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CA2752232C - A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent - Google Patents

A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent Download PDF

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Publication number
CA2752232C
CA2752232C CA2752232A CA2752232A CA2752232C CA 2752232 C CA2752232 C CA 2752232C CA 2752232 A CA2752232 A CA 2752232A CA 2752232 A CA2752232 A CA 2752232A CA 2752232 C CA2752232 C CA 2752232C
Authority
CA
Canada
Prior art keywords
cancer
dihydro
quinolin
pyrrolo
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2752232A
Other languages
English (en)
French (fr)
Other versions
CA2752232A1 (en
Inventor
Thomas C. K. Chan
Dennis S. France
Kenichi Ishii
Paolo Pucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Co Ltd
Arqule Inc
Original Assignee
Kyowa Hakko Kirin Co Ltd
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, Arqule Inc filed Critical Kyowa Hakko Kirin Co Ltd
Publication of CA2752232A1 publication Critical patent/CA2752232A1/en
Application granted granted Critical
Publication of CA2752232C publication Critical patent/CA2752232C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2752232A 2009-02-12 2010-02-11 A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent Expired - Fee Related CA2752232C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15213809P 2009-02-12 2009-02-12
US61/152,138 2009-02-12
US17047109P 2009-04-17 2009-04-17
US61/170,471 2009-04-17
PCT/US2010/023893 WO2010093789A2 (en) 2009-02-12 2010-02-11 Combinational compositions and methods for treatment of cancer

Publications (2)

Publication Number Publication Date
CA2752232A1 CA2752232A1 (en) 2010-08-19
CA2752232C true CA2752232C (en) 2016-11-22

Family

ID=42126095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2752232A Expired - Fee Related CA2752232C (en) 2009-02-12 2010-02-11 A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent

Country Status (13)

Country Link
US (2) US20100297075A1 (es)
EP (1) EP2396003B1 (es)
JP (1) JP5687209B2 (es)
KR (1) KR101620654B1 (es)
CN (1) CN102481299B (es)
AU (1) AU2010213696B2 (es)
BR (1) BRPI1007972A2 (es)
CA (1) CA2752232C (es)
IL (1) IL214348A (es)
MX (1) MX2011008584A (es)
TW (1) TWI460178B (es)
WO (1) WO2010093789A2 (es)
ZA (1) ZA201105611B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011008584A (es) 2009-02-12 2012-01-27 Kyowa Hakko Kirin Co Ltd Composiciones combinacionales y metodos para el tratamiento del cancer.
US8580764B2 (en) 2010-07-01 2013-11-12 Arqule, Inc. Combinational compositions and methods for treatment of cancer
WO2012030896A2 (en) 2010-09-01 2012-03-08 Arqule, Inc. Methods for treatment of non-small cell lung cancer
JP6013359B2 (ja) * 2010-12-17 2016-10-25 ノバルティス アーゲー 組合せ
TWI525091B (zh) * 2010-12-23 2016-03-11 亞闊股份有限公司 吡咯並喹啉基－吡咯啶－２，５－二酮組成物類及製備和使用彼等之方法
BR112013022391A2 (pt) 2011-03-02 2018-01-16 SCHENTAG Jerome composições, métodos de tratamento e diagnóstico para o tratamento de esteatose hepática apenas ou em combinação com uma infecção pelo vírus da hepatite c e uso dessas composições
US9180099B2 (en) * 2011-07-07 2015-11-10 Arqule Inc. Pyrroloquinolinyl-pyrrolidine-2,5-dione formulations and methods for preparing and using same
AR087918A1 (es) * 2011-09-19 2014-04-23 Genentech Inc Tratamientos combinados que comprenden antagonistas de c-met y antagonistas de b-raf
WO2013085902A1 (en) * 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
TWI594986B (zh) * 2011-12-28 2017-08-11 Taiho Pharmaceutical Co Ltd Antineoplastic agent effect enhancer
KR20150003768A (ko) * 2012-04-23 2015-01-09 아르퀼 인코포레이티드 고순도 피롤로퀴놀리닐-피롤-2,5-디온 및 피롤로퀴놀리닐-피롤리딘-2,5-디온 및 이의 제조 방법
CN102757435B (zh) * 2012-06-21 2014-05-28 成都苑东药业有限公司 一种反式-3-吲哚基-4-吲哚并二氮杂卓环庚烷基-2,5-吡咯烷-2,5-二酮化合物及其制备方法
CA2943329A1 (en) 2014-03-24 2015-10-01 Genentech, Inc. Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
ES2926781T3 (es) * 2015-12-07 2022-10-28 Hinova Pharmaceuticals Inc Compuestos de quinoleína, método de preparación de los mismos, y uso de los mismos como fármaco inhibidor del transportador de urato
PT3583943T (pt) 2017-02-15 2024-10-15 Taiho Pharmaceutical Co Ltd Composição farmacêutica
JP7074760B2 (ja) 2017-09-08 2022-05-24 大鵬薬品工業株式会社 抗腫瘍剤及び抗腫瘍効果増強剤
CN108546244B (zh) * 2018-07-05 2021-04-23 南昌航空大学 一种3,3’-二吲哚乙烷类化合物的合成方法
WO2022150559A1 (en) * 2021-01-08 2022-07-14 Duke University Methods for treatment of cancer using abl inhibitors and drugs targeting the mevalonate pathway
EP4601643A1 (en) * 2022-11-18 2025-08-20 Council Of Scientific & Industrial Research Composition for treating paclitaxel-resistant breast cancer and method for preparation thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CA2599611C (en) * 2005-02-09 2013-07-30 Chiang J. Li Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
DK2076289T3 (da) 2007-04-13 2015-02-09 Dana Farber Cancer Inst Inc Fremgangsmåder til behandling af cancerresistens over for ErbB-lægemider
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
MX2010004327A (es) 2007-10-22 2010-05-13 Schering Corp Anticuerpos anti-vegf completamente humanos y metodos de uso.
CA2718918A1 (en) 2008-03-25 2009-11-26 Schering Corporation Methods for treating or preventing colorectal cancer
MX2011008584A (es) 2009-02-12 2012-01-27 Kyowa Hakko Kirin Co Ltd Composiciones combinacionales y metodos para el tratamiento del cancer.
US8580764B2 (en) * 2010-07-01 2013-11-12 Arqule, Inc. Combinational compositions and methods for treatment of cancer
WO2012030896A2 (en) * 2010-09-01 2012-03-08 Arqule, Inc. Methods for treatment of non-small cell lung cancer

Also Published As

Publication number Publication date
JP2012517477A (ja) 2012-08-02
KR20110118817A (ko) 2011-11-01
BRPI1007972A2 (pt) 2016-09-13
EP2396003A2 (en) 2011-12-21
CN102481299B (zh) 2015-02-25
IL214348A0 (en) 2011-09-27
AU2010213696B2 (en) 2015-10-01
US20150328208A1 (en) 2015-11-19
ZA201105611B (en) 2012-10-31
TWI460178B (zh) 2014-11-11
HK1164159A1 (en) 2012-09-21
IL214348A (en) 2015-05-31
CA2752232A1 (en) 2010-08-19
EP2396003B1 (en) 2013-04-17
MX2011008584A (es) 2012-01-27
WO2010093789A2 (en) 2010-08-19
JP5687209B2 (ja) 2015-03-18
KR101620654B1 (ko) 2016-05-12
WO2010093789A8 (en) 2011-03-17
CN102481299A (zh) 2012-05-30
US9642847B2 (en) 2017-05-09
AU2010213696A1 (en) 2011-08-18
TW201043626A (en) 2010-12-16
US20100297075A1 (en) 2010-11-25
WO2010093789A3 (en) 2010-12-02

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