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CL2012001399A1 - Method to manufacture adjuvant for vaccine (oil / water emulsion with squalene, polysorbate 80 and sorbitan trioleate), which comprises (i) forming the first emulsion in a homogenizer from one container to another to form a second emulsion, (ii) and microfluidizing the first emulsion to form second emulsion. - Google Patents

Method to manufacture adjuvant for vaccine (oil / water emulsion with squalene, polysorbate 80 and sorbitan trioleate), which comprises (i) forming the first emulsion in a homogenizer from one container to another to form a second emulsion, (ii) and microfluidizing the first emulsion to form second emulsion.

Info

Publication number
CL2012001399A1
CL2012001399A1 CL2012001399A CL2012001399A CL2012001399A1 CL 2012001399 A1 CL2012001399 A1 CL 2012001399A1 CL 2012001399 A CL2012001399 A CL 2012001399A CL 2012001399 A CL2012001399 A CL 2012001399A CL 2012001399 A1 CL2012001399 A1 CL 2012001399A1
Authority
CL
Chile
Prior art keywords
emulsion
container
homogenizer
components
adjuvant
Prior art date
Application number
CL2012001399A
Other languages
Spanish (es)
Inventor
Harald Rueckl
Hanno Scheffczik
Barbara Santry
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62623433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012001399(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102009056883A external-priority patent/DE102009056883B4/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012001399A1 publication Critical patent/CL2012001399A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La solicitud 201201399 describe a un método para la fabricación de un adyuvante para vacunas que es una emulsión de aceite en agua porque el adyuvante comprende escualeno, polisorbato 80 y trioleato de sorbitán, y porque el método comprende las etapas de: (i) formar una primera emulsión, que tiene un primer tamaño promedio de gotita de aceite usando un homogeneizador, en donde la primera emulsión se forma por circulación que comprende: (a) una circulación de tipo I que transfiere los componentes de la primera emulsión entre un primer contenedor y un homogeneizador, seguido por: (b) una circulación de tipo II que transfiere los componentes de la primera emulsión entre el primer contenedor hacia un segundo contenedor, a través del mismo homogeneizador, en donde todos los componentes de la emulsión desde el primer contenedor se hacen pasar a través del homogeneizador hacia el segundo contenedor, y luego, todos los componentes de la emulsión del segundo contenedor se hacen pasar a través del homogeneizador de vuelta hacia el primer contenedor; (ii) microfluidizar la primera emulsión para formar una segunda emulsión, circulando los componentes de la segunda emulsión a través de un equipo de microfluidización varias veces, en donde la circulación comprende transferir los componentes de la segunda emulsión desde un primer contenedor de emulsión a través del equipo de microfluidización hacia un segundo contenedor de emulsión, y luego a través del mismo equipo de microfluidización.The application 201201399 describes a method for the manufacture of a vaccine adjuvant which is an oil-in-water emulsion because the adjuvant comprises squalene, polysorbate 80 and sorbitan trioleate, and because the method comprises the steps of: (i) forming a first emulsion, having a first average oil droplet size using a homogenizer, wherein the first emulsion is formed by circulation comprising: (a) a type I circulation that transfers the components of the first emulsion between a first container and a homogenizer, followed by: (b) a type II circulation that transfers the components of the first emulsion between the first container to a second container, through the same homogenizer, where all the components of the emulsion from the first container are are passed through the homogenizer into the second container, and then all components of the emulsion from the second container are passed through d the homogenizer back to the first container; (ii) microfluidizing the first emulsion to form a second emulsion by circulating the components of the second emulsion through microfluidization equipment several times, wherein the circulation comprises transferring the components of the second emulsion from a first emulsion container through from microfluidization equipment into a second emulsion container, and then through the same microfluidization equipment.

CL2012001399A 2009-12-03 2012-05-30 Method to manufacture adjuvant for vaccine (oil / water emulsion with squalene, polysorbate 80 and sorbitan trioleate), which comprises (i) forming the first emulsion in a homogenizer from one container to another to form a second emulsion, (ii) and microfluidizing the first emulsion to form second emulsion. CL2012001399A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28351809P 2009-12-03 2009-12-03
DE102009056883A DE102009056883B4 (en) 2009-12-03 2009-12-03 Vaccine adjuvants and improved methods of making the same

Publications (1)

Publication Number Publication Date
CL2012001399A1 true CL2012001399A1 (en) 2013-03-08

Family

ID=62623433

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001399A CL2012001399A1 (en) 2009-12-03 2012-05-30 Method to manufacture adjuvant for vaccine (oil / water emulsion with squalene, polysorbate 80 and sorbitan trioleate), which comprises (i) forming the first emulsion in a homogenizer from one container to another to form a second emulsion, (ii) and microfluidizing the first emulsion to form second emulsion.

Country Status (2)

Country Link
US (1) USRE46906E1 (en)
CL (1) CL2012001399A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012006216A (en) * 2009-12-03 2012-07-12 Novartis Ag Circulation of components during homogenization of emulsions.

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1096717A (en) 1965-05-05 1967-12-29 Henry Milton Hayward Bulk cooking of tinned foodstuffs
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
DE69229703T2 (en) 1991-05-08 2000-04-27 Schweiz Serum & Impfinst Restored influenza virosomes with immunostimulatory and immuno-enhancing properties and vaccines containing them
CA2142103C (en) 1992-08-28 2003-07-08 Haim Aviv Submicron emulsions as ocular drug delivery vehicles
US6645463B1 (en) 1994-05-16 2003-11-11 The Board Of Regents Of The University Of Michigan Blood-pool selective carrier for lipophilic imaging agents
US5843334A (en) 1994-06-20 1998-12-01 Nippon Shinyaku Co., Ltd. Method of producing emulsions and an emulsification apparatus
US5487965A (en) 1994-09-06 1996-01-30 Xerox Corporation Processes for the preparation of developer compositions
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
DE19542499A1 (en) 1995-11-15 1997-05-22 Bayer Ag Method and device for producing a parenteral drug preparation
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
JP3995830B2 (en) 1999-01-13 2007-10-24 富士フイルム株式会社 Thermally developed image recording material
AU2426500A (en) 1999-02-03 2000-08-25 Forbes Medi-Tech Inc. Method of preparing microparticles of phytosterols or phytostanols
JP2002537102A (en) 1999-02-26 2002-11-05 カイロン コーポレイション Microemulsion with adsorbed polymer and fine particles
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
KR100310234B1 (en) 1999-08-20 2001-11-14 안복현 Preparation method of metal oxide slurry for cmp of semiconductor
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
DE10059430A1 (en) 2000-11-30 2002-06-06 Cognis Deutschland Gmbh Finely divided emulsions
US20060148776A1 (en) 2003-03-13 2006-07-06 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US20040185068A1 (en) 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
SI1613346T1 (en) 2003-04-04 2013-02-28 Pah Usa 15 Llc Microfluidized oil-in-water emulsions and vaccine compositions
WO2005027872A2 (en) 2003-06-04 2005-03-31 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
US20050208083A1 (en) 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
GB0319500D0 (en) 2003-08-19 2003-09-17 Resolution Chemicals Ltd Particle-size reduction apparatus,and use thereof
GB0406515D0 (en) 2004-03-23 2004-04-28 Novartis Ag Organic compounds
WO2005089718A2 (en) 2004-03-23 2005-09-29 Novartis Ag Pharmaceutical compositions
RU2347586C2 (en) 2004-04-05 2009-02-27 Пфайзер Продактс Инк. Microfluidised oil-in-water emulsions and vaccine compositions
GB0411411D0 (en) * 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
DE102004031550A1 (en) 2004-06-29 2006-02-02 Cognis Ip Management Gmbh Highly concentrated, self-emulsifying emulsion bases for the preparation of oil-in-water emulsions
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
TW200611880A (en) 2004-10-14 2006-04-16 Bi-Chang Li The microprocessor unit of bio-sludge-hydrolyzing equipment
CA2586074C (en) 2004-11-09 2013-07-23 Novagali Pharma Sa Ophthalmic oil-in-water type emulsion with stable positive zeta potential
GB0427568D0 (en) 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
EA200701787A1 (en) 2005-03-23 2008-08-29 Глаксосмитклайн Байолоджикалс С.А. IMMUNE COMPOSITION, METHOD FOR ITS MANUFACTURE, ITS APPLICATION AND VACCINATION METHOD
JP2009504805A (en) 2005-08-09 2009-02-05 ナノバイオ コーポレーション Nanoemulsion composition having anti-inflammatory activity
EP1945271B1 (en) 2005-10-24 2019-10-16 Magsense Life Sciences, INC. Method for preparing polymer coated microparticles
US20100226932A1 (en) 2006-02-22 2010-09-09 Novavax, Inc. Adjuvant and Vaccine Compositions
EP1849452A1 (en) 2006-04-27 2007-10-31 Cognis IP Management GmbH Dispersions containing acylglutamate
DK2043682T3 (en) 2006-07-17 2014-06-02 Glaxosmithkline Biolog Sa INFLUENZA VACCINE
CN101553252A (en) 2006-12-06 2009-10-07 诺华有限公司 Vaccine comprising antigens from four strains of influenza virus
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
KR20110009128A (en) 2008-04-04 2011-01-27 로버트 쇼어 Lipid-oil-water Nanoemulsion Delivery System for Microtubule-Interacting Agents
US8187554B2 (en) 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
EP2307021A4 (en) 2008-06-19 2011-08-10 Neurosystec Corp Formulations
DE102009056871A1 (en) 2009-12-03 2011-06-22 Novartis AG, 4056 Vaccine adjuvants and improved methods of making the same
SG10201501612RA (en) 2009-12-03 2015-04-29 Novartis Ag Hydrophilic filtration during manufacture of vaccine adjuvants
DE102009056884B4 (en) 2009-12-03 2021-03-18 Novartis Ag Vaccine Adjuvants and Improved Methods for Making Same
CA2782650C (en) 2009-12-03 2014-02-04 Novartis Ag Arranging interaction and back pressure chambers for microfluidization
DE102009056883B4 (en) 2009-12-03 2012-08-16 Novartis Ag Vaccine adjuvants and improved methods of making the same
MX2012006216A (en) 2009-12-03 2012-07-12 Novartis Ag Circulation of components during homogenization of emulsions.
WO2011106565A1 (en) 2010-02-24 2011-09-01 Travers William A Methods and devices for controlling particle size and particle size distribution
GB201009671D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process

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Publication number Publication date
USRE46906E1 (en) 2018-06-26

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