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CL2011003052A1 - Compuesto 8-(2,4-dimetoxi-pirimidin-5-il)-1-(1-etil-3-metil-1h-pirazol-4-il)-3-metil-1,3-dihidro-imidazo[4,5-c]quinolin-2-ona; su composicion farmaceutica; util en el tratamiento de enfermedades dependientes de la cinasa de lipido y/o de proteina, en el tratamiento de enfermedades proliferativas, tales como tumores y carcinomas de cerebro, riñon, higado, entre otras. - Google Patents

Compuesto 8-(2,4-dimetoxi-pirimidin-5-il)-1-(1-etil-3-metil-1h-pirazol-4-il)-3-metil-1,3-dihidro-imidazo[4,5-c]quinolin-2-ona; su composicion farmaceutica; util en el tratamiento de enfermedades dependientes de la cinasa de lipido y/o de proteina, en el tratamiento de enfermedades proliferativas, tales como tumores y carcinomas de cerebro, riñon, higado, entre otras.

Info

Publication number
CL2011003052A1
CL2011003052A1 CL2011003052A CL2011003052A CL2011003052A1 CL 2011003052 A1 CL2011003052 A1 CL 2011003052A1 CL 2011003052 A CL2011003052 A CL 2011003052A CL 2011003052 A CL2011003052 A CL 2011003052A CL 2011003052 A1 CL2011003052 A1 CL 2011003052A1
Authority
CL
Chile
Prior art keywords
methyl
treatment
imidazo
compound
pharmaceutical composition
Prior art date
Application number
CL2011003052A
Other languages
English (en)
Inventor
Pascal Furet
Frank Stephan Mah Robert Ragot Christian Stauffer Frederic Kalthoff
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011003052(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2011003052A1 publication Critical patent/CL2011003052A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos heterocíclicos derivados de 1-h-imidazo-[4,5-c]-quinolinona; composición farmacéutica; uso del compuesto para tratar una enfermedad proliferativa tal como cáncer de vejiga, mama, estómago, ovarios, páncreas, pulmón, entre otras.
CL2011003052A 2009-06-04 2011-12-02 Compuesto 8-(2,4-dimetoxi-pirimidin-5-il)-1-(1-etil-3-metil-1h-pirazol-4-il)-3-metil-1,3-dihidro-imidazo[4,5-c]quinolin-2-ona; su composicion farmaceutica; util en el tratamiento de enfermedades dependientes de la cinasa de lipido y/o de proteina, en el tratamiento de enfermedades proliferativas, tales como tumores y carcinomas de cerebro, riñon, higado, entre otras. CL2011003052A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18414109P 2009-06-04 2009-06-04

Publications (1)

Publication Number Publication Date
CL2011003052A1 true CL2011003052A1 (es) 2012-08-31

Family

ID=42697442

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011003052A CL2011003052A1 (es) 2009-06-04 2011-12-02 Compuesto 8-(2,4-dimetoxi-pirimidin-5-il)-1-(1-etil-3-metil-1h-pirazol-4-il)-3-metil-1,3-dihidro-imidazo[4,5-c]quinolin-2-ona; su composicion farmaceutica; util en el tratamiento de enfermedades dependientes de la cinasa de lipido y/o de proteina, en el tratamiento de enfermedades proliferativas, tales como tumores y carcinomas de cerebro, riñon, higado, entre otras.

Country Status (30)

Country Link
US (2) US8476294B2 (es)
EP (1) EP2438064A1 (es)
JP (1) JP5596137B2 (es)
KR (1) KR101445458B1 (es)
CN (1) CN102574845B (es)
AR (1) AR076949A1 (es)
AU (1) AU2010255727B2 (es)
BR (1) BRPI1010621A2 (es)
CA (1) CA2763821A1 (es)
CL (1) CL2011003052A1 (es)
CO (1) CO6470887A2 (es)
CR (1) CR20110608A (es)
CU (1) CU24064B1 (es)
DO (1) DOP2011000373A (es)
EA (1) EA020715B1 (es)
EC (1) ECSP11011500A (es)
GE (1) GEP20156267B (es)
IL (1) IL216452A0 (es)
MA (1) MA33332B1 (es)
MX (1) MX2011012943A (es)
NI (1) NI201100209A (es)
NZ (1) NZ596487A (es)
PE (1) PE20120224A1 (es)
SG (1) SG176572A1 (es)
TN (1) TN2011000626A1 (es)
TW (1) TWI464168B (es)
UA (1) UA106074C2 (es)
UY (1) UY32682A (es)
WO (1) WO2010139731A1 (es)
ZA (1) ZA201108439B (es)

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DE102010035744A1 (de) * 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CA2819955A1 (en) * 2010-12-06 2012-06-14 Piramal Enterprises Limited Substituted imidazoquinoline derivatives
JO3003B1 (ar) 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
JP5820080B2 (ja) * 2011-11-17 2015-11-24 山▲東▼▲軒▼竹医▲葯▼科技有限公司 三環系ＰＩ３Ｋ及び／又はｍＴＯＲ抑制剤
WO2014141118A1 (en) * 2013-03-14 2014-09-18 Piramal Enterprises Limited Imidazo[4,5-c]quinoline derivatives and uses thereof
PL2986594T3 (pl) 2013-04-15 2017-10-31 Fmc Corp Amidy grzybobójcze
EP3044285A1 (de) 2013-09-11 2016-07-20 Merck Patent GmbH Heterocyclische verbindungen
WO2015043398A1 (zh) 2013-09-30 2015-04-02 上海璎黎药业有限公司 稠合嘧啶类化合物、中间体、其制备方法、组合物和应用
EP3056210B1 (en) * 2013-10-11 2022-05-11 National University Corporation Tokyo Medical and Dental University Drug for prevention or treatment of spinocerebellar degeneration
CN104447740B (zh) * 2013-11-20 2017-02-22 北京富龙康泰生物技术有限公司 咪唑酮类衍生物、其药物组合物和用途
NO2714752T3 (es) 2014-05-08 2018-04-21
MA40281B1 (fr) 2014-06-03 2018-11-30 Idorsia Pharmaceuticals Ltd Composés de pyrazole et leur utilisation en tant qu' agents de blocage des canaux calciques de type t
RU2743343C2 (ru) * 2015-04-02 2021-02-17 Мерк Патент Гмбх Имидазолонилхинолины и их применение в качестве ингибиторов киназы атм
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
BR112019007594A2 (pt) 2016-10-13 2019-07-02 Loyola University Of Chicago método para bloquear a transmissão do parasita da malária
PT3554490T (pt) 2016-12-16 2022-03-17 Idorsia Pharmaceuticals Ltd Combinação farmacêutica compreendendo um bloqueador de canais de cálcio de tipo t
MX376203B (es) 2017-02-06 2025-03-07 Idorsia Pharmaceuticals Ltd Un proceso novedoso para la sintesis de 1-aril-1-trifluoro-metil-ciclopropanos.
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CA3085366A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
KR20220068243A (ko) * 2019-09-23 2022-05-25 난징 젱시앙 파마슈티칼스 컴퍼니 리미티드 포스포디에스테라제 억제제 및 용도
CN116056698B (zh) * 2020-09-21 2024-11-19 威尚（上海）生物医药有限公司 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物
WO2022160109A1 (zh) * 2021-01-26 2022-08-04 京东方科技集团股份有限公司 量子点发光器件、显示装置和制作方法
CN116768928A (zh) * 2023-06-15 2023-09-19 上海毕臣生化科技有限公司 一种3-叔丁基-5-硼酸酯基吡啶的合成方法
CN117384154A (zh) * 2023-09-04 2024-01-12 广州医科大学 一种吡咯并喹啉酮化合物、合成方法及其应用

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Also Published As

Publication number Publication date
ECSP11011500A (es) 2012-01-31
UA106074C2 (uk) 2014-07-25
BRPI1010621A2 (pt) 2016-06-21
AU2010255727B2 (en) 2013-02-28
CA2763821A1 (en) 2010-12-09
CO6470887A2 (es) 2012-06-29
EA020715B1 (ru) 2015-01-30
IL216452A0 (en) 2012-01-31
NI201100209A (es) 2012-02-02
DOP2011000373A (es) 2011-12-31
CU20110221A7 (es) 2012-03-15
JP2012528828A (ja) 2012-11-15
US20100317657A1 (en) 2010-12-16
CN102574845B (zh) 2015-09-02
KR20120034710A (ko) 2012-04-12
AR076949A1 (es) 2011-07-20
NZ596487A (en) 2012-11-30
UY32682A (es) 2011-01-31
EA201101704A1 (ru) 2012-07-30
US20140005163A1 (en) 2014-01-02
WO2010139731A1 (en) 2010-12-09
JP5596137B2 (ja) 2014-09-24
TW201102386A (en) 2011-01-16
CR20110608A (es) 2012-01-16
TN2011000626A1 (en) 2013-05-24
GEP20156267B (en) 2015-04-14
MA33332B1 (fr) 2012-06-01
MX2011012943A (es) 2012-01-27
CN102574845A (zh) 2012-07-11
EP2438064A1 (en) 2012-04-11
TWI464168B (zh) 2014-12-11
KR101445458B1 (ko) 2014-10-07
ZA201108439B (en) 2012-08-29
US8476294B2 (en) 2013-07-02
CU24064B1 (es) 2014-12-26
PE20120224A1 (es) 2012-04-04
SG176572A1 (en) 2012-01-30
AU2010255727A1 (en) 2011-12-08

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