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MX2016006025A - Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres. - Google Patents

Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.

Info

Publication number
MX2016006025A
MX2016006025A MX2016006025A MX2016006025A MX2016006025A MX 2016006025 A MX2016006025 A MX 2016006025A MX 2016006025 A MX2016006025 A MX 2016006025A MX 2016006025 A MX2016006025 A MX 2016006025A MX 2016006025 A MX2016006025 A MX 2016006025A
Authority
MX
Mexico
Prior art keywords
treatment
active agents
mdm2 inhibitor
combination therapy
canceres
Prior art date
Application number
MX2016006025A
Other languages
English (en)
Other versions
MX378969B (es
Inventor
Caenepeel Sean
Canon Jude
Hughes Paul
D Oliner Jonathan
J Rickles Richard
Y Saiki Anne
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2016006025A publication Critical patent/MX2016006025A/es
Publication of MX378969B publication Critical patent/MX378969B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención proporciona una terapia de combinación que incluye un inhibidor MDM2 y uno o más agentes farmacéuticamente activos adicionales, particularmente para el tratamiento de cánceres. La invención también se refiere a composiciones farmacéuticas que contiene un inhibidor MDM2 y uno o más agentes farmacéuticamente activos adicionales para el tratamiento de cánceres.
MX2016006025A 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres. MX378969B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Publications (2)

Publication Number Publication Date
MX2016006025A true MX2016006025A (es) 2016-12-02
MX378969B MX378969B (es) 2025-03-11

Family

ID=52001089

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2020001550A MX391859B (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres
MX2016006025A MX378969B (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.
MX2019009853A MX393610B (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres
MX2020013670A MX2020013670A (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.
MX2022012320A MX2022012320A (es) 2013-11-11 2016-05-06 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.
MX2022008175A MX2022008175A (es) 2013-11-11 2016-05-06 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020001550A MX391859B (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2019009853A MX393610B (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres
MX2020013670A MX2020013670A (es) 2013-11-11 2014-11-11 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.
MX2022012320A MX2022012320A (es) 2013-11-11 2016-05-06 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.
MX2022008175A MX2022008175A (es) 2013-11-11 2016-05-06 Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres.

Country Status (33)

Country Link
US (3) US20160287569A1 (es)
EP (2) EP3068393B9 (es)
JP (5) JP2016535795A (es)
KR (3) KR102473485B1 (es)
CN (2) CN112933236A (es)
AP (1) AP2016009243A0 (es)
AU (3) AU2014346354A1 (es)
BR (1) BR112016010564A2 (es)
CA (1) CA2930244A1 (es)
CL (1) CL2016001131A1 (es)
CY (1) CY1125358T1 (es)
DK (1) DK3068393T5 (es)
EA (2) EA036942B1 (es)
ES (1) ES2916721T3 (es)
HR (1) HRP20220718T1 (es)
HU (1) HUE059351T2 (es)
IL (2) IL245568B (es)
LT (1) LT3068393T (es)
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