CL2012001399A1 - Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. - Google Patents
Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.Info
- Publication number
- CL2012001399A1 CL2012001399A1 CL2012001399A CL2012001399A CL2012001399A1 CL 2012001399 A1 CL2012001399 A1 CL 2012001399A1 CL 2012001399 A CL2012001399 A CL 2012001399A CL 2012001399 A CL2012001399 A CL 2012001399A CL 2012001399 A1 CL2012001399 A1 CL 2012001399A1
- Authority
- CL
- Chile
- Prior art keywords
- emulsion
- container
- homogenizer
- components
- adjuvant
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 17
- 238000000034 method Methods 0.000 title abstract 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004147 Sorbitan trioleate Substances 0.000 title abstract 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 title abstract 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title abstract 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 title abstract 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 title abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 title abstract 2
- 229940068968 polysorbate 80 Drugs 0.000 title abstract 2
- 235000019337 sorbitan trioleate Nutrition 0.000 title abstract 2
- 229960000391 sorbitan trioleate Drugs 0.000 title abstract 2
- 229940031439 squalene Drugs 0.000 title abstract 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 239000012646 vaccine adjuvant Substances 0.000 abstract 1
- 229940124931 vaccine adjuvant Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La solicitud 201201399 describe a un método para la fabricación de un adyuvante para vacunas que es una emulsión de aceite en agua porque el adyuvante comprende escualeno, polisorbato 80 y trioleato de sorbitán, y porque el método comprende las etapas de: (i) formar una primera emulsión, que tiene un primer tamaño promedio de gotita de aceite usando un homogeneizador, en donde la primera emulsión se forma por circulación que comprende: (a) una circulación de tipo I que transfiere los componentes de la primera emulsión entre un primer contenedor y un homogeneizador, seguido por: (b) una circulación de tipo II que transfiere los componentes de la primera emulsión entre el primer contenedor hacia un segundo contenedor, a través del mismo homogeneizador, en donde todos los componentes de la emulsión desde el primer contenedor se hacen pasar a través del homogeneizador hacia el segundo contenedor, y luego, todos los componentes de la emulsión del segundo contenedor se hacen pasar a través del homogeneizador de vuelta hacia el primer contenedor; (ii) microfluidizar la primera emulsión para formar una segunda emulsión, circulando los componentes de la segunda emulsión a través de un equipo de microfluidización varias veces, en donde la circulación comprende transferir los componentes de la segunda emulsión desde un primer contenedor de emulsión a través del equipo de microfluidización hacia un segundo contenedor de emulsión, y luego a través del mismo equipo de microfluidización.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28351809P | 2009-12-03 | 2009-12-03 | |
| DE102009056883A DE102009056883B4 (de) | 2009-12-03 | 2009-12-03 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001399A1 true CL2012001399A1 (es) | 2013-03-08 |
Family
ID=62623433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001399A CL2012001399A1 (es) | 2009-12-03 | 2012-05-30 | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | USRE46906E1 (es) |
| CL (1) | CL2012001399A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012006216A (es) * | 2009-12-03 | 2012-07-12 | Novartis Ag | Circulacion de componentes durante la homogenizacion de emulsiones. |
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| US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| EP0538437B1 (en) | 1991-05-08 | 1999-08-04 | SCHWEIZ. SERUM- & IMPFINSTITUT BERN | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them |
| AU680813B2 (en) | 1992-08-28 | 1997-08-14 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
| US6645463B1 (en) | 1994-05-16 | 2003-11-11 | The Board Of Regents Of The University Of Michigan | Blood-pool selective carrier for lipophilic imaging agents |
| US5843334A (en) | 1994-06-20 | 1998-12-01 | Nippon Shinyaku Co., Ltd. | Method of producing emulsions and an emulsification apparatus |
| US5487965A (en) | 1994-09-06 | 1996-01-30 | Xerox Corporation | Processes for the preparation of developer compositions |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| DE19542499A1 (de) | 1995-11-15 | 1997-05-22 | Bayer Ag | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
| US6168718B1 (en) | 1996-11-08 | 2001-01-02 | Pall Corporation | Method for purifying blood plasma and apparatus suitable therefor |
| JP3995830B2 (ja) | 1999-01-13 | 2007-10-24 | 富士フイルム株式会社 | 熱現像画像記録材料 |
| JP2002535975A (ja) | 1999-02-03 | 2002-10-29 | フォーブス メディ−テック インコーポレーテッド | フィトステロールまたはフィトスタノールの微粒子を製造する方法 |
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| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
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-
2012
- 2012-05-30 CL CL2012001399A patent/CL2012001399A1/es unknown
-
2015
- 2015-10-13 US US14/881,575 patent/USRE46906E1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| USRE46906E1 (en) | 2018-06-26 |
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