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MA33332B1 - Dérivés de la 1h-imidazo[4,5-c]quinolinone - Google Patents

Dérivés de la 1h-imidazo[4,5-c]quinolinone

Info

Publication number
MA33332B1
MA33332B1 MA34404A MA34404A MA33332B1 MA 33332 B1 MA33332 B1 MA 33332B1 MA 34404 A MA34404 A MA 34404A MA 34404 A MA34404 A MA 34404A MA 33332 B1 MA33332 B1 MA 33332B1
Authority
MA
Morocco
Prior art keywords
imidazo
quinolinone
kinase
derivatives
treatment
Prior art date
Application number
MA34404A
Other languages
Arabic (ar)
English (en)
Inventor
Pascal Furet
Frank Stephan Kalthoff
Robert Mah
Christian Ragot
Frédéric Stauffer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33332(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33332B1 publication Critical patent/MA33332B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/12Keratolytics, e.g. wart or anti-corn preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE L'UTILISATION DE DÉRIVÉS DE LA 1H-IMIDAZO[4,5-C]QUINOLINONE ET DE LEURS SELS DANS LE TRAITEMENT DE MALADIES DÉPENDANTES D'UNE PROTÉINE-KINASE ET/OU D'UNE LIPIDE-KINASE ET DANS LA FABRICATION DE PRÉPARATIONS PHARMACEUTIQUES POUR LE TRAITEMENT DESDITES MALADIES. L'INVENTION CONCERNE DES DÉRIVÉS DE LA 1H-IMIDAZO[4,5-C] QUINOLINONE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES DÉPENDANTES D'UNE PROTÉINE-KINASE ET/OU D'UNE LIPIDE-KINASE, UN PROCÉDÉ DE TRAITEMENT CONTRE LESDITES MALADIES, CONSISTANT À ADMINISTRER LES DÉRIVÉS DE LA 1H- IMIDAZO[4,5-C] QUINOLINONE À UN ANIMAL À SANG CHAUD, PARTICULIÈREMENT UN HUMAIN, DES PRÉPARATIONS PHARMACEUTIQUES COMPRENANT UN DÉRIVÉ DE LA 1H-IMIDAZO[4,5-C] QUINOLINONE, PARTICULIÈREMENT POUR LE TRAITEMENT D'UNE MALADIE DÉPENDANTE D'UNE PROTÉINE-KINASE ET/OU D'UNE LIPIDE-KINASE, DE NOUVEAUX DÉRIVÉS DE LA H- IMIDAZO[4,5-C] QUINOLINONE, ET UN PROCÉDÉ DE PRÉPARATION DES NOUVEAUX DÉRIVÉS DE LA 1H- IMIDAZO[4,5-C] QUINOLINONE.
MA34404A 2009-06-04 2010-06-02 Dérivés de la 1h-imidazo[4,5-c]quinolinone MA33332B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18414109P 2009-06-04 2009-06-04
PCT/EP2010/057719 WO2010139731A1 (fr) 2009-06-04 2010-06-02 Dérivés de la 1h-imidazo[4,5-c]quinolinone

Publications (1)

Publication Number Publication Date
MA33332B1 true MA33332B1 (fr) 2012-06-01

Family

ID=42697442

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34404A MA33332B1 (fr) 2009-06-04 2010-06-02 Dérivés de la 1h-imidazo[4,5-c]quinolinone

Country Status (30)

Country Link
US (2) US8476294B2 (fr)
EP (1) EP2438064A1 (fr)
JP (1) JP5596137B2 (fr)
KR (1) KR101445458B1 (fr)
CN (1) CN102574845B (fr)
AR (1) AR076949A1 (fr)
AU (1) AU2010255727B2 (fr)
BR (1) BRPI1010621A2 (fr)
CA (1) CA2763821A1 (fr)
CL (1) CL2011003052A1 (fr)
CO (1) CO6470887A2 (fr)
CR (1) CR20110608A (fr)
CU (1) CU24064B1 (fr)
DO (1) DOP2011000373A (fr)
EA (1) EA020715B1 (fr)
EC (1) ECSP11011500A (fr)
GE (1) GEP20156267B (fr)
IL (1) IL216452A0 (fr)
MA (1) MA33332B1 (fr)
MX (1) MX2011012943A (fr)
NI (1) NI201100209A (fr)
NZ (1) NZ596487A (fr)
PE (1) PE20120224A1 (fr)
SG (1) SG176572A1 (fr)
TN (1) TN2011000626A1 (fr)
TW (1) TWI464168B (fr)
UA (1) UA106074C2 (fr)
UY (1) UY32682A (fr)
WO (1) WO2010139731A1 (fr)
ZA (1) ZA201108439B (fr)

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JO3003B1 (ar) 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
EP2781520B1 (fr) * 2011-11-17 2016-05-04 Xuanzhu Pharma Co., Ltd. Inhibiteur tricyclique de pi3k et/ou mtor
WO2014141118A1 (fr) * 2013-03-14 2014-09-18 Piramal Enterprises Limited Dérivés d'imidazo[4,5-c]quinoléine et leurs utilisations
KR102227271B1 (ko) 2013-04-15 2021-03-12 에프엠씨 코포레이션 살진균성 아미드
EP3044285A1 (fr) 2013-09-11 2016-07-20 Merck Patent GmbH Composés hétérocycliques
US9745321B2 (en) 2013-09-30 2017-08-29 Shanghai Yingli Pharmaceutical Co., Ltd Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
JP6606428B2 (ja) * 2013-10-11 2019-11-13 国立大学法人 東京医科歯科大学 脊髄小脳変性症を予防又は治療するための薬剤
CN104447740B (zh) * 2013-11-20 2017-02-22 北京富龙康泰生物技术有限公司 咪唑酮类衍生物、其药物组合物和用途
NO2714752T3 (fr) 2014-05-08 2018-04-21
SG11201609974PA (en) 2014-06-03 2016-12-29 Actelion Pharmaceuticals Ltd Pyrazole compounds and their use as t-type calcium channel blockers
DK3560924T3 (da) 2015-04-02 2021-06-28 Merck Patent Gmbh Imidazolonylquinoliner og deres anvendelse som atm-kinase-inhibitorer
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
EP3526220B1 (fr) 2016-10-13 2025-06-11 The United States of America, as represented by the Secretary, Department of Health and Human Services Composés et méthode de blocage de la transmission d'un parasite du paludisme
AU2017378092B2 (en) 2016-12-16 2023-11-23 Idorsia Pharmaceuticals Ltd Pharmaceutical combination comprising a T-type calcium channel blocker
WO2018141961A1 (fr) 2017-02-06 2018-08-09 Idorsia Pharmaceuticals Ltd Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
JP7569688B2 (ja) 2017-12-22 2024-10-18 ハイバーセル,インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
WO2021061803A1 (fr) * 2019-09-23 2021-04-01 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Inhibiteurs de phosphodiestérase et leur utilisation
JP7669473B2 (ja) * 2020-09-21 2025-04-28 ウェイ ジョン 血液脳関門透過能力を有する置換1-(3,3-ジフルオロピペリジン-4-イル)-イミダゾ[4,5-c]キノリン-2-オン化合物
CN115136336A (zh) * 2021-01-26 2022-09-30 京东方科技集团股份有限公司 量子点发光器件、显示装置和制作方法
CN116768928A (zh) * 2023-06-15 2023-09-19 上海毕臣生化科技有限公司 一种3-叔丁基-5-硼酸酯基吡啶的合成方法
CN117384154A (zh) * 2023-09-04 2024-01-12 广州医科大学 一种吡咯并喹啉酮化合物、合成方法及其应用

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Also Published As

Publication number Publication date
TWI464168B (zh) 2014-12-11
WO2010139731A1 (fr) 2010-12-09
AU2010255727B2 (en) 2013-02-28
NZ596487A (en) 2012-11-30
CA2763821A1 (fr) 2010-12-09
US8476294B2 (en) 2013-07-02
EA020715B1 (ru) 2015-01-30
GEP20156267B (en) 2015-04-14
CU20110221A7 (es) 2012-03-15
IL216452A0 (en) 2012-01-31
ZA201108439B (en) 2012-08-29
EA201101704A1 (ru) 2012-07-30
DOP2011000373A (es) 2011-12-31
CL2011003052A1 (es) 2012-08-31
UA106074C2 (uk) 2014-07-25
JP2012528828A (ja) 2012-11-15
EP2438064A1 (fr) 2012-04-11
PE20120224A1 (es) 2012-04-04
CO6470887A2 (es) 2012-06-29
SG176572A1 (en) 2012-01-30
KR101445458B1 (ko) 2014-10-07
AR076949A1 (es) 2011-07-20
TW201102386A (en) 2011-01-16
BRPI1010621A2 (pt) 2016-06-21
TN2011000626A1 (en) 2013-05-24
JP5596137B2 (ja) 2014-09-24
UY32682A (es) 2011-01-31
AU2010255727A1 (en) 2011-12-08
US20100317657A1 (en) 2010-12-16
NI201100209A (es) 2012-02-02
KR20120034710A (ko) 2012-04-12
CN102574845A (zh) 2012-07-11
CR20110608A (es) 2012-01-16
MX2011012943A (es) 2012-01-27
US20140005163A1 (en) 2014-01-02
CN102574845B (zh) 2015-09-02
ECSP11011500A (es) 2012-01-31
CU24064B1 (es) 2014-12-26

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