|
GB699812A
(en)
|
1950-11-29 |
1953-11-18 |
British Ind Solvents Ltd |
Manufacture of substituted pyrimidones
|
|
DE1249281B
(es)
|
1963-05-18 |
|
|
|
|
DE1670912C3
(de)
|
1967-08-18 |
1981-06-11 |
Bayer Ag, 5090 Leverkusen |
Herbizide Mittel auf Basis von 1,2,4-Triazin-5-onen
|
|
GB1377642A
(en)
|
1971-01-14 |
1974-12-18 |
Koninklijke Gist Spiritus |
Penicillanic and cephalosporanic acid derivatives
|
|
US3960949A
(en)
|
1971-04-02 |
1976-06-01 |
Schering Aktiengesellschaft |
1,2-Biguanides
|
|
DE2150686A1
(de)
|
1971-10-12 |
1973-04-19 |
Basf Ag |
6-amino-uracil-5-carbonsaeurethioamide
|
|
BE792206A
(es)
|
1971-12-02 |
1973-06-01 |
Byk Gulden Lomberg Chem Fab |
|
|
AU5996573A
(en)
|
1972-09-11 |
1975-03-06 |
Commonwealth Scientific And Industrial Research Organisation |
Pyridinium salts
|
|
US3823135A
(en)
|
1972-12-26 |
1974-07-09 |
Shell Oil Co |
Pyrimidone herbicides
|
|
GB1464248A
(en)
|
1973-11-01 |
1977-02-09 |
Ici Ltd |
Substituted triazinediones their preparation and use as herbicides
|
|
DE2361551A1
(de)
|
1973-12-11 |
1975-06-19 |
Basf Ag |
Wasserloesliche azofarbstoffe
|
|
DE2500024A1
(de)
|
1975-01-02 |
1976-07-08 |
Basf Ag |
Wasserloesliche azofarbstoffe
|
|
JPS535180A
(en)
|
1976-07-01 |
1978-01-18 |
Sumitomo Chem Co Ltd |
Preparation of 3,4-dihydro-2 (1h) quinazoline derivatives
|
|
DE2720085A1
(de)
|
1977-05-05 |
1978-11-16 |
Hoechst Ag |
Pyrimido(6,1-a)isochinolin-2-on- derivate
|
|
US4494978A
(en)
|
1976-12-30 |
1985-01-22 |
Chevron Research Company |
Herbicidal N-(N'-hydrocarbyloxycarbamylalkyl)-2,6-dialkyl-alpha-haloacetanilides
|
|
CH657851A5
(de)
|
1983-06-28 |
1986-09-30 |
Ciba Geigy Ag |
Chromogene chinazolonverbindungen.
|
|
AR240698A1
(es)
*
|
1985-01-19 |
1990-09-28 |
Takeda Chemical Industries Ltd |
Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
|
|
US5614492A
(en)
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
|
ATE186724T1
(de)
*
|
1987-09-04 |
1999-12-15 |
Beecham Group Plc |
Substituierte thiazolidindionderivate
|
|
US4935493A
(en)
|
1987-10-06 |
1990-06-19 |
E. I. Du Pont De Nemours And Company |
Protease inhibitors
|
|
GB8900382D0
(en)
|
1989-01-09 |
1989-03-08 |
Janssen Pharmaceutica Nv |
2-aminopyrimidinone derivatives
|
|
US5433955A
(en)
|
1989-01-23 |
1995-07-18 |
Akzo N.V. |
Site specific in vivo activation of therapeutic drugs
|
|
IE63502B1
(en)
|
1989-04-21 |
1995-05-03 |
Zeneca Ltd |
Aminopyrimidine derivatives useful for treating cardiovascular disorders
|
|
US5814460A
(en)
|
1990-02-14 |
1998-09-29 |
Diatide, Inc. |
Method for generating and screening useful peptides
|
|
US5366862A
(en)
|
1990-02-14 |
1994-11-22 |
Receptor Laboratories, Inc. |
Method for generating and screening useful peptides
|
|
US5462928A
(en)
|
1990-04-14 |
1995-10-31 |
New England Medical Center Hospitals, Inc. |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
|
DE4110019C2
(de)
|
1991-03-27 |
2000-04-13 |
Merck Patent Gmbh |
Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
|
|
US5387512A
(en)
|
1991-06-07 |
1995-02-07 |
Merck & Co. Inc. |
Preparation of 3-[z-benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2-(1H)-pyridinone by biotransformation
|
|
DE69231674T2
(de)
|
1991-10-22 |
2001-08-09 |
New England Medical Center Hospitals, Inc. |
Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv
|
|
US6825169B1
(en)
|
1991-10-22 |
2004-11-30 |
Trustees Of Tufts College |
Inhibitors of dipeptidyl-aminopeptidase type IV
|
|
US5350752A
(en)
|
1991-12-16 |
1994-09-27 |
E. R. Squibb & Sons, Inc. |
Dihydropyrimidine derivatives
|
|
DE4141788A1
(de)
|
1991-12-18 |
1993-06-24 |
Merck Patent Gmbh |
Imidazopyridine
|
|
DE4305602A1
(de)
|
1992-06-17 |
1993-12-23 |
Merck Patent Gmbh |
Imidazopyridine
|
|
IL106877A
(en)
|
1992-09-10 |
1998-03-10 |
Lilly Co Eli |
Rhodanine derivatives for use as medicaments for the treatment of alzheimer's disease
|
|
IL106998A0
(en)
|
1992-09-17 |
1993-12-28 |
Univ Florida |
Brain-enhanced delivery of neuroactive peptides by sequential metabolism
|
|
US5811281A
(en)
|
1993-07-12 |
1998-09-22 |
Cornell Research Foundation, Inc. |
Immortalized intestinal epithelial cell lines
|
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
|
DE4341453A1
(de)
|
1993-12-06 |
1995-06-08 |
Merck Patent Gmbh |
Imidazopyridine
|
|
EP0749974B1
(en)
|
1994-03-08 |
2001-06-27 |
Otsuka Pharmaceutical Factory, Inc. |
Phosphonic diester derivative
|
|
US5580979A
(en)
|
1994-03-15 |
1996-12-03 |
Trustees Of Tufts University |
Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
|
|
US5543396A
(en)
|
1994-04-28 |
1996-08-06 |
Georgia Tech Research Corp. |
Proline phosphonate derivatives
|
|
WO1995034538A2
(en)
|
1994-06-10 |
1995-12-21 |
Universitaire Instelling Antwerpen |
Purification of serine proteases and synthetic inhibitors thereof
|
|
US5601986A
(en)
|
1994-07-14 |
1997-02-11 |
Amgen Inc. |
Assays and devices for the detection of extrahepatic biliary atresia
|
|
DE4432860A1
(de)
|
1994-09-15 |
1996-03-21 |
Merck Patent Gmbh |
Imidazopyridine
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
US5614379A
(en)
|
1995-04-26 |
1997-03-25 |
Eli Lilly And Company |
Process for preparing anti-obesity protein
|
|
US6325989B1
(en)
|
1995-06-01 |
2001-12-04 |
Dana-Farber Cancer Institute, Inc. |
Form of dipeptidylpeptidase IV (CD26) found in human serum
|
|
US6265551B1
(en)
|
1995-06-01 |
2001-07-24 |
Dana-Farber Cancer Institute, Inc. |
Form of dipeptidylpeptidase IV (CD26) found in human serum, antibodies thereto, and uses thereof
|
|
DK0748800T3
(da)
|
1995-06-09 |
2001-08-27 |
Hoffmann La Roche |
Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister
|
|
JPH0928376A
(ja)
|
1995-07-21 |
1997-02-04 |
Ajinomoto Co Inc |
新規ジペプチジルペプチダーゼｉｖとその製造方法
|
|
BR9609883A
(pt)
*
|
1995-08-08 |
1999-03-23 |
Fibrogen Inc |
Composto tendo efeito inibidor em proteinase c composição farmacéutica e processo para tratar doenças relacionadas com a produção inapropriada ou desregulada de colágeno
|
|
US6492428B1
(en)
*
|
2000-07-26 |
2002-12-10 |
The Picower Institute For Medical Research |
Compounds having MIF antagonist activity
|
|
US20020006899A1
(en)
|
1998-10-06 |
2002-01-17 |
Pospisilik Andrew J. |
Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
|
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
US5965532A
(en)
|
1996-06-28 |
1999-10-12 |
Trustees Of Tufts College |
Multivalent compounds for crosslinking receptors and uses thereof
|
|
AU744518B2
(en)
|
1996-07-01 |
2002-02-28 |
Dr. Reddy's Laboratories Limited |
Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
|
|
US5885997A
(en)
|
1996-07-01 |
1999-03-23 |
Dr. Reddy's Research Foundation |
Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
|
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US7235627B2
(en)
|
1996-08-30 |
2007-06-26 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US6006753A
(en)
|
1996-08-30 |
1999-12-28 |
Eli Lilly And Company |
Use of GLP-1 or analogs to abolish catabolic changes after surgery
|
|
US6011155A
(en)
|
1996-11-07 |
2000-01-04 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
GB9702701D0
(en)
|
1997-02-01 |
1997-04-02 |
Univ Newcastle Ventures Ltd |
Quinazolinone compounds
|
|
US20030060434A1
(en)
|
1997-02-18 |
2003-03-27 |
Loretta Nielsen |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
|
|
US6100234A
(en)
|
1997-05-07 |
2000-08-08 |
Tufts University |
Treatment of HIV
|
|
ATE414775T1
(de)
|
1997-05-16 |
2008-12-15 |
Novozymes Inc |
Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren
|
|
EP0897012A1
(en)
|
1997-07-05 |
1999-02-17 |
Societe Des Produits Nestle S.A. |
Cloning of the prolyl-dipeptidyl-peptidase from aspergillus oryzae
|
|
US6235493B1
(en)
|
1997-08-06 |
2001-05-22 |
The Regents Of The University Of California |
Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue
|
|
JP2001518290A
(ja)
|
1997-09-29 |
2001-10-16 |
ポイント セラピューティクス， インコーポレイテッド |
インビトロでの造血細胞の刺激
|
|
US6485955B1
(en)
|
1997-10-06 |
2002-11-26 |
The Trustees Of Tufts University |
Quiescent cell dipeptidyl peptidase: a novel cytoplasmic serine protease
|
|
US6342611B1
(en)
|
1997-10-10 |
2002-01-29 |
Cytovia, Inc. |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
|
|
CA2310400C
(en)
|
1997-11-18 |
2008-02-19 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Novel physiologically active substance sulphostin, process for producing the same, and use thereof
|
|
FR2771004B1
(fr)
|
1997-11-19 |
2000-02-18 |
Inst Curie |
Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
|
|
JP3979622B2
(ja)
|
1997-12-16 |
2007-09-19 |
ノボザイムス アクティーゼルスカブ |
アミノペプチダーゼ活性を有するポリペプチド及びこれをコードする核酸
|
|
US6380357B2
(en)
|
1997-12-16 |
2002-04-30 |
Eli Lilly And Company |
Glucagon-like peptide-1 crystals
|
|
EP2433623A1
(en)
|
1998-02-02 |
2012-03-28 |
Trustees Of Tufts College |
Use of dipeptidylpeptidase inhibitors to regulate glucose metabolism
|
|
US20020061839A1
(en)
|
1998-03-09 |
2002-05-23 |
Scharpe Simon Lodewijk |
Serine peptidase modulators
|
|
JP2003504301A
(ja)
|
1998-04-01 |
2003-02-04 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
インテグリンアンタゴニスト
|
|
FR2777283B1
(fr)
|
1998-04-10 |
2000-11-24 |
Adir |
Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE19823831A1
(de)
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
|
EP1084129B1
(en)
|
1998-06-05 |
2003-01-22 |
Point Therapeutics, Inc. |
Cyclic boroproline compounds
|
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
|
US6129911A
(en)
|
1998-07-10 |
2000-10-10 |
Rhode Island Hospital, A Lifespan Partner |
Liver stem cell
|
|
DE19834591A1
(de)
|
1998-07-31 |
2000-02-03 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Steigerung des Blutglukosespiegels in Säugern
|
|
EP1105460B1
(en)
|
1998-08-10 |
2009-10-07 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof
|
|
CA2344246A1
(en)
|
1998-09-17 |
2000-03-23 |
Akesis Pharmaceuticals, Inc. |
Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders
|
|
US20030176357A1
(en)
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
ATE482717T1
(de)
|
1999-02-10 |
2010-10-15 |
Curis Inc |
Peptid yy (pyy) zur behandlung von glukose stoffwechselkrankheiten
|
|
GB9906714D0
(en)
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for improving fertility
|
|
GB9906715D0
(en)
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for promoting growth
|
|
WO2000057721A2
(en)
|
1999-03-26 |
2000-10-05 |
Akesis Pharmaceuticals, Inc. |
Edible solids for treatment of glucose metabolism disorders
|
|
US6548529B1
(en)
|
1999-04-05 |
2003-04-15 |
Bristol-Myers Squibb Company |
Heterocyclic containing biphenyl aP2 inhibitors and method
|
|
WO2000063209A1
(en)
|
1999-04-20 |
2000-10-26 |
Novo Nordisk A/S |
New compounds, their preparation and use
|
|
DK1180121T3
(da)
|
1999-05-17 |
2004-03-01 |
Conjuchem Inc |
Langtidsvirkende insulinotrope peptider
|
|
DE19926233C1
(de)
|
1999-06-10 |
2000-10-19 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Herstellung von Thiazolidin
|
|
US6107317A
(en)
|
1999-06-24 |
2000-08-22 |
Novartis Ag |
N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
US6110949A
(en)
|
1999-06-24 |
2000-08-29 |
Novartis Ag |
N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
US6172081B1
(en)
|
1999-06-24 |
2001-01-09 |
Novartis Ag |
Tetrahydroisoquinoline 3-carboxamide derivatives
|
|
US6528486B1
(en)
|
1999-07-12 |
2003-03-04 |
Zealand Pharma A/S |
Peptide agonists of GLP-1 activity
|
|
US6617340B1
(en)
|
1999-07-29 |
2003-09-09 |
Novartis Ag |
N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
DE19940130A1
(de)
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
|
US6559188B1
(en)
|
1999-09-17 |
2003-05-06 |
Novartis Ag |
Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
|
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
KR20020047185A
(ko)
|
1999-09-28 |
2002-06-21 |
플레믹 크리스티안 |
퀴나졸리논
|
|
US6251391B1
(en)
|
1999-10-01 |
2001-06-26 |
Klaire Laboratories, Inc. |
Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons
|
|
US6447772B1
(en)
|
1999-10-01 |
2002-09-10 |
Klaire Laboratories, Inc. |
Compositions and methods relating to reduction of symptoms of autism
|
|
EP1229024A1
(en)
|
1999-10-08 |
2002-08-07 |
Meiji Seika Kaisha Ltd. |
m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM
|
|
US6261794B1
(en)
|
1999-10-14 |
2001-07-17 |
Saint Louis University |
Methods for identifying inhibitors of methionine aminopeptidases
|
|
US7230000B1
(en)
|
1999-10-27 |
2007-06-12 |
Cytokinetics, Incorporated |
Methods and compositions utilizing quinazolinones
|
|
US6358954B1
(en)
*
|
1999-11-09 |
2002-03-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
|
|
US20040152745A1
(en)
|
1999-11-12 |
2004-08-05 |
Guilford Pharmaceuticals, Inc. |
Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
|
|
JP2003535034A
(ja)
|
1999-11-12 |
2003-11-25 |
ギルフォード ファーマシューティカルズ インコーポレイテッド |
ジペプチジルペプチダーゼｉｖ阻害剤並びにジペプチジルペプチダーゼｉｖ阻害剤の製造及び使用法
|
|
GB9928330D0
(en)
|
1999-11-30 |
2000-01-26 |
Ferring Bv |
Novel antidiabetic agents
|
|
WO2001041779A2
(en)
|
1999-12-08 |
2001-06-14 |
1149336 Ontario Inc. |
Combined use of glp-2 receptor agonist and chemotherapeutic agent in treatment
|
|
US6380398B2
(en)
|
2000-01-04 |
2002-04-30 |
Novo Nordisk A/S |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
|
EP1741445B1
(en)
|
2000-01-21 |
2013-08-14 |
Novartis AG |
Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents
|
|
AU2001232735A1
(en)
|
2000-01-27 |
2001-08-07 |
Eli Lilly And Company |
Process for solubilizing glucagon-like peptide 1 compounds
|
|
US6569901B2
(en)
|
2000-01-28 |
2003-05-27 |
Novo Nordisk A/S |
Alkynyl-substituted propionic acid derivatives, their preparation and use
|
|
US7217722B2
(en)
|
2000-02-01 |
2007-05-15 |
Kirin Beer Kabushiki Kaisha |
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
|
|
JP2003523396A
(ja)
|
2000-02-25 |
2003-08-05 |
ノボ ノルディスク アクティーゼルスカブ |
ベータ細胞変性の抑制
|
|
US6448045B1
(en)
|
2000-03-10 |
2002-09-10 |
The Regents Of The University Of California |
Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
|
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
|
US6608038B2
(en)
|
2000-03-15 |
2003-08-19 |
Novartis Ag |
Methods and compositions for treatment of diabetes and related conditions via gene therapy
|
|
EP1136482A1
(en)
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-Amino-3-(alkyl)-pyrimidone derivatives as GSK3beta inhibitors
|
|
US6555519B2
(en)
|
2000-03-30 |
2003-04-29 |
Bristol-Myers Squibb Company |
O-glucosylated benzamide SGLT2 inhibitors and method
|
|
WO2001072290A2
(en)
|
2000-03-31 |
2001-10-04 |
Probiodrug Ag |
Method for the improvement of islet signaling in diabetes mellitus and for its prevention
|
|
US6573096B1
(en)
|
2000-04-01 |
2003-06-03 |
The Research Foundation At State University Of New York |
Compositions and methods for inhibition of cancer invasion and angiogenesis
|
|
US6545170B2
(en)
|
2000-04-13 |
2003-04-08 |
Pharmacia Corporation |
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
|
|
US6518277B1
(en)
|
2000-04-25 |
2003-02-11 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
GB0010188D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
GB0010183D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
US6783757B2
(en)
|
2000-06-01 |
2004-08-31 |
Kirkman Group, Inc. |
Composition and method for increasing exorphin catabolism to treat autism
|
|
TW583185B
(en)
|
2000-06-13 |
2004-04-11 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
|
|
US6432969B1
(en)
|
2000-06-13 |
2002-08-13 |
Novartis Ag |
N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
US6620821B2
(en)
|
2000-06-15 |
2003-09-16 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
|
US6627636B2
(en)
|
2000-06-15 |
2003-09-30 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
|
GB0014969D0
(en)
|
2000-06-19 |
2000-08-09 |
Smithkline Beecham Plc |
Novel method of treatment
|
|
US7078397B2
(en)
|
2000-06-19 |
2006-07-18 |
Smithkline Beecham Corporation |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
|
|
HUP0301622A3
(en)
|
2000-07-04 |
2006-05-29 |
Novo Nordisk As |
Purine derivatives inhibiting the enzyme dipeptidyl petidase iv (dpp-iv) and pharmaceutical compositions containing them
|
|
JP2002042960A
(ja)
|
2000-07-25 |
2002-02-08 |
Yazaki Corp |
コネクタ支持機構
|
|
AU2001281083A1
(en)
|
2000-08-01 |
2002-02-13 |
Pharmacia Corporation |
Hexahydro-7-1h-azepin-2-yl-haxanoic acid derivatives as inhibitors of inducible nitric oxide synthase
|
|
AP1333A
(en)
|
2000-08-04 |
2004-11-28 |
Warner Lambert Co |
2-(4-pyridyl) amino-6-dialkoxyphenyl-pyrido [2,3-d] pyrimidin-7-ones.
|
|
PT1308439E
(pt)
|
2000-08-10 |
2008-12-12 |
Mitsubishi Tanabe Pharma Corp |
Derivados de prolina e sua utilização como fármacos
|
|
US20020165237A1
(en)
|
2000-08-11 |
2002-11-07 |
Fryburg David Albert |
Treatment of the insulin resistance syndrome
|
|
US20020037829A1
(en)
|
2000-08-23 |
2002-03-28 |
Aronson Peter S. |
Use of DPPIV inhibitors as diuretic and anti-hypertensive agents
|
|
US6900226B2
(en)
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
PE20020453A1
(es)
|
2000-09-27 |
2002-06-06 |
Merck & Co Inc |
Derivados del acido benzopirancarboxilico para el tratamiento de la diabetes y los trastornos de lipidos
|
|
US20020064736A1
(en)
|
2000-09-27 |
2002-05-30 |
Fuji Photo Film Co., Ltd. |
Dye-forming coupler, silver halide photographic light-sensitive material, and method for producing an azomethine dye
|
|
DE60135764D1
(de)
|
2000-10-06 |
2008-10-23 |
Mitsubishi Tanabe Pharma Corp |
Stickstoffhaltige, fünfgliedrige ringverbindungen
|
|
KR100875221B1
(ko)
|
2000-10-12 |
2008-12-19 |
페링 비.브이 |
디피피포에 관련된 신규 세린 프로티아제 유전자
|
|
AU2177302A
(en)
|
2000-10-27 |
2002-05-06 |
Probiodrug Ag |
Method for the treatment of neurological and neuropsychological disorders
|
|
AUPR107800A0
(en)
|
2000-10-27 |
2000-11-23 |
University Of Sydney, The |
Peptide and nucleic acid molecule ii
|
|
JP2004518718A
(ja)
|
2000-10-30 |
2004-06-24 |
オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド |
抗糖尿病薬および抗痙攣薬を含んで成る併用療法
|
|
AU2002246568A1
(en)
|
2000-10-31 |
2002-08-06 |
Vanderbilt University |
Biological markers and diagnostic tests for angiotensin converting enzyme inhibitor- and vasopeptidase inhibitor-associated angioedema
|
|
AU2002248221B2
(en)
|
2000-10-31 |
2006-08-17 |
Merck & Co., Inc. |
Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
|
|
US6864363B2
(en)
|
2000-11-08 |
2005-03-08 |
University Of Georgia Research Foundation, Inc. |
Dipeptidylpeptidases and methods of use
|
|
US20030055052A1
(en)
|
2000-11-10 |
2003-03-20 |
Stefan Peters |
FAP-activated anti-tumor compounds
|
|
TWI243162B
(en)
|
2000-11-10 |
2005-11-11 |
Taisho Pharmaceutical Co Ltd |
Cyanopyrrolidine derivatives
|
|
US20020155565A1
(en)
|
2000-11-10 |
2002-10-24 |
Pilar Garin-Chesa |
FAP-activated anti-tumor compounds
|
|
US20030203946A1
(en)
|
2000-11-17 |
2003-10-30 |
Carsten Behrens |
Glucagon antagonists/inverse agonists
|
|
CA2436854A1
(en)
|
2000-11-20 |
2002-05-23 |
Bristol-Myers Squibb Company |
Pyridone derivatives as ap2 inhibitors
|
|
PL366311A1
(en)
|
2000-12-11 |
2005-01-24 |
Tularik Inc. |
Cxcr3 antagonists
|
|
JPWO2002051836A1
(ja)
|
2000-12-27 |
2004-04-22 |
協和醗酵工業株式会社 |
ジペプチジルペプチダーゼ−ｉｖ阻害剤
|
|
ATE534433T1
(de)
|
2001-01-02 |
2011-12-15 |
Imtm Gmbh |
Kombinierte verwendung von enzyminhibitoren zur therapie und prävention allergischer reaktionen vom typ i nach gell und coombs und zur therapie und prävention dermatologischer erkrankungen mit follikulären und epidermalen hyperkeratosen und einer verstärkten keratinozytenproliferation
|
|
DE10100053A1
(de)
|
2001-01-02 |
2002-08-22 |
Keyneurotek Ag I G |
Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
|
|
IL157179A0
(en)
|
2001-02-02 |
2004-02-08 |
Takeda Chemical Industries Ltd |
Fused heterocyclic compounds
|
|
TWI255817B
(en)
|
2001-02-14 |
2006-06-01 |
Kissei Pharmaceutical |
Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
|
|
SK286975B6
(sk)
|
2001-02-24 |
2009-08-06 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xantínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
US6337069B1
(en)
|
2001-02-28 |
2002-01-08 |
B.M.R.A. Corporation B.V. |
Method of treating rhinitis or sinusitis by intranasally administering a peptidase
|
|
JP4178816B2
(ja)
|
2001-03-15 |
2008-11-12 |
田辺三菱製薬株式会社 |
医薬組成物
|
|
TWI331525B
(en)
|
2001-03-19 |
2010-10-11 |
Novartis Ag |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
|
|
DE60226723D1
(de)
|
2001-03-27 |
2008-07-03 |
Merck & Co Inc |
Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
|
|
FR2822826B1
(fr)
|
2001-03-28 |
2003-05-09 |
Servier Lab |
Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE10115921A1
(de)
|
2001-03-30 |
2002-10-02 |
Boehringer Ingelheim Pharma |
Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
|
|
US6890905B2
(en)
|
2001-04-02 |
2005-05-10 |
Prosidion Limited |
Methods for improving islet signaling in diabetes mellitus and for its prevention
|
|
GB0109146D0
(en)
|
2001-04-11 |
2001-05-30 |
Ferring Bv |
Treatment of type 2 diabetes
|
|
PE20021080A1
(es)
|
2001-04-12 |
2003-02-12 |
Boehringer Ingelheim Int |
Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer
|
|
US6573287B2
(en)
|
2001-04-12 |
2003-06-03 |
Bristo-Myers Squibb Company |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
|
|
FR2824825B1
(fr)
|
2001-05-15 |
2005-05-06 |
Servier Lab |
Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US20030060494A1
(en)
|
2001-05-18 |
2003-03-27 |
Nobuyuki Yasuda |
Pharmaceutical use of N-carbamoylazole derivatives
|
|
IL143366A0
(en)
|
2001-05-24 |
2002-04-21 |
Harasit Medical Res Services & |
Treatment of renal fibrosis
|
|
US7105556B2
(en)
|
2001-05-30 |
2006-09-12 |
Bristol-Myers Squibb Company |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
|
|
US6794379B2
(en)
|
2001-06-06 |
2004-09-21 |
Tularik Inc. |
CXCR3 antagonists
|
|
WO2003000180A2
(en)
|
2001-06-20 |
2003-01-03 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
|
AU2002310465B2
(en)
|
2001-06-20 |
2006-06-15 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
|
GB0115517D0
(en)
|
2001-06-25 |
2001-08-15 |
Ferring Bv |
Novel antidiabetic agents
|
|
AU2002322344C1
(en)
|
2001-06-27 |
2006-02-16 |
Smithkline Beecham Corporation |
Fluoropyrrolidines as dipeptidyl peptidase inhibitors
|
|
US20030130199A1
(en)
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
|
US20030135023A1
(en)
|
2001-06-27 |
2003-07-17 |
Hans-Ulrich Demuth |
Peptide structures useful for competitive modulation of dipeptidyl peptidase IV catalysis
|
|
DE10154689A1
(de)
|
2001-11-09 |
2003-05-22 |
Probiodrug Ag |
Substituierte Aminoketonverbindungen
|
|
US7368421B2
(en)
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
|
DE60223920T2
(de)
|
2001-06-27 |
2008-11-13 |
Smithkline Beecham Corp. |
Pyrrolidine als dipeptidyl-peptidase-inhibitoren
|
|
WO2003002553A2
(en)
|
2001-06-27 |
2003-01-09 |
Smithkline Beecham Corporation |
Fluoropyrrolidines as dipeptidyl peptidase inhibitors
|
|
CA2418543A1
(en)
|
2001-06-27 |
2003-01-09 |
Probiodrug Ag |
New dipeptidyl peptidase iv inhibitors and their uses as anti-cancer agents
|
|
DE10150203A1
(de)
|
2001-10-12 |
2003-04-17 |
Probiodrug Ag |
Peptidylketone als Inhibitoren der DPIV
|
|
US6869947B2
(en)
|
2001-07-03 |
2005-03-22 |
Novo Nordisk A/S |
Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
|
US20030144350A1
(en)
|
2001-07-20 |
2003-07-31 |
Adipogenix, Inc. |
Fat accumulation-modulation compounds
|
|
AU2002330672A1
(en)
|
2001-07-25 |
2003-02-17 |
Genset S.A. |
Gmg-1 polynucleotides and polypeptides and uses thereof
|
|
CA2453653A1
(en)
|
2001-07-26 |
2003-02-06 |
Genset S.A. |
Gmg-2 polynucleotides and polypeptides and uses thereof
|
|
EP1411968B1
(en)
|
2001-07-31 |
2008-09-17 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Glp-1 exendin-4 peptide analogs and uses thereof
|
|
AU2002327430A1
(en)
|
2001-08-08 |
2003-02-24 |
Genzyme Corporation |
Methods for treating diabetes and other blood sugar disorders
|
|
EP1285922A1
(en)
*
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
|
|
WO2003016335A2
(en)
|
2001-08-13 |
2003-02-27 |
Probiodrug Ag |
Irreversible cysteine protease inhibitors of legumain
|
|
JP2003128551A
(ja)
|
2001-08-15 |
2003-05-08 |
Sankyo Co Ltd |
新規抗糖尿病医薬組成物
|
|
DE10143840A1
(de)
|
2001-09-06 |
2003-03-27 |
Probiodrug Ag |
Neue Inhibitoren der Dipeptidylpeptidase I
|
|
US6844316B2
(en)
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
|
US20030186963A1
(en)
|
2001-09-14 |
2003-10-02 |
Dorwald Florencio Zaragoza |
Substituted piperidines
|
|
KR20040033048A
(ko)
|
2001-09-14 |
2004-04-17 |
미츠비시 웰파마 가부시키가이샤 |
티아졸리딘 유도체 및 이의 약학적 용도
|
|
US6673829B2
(en)
|
2001-09-14 |
2004-01-06 |
Novo Nordisk A/S |
Aminoazetidine,-pyrrolidine and -piperidine derivatives
|
|
EP1463727A2
(en)
|
2001-09-19 |
2004-10-06 |
Novo Nordisk A/S |
Heterocyclic compounds that are inhibitors of the enzyme dpp-iv
|
|
IL160693A0
(en)
|
2001-09-21 |
2004-08-31 |
Bristol Myers Squibb Co |
Lactam-containing compounds and derivatives thereof as factor xa inhibitors
|
|
KR100881821B1
(ko)
|
2001-09-21 |
2009-02-03 |
미쓰비시 타나베 파마 코퍼레이션 |
3-치환-4-피리미돈 유도체
|
|
AR036604A1
(es)
|
2001-09-21 |
2004-09-22 |
Mitsubishi Pharma Corp |
Derivados de 4-pirimidona 3-sustituida
|
|
US7019010B2
(en)
|
2001-09-27 |
2006-03-28 |
Novertis Ag |
Combinations
|
|
IL160990A0
(en)
|
2001-10-01 |
2004-08-31 |
Bristol Myers Squibb Co |
Spiro-hydantoin compounds useful as anti-inflammatory agents
|
|
WO2003030946A1
(en)
|
2001-10-09 |
2003-04-17 |
Novartis Ag |
Regulation of insulin production
|
|
US7064135B2
(en)
|
2001-10-12 |
2006-06-20 |
Novo Nordisk Inc. |
Substituted piperidines
|
|
CA2463908A1
(en)
|
2001-10-18 |
2003-04-24 |
Bristol-Myers Squibb Company |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
|
|
TWI301834B
(en)
|
2001-10-22 |
2008-10-11 |
Eisai R&D Man Co Ltd |
Pyrimidone compound and pharmaceutical composition including the same
|
|
GB0125445D0
(en)
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Protease Inhibitors
|
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
|
US6673815B2
(en)
|
2001-11-06 |
2004-01-06 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
US20030125304A1
(en)
|
2001-11-09 |
2003-07-03 |
Hans-Ulrich Demuth |
Substituted amino ketone compounds
|
|
US20030089935A1
(en)
|
2001-11-13 |
2003-05-15 |
Macronix International Co., Ltd. |
Non-volatile semiconductor memory device with multi-layer gate insulating structure
|
|
CA2837936A1
(en)
|
2001-11-26 |
2003-06-05 |
Trustees Of Tufts College |
Peptidomimetic inhibitors of post-proline cleaving enzymes
|
|
ES2333415T3
(es)
|
2001-11-26 |
2010-02-22 |
Schering Corporation |
Antagonistas de la mch basados en piperidina para el tratamiento de la obesidad y de trastornos del snc.
|
|
EP2769715A3
(en)
|
2001-11-26 |
2014-09-17 |
Trustees Of Tufts College |
Methods for treating autoimmune disorders, and reagents related thereto
|
|
WO2003048081A2
(en)
|
2001-12-04 |
2003-06-12 |
Bristol-Myers Squibb Company |
Glycinamides as factor xa inhibitors
|
|
GB0129988D0
(en)
|
2001-12-14 |
2002-02-06 |
Ferring Bv |
Imidazolidineacetic acid derivatives
|
|
CZ2004714A3
(cs)
|
2001-12-14 |
2004-10-13 |
Novoánordiskáa@S |
Sloučeniny a jejich použití ke snížení aktivity lipázy citlivé vůči hormonu
|
|
SE0104340D0
(sv)
|
2001-12-20 |
2001-12-20 |
Astrazeneca Ab |
New compounds
|
|
EP1458382A1
(en)
|
2001-12-21 |
2004-09-22 |
Novo Nordisk A/S |
Amide derivatives as gk activators
|
|
TW200301698A
(en)
|
2001-12-21 |
2003-07-16 |
Bristol Myers Squibb Co |
Acridone inhibitors of IMPDH enzyme
|
|
AU2002360732A1
(en)
|
2001-12-26 |
2003-07-24 |
Guilford Pharmaceuticals |
Change inhibitors of dipeptidyl peptidase iv
|
|
US6727261B2
(en)
|
2001-12-27 |
2004-04-27 |
Hoffman-La Roche Inc. |
Pyrido[2,1-A]Isoquinoline derivatives
|
|
EP1790353A1
(en)
|
2001-12-29 |
2007-05-30 |
Novo Nordisk A/S |
Combined use of a GLP-1 compound and a modulator of diabetic late complications
|
|
ATE409466T1
(de)
|
2002-01-11 |
2008-10-15 |
Novo Nordisk As |
Verfahren und zusammensetzung zur behandlung von diabetes, hypertonie, chronischer herzinsuffizienz und mit flüssigkeitsretention einhergehenden zuständen
|
|
AU2003207717B9
(en)
|
2002-02-01 |
2009-05-07 |
Merck & Co., Inc. |
11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
|
|
WO2003063903A2
(en)
|
2002-02-01 |
2003-08-07 |
Probiodrug Ag |
Modulation of t lymphocytes using dp iv inhibitors
|
|
US7101898B2
(en)
|
2002-02-01 |
2006-09-05 |
Novo Nordisk A/S |
Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
|
|
KR100608414B1
(ko)
|
2002-02-13 |
2006-08-02 |
에프. 호프만-라 로슈 아게 |
신규한 피리딘- 및 피리미딘-유도체
|
|
CA2474460C
(en)
|
2002-02-13 |
2009-12-22 |
F. Hoffmann-La Roche Ag |
Pyridine- and quinoline-derivatives
|
|
PL372887A1
(en)
|
2002-02-27 |
2005-08-08 |
Pfizer Products Inc. |
Acc inhibitors
|
|
EP1480961B1
(en)
|
2002-02-28 |
2006-12-27 |
Prosidion Ltd. |
Glutaminyl based dpiv inhibitors
|
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
|
AU2003228283A1
(en)
|
2002-03-07 |
2003-09-22 |
X-Ceptor Therapeutics, Inc. |
Quinazolinone modulators of nuclear receptors
|
|
AR039090A1
(es)
|
2002-03-22 |
2005-02-09 |
Novartis Ag |
Combinacion de compuestos organicos
|
|
ATE373660T1
(de)
|
2002-03-25 |
2007-10-15 |
Merck & Co Inc |
Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
|
|
US20030232761A1
(en)
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
|
US20040106802A1
(en)
|
2002-04-08 |
2004-06-03 |
Torrent Pharmaceuticals Ltd. |
Novel compounds and therapeutic uses thereof
|
|
CA2481995A1
(en)
|
2002-04-08 |
2003-10-16 |
Torrent Pharmaceuticals Ltd. |
Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors
|
|
JP2003300977A
(ja)
|
2002-04-10 |
2003-10-21 |
Sumitomo Pharmaceut Co Ltd |
キサンチン誘導体
|
|
EP2204181A3
(en)
|
2002-04-30 |
2010-09-22 |
Trustees Of Tufts College |
Protease inhibitors
|
|
TW200307667A
(en)
|
2002-05-06 |
2003-12-16 |
Bristol Myers Squibb Co |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
|
|
US7057046B2
(en)
|
2002-05-20 |
2006-06-06 |
Bristol-Myers Squibb Company |
Lactam glycogen phosphorylase inhibitors and method of use
|
|
EP1551834B1
(en)
|
2002-05-23 |
2010-08-25 |
Novartis Vaccines and Diagnostics, Inc. |
Substituted quinazolinone compounds
|
|
GB0212412D0
(en)
|
2002-05-29 |
2002-07-10 |
Novartis Ag |
Combination of organic compounds
|
|
US6710040B1
(en)
|
2002-06-04 |
2004-03-23 |
Pfizer Inc. |
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
|
|
WO2003101449A2
(en)
|
2002-06-04 |
2003-12-11 |
Pfizer Products Inc. |
Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
|
|
BR0311608A
(pt)
|
2002-06-04 |
2005-02-22 |
Pfizer Prod Inc |
Amidas cìclicas fluoradas como inibidores da dipeptidil-peptidase iv
|
|
PL374007A1
(en)
|
2002-06-06 |
2005-09-19 |
Eisai Co, Ltd. |
Novel fused imidazole derivative
|
|
AR040241A1
(es)
|
2002-06-10 |
2005-03-23 |
Merck & Co Inc |
Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
|
|
HUP0202001A2
(hu)
|
2002-06-14 |
2005-08-29 |
Sanofi-Aventis |
DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
|
|
WO2003106628A2
(en)
|
2002-06-17 |
2003-12-24 |
Bristol-Myers Squibb Company |
Benzodiazepine inhibitors of mitochondial f1f0 atp hydrolase and methods of inhibiting f1f0 atp hydrolase
|
|
IL165286A0
(en)
|
2002-06-17 |
2005-12-18 |
Smithkline Beecham Corp |
Chemical process
|
|
SE0201976D0
(sv)
*
|
2002-06-24 |
2002-06-24 |
Astrazeneca Ab |
Novel compounds
|
|
US20040006004A1
(en)
|
2002-06-27 |
2004-01-08 |
Markku Koulu |
Method for prevention and treatment of diseases or disorders related to excessive formation of vascular tissue or blood vessels
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
US20040054171A1
(en)
|
2002-07-04 |
2004-03-18 |
Jensen Anette Frost |
Polymorphic forms of a 4H-thieno[3,2-E]-1,2,4-thiadiazine 1,1-dioxide derivative
|
|
IL166156A0
(en)
|
2002-07-09 |
2006-01-15 |
Point Therapeutics Inc |
Boroproline compound combination therapy
|
|
HRP20050001A2
(en)
|
2002-07-09 |
2005-08-31 |
Bristol-Myers Squibb Company A Delaware (Usa) Corp |
Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
|
|
WO2004004665A2
(en)
|
2002-07-09 |
2004-01-15 |
Bristol-Myers Squibb Company |
Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
|
|
DE60322224D1
(de)
|
2002-08-08 |
2008-08-28 |
Takeda Pharmaceutical |
Kondensierte heterozyklische verbindungen als petidase inhibitoren
|
|
DK1528931T3
(da)
|
2002-08-09 |
2008-09-08 |
Prosidion Ltd |
Dipeptidylpeptidase-IV-inhibitorer til reduktion af hastigheden af kronisk vægtforögelse
|
|
KR101150449B1
(ko)
|
2002-08-21 |
2012-06-01 |
베링거 잉겔하임 파르마 게엠베하 운트 코 카게 |
8-［3-아미노-피페리딘-1-일］-크산틴, 이의 제조방법 및 이를 포함하는 약제학적 조성물
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
DE10238470A1
(de)
|
2002-08-22 |
2004-03-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US7495005B2
(en)
|
2002-08-22 |
2009-02-24 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, their preparation and their use in pharmaceutical compositions
|
|
US6998502B1
(en)
*
|
2002-09-05 |
2006-02-14 |
Sabinsa Corporation |
Convenient process of manufacture for difluoromethylornithine and related compounds
|
|
EP1398032A1
(en)
|
2002-09-10 |
2004-03-17 |
PheneX Pharmaceuticals AG |
4-Oxo-quinazolines as LXR nuclear receptor binding compounds
|
|
JP2004123738A
(ja)
|
2002-09-11 |
2004-04-22 |
Takeda Chem Ind Ltd |
徐放性製剤
|
|
US20040058876A1
(en)
|
2002-09-18 |
2004-03-25 |
Torsten Hoffmann |
Secondary binding site of dipeptidyl peptidase IV (DP IV)
|
|
US20050176622A1
(en)
|
2002-09-18 |
2005-08-11 |
Kerstin Kuhn-Wache |
Secondary binding site of dipeptidyl peptidase IV (DPIV)
|
|
US7262207B2
(en)
|
2002-09-19 |
2007-08-28 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
PT1560811E
(pt)
|
2002-09-19 |
2007-11-14 |
Abbott Lab |
Composições farmacêuticas como inibidores de dipeptidilpeptidase-iv ( dpp-iv)
|
|
US6869966B2
(en)
|
2002-09-30 |
2005-03-22 |
Banyu Pharmaceutical Co., Ltd. |
N-substituted-2-oxodihydropyridine derivatives
|
|
DE60315687T2
(de)
|
2002-10-07 |
2008-06-05 |
Merck & Co., Inc. |
Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase
|
|
AU2003269850A1
(en)
|
2002-10-08 |
2004-05-04 |
Novo Nordisk A/S |
Hemisuccinate salts of heterocyclic dpp-iv inhibitors
|
|
AU2003282510A1
(en)
|
2002-10-11 |
2004-05-04 |
Bristol-Myers Squibb Company |
Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
|
|
ES2301879T3
(es)
|
2002-10-18 |
2008-07-01 |
MERCK & CO., INC. |
Inhibidores de dipeptidilpeptidasa heterociclica beta-amino para el tratamiento o prevencion de diabetes.
|
|
AU2003301662A1
(en)
|
2002-10-21 |
2004-05-13 |
Bristol-Myers Squibb Company |
Quinazolinones and derivatives thereof as factor xa inhibitors
|
|
US6995180B2
(en)
|
2002-10-23 |
2006-02-07 |
Bristol Myers Squibb Company |
Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7482337B2
(en)
|
2002-11-08 |
2009-01-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
EP1565437A1
(en)
|
2002-11-18 |
2005-08-24 |
Pfizer Products Inc. |
Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides
|
|
DE10254304A1
(de)
|
2002-11-21 |
2004-06-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
AU2002952946A0
(en)
|
2002-11-27 |
2002-12-12 |
Fujisawa Pharmaceutical Co., Ltd. |
Dpp-iv inhibitor
|
|
US7109192B2
(en)
|
2002-12-03 |
2006-09-19 |
Boehringer Ingelheim Pharma Gmbh & Co Kg |
Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
|
|
US7309714B2
(en)
|
2002-12-04 |
2007-12-18 |
Merck & Co., Inc. |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
US7420079B2
(en)
|
2002-12-09 |
2008-09-02 |
Bristol-Myers Squibb Company |
Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
|
|
US7135467B2
(en)
|
2003-01-13 |
2006-11-14 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
CA2512546A1
(en)
|
2003-01-17 |
2004-08-05 |
Merck & Co., Inc. |
3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
AU2004210149A1
(en)
|
2003-01-31 |
2004-08-19 |
Merck & Co., Inc. |
3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
WO2004071454A2
(en)
|
2003-02-13 |
2004-08-26 |
Guilford Pharmaceuticals Inc. |
Substituted azetidine compounds as inhibitors of dipeptidyl peptidase iv
|
|
DE10308353A1
(de)
|
2003-02-27 |
2004-12-02 |
Aventis Pharma Deutschland Gmbh |
Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US7148246B2
(en)
|
2003-02-27 |
2006-12-12 |
Sanofi-Aventis Deutschland Gmbh |
Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
|
|
WO2004078777A2
(en)
|
2003-03-04 |
2004-09-16 |
Biorexis Pharmaceutical Corporation |
Dipeptidyl-peptidase protected proteins
|
|
AR043443A1
(es)
|
2003-03-07 |
2005-07-27 |
Merck & Co Inc |
Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios
|
|
US20050014732A1
(en)
|
2003-03-14 |
2005-01-20 |
Pharmacia Corporation |
Combination of an aldosterone receptor antagonist and an anti-diabetic agent
|
|
WO2004085661A2
(en)
|
2003-03-24 |
2004-10-07 |
Merck & Co., Inc |
Process to chiral beta-amino acid derivatives
|
|
US7550590B2
(en)
|
2003-03-25 |
2009-06-23 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
WO2004087880A2
(en)
|
2003-03-26 |
2004-10-14 |
Bayer Pharmaceuticals Corporation |
Compounds and their use to treat diabetes and related disorders
|
|
TWI357408B
(en)
|
2003-03-26 |
2012-02-01 |
Mitsubishi Tanabe Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
WO2004087650A2
(en)
|
2003-03-27 |
2004-10-14 |
Merck & Co. Inc. |
Process and intermediates for the preparation of beta-amino acid amide dipeptidyl peptidase-iv inhibitors
|
|
NZ568459A
(en)
|
2003-05-05 |
2009-06-26 |
Probiodrug Ag |
Use of effectors of glutaminyl and glutamate cyclases
|
|
WO2004099134A2
(en)
|
2003-05-05 |
2004-11-18 |
Prosidion Ltd. |
Glutaminyl based dp iv-inhibitors
|
|
DE602004026289D1
(de)
*
|
2003-05-05 |
2010-05-12 |
Probiodrug Ag |
Glutaminylcyclase-hemmer
|
|
CA2524531A1
(en)
|
2003-05-14 |
2004-12-02 |
Merck And Co., Inc. |
3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
EP1625122A1
(en)
|
2003-05-14 |
2006-02-15 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
AU2004249163A1
(en)
|
2003-06-17 |
2004-12-29 |
Merck & Co., Inc. |
Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
US7566707B2
(en)
|
2003-06-18 |
2009-07-28 |
Boehringer Ingelheim International Gmbh |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
|
|
RS52397B
(sr)
|
2003-06-20 |
2013-02-28 |
F.Hoffmann-La Roche Ag |
Derivati pirido /2,1-a/izohinolina kao dpp-iv inhibitori
|
|
EP1638968B1
(en)
|
2003-06-20 |
2009-07-29 |
F.Hoffmann-La Roche Ag |
Hexahydropyridoisoqinolines as dpp-iv inhibitors
|
|
JO2625B1
(en)
|
2003-06-24 |
2011-11-01 |
ميرك شارب اند دوم كوربوريشن |
Phosphoric acid salts of dipeptidyl betidase inhibitor 4
|
|
DE10330842A1
(de)
|
2003-07-08 |
2005-02-10 |
Institut für Medizintechnologie Magdeburg GmbH, IMTM |
Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit Hyperproliferation und veränderten Differenzierungszuständen von Fibroblasten
|
|
EP1651623B1
(en)
|
2003-07-31 |
2008-12-17 |
Merck & Co., Inc. |
Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
US6995183B2
(en)
|
2003-08-01 |
2006-02-07 |
Bristol Myers Squibb Company |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US20050070531A1
(en)
|
2003-08-13 |
2005-03-31 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
|
WO2005019168A2
(en)
|
2003-08-20 |
2005-03-03 |
Pfizer Products Inc. |
Fluorinated lysine derivatives as dipeptidyl peptidase iv inhibitors
|
|
JP2007513058A
(ja)
|
2003-09-08 |
2007-05-24 |
武田薬品工業株式会社 |
ジペプチジルぺプチダーゼ阻害剤
|
|
JP2007505121A
(ja)
|
2003-09-08 |
2007-03-08 |
武田薬品工業株式会社 |
ジペプチジルぺプチダーゼ阻害剤
|
|
CN1918131B
(zh)
*
|
2004-02-05 |
2011-05-04 |
前体生物药物股份公司 |
谷氨酰胺酰基环化酶抑制剂
|
|
GEP20094679B
(en)
*
|
2004-03-15 |
2009-05-10 |
Takeda Pharmaceuticals Co |
Dipeptidyl peptidase inhibitors
|
|
AU2005270039B2
(en)
|
2004-07-02 |
2011-09-01 |
Corcept Therapeutics, Inc. |
Modified pyrimidine glucocorticoid receptor modulators
|
|
EP1828192B1
(en)
|
2004-12-21 |
2014-12-03 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
MX2007007483A
(es)
*
|
2004-12-24 |
2007-07-20 |
Dainippon Sumitomo Pharma Co |
Derivados de pirroles biciclicos.
|
|
US20070060530A1
(en)
|
2005-09-14 |
2007-03-15 |
Christopher Ronald J |
Administration of dipeptidyl peptidase inhibitors
|
|
US20070060529A1
(en)
*
|
2005-09-14 |
2007-03-15 |
Christopher Ronald J |
Administration of dipeptidyl peptidase inhibitors
|
|
EA015735B1
(ru)
|
2005-09-14 |
2011-10-31 |
Такеда Фармасьютикал Компани Лимитед |
Фармацевтические композиции на основе 2-[[6-[(3r)-3-амино-1-пиперидинил]-3,4-дигидро-3-метил-2,4-диоксо-1(2н)-пиримидинил]метил]бензонитрила
|
|
TW200745079A
(en)
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|