CL2003002356A1 - Compuestos derivados de 1-(1-acetil-piperidin-4-il)-(ester o amida)-4-(bencidrilo sustituido)-2-tert-butil-piperazina, composicion farmaceutica, y su uso en la inhibicion de 17b-hidroxiesteroide deshidrogenasa de tipo 3 y de enfermedades que dependen - Google Patents

Compuestos derivados de 1-(1-acetil-piperidin-4-il)-(ester o amida)-4-(bencidrilo sustituido)-2-tert-butil-piperazina, composicion farmaceutica, y su uso en la inhibicion de 17b-hidroxiesteroide deshidrogenasa de tipo 3 y de enfermedades que dependen

Info

Publication number: CL2003002356A1
Authority: CL; Chile
Prior art keywords: bencidrile; butil; amida; piperidin; piperazine
Prior art date: 2002-11-18

Application number

CL200302356A

Other languages

English (en)

Inventor

Kamil Guzi Timothy J Paruch

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-18

Filing date

2003-11-14

Publication date

2005-02-11

2003-11-14 Application filed by Schering Corp filed Critical Schering Corp

2005-02-11 Publication of CL2003002356A1 publication Critical patent/CL2003002356A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CL200302356A 2002-11-18 2003-11-14 Compuestos derivados de 1-(1-acetil-piperidin-4-il)-(ester o amida)-4-(bencidrilo sustituido)-2-tert-butil-piperazina, composicion farmaceutica, y su uso en la inhibicion de 17b-hidroxiesteroide deshidrogenasa de tipo 3 y de enfermedades que dependen CL2003002356A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US42726302P	2002-11-18	2002-11-18

Publications (1)

Publication Number	Publication Date
CL2003002356A1 true CL2003002356A1 (es)	2005-02-11

Family

ID=32326512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200302356A CL2003002356A1 (es)	2002-11-18	2003-11-14	Compuestos derivados de 1-(1-acetil-piperidin-4-il)-(ester o amida)-4-(bencidrilo sustituido)-2-tert-butil-piperazina, composicion farmaceutica, y su uso en la inhibicion de 17b-hidroxiesteroide deshidrogenasa de tipo 3 y de enfermedades que dependen

Country Status (16)

Country	Link
US (2)	US7074795B2 (es)
EP (1)	EP1562901B1 (es)
JP (2)	JP4614770B2 (es)
CN (1)	CN100374421C (es)
AR (1)	AR042046A1 (es)
AT (1)	ATE469886T1 (es)
AU (1)	AU2003290799A1 (es)
CA (1)	CA2506290C (es)
CL (1)	CL2003002356A1 (es)
DE (1)	DE60332862D1 (es)
ES (1)	ES2345146T3 (es)
MX (1)	MXPA05005360A (es)
MY (1)	MY130792A (es)
PE (1)	PE20040750A1 (es)
TW (1)	TW200412964A (es)
WO (1)	WO2004046111A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60323765D1 (de)	2002-12-17	2008-11-06	Schering Corp	Inhibitoren der 17 beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
GB0513702D0 (en)	2005-07-04	2005-08-10	Sterix Ltd	Compound
CA2606004A1 (en) *	2005-08-02	2007-02-08	Neurogen Corporation	Dipiperazinyl ketones and related analogues
US8080540B2 (en)	2006-09-19	2011-12-20	Abbott Products Gmbh	Therapeutically active triazoles and their use
US8288367B2 (en)	2006-11-30	2012-10-16	Solvay Pharmaceuticals Gmbh	Substituted estratriene derivatives as 17BETA HSD inhibitors
US8501940B2 (en) *	2008-07-15	2013-08-06	Hoffmann-La Roche Inc.	Tetrahydrocinnoline derivatives
PL2702982T3 (pl) *	2011-04-25	2017-07-31	Jun-Hyoung Park	Kompozycja do miejscowego stosowania do zapobiegania wypadaniu włosów i stymulowania porostu włosów
AU2014300894A1 (en)	2013-06-25	2016-01-28	Forendo Pharma Ltd	Therapeutically active 17-nitrogen substituted estratrienthiazole derivatives as inhibitors of 17.beta.-hydroxysteroid dehydrogenase
US10377791B2 (en)	2013-06-25	2019-08-13	Forendo Pharma Ltd.	Therapeutically active estratrienthiazole derivatives as inhibitors of 17 B-hydroxysteroid dehydrogenase, type 1
WO2014207311A1 (en)	2013-06-25	2014-12-31	Forendo Pharma Ltd	Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta.-hydroxy-steroid dehydrogenase, type 1
CN107207561B (zh)	2014-12-23	2020-03-31	佛恩多制药有限公司	17β-HSD1–抑制剂的前药
EP3237430B1 (en)	2014-12-23	2019-03-20	Forendo Pharma Ltd	PRODRUGS OF 17ß -HSD1 -INHIBITORS
UY36875A (es)	2015-09-02	2017-03-31	Glaxosmithkline Intellectual Property (No 2) Ltd	Composiciones inhibidoras de bromodominios para el tratamiento de diversas enfermedades
AU2018279205B2 (en)	2017-06-08	2021-04-15	Forendo Pharma Ltd	15.beta.-(3-propanamido)-substituted estra-1,3,5(10)-trien-17-one compounds and their 17-oximes for use in inhibition of 17.beta.-hydroxysteroid dehydrogenases
IL275337B2 (en)	2017-12-15	2024-06-01	Inthera Bioscience AG	1-(piperidinocarbonylmethyl)-2-oxopyrazine derivatives for cancer therapy
US20220041647A1 (en)	2018-12-05	2022-02-10	Forendo Pharma Ltd	Estra-1,3,5(10)-triene compounds condensed in position 16(17) with a pyrazole ring as inhibitors of 17-hsd1

Family Cites Families (11)

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Publication number	Priority date	Publication date	Assignee	Title
DE3590389T1 (de)	1984-08-02	1986-08-28	Schering Corp., Kenilworth, N.J.	Pharmazeutische Zusammensetzung für eine Kombinationstherapie hormon-abhängiger Cancer
ES2077675T3 (es)	1989-03-10	1995-12-01	Endorecherche Inc	Terapia combinada para el tratamiento de enfermedades sensibles a los estrogenos.
ES2222633T3 (es)	1989-07-07	2005-02-01	Endorecherche Inc.	Terapia combinada para la profilaxis y/o el tratamiento de la hiperplasia prostatica benigna.
DE69034035T2 (de)	1989-07-07	2004-01-22	Endorecherche Inc., Ste-Foy	Methode zur behandlung androgenbedingter krankheiten
US6060503A (en)	1991-12-02	2000-05-09	Endorecherche, Inc.	Benzopyran-containing compounds and method for their use
EP0650495B1 (en)	1993-05-17	2000-11-08	Endorecherche Inc.	Improved antiandrogens
US6124115A (en)	1995-09-22	2000-09-26	Endorecherche Inc.	Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase
WO1998011092A1 (en) *	1996-09-13	1998-03-19	Schering Corporation	Tricyclic antitumor compounds being farnesyl protein transferase inhibitors
BR9908592A (pt) *	1998-03-11	2001-04-24	Endorech Inc	Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit
EP1423381B1 (en) *	2001-09-06	2007-01-03	Schering Corporation	17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
JP4309761B2 (ja) *	2001-10-17	2009-08-05	シェーリングコーポレイション	アンドロゲン依存性疾患の治療を目的とする１７βヒドロキシステロイドデヒドロゲナーゼ３型の阻害剤としてのピペリジンアセトアミンおよびピペラジンアセトアミン

2003
- 2003-11-14 AT AT03783382T patent/ATE469886T1/de not_active IP Right Cessation
- 2003-11-14 MX MXPA05005360A patent/MXPA05005360A/es active IP Right Grant
- 2003-11-14 MY MYPI20034363A patent/MY130792A/en unknown
- 2003-11-14 CN CNB2003801086673A patent/CN100374421C/zh not_active Expired - Fee Related
- 2003-11-14 US US10/713,828 patent/US7074795B2/en not_active Expired - Fee Related
- 2003-11-14 TW TW092131992A patent/TW200412964A/zh unknown
- 2003-11-14 CA CA2506290A patent/CA2506290C/en not_active Expired - Fee Related
- 2003-11-14 JP JP2004553612A patent/JP4614770B2/ja not_active Expired - Fee Related
- 2003-11-14 ES ES03783382T patent/ES2345146T3/es not_active Expired - Lifetime
- 2003-11-14 AU AU2003290799A patent/AU2003290799A1/en not_active Abandoned
- 2003-11-14 EP EP03783382A patent/EP1562901B1/en not_active Expired - Lifetime
- 2003-11-14 AR ARP030104210A patent/AR042046A1/es unknown
- 2003-11-14 PE PE2003001156A patent/PE20040750A1/es not_active Application Discontinuation
- 2003-11-14 WO PCT/US2003/036203 patent/WO2004046111A1/en not_active Ceased
- 2003-11-14 CL CL200302356A patent/CL2003002356A1/es unknown
- 2003-11-14 DE DE60332862T patent/DE60332862D1/de not_active Expired - Lifetime
2006
- 2006-02-24 US US11/362,217 patent/US7476681B2/en not_active Expired - Fee Related
2010
- 2010-03-15 JP JP2010058356A patent/JP2010138204A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
CA2506290C (en)	2012-04-24
MXPA05005360A (es)	2005-08-03
CA2506290A1 (en)	2004-06-03
TW200412964A (en)	2004-08-01
JP4614770B2 (ja)	2011-01-19
AR042046A1 (es)	2005-06-08
WO2004046111A1 (en)	2004-06-03
CN100374421C (zh)	2008-03-12
EP1562901A1 (en)	2005-08-17
US7476681B2 (en)	2009-01-13
US20040127503A1 (en)	2004-07-01
MY130792A (en)	2007-07-31
ES2345146T3 (es)	2010-09-16
ATE469886T1 (de)	2010-06-15
PE20040750A1 (es)	2004-11-06
AU2003290799A1 (en)	2004-06-15
US20060148816A1 (en)	2006-07-06
JP2010138204A (ja)	2010-06-24
HK1073313A1 (en)	2005-09-30
CN1738800A (zh)	2006-02-22
DE60332862D1 (de)	2010-07-15
EP1562901B1 (en)	2010-06-02
US7074795B2 (en)	2006-07-11
JP2006513169A (ja)	2006-04-20

Publication	Publication Date	Title
CL2003002356A1 (es)	2005-02-11	Compuestos derivados de 1-(1-acetil-piperidin-4-il)-(ester o amida)-4-(bencidrilo sustituido)-2-tert-butil-piperazina, composicion farmaceutica, y su uso en la inhibicion de 17b-hidroxiesteroide deshidrogenasa de tipo 3 y de enfermedades que dependen
EE05585B1 (et)	2012-10-15	Indasoolihendid ja farmatseutilised kompositsioonid proteiini kinaaside inhibeerimiseks ning nende kasutamine
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CL2004001174A1 (es)	2005-05-06	Composicion farmaceutica que comprende: 1-(4-fluorofenil)-3(r)-[3-(4-fluorofenil)-3(s)-hidroxipropil]-4(s)-(4-hidroxifenil)-2-acetidinona (ezetimiba) y excipientes; y su uso en el tratamiento y/o prevencion de aterosclerosis, hipercolesterolemia, dia
AU2001284690A1 (en)	2002-02-13	Compositions exhibiting synergistic inhibition of the expression and/or activityof cyclooxygenase-2
NO20043913L (no)	2004-11-16	Blandinger med modifisert frigjoring av i det minste en form av tramadol
IT1309427B1 (it)	2002-01-23	Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso
CL2007002916A1 (es)	2008-04-18	Compuestos derivados de pirazoliltienopiridinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en la inhibicion de escaras.
PT1313489E (pt)	2005-05-31	Composicoes farmaceuticas para o tratamento de mucosite, estomatite e sindroma de behcet
BRPI0415121A (pt)	2006-11-28	material particulado, forma de dosagem sólida, método para fabricar a mesma, e, uso de um material particulado ou de uma forma de dosagem sólida
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CL2007000789A1 (es)	2008-01-18	Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer.
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UY27993A1 (es)	2004-03-31	Derivados de 4-pirrolidino-fenil-bencil eter
IL164022A0 (en)	2005-12-18	Phosphate derivatives of fluoroxindole and pharmaceutical compositions containing the same
DK1467724T3 (da)	2006-08-28	Farmaceutisk sammensætning med agomelatin til dispergering i mundhulen
DE60013098D1 (de)	2004-09-23	Zusammensetzung zur hautdesinfizierung
IL184266A (en)	2013-04-30	Benzazole analogues, preparations containing them and their use as inhibitors of protein kinase
DE60323765D1 (de)	2008-11-06	Inhibitoren der 17 beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
DK1250152T3 (da)	2013-08-26	Synergistisk sammensætning indeholdende hyaluronsyre til behandling af cancer
BRPI0515645A (pt)	2008-03-04	métodos terapêuticos, composições, compostos e usos de compostos
ITMI20020189A0 (it)	2002-02-01	Composizione per uso farmaceutico o dietetico per contrastare la caduta dei capelli
CL2007003643A1 (es)	2008-03-24	Composicion farmaceutica de azimilidina que comprende 0,5% a aproximadamente 2,5% (w/w) de agua; y uso para el tratamiento de arritmias cardiacas.