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CL2008003006A1 - Uso de ester metilico del acido (-)-(3ar,4s,7ar)-4-hidroxi-4-m-toliletinil-octahidro-indol-1-carboxilico en base libre o en forma de sal para el tratamiento, prevencion o retraso de la progresion de la disquinesia de parkinson asociada a l-dopa; uso de la composicion farmaceutica; uso de una composicion que ademas comprende l-dopa. - Google Patents

Uso de ester metilico del acido (-)-(3ar,4s,7ar)-4-hidroxi-4-m-toliletinil-octahidro-indol-1-carboxilico en base libre o en forma de sal para el tratamiento, prevencion o retraso de la progresion de la disquinesia de parkinson asociada a l-dopa; uso de la composicion farmaceutica; uso de una composicion que ademas comprende l-dopa.

Info

Publication number
CL2008003006A1
CL2008003006A1 CL2008003006A CL2008003006A CL2008003006A1 CL 2008003006 A1 CL2008003006 A1 CL 2008003006A1 CL 2008003006 A CL2008003006 A CL 2008003006A CL 2008003006 A CL2008003006 A CL 2008003006A CL 2008003006 A1 CL2008003006 A1 CL 2008003006A1
Authority
CL
Chile
Prior art keywords
dopa
composition
parkinson
progression
prevention
Prior art date
Application number
CL2008003006A
Other languages
English (en)
Inventor
Daniel Umbricht
Fabrizio Gasparini
Paolo Therese Di
Baltazar Gomez-Mancilla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2008003006A1 publication Critical patent/CL2008003006A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

Uso de un modulador de mglur para el tratamiento, prevención o retrasar la progresión del Parkinson y/o un desorden asociado con la Enfermedad de Parkinson.
CL2008003006A 2007-10-12 2008-10-10 Uso de ester metilico del acido (-)-(3ar,4s,7ar)-4-hidroxi-4-m-toliletinil-octahidro-indol-1-carboxilico en base libre o en forma de sal para el tratamiento, prevencion o retraso de la progresion de la disquinesia de parkinson asociada a l-dopa; uso de la composicion farmaceutica; uso de una composicion que ademas comprende l-dopa. CL2008003006A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97948607P 2007-10-12 2007-10-12
US5033308P 2008-05-05 2008-05-05

Publications (1)

Publication Number Publication Date
CL2008003006A1 true CL2008003006A1 (es) 2009-05-08

Family

ID=40348021

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003006A CL2008003006A1 (es) 2007-10-12 2008-10-10 Uso de ester metilico del acido (-)-(3ar,4s,7ar)-4-hidroxi-4-m-toliletinil-octahidro-indol-1-carboxilico en base libre o en forma de sal para el tratamiento, prevencion o retraso de la progresion de la disquinesia de parkinson asociada a l-dopa; uso de la composicion farmaceutica; uso de una composicion que ademas comprende l-dopa.

Country Status (19)

Country Link
US (2) US20100249136A1 (es)
EP (1) EP2211859B1 (es)
JP (2) JP5743545B2 (es)
KR (1) KR101572280B1 (es)
CN (1) CN101854935A (es)
AU (1) AU2008309621A1 (es)
BR (1) BRPI0818560A2 (es)
CA (1) CA2701853A1 (es)
CL (1) CL2008003006A1 (es)
IL (1) IL204954A0 (es)
MA (1) MA31798B1 (es)
MX (1) MX2010003913A (es)
NZ (1) NZ584856A (es)
RU (1) RU2508107C2 (es)
SG (1) SG185293A1 (es)
TN (1) TN2010000155A1 (es)
TW (1) TW200924745A (es)
WO (1) WO2009047296A2 (es)
ZA (1) ZA201002423B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0913642A2 (pt) * 2008-06-30 2015-11-24 Novartis Ag produtos de combinação
BRPI0917492A8 (pt) * 2008-08-12 2016-07-05 Novartis Ag processos para preparação de metil éster de ácido 4-oxo-octa-hidro-indol-1-carboxílico e derivados dos mesmos
JP2013505262A (ja) * 2009-09-17 2013-02-14 バンダービルト ユニバーシティー mGluR5ネガティブアロステリックモジュレータとしての置換ヘテロアリールアミンカルボキサミド類似体、ならびに、その形成方法および使用方法
AU2012223720A1 (en) * 2011-03-03 2013-09-26 Vanderbilt University 6-alkyl-n-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
BR112013023813A2 (pt) 2011-03-18 2016-12-13 Novartis Ag combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson
GB201204962D0 (en) 2012-03-21 2012-05-02 Addex Pharmaceuticals Sa Pharmaceutical combination products for parkinsons disease
EP3071568A1 (en) 2013-11-19 2016-09-28 Vanderbilt University Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5
US9533982B2 (en) 2014-03-20 2017-01-03 Vanderbilt University Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
US9550778B2 (en) 2014-10-03 2017-01-24 Vanderbilt University Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
KR101749675B1 (ko) * 2015-07-20 2017-06-26 동국대학교 산학협력단 멜라닌 응집 호르몬을 유효성분으로 포함하는 파킨슨병 치료 및 레보도파 부작용 억제용 약학 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379666B1 (en) * 1999-02-24 2002-04-30 Edward L. Tobinick TNF inhibitors for the treatment of neurological, retinal and muscular disorders
DE60022050C5 (de) * 1999-06-02 2007-10-11 NPS Pharmaceuticals, Inc., Salt Lake City Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
US7105548B2 (en) * 2001-12-18 2006-09-12 Merck & Co., Inc. Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
US7105533B2 (en) * 2002-09-13 2006-09-12 Merck & Co., Inc. Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators
EP1596808A4 (en) * 2003-02-07 2007-04-04 Yissum Res Dev Co L-DOPA AMID DERIVATIVES AND THEIR USE
EP1667983A4 (en) * 2003-09-23 2010-07-21 Merck Sharp & Dohme PYRAZOL MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
US20070149547A1 (en) * 2004-02-12 2007-06-28 Celine Bonnefous Bipyridyl amides as modulators of metabotropic glutamate receptor-5
AU2006222289A1 (en) * 2005-03-04 2006-09-14 F. Hoffmann-La Roche Ag Pyridine-2-carboxamide derivatives as mG1uR5 antagonists
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
AU2006329007A1 (en) * 2005-12-20 2007-06-28 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutamate receptors
CA2663113A1 (en) * 2006-09-11 2008-03-20 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutanate receptors
BRPI0913642A2 (pt) * 2008-06-30 2015-11-24 Novartis Ag produtos de combinação

Also Published As

Publication number Publication date
ZA201002423B (en) 2010-12-29
EP2211859A2 (en) 2010-08-04
JP5743545B2 (ja) 2015-07-01
US20150272929A1 (en) 2015-10-01
SG185293A1 (en) 2012-11-29
TN2010000155A1 (en) 2011-11-11
CN101854935A (zh) 2010-10-06
WO2009047296A2 (en) 2009-04-16
NZ584856A (en) 2012-12-21
RU2010118454A (ru) 2011-11-20
JP2014240425A (ja) 2014-12-25
EP2211859B1 (en) 2016-01-06
CA2701853A1 (en) 2009-04-16
MX2010003913A (es) 2010-04-27
US20100249136A1 (en) 2010-09-30
MA31798B1 (fr) 2010-10-01
WO2009047296A3 (en) 2009-08-20
IL204954A0 (en) 2010-11-30
RU2508107C2 (ru) 2014-02-27
JP2011500529A (ja) 2011-01-06
AU2008309621A1 (en) 2009-04-16
KR101572280B1 (ko) 2015-11-26
BRPI0818560A2 (pt) 2019-09-24
KR20100088136A (ko) 2010-08-06
TW200924745A (en) 2009-06-16

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