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CL2008000861A1 - Composicion farmaceutica que contiene sal clorhidrato del isobutirato de (2r, 3s, 4r, 5r)-5-(4-amino-2-oxo-2h-pirimidin-1-il)-2-azido-3,4-bis-isobutiriloxi-tetrahidro-furan-2-ilmetilo (i) y un copolemero de bloques de polietilenglicol (peg)/polipropilenglicol (ppg), util en enfermedades virales como hepatitis c. - Google Patents

Composicion farmaceutica que contiene sal clorhidrato del isobutirato de (2r, 3s, 4r, 5r)-5-(4-amino-2-oxo-2h-pirimidin-1-il)-2-azido-3,4-bis-isobutiriloxi-tetrahidro-furan-2-ilmetilo (i) y un copolemero de bloques de polietilenglicol (peg)/polipropilenglicol (ppg), util en enfermedades virales como hepatitis c.

Info

Publication number
CL2008000861A1
CL2008000861A1 CL2008000861A CL2008000861A CL2008000861A1 CL 2008000861 A1 CL2008000861 A1 CL 2008000861A1 CL 2008000861 A CL2008000861 A CL 2008000861A CL 2008000861 A CL2008000861 A CL 2008000861A CL 2008000861 A1 CL2008000861 A1 CL 2008000861A1
Authority
CL
Chile
Prior art keywords
isobutyryloxy
ppg
azido
pyrimidin
ylmethyl
Prior art date
Application number
CL2008000861A
Other languages
English (en)
Inventor
Birudaraj Kondamraj
Thomas Brandi Michael
Hegde Shridar
Sana Felix
Stefanidis Dimitrios
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2008000861A1 publication Critical patent/CL2008000861A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Composición farmacéutica que contiene clorhidrato de isobutirato de (2r,3s,4r,5r)-5-(4-amino-2-oxo-2h-pirimidin-1-il)-2-azido-3,4-bis-isobutiriloxi-tetrahidro-furan-2-ilmetilo y un copolímero de bloques de polietilenglicol (peg)/polipropilenglicol (ppg).
CL2008000861A 2007-03-29 2008-03-26 Composicion farmaceutica que contiene sal clorhidrato del isobutirato de (2r, 3s, 4r, 5r)-5-(4-amino-2-oxo-2h-pirimidin-1-il)-2-azido-3,4-bis-isobutiriloxi-tetrahidro-furan-2-ilmetilo (i) y un copolemero de bloques de polietilenglicol (peg)/polipropilenglicol (ppg), util en enfermedades virales como hepatitis c. CL2008000861A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92058607P 2007-03-29 2007-03-29

Publications (1)

Publication Number Publication Date
CL2008000861A1 true CL2008000861A1 (es) 2008-11-07

Family

ID=39541351

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008000861A CL2008000861A1 (es) 2007-03-29 2008-03-26 Composicion farmaceutica que contiene sal clorhidrato del isobutirato de (2r, 3s, 4r, 5r)-5-(4-amino-2-oxo-2h-pirimidin-1-il)-2-azido-3,4-bis-isobutiriloxi-tetrahidro-furan-2-ilmetilo (i) y un copolemero de bloques de polietilenglicol (peg)/polipropilenglicol (ppg), util en enfermedades virales como hepatitis c.

Country Status (12)

Country Link
US (1) US7893037B2 (es)
EP (1) EP2142178B1 (es)
JP (1) JP2010522705A (es)
CN (1) CN101668515B (es)
AR (1) AR065853A1 (es)
AT (1) ATE540672T1 (es)
CA (1) CA2682638C (es)
CL (1) CL2008000861A1 (es)
ES (1) ES2377760T3 (es)
PE (1) PE20090066A1 (es)
TW (1) TW200909006A (es)
WO (1) WO2008119659A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2455068A1 (en) * 2010-11-09 2012-05-23 F. Hoffmann-La Roche AG Pharmaceutical composition for treating HCV infections
US8889159B2 (en) * 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2019113462A1 (en) 2017-12-07 2019-06-13 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN112957335B (zh) * 2021-02-23 2022-10-04 上海纳为生物技术有限公司 一种乙酰氨基葡萄糖口腔崩解片及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230497A (en) * 1988-09-02 1992-05-26 Du Pont Layered, granular water-soluble or water-dispersible pesticide
JP4334869B2 (ja) * 2000-12-01 2009-09-30 協和発酵キリン株式会社 溶解性または経口吸収性の改善された組成物
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2005023826A2 (en) * 2003-09-11 2005-03-17 F.Hoffmann-La Roche Ag Polymorphic nucleoside compounds
CA2548376A1 (en) * 2003-12-31 2005-07-21 Pfizer Products Inc. Solid compositions of low-solubility drugs and poloxamers
ATE482690T1 (de) 2005-12-14 2010-10-15 Hoffmann La Roche Hcv-prodrug-formulierung

Also Published As

Publication number Publication date
EP2142178A2 (en) 2010-01-13
JP2010522705A (ja) 2010-07-08
CA2682638A1 (en) 2008-10-09
CN101668515B (zh) 2013-03-20
WO2008119659A3 (en) 2009-03-05
ES2377760T3 (es) 2012-03-30
US20080260826A1 (en) 2008-10-23
AR065853A1 (es) 2009-07-08
EP2142178B1 (en) 2012-01-11
US7893037B2 (en) 2011-02-22
CA2682638C (en) 2012-07-17
TW200909006A (en) 2009-03-01
ATE540672T1 (de) 2012-01-15
CN101668515A (zh) 2010-03-10
PE20090066A1 (es) 2009-02-13
WO2008119659A2 (en) 2008-10-09

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