BRPI1010957A2 - variantes de celulase com expressão, atividade e/ou estabilidade aprimorada e uso das mesmas. - Google Patents
variantes de celulase com expressão, atividade e/ou estabilidade aprimorada e uso das mesmas.Info
- Publication number
- BRPI1010957A2 BRPI1010957A2 BRPI1010957A BRPI1010957A BRPI1010957A2 BR PI1010957 A2 BRPI1010957 A2 BR PI1010957A2 BR PI1010957 A BRPI1010957 A BR PI1010957A BR PI1010957 A BRPI1010957 A BR PI1010957A BR PI1010957 A2 BRPI1010957 A2 BR PI1010957A2
- Authority
- BR
- Brazil
- Prior art keywords
- activity
- stability
- improved expression
- cellulase variants
- cellulase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18395909P | 2009-06-03 | 2009-06-03 | |
| PCT/US2010/037328 WO2010141779A1 (en) | 2009-06-03 | 2010-06-03 | Cellulase variants with improved expression, activity and/or stability, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1010957A2 true BRPI1010957A2 (pt) | 2018-02-06 |
Family
ID=42493879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1010957A BRPI1010957A2 (pt) | 2009-06-03 | 2010-06-03 | variantes de celulase com expressão, atividade e/ou estabilidade aprimorada e uso das mesmas. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8679816B2 (pt) |
| EP (1) | EP2438164B1 (pt) |
| JP (1) | JP2012528598A (pt) |
| KR (1) | KR20120062643A (pt) |
| CN (2) | CN102803482B (pt) |
| AU (1) | AU2010256519B2 (pt) |
| BR (1) | BRPI1010957A2 (pt) |
| CA (1) | CA2764094A1 (pt) |
| CO (1) | CO6470854A2 (pt) |
| MX (1) | MX2011012841A (pt) |
| RU (1) | RU2011154243A (pt) |
| WO (1) | WO2010141779A1 (pt) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0913624A2 (pt) | 2008-06-06 | 2015-08-04 | Danisco Us Inc | Composições e métodos compreendendo variantes de celulase com afinidade reduzida por materiais não celulósicos |
| AU2009270398A1 (en) * | 2008-07-16 | 2010-01-21 | Iogen Energy Corporation | Modified family 6 glycosidases with altered substrate specificity |
| AU2010234521B2 (en) * | 2009-04-06 | 2015-01-29 | California Institute Of Technology | Polypeptides having cellulase activity |
| JP5932648B2 (ja) | 2009-09-23 | 2016-06-15 | ダニスコ・ユーエス・インク | 新規なグリコシルヒドロラーゼ酵素及びその用途 |
| CN107287250A (zh) | 2009-12-23 | 2017-10-24 | 丹尼斯科美国公司 | 提高同步糖化发酵反应效率的方法 |
| BR112012020804A2 (pt) | 2010-02-11 | 2015-09-15 | Iogen Energy Corp | módulos de ligação de carboidrato com ligação reduzida à lignina |
| WO2011123450A1 (en) | 2010-03-31 | 2011-10-06 | Novozymes, Inc. | Cellobiohydrolase variants and polynucleotides encoding same |
| EP2569426A4 (en) | 2010-05-14 | 2013-10-09 | Codexis Inc | ZELLBIOHYDROLASE VARIANTS |
| WO2011153449A1 (en) | 2010-06-03 | 2011-12-08 | Danisco Us Inc. | Filamentous fungal host strains and dna constructs, and methods of use thereof |
| ES2664178T3 (es) | 2010-09-06 | 2018-04-18 | Dupont Nutrition Biosciences Aps | Aditivo alimentario que comprende una amidasa para degradar la ocratoxina |
| US9080161B2 (en) | 2011-01-26 | 2015-07-14 | Novozymes, Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| SG192098A1 (en) | 2011-03-17 | 2013-08-30 | Danisco Us Inc | Method for reducing viscosity in saccharification process |
| WO2012130950A1 (en) * | 2011-04-01 | 2012-10-04 | Dsm Ip Assets B.V. | Novel cell wall deconstruction enzymes of talaromyces thermophilus and uses thereof |
| US20120276594A1 (en) * | 2011-04-27 | 2012-11-01 | Codexis, Inc. | Cellobiohydrolase variants |
| JP2012235767A (ja) * | 2011-04-27 | 2012-12-06 | Toyota Motor Corp | 変異トリコデルマ属微生物及びこれを用いたタンパク質の製造方法 |
| BR112014003740A2 (pt) | 2011-08-23 | 2018-08-14 | Codexis Inc | variantes da celobiohidrolase |
| DK2791350T3 (da) | 2011-12-13 | 2019-05-06 | Danisco Us Inc | Enzymcocktails fremstillet af blandede kulturer |
| DK2794869T3 (en) * | 2011-12-20 | 2018-01-02 | Novozymes Inc | CELLOBIO HYDROLASE VARIABLES AND POLYNUCLEOTIDES CODING THEM |
| DK2794886T3 (en) | 2011-12-21 | 2017-02-27 | Danisco Us Inc | IMPROVEMENT OF FUNGAL Gene EXPRESSION USING ISOLATOR DNA SEQUENCES |
| CN104011067B (zh) | 2011-12-22 | 2017-12-26 | 杜邦营养生物科学有限公司 | 具有葡糖淀粉酶活性的多肽及其制备方法 |
| MX2015002099A (es) | 2012-08-22 | 2015-05-11 | Dupont Nutrition Biosci Aps | Variantes que tienen actividad glucoamilasa. |
| MX2015005427A (es) | 2012-10-31 | 2015-08-05 | Danisco Inc | Beta-glucosidasa de magnaporthe grisea. |
| JP2015533293A (ja) | 2012-10-31 | 2015-11-24 | ダニスコ・ユーエス・インク | 組成物及び使用方法 |
| EP2914718A1 (en) | 2012-10-31 | 2015-09-09 | Danisco US Inc. | Beta-glucosidase from neurospora crassa |
| US20150376589A1 (en) * | 2012-11-15 | 2015-12-31 | Bp Corporation North America Inc. | Variant cbhii polypeptides with improved specific activity |
| DK2929022T3 (en) | 2012-12-07 | 2017-02-13 | Danisco Us Inc | COMPOSITIONS AND METHODS OF USE |
| CA2892054A1 (en) | 2012-12-07 | 2014-06-12 | Ling Hua | Compositions and methods of use |
| WO2014093282A1 (en) | 2012-12-12 | 2014-06-19 | Danisco Us Inc. | Variants of cellobiohydrolases |
| US20160272959A1 (en) | 2012-12-12 | 2016-09-22 | Danisco Us Inc. | Variants of cellobiohydrolases |
| WO2014093275A1 (en) | 2012-12-12 | 2014-06-19 | Danisco Us Inc. | Variants of cellobiohydrolases |
| EP2931886A1 (en) | 2012-12-12 | 2015-10-21 | Danisco US Inc. | Variants of cellobiohydrolases |
| KR20150093729A (ko) | 2012-12-12 | 2015-08-18 | 다니스코 유에스 인크. | 셀로바이오하이드롤라제의 변이체 |
| US8778641B1 (en) * | 2013-02-12 | 2014-07-15 | Novozymes Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| US8778640B1 (en) * | 2013-02-12 | 2014-07-15 | Novozymes Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| CN105164254B (zh) * | 2013-03-08 | 2019-06-28 | 诺维信公司 | 纤维二糖水解酶变体和编码它们的多核苷酸 |
| US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
| US10081802B2 (en) * | 2013-07-29 | 2018-09-25 | Danisco Us Inc. | Variant Enzymes |
| BR112016012627A2 (pt) | 2013-12-04 | 2017-09-26 | Danisco Us Inc | composições compreendendo um polipeptídeo de beta-glicosidase e métodos de uso |
| US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
| US20170218351A1 (en) | 2014-09-30 | 2017-08-03 | Danisco Us Inc. | Compositions comprising beta-mannanase and methods of use |
| US20170233707A1 (en) | 2014-09-30 | 2017-08-17 | Danisco Us Inc | Compositions comprising beta-mannanase and methods of use |
| WO2016054205A1 (en) | 2014-09-30 | 2016-04-07 | Danisco Us Inc | Compositions comprising beta mannanase and methods of use |
| EP3201331A1 (en) | 2014-09-30 | 2017-08-09 | Danisco US Inc. | Compositions comprising beta mannanase and methods of use |
| US20170226494A1 (en) | 2014-09-30 | 2017-08-10 | Danisco Us Inc. | Compositions comprising beta-mannanase and methods of use |
| BR112017008595A2 (pt) | 2014-10-27 | 2017-12-19 | Danisco Us Inc | composições e métodos referentes à beta-glucosidase |
| WO2017007907A1 (en) | 2015-07-07 | 2017-01-12 | Danisco Us Inc. | Induction of gene expression using a high concentration sugar mixture |
| JP7103948B2 (ja) | 2016-03-04 | 2022-07-20 | ダニスコ・ユーエス・インク | 微生物におけるタンパク質産生のための遺伝子操作されたリボソームプロモーター |
| WO2018053058A1 (en) | 2016-09-14 | 2018-03-22 | Danisco Us Inc. | Lignocellulosic biomass fermentation-based processes |
| WO2018067599A1 (en) | 2016-10-04 | 2018-04-12 | Danisco Us Inc. | Protein production in filamentous fungal cells in the absence of inducing substrates |
| WO2018106656A1 (en) | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
| DK3555279T3 (da) * | 2016-12-15 | 2025-09-29 | Danisco Us Inc | Polypeptider med endoglucanase-aktivitet og anvendelser deraf |
| MX2019007335A (es) | 2016-12-21 | 2019-09-09 | Dupont Nutrition Biosci Aps | Métodos para usar serina proteasas termoestables. |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| EP3703661A1 (en) | 2017-11-02 | 2020-09-09 | Danisco US Inc. | Freezing point depressed solid matrix compositions for melt granulation of enzymes |
| CN109897840B (zh) * | 2017-12-08 | 2021-10-22 | 中国科学院天津工业生物技术研究所 | 聚磷酸依赖型葡萄糖激酶变体及其应用 |
| EP3530743A1 (en) | 2018-02-21 | 2019-08-28 | Cambridge Glycoscience Ltd | Method of production |
| US20210269972A1 (en) * | 2018-07-10 | 2021-09-02 | Novozymes A/S | Method of making paper or board |
| JP7374991B2 (ja) | 2018-08-15 | 2023-11-07 | ケンブリッジ グリコサイエンス エルティーディー | 新規組成物、それらの使用、およびそれらの形成方法 |
| CN114727642B (zh) | 2019-08-16 | 2025-02-14 | 剑桥糖质科学有限公司 | 处理生物质以生产寡糖的方法和相关组合物 |
| CN115279208B (zh) | 2019-12-12 | 2024-12-17 | 剑桥糖质科学有限公司 | 低糖多相食品 |
| CN116334020B (zh) * | 2023-02-28 | 2025-11-11 | 南京工业大学 | 一种6'-唾液酸转移酶突变体及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US245269A (en) | 1881-08-09 | Machine for rasping pegs | ||
| GB1368599A (en) | 1970-09-29 | 1974-10-02 | Unilever Ltd | Softening compositions |
| GB1358599A (en) | 1970-12-22 | 1974-07-03 | Monacelli Umberto | Gun for firing tacks |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| GB2095275B (en) | 1981-03-05 | 1985-08-07 | Kao Corp | Enzyme detergent composition |
| GB2094826B (en) | 1981-03-05 | 1985-06-12 | Kao Corp | Cellulase enzyme detergent composition |
| US4822516A (en) | 1986-12-08 | 1989-04-18 | Kao Corporation | Detergent composition for clothing incorporating a cellulase |
| EP0406314B1 (en) | 1988-03-24 | 1993-12-01 | Novo Nordisk A/S | A cellulase preparation |
| US5776757A (en) | 1988-03-24 | 1998-07-07 | Novo Nordisk A/S | Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof |
| DK494089D0 (pt) | 1989-10-06 | 1989-10-06 | Novo Nordisk As | |
| WO1992006209A1 (en) | 1990-10-05 | 1992-04-16 | Genencor International Inc. | Trichoderma reesei containing deleted and/or enriched cellulase and other enzyme genes and cellulase compositions derived therefrom |
| CA2093422C (en) | 1990-10-05 | 2001-04-03 | Genencor International, Inc. | DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS |
| US5246853A (en) | 1990-10-05 | 1993-09-21 | Genencor International, Inc. | Method for treating cotton-containing fabric with a cellulase composition containing endoglucanase components and which composition is free of exo-cellobiohydrolase I |
| US5475101A (en) | 1990-10-05 | 1995-12-12 | Genencor International, Inc. | DNA sequence encoding endoglucanase III cellulase |
| US5650322A (en) | 1990-10-05 | 1997-07-22 | Genencor International, Inc. | Methods for stonewashing fabrics using endoglucanases |
| FI932521A0 (fi) | 1993-06-02 | 1993-06-02 | Alko Ab Oy | Nytt endoglukanasenzym |
| US5861271A (en) | 1993-12-17 | 1999-01-19 | Fowler; Timothy | Cellulase enzymes and systems for their expressions |
| IL129722A0 (en) | 1996-11-13 | 2000-02-29 | Du Pont | Method for the production of 1,3-propanediol by recombinant organisms |
| US6265204B1 (en) | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| WO1998045455A1 (en) | 1997-04-07 | 1998-10-15 | Unilever N.V. | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus aspergillus |
| US6599722B2 (en) | 1998-12-22 | 2003-07-29 | Genencor International, Inc. | Method for producing ascorbic acid intermediates |
| DK1862626T3 (da) | 2003-05-29 | 2011-12-12 | Genencor Int | Nye Trichoderma-gener |
| US7413887B2 (en) | 2004-05-27 | 2008-08-19 | Genecor International, Inc. | Trichoderma reesei glucoamylase and homologs thereof |
| DK1838849T3 (en) | 2004-12-30 | 2015-11-30 | Danisco Us Inc | CBH2 CELLULASE VARIETIES OF HYPOCREA JECORINA |
| CN101160405B (zh) | 2005-04-12 | 2014-01-01 | 纳幕尔杜邦公司 | 处理生物质以获得目标化学物质 |
| US7785854B2 (en) * | 2006-08-31 | 2010-08-31 | Iogen Energy Corporation | Modified cellulases with increased thermostability, thermophilicity, and alkalophilicity |
| BRPI0718518B1 (pt) | 2006-09-22 | 2017-12-05 | Danisco Us Inc., Genencor Division | Polynucleotyde encoding selected marker of acetolactate sintase (als) of trichoderma reesei, transgenic microorganism and method of selection of a cell |
| US9133425B2 (en) * | 2007-06-06 | 2015-09-15 | Danisco Us Inc. | Methods for improving multiple protein properties |
| EP2195422A1 (en) | 2007-10-09 | 2010-06-16 | Danisco US Inc. | Glucoamylase variants |
| BRPI0913624A2 (pt) * | 2008-06-06 | 2015-08-04 | Danisco Us Inc | Composições e métodos compreendendo variantes de celulase com afinidade reduzida por materiais não celulósicos |
| KR101050460B1 (ko) | 2009-03-25 | 2011-07-20 | 삼성모바일디스플레이주식회사 | 유기 발광 표시 장치 및 그의 제조 방법 |
-
2010
- 2010-06-03 RU RU2011154243/10A patent/RU2011154243A/ru not_active Application Discontinuation
- 2010-06-03 US US13/321,928 patent/US8679816B2/en not_active Expired - Fee Related
- 2010-06-03 CN CN201080024295.6A patent/CN102803482B/zh not_active Expired - Fee Related
- 2010-06-03 EP EP10722895.9A patent/EP2438164B1/en not_active Not-in-force
- 2010-06-03 AU AU2010256519A patent/AU2010256519B2/en not_active Expired - Fee Related
- 2010-06-03 MX MX2011012841A patent/MX2011012841A/es not_active Application Discontinuation
- 2010-06-03 CA CA2764094A patent/CA2764094A1/en not_active Abandoned
- 2010-06-03 BR BRPI1010957A patent/BRPI1010957A2/pt not_active Application Discontinuation
- 2010-06-03 KR KR1020117028397A patent/KR20120062643A/ko not_active Withdrawn
- 2010-06-03 WO PCT/US2010/037328 patent/WO2010141779A1/en not_active Ceased
- 2010-06-03 CN CN201510187939.8A patent/CN104862293A/zh active Pending
- 2010-06-03 JP JP2012514152A patent/JP2012528598A/ja active Pending
-
2011
- 2011-12-01 CO CO11165857A patent/CO6470854A2/es not_active Application Discontinuation
-
2014
- 2014-02-25 US US14/189,943 patent/US9523087B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010256519A1 (en) | 2011-11-24 |
| US8679816B2 (en) | 2014-03-25 |
| US9523087B2 (en) | 2016-12-20 |
| MX2011012841A (es) | 2012-01-27 |
| CO6470854A2 (es) | 2012-06-29 |
| KR20120062643A (ko) | 2012-06-14 |
| US20140302585A1 (en) | 2014-10-09 |
| AU2010256519B2 (en) | 2016-03-17 |
| EP2438164B1 (en) | 2017-08-02 |
| CN102803482A (zh) | 2012-11-28 |
| EP2438164A1 (en) | 2012-04-11 |
| WO2010141779A1 (en) | 2010-12-09 |
| US20120135500A1 (en) | 2012-05-31 |
| CA2764094A1 (en) | 2010-12-09 |
| CN102803482B (zh) | 2015-04-29 |
| CN104862293A (zh) | 2015-08-26 |
| RU2011154243A (ru) | 2013-07-20 |
| JP2012528598A (ja) | 2012-11-15 |
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