substitueret 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinolin-4-carboxamider til antimalaria-terapier
EP2696677A4 (en) CLEANSING, INSECTICIDES, INSECTRIC, EMPTYING AND IRRITANT COMPOSITION
HUE036048T2 (hu) Gyógyszerészetileg aktív vegyületek
IL280316B (en) Bolaamphiphilic compounds, compositions and uses thereof
FR2971397B1 (fr) Recifs artificiels notamment pour especes sedentaires
IT1401253B1 (it) Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.
BR112014016122A8 (pt) composto, e, composição farmacêutica