CL2013002027A1 - Formas cristalinas i y ii de (r)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7(tetrahidrofuran-2-il)-1h-benzimidazol-2-il]urea, inhibidor de girasa; composicion farmeceutica; y uso poara tratar o reducir una infeccion bacteriana. - Google Patents
Formas cristalinas i y ii de (r)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7(tetrahidrofuran-2-il)-1h-benzimidazol-2-il]urea, inhibidor de girasa; composicion farmeceutica; y uso poara tratar o reducir una infeccion bacteriana.Info
- Publication number
- CL2013002027A1 CL2013002027A1 CL2013002027A CL2013002027A CL2013002027A1 CL 2013002027 A1 CL2013002027 A1 CL 2013002027A1 CL 2013002027 A CL2013002027 A CL 2013002027A CL 2013002027 A CL2013002027 A CL 2013002027A CL 2013002027 A1 CL2013002027 A1 CL 2013002027A1
- Authority
- CL
- Chile
- Prior art keywords
- ethyl
- benzimidazol
- pyrimidin
- fluoro
- tetrahydrofuran
- Prior art date
Links
- BKUISYCLLXCBJV-CQSZACIVSA-N 1-ethyl-3-[5-fluoro-6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-4-[(2r)-oxolan-2-yl]-1h-benzimidazol-2-yl]urea Chemical compound C=12NC(NC(=O)NCC)=NC2=CC(C=2C=NC(=NC=2)C(C)(C)O)=C(F)C=1[C@H]1CCCO1 BKUISYCLLXCBJV-CQSZACIVSA-N 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 239000002271 gyrase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161433169P | 2011-01-14 | 2011-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002027A1 true CL2013002027A1 (es) | 2013-12-13 |
Family
ID=45558414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002027A CL2013002027A1 (es) | 2011-01-14 | 2013-07-12 | Formas cristalinas i y ii de (r)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7(tetrahidrofuran-2-il)-1h-benzimidazol-2-il]urea, inhibidor de girasa; composicion farmeceutica; y uso poara tratar o reducir una infeccion bacteriana. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8476281B2 (es) |
| EP (1) | EP2663562B1 (es) |
| JP (1) | JP6120775B2 (es) |
| KR (1) | KR101900249B1 (es) |
| CN (1) | CN103403000B (es) |
| AR (1) | AR085308A1 (es) |
| AU (1) | AU2012205419B2 (es) |
| BR (1) | BR112013017985B1 (es) |
| CA (1) | CA2824403C (es) |
| CL (1) | CL2013002027A1 (es) |
| ES (1) | ES2705923T3 (es) |
| IL (1) | IL227408B (es) |
| MX (1) | MX341342B (es) |
| RU (1) | RU2625305C2 (es) |
| SG (1) | SG191927A1 (es) |
| TW (1) | TWI535714B (es) |
| WO (1) | WO2012097273A1 (es) |
| ZA (1) | ZA201305231B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339455B (es) * | 2011-01-14 | 2016-05-27 | Vertex Pharma | Inhibidores de pirimidina y topoisomerasa iv. |
| CN103403000B (zh) | 2011-01-14 | 2017-05-31 | 斯派罗吹耐姆公司 | 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲 |
| RU2619116C2 (ru) | 2011-01-14 | 2017-05-12 | Сперо Тринем, Инк. | Способ получения ингибиторов гиразы и топоизомеразы iv |
| MX351555B (es) * | 2011-01-14 | 2017-10-19 | Spero Trinem Inc | Formas solidas de inhibidor de girasa (r)-1-etil-3-[5-[2-(1-hidrox i-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzim idazol-2-il]urea. |
| US9125922B2 (en) | 2011-06-20 | 2015-09-08 | Vertex Pharmaceuticals Incorporated | Phosphate esters of gyrase and topoisomerase inhibitors |
| AR093226A1 (es) * | 2012-07-18 | 2015-05-27 | Vertex Pharma | Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
| KR20160115986A (ko) | 2014-02-03 | 2016-10-06 | 스페로 자이레이스, 인크 | 폴리믹신을 포함하는 항균성 조합 |
| TWI732337B (zh) * | 2014-06-20 | 2021-07-01 | 美商梅琳塔有限責任公司 | 醫藥組成物及其用途 |
| EP3763713A4 (en) * | 2018-03-05 | 2021-11-24 | Guangdong Raynovent Biotech Co., Ltd. | CRYSTAL FORM AND SALT FORM OF A PYRIDOIMIDAZOLE COMPOUND AND THE METHOD FOR MANUFACTURING IT |
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| HRP960159A2 (en) | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
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| AR042956A1 (es) | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| US7582641B2 (en) | 2003-01-31 | 2009-09-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
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| MX339455B (es) * | 2011-01-14 | 2016-05-27 | Vertex Pharma | Inhibidores de pirimidina y topoisomerasa iv. |
| CN103403000B (zh) | 2011-01-14 | 2017-05-31 | 斯派罗吹耐姆公司 | 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲 |
| MX351555B (es) * | 2011-01-14 | 2017-10-19 | Spero Trinem Inc | Formas solidas de inhibidor de girasa (r)-1-etil-3-[5-[2-(1-hidrox i-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1h-benzim idazol-2-il]urea. |
| RU2619116C2 (ru) * | 2011-01-14 | 2017-05-12 | Сперо Тринем, Инк. | Способ получения ингибиторов гиразы и топоизомеразы iv |
| US9125922B2 (en) * | 2011-06-20 | 2015-09-08 | Vertex Pharmaceuticals Incorporated | Phosphate esters of gyrase and topoisomerase inhibitors |
| US8906902B2 (en) | 2012-03-22 | 2014-12-09 | Biota Europe Limited | Antibacterial compounds |
| AR093226A1 (es) * | 2012-07-18 | 2015-05-27 | Vertex Pharma | Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales |
| US9572809B2 (en) * | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
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2012
- 2012-01-13 CN CN201280009901.6A patent/CN103403000B/zh active Active
- 2012-01-13 ES ES12701811T patent/ES2705923T3/es active Active
- 2012-01-13 US US13/349,984 patent/US8476281B2/en active Active
- 2012-01-13 BR BR112013017985-6A patent/BR112013017985B1/pt active IP Right Grant
- 2012-01-13 JP JP2013549578A patent/JP6120775B2/ja active Active
- 2012-01-13 TW TW101101535A patent/TWI535714B/zh active
- 2012-01-13 SG SG2013053186A patent/SG191927A1/en unknown
- 2012-01-13 AU AU2012205419A patent/AU2012205419B2/en active Active
- 2012-01-13 WO PCT/US2012/021280 patent/WO2012097273A1/en not_active Ceased
- 2012-01-13 MX MX2013008161A patent/MX341342B/es active IP Right Grant
- 2012-01-13 EP EP12701811.7A patent/EP2663562B1/en active Active
- 2012-01-13 KR KR1020137018402A patent/KR101900249B1/ko active Active
- 2012-01-13 CA CA2824403A patent/CA2824403C/en active Active
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2013
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- 2013-07-11 ZA ZA2013/05231A patent/ZA201305231B/en unknown
- 2013-07-12 CL CL2013002027A patent/CL2013002027A1/es unknown
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| Publication number | Publication date |
|---|---|
| CA2824403C (en) | 2019-09-24 |
| US8476281B2 (en) | 2013-07-02 |
| RU2625305C2 (ru) | 2017-07-13 |
| RU2013137752A (ru) | 2015-02-20 |
| US20130267540A1 (en) | 2013-10-10 |
| JP6120775B2 (ja) | 2017-04-26 |
| AR085308A1 (es) | 2013-09-25 |
| ZA201305231B (en) | 2014-11-26 |
| MX2013008161A (es) | 2013-08-27 |
| BR112013017985A2 (pt) | 2019-10-01 |
| MX341342B (es) | 2016-08-17 |
| CN103403000B (zh) | 2017-05-31 |
| AU2012205419A1 (en) | 2013-08-01 |
| CA2824403A1 (en) | 2012-07-19 |
| WO2012097273A1 (en) | 2012-07-19 |
| SG191927A1 (en) | 2013-08-30 |
| US20120184564A1 (en) | 2012-07-19 |
| US9040542B2 (en) | 2015-05-26 |
| EP2663562B1 (en) | 2018-11-07 |
| AU2012205419B2 (en) | 2016-12-15 |
| CN103403000A (zh) | 2013-11-20 |
| EP2663562A1 (en) | 2013-11-20 |
| JP2014502640A (ja) | 2014-02-03 |
| TWI535714B (zh) | 2016-06-01 |
| IL227408A0 (en) | 2013-09-30 |
| NZ612918A (en) | 2015-10-30 |
| KR101900249B1 (ko) | 2018-11-02 |
| ES2705923T3 (es) | 2019-03-27 |
| TW201309678A (zh) | 2013-03-01 |
| KR20140037030A (ko) | 2014-03-26 |
| BR112013017985B1 (pt) | 2021-06-29 |
| IL227408B (en) | 2018-04-30 |
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