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CL2009000236A1 - Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios. - Google Patents

Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios.

Info

Publication number
CL2009000236A1
CL2009000236A1 CL2009000236A CL2009000236A CL2009000236A1 CL 2009000236 A1 CL2009000236 A1 CL 2009000236A1 CL 2009000236 A CL2009000236 A CL 2009000236A CL 2009000236 A CL2009000236 A CL 2009000236A CL 2009000236 A1 CL2009000236 A1 CL 2009000236A1
Authority
CL
Chile
Prior art keywords
triazolopyridazine
hypercoagulability
embolism
thrombosis
prophylaxis
Prior art date
Application number
CL2009000236A
Other languages
English (en)
Inventor
Wolkmar Wehner
Uwe Heinelt
Matthias Hermann
Karl Schoenafinger
Henning Steinhagen
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2009000236A1 publication Critical patent/CL2009000236A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCIóN SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRIDAZINAS DE FÓRMULA (I), DONDE<br /> R1-R8 Y 01-03 SE DEFINEN EN LA MEMORIA DESCRIPTIVA, CON ACTIVIDAD ANTITROMBÓTICA, QUE INHIBEN<br /> ESPECIALMENTE EL RECEPTOR 1 ACTIVADO POR PROTEASA , A PROCEDIMIENTOS DE PREPARACIÓN Y A SU USO<br /> PARA PREPARAR MEDICAMENTOS<br />  
CL2009000236A 2008-02-05 2009-02-03 Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios. CL2009000236A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290112 2008-02-05

Publications (1)

Publication Number Publication Date
CL2009000236A1 true CL2009000236A1 (es) 2009-06-05

Family

ID=39539711

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000236A CL2009000236A1 (es) 2008-02-05 2009-02-03 Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios.

Country Status (31)

Country Link
US (2) US8076336B2 (es)
EP (1) EP2240487B1 (es)
JP (1) JP5526040B2 (es)
KR (1) KR20100114514A (es)
CN (1) CN101981034B (es)
AR (1) AR070410A1 (es)
AT (1) ATE537172T1 (es)
AU (1) AU2009211887B2 (es)
BR (1) BRPI0907486A2 (es)
CA (1) CA2713550C (es)
CL (1) CL2009000236A1 (es)
CO (1) CO6260083A2 (es)
CY (1) CY1113228T1 (es)
DK (1) DK2240487T3 (es)
ES (1) ES2379447T3 (es)
HR (1) HRP20120230T1 (es)
IL (1) IL207205A0 (es)
MA (1) MA32061B1 (es)
MX (1) MX2010008490A (es)
MY (1) MY152040A (es)
NZ (1) NZ587141A (es)
PA (1) PA8814801A1 (es)
PE (1) PE20091455A1 (es)
PL (1) PL2240487T3 (es)
PT (1) PT2240487E (es)
RS (1) RS52264B (es)
RU (1) RU2499797C2 (es)
SI (1) SI2240487T1 (es)
TW (1) TW200946532A (es)
WO (1) WO2009097970A1 (es)
ZA (1) ZA201004467B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ575548A (en) * 2006-09-18 2011-09-30 Vertex Pharma Heterocyclic inhibitors of c-Met and uses thereof
MY148732A (en) 2008-02-05 2013-05-31 Sanofi Aventis Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
MX2021013507A (es) * 2019-06-19 2021-12-10 Nmd Pharma As Proceso para la preparacion de inhibidores del canal de cloruro ciec-1.
JOP20220063A1 (ar) 2019-09-16 2023-01-30 Takeda Pharmaceuticals Co مشتقات بيريدازين-3(2h)-أون ملتحمة بأزول
CN117304210A (zh) * 2022-06-21 2023-12-29 南京理工大学 二硝胺类四并环高能量密度材料及其合成方法
CN119528900A (zh) * 2024-08-08 2025-02-28 河南科技大学 具有抗肝癌活性的甲基噻唑衍生物及其制备方法和应用

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US4578464A (en) * 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
AU695377B2 (en) * 1994-09-16 1998-08-13 Takeda Chemical Industries Ltd. Triazolopyridazines process and intermediates for their preparation and their use as medicaments
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7488742B2 (en) 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
CA2446924C (en) * 2001-04-19 2011-02-08 Eisai Co., Ltd. 2-iminopyrrolidine derivatives
US6956046B2 (en) 2001-05-25 2005-10-18 Mochida Pharmaceutical Co., Ltd. 4-hydroxypiperidine derivatives having analgesic activity
EP1439178A4 (en) * 2001-10-05 2005-11-16 Takeda Pharmaceutical Heterocyclic compounds, oxazole derivatives, process for their preparation and their use
MY139335A (en) 2001-10-18 2009-09-30 Schering Corp Substituted tricyclic himbacine derivatives that are useful as thrombin receptor antagonists
ATE455774T1 (de) 2002-04-16 2010-02-15 Schering Corp Trizyklische thrombinrezeptorantagonisten
EP2444393A1 (en) * 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
TW200531688A (en) * 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
EP1813282A4 (en) 2004-11-09 2011-03-02 Eisai R&D Man Co Ltd MEANS FOR THE TREATMENT OF ANGIOSPASM IN SUBARACHO-OAL BLOODING WITH THROMBIN RECEPTOR ANTAGONIST AS AN ACTIVE AGENT
WO2007075567A1 (en) * 2005-12-21 2007-07-05 Janssen Pharmaceutica, N.V. Triazolopyridazines as tyrosine kinase modulators
DE102006025318A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Ag Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung
DE102006036023A1 (de) * 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
MY148732A (en) * 2008-02-05 2013-05-31 Sanofi Aventis Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
SI2242740T1 (sl) * 2008-02-05 2013-03-29 Sanofi SF5-derivati kot PAR1 inhibitorji, njihova priprava in uporaba kot zdravila
EP2240179B1 (de) * 2008-02-05 2016-08-17 Sanofi Imidazopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
US8324241B2 (en) * 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
WO2009126861A2 (en) * 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolopyridine compounds useful as dgat1 inhibitors

Also Published As

Publication number Publication date
RS52264B (sr) 2012-10-31
ATE537172T1 (de) 2011-12-15
RU2499797C2 (ru) 2013-11-27
BRPI0907486A2 (pt) 2015-07-14
PA8814801A1 (es) 2009-09-17
PE20091455A1 (es) 2009-10-22
HK1149011A1 (en) 2011-09-23
PT2240487E (pt) 2012-03-08
PL2240487T3 (pl) 2012-05-31
AU2009211887A1 (en) 2009-08-13
KR20100114514A (ko) 2010-10-25
AR070410A1 (es) 2010-04-07
MX2010008490A (es) 2010-08-18
SI2240487T1 (sl) 2012-04-30
CO6260083A2 (es) 2011-03-22
CA2713550A1 (en) 2009-08-13
MY152040A (en) 2014-08-15
RU2010136957A (ru) 2012-03-20
EP2240487A1 (de) 2010-10-20
CN101981034A (zh) 2011-02-23
CN101981034B (zh) 2013-08-14
NZ587141A (en) 2012-04-27
ES2379447T3 (es) 2012-04-26
TW200946532A (en) 2009-11-16
US20110034451A1 (en) 2011-02-10
CY1113228T1 (el) 2016-04-13
US9079906B2 (en) 2015-07-14
IL207205A0 (en) 2010-12-30
EP2240487B1 (de) 2011-12-14
JP2011511016A (ja) 2011-04-07
ZA201004467B (en) 2011-09-28
JP5526040B2 (ja) 2014-06-18
WO2009097970A1 (de) 2009-08-13
MA32061B1 (fr) 2011-02-01
DK2240487T3 (da) 2012-04-02
US8076336B2 (en) 2011-12-13
AU2009211887B2 (en) 2013-09-19
US20120010203A1 (en) 2012-01-12
CA2713550C (en) 2016-06-14
HRP20120230T1 (hr) 2012-04-30

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