BRPI1007476A2 - análogos de ciclosporina para prevenir ou tratar infecção por hepatite c - Google Patents

análogos de ciclosporina para prevenir ou tratar infecção por hepatite c

Info

Publication number: BRPI1007476A2
Authority: BR; Brazil
Prior art keywords: infection; prevent; treat hepatitis; cyclosporine analogues; cyclosporine
Prior art date: 2009-01-30

Application number

BRPI1007476A

Other languages

English (en)

Inventor

Jiang Long

Quoqiang Wang

Xuri Gao

Yat Sun Or

Original Assignee

Enanta Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-30

Filing date

2010-01-30

Publication date

2016-02-16

2010-01-30 Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc

2016-02-16 Publication of BRPI1007476A2 publication Critical patent/BRPI1007476A2/pt

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
208000005176 Hepatitis C Diseases 0.000 title 1
208000010710 hepatitis C virus infection Diseases 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Biotechnology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

BRPI1007476A 2009-01-30 2010-01-30 análogos de ciclosporina para prevenir ou tratar infecção por hepatite c BRPI1007476A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14858309P	2009-01-30	2009-01-30
PCT/US2010/022675 WO2010088573A1 (en)	2009-01-30	2010-01-30	Cyclosporin analogues for preventing or treating hepatitis c infection

Publications (1)

Publication Number	Publication Date
BRPI1007476A2 true BRPI1007476A2 (pt)	2016-02-16

Family

ID=42396050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007476A BRPI1007476A2 (pt)	2009-01-30	2010-01-30	análogos de ciclosporina para prevenir ou tratar infecção por hepatite c

Country Status (14)

Country	Link
US (3)	US8367618B2 (pt)
EP (1)	EP2391376A4 (pt)
JP (1)	JP5406943B2 (pt)
KR (2)	KR101476626B1 (pt)
CN (1)	CN102365094A (pt)
AU (1)	AU2010208071C1 (pt)
BR (1)	BRPI1007476A2 (pt)
CA (1)	CA2751210C (pt)
IL (1)	IL214278A0 (pt)
MX (1)	MX2011008000A (pt)
NZ (1)	NZ594755A (pt)
RU (1)	RU2492181C2 (pt)
SG (1)	SG173180A1 (pt)
WO (1)	WO2010088573A1 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101476626B1 (ko) *	2009-01-30	2014-12-26	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8349312B2 (en) *	2009-07-09	2013-01-08	Enanta Pharmaceuticals, Inc.	Proline substituted cyclosporin analogues
US8367053B2 (en) *	2009-07-09	2013-02-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
EP2519538A1 (en) *	2009-12-30	2012-11-07	Scynexis, Inc.	Cyclosporine analogues
US8623814B2 (en) *	2010-02-23	2014-01-07	Enanta Pharmaceuticals, Inc.	Antiviral agents
WO2012009715A2 (en)	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en) *	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012075494A1 (en) *	2010-12-03	2012-06-07	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
CN103443119B (zh)	2010-12-15	2017-09-22	康卓维尔制药公司	在氨基酸1和3位修改的环孢菌素类似分子
US9428845B1 (en)	2010-12-28	2016-08-30	Warp Drive Bio, Inc.	Identifying new therapeutic agents
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
JP2015519368A (ja)	2012-06-01	2015-07-09	アラーガンインコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ類似体
WO2014049540A2 (en)	2012-09-29	2014-04-03	Novartis Ag	Cyclic peptides and use as medicines
US8906853B2 (en)	2012-11-28	2014-12-09	Enanta Pharmaceuticals, Inc.	[N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
WO2015031381A1 (en) *	2013-08-26	2015-03-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis c
JP6413455B2 (ja) *	2014-08-07	2018-10-31	日本電気株式会社	給湯機制御装置、給湯機制御システム、給湯機制御方法およびプログラム
GB201414806D0 (en)	2014-08-20	2014-10-01	Ucl Business Plc	Cyclosporin conjugates
WO2016073480A1 (en) *	2014-11-03	2016-05-12	Enanta Pharmaceuticals, Inc.	Novel cyclosporin analogues for preventing or treating hepatitis c infection
CN105693820A (zh) *	2014-11-27	2016-06-22	武汉药明康德新药开发有限公司	一种降解环孢菌素a的方法
TW201639873A (zh)	2015-01-08	2016-11-16	歐樂根公司	Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
EP3247378B8 (en)	2015-01-09	2023-08-23	Revolution Medicines, Inc.	Macrocyclic compounds that participate in cooperative binding and medical uses thereof
TW201629069A (zh)	2015-01-09	2016-08-16	霍普驅動生物科技股份有限公司	參與協同結合之化合物及其用途
US9989535B2 (en)	2015-10-01	2018-06-05	Warp Drive Bio, Inc.	Methods and reagents for analyzing protein-protein interfaces
KR102359972B1 (ko)	2016-04-12	2022-02-10	징코 바이오웍스, 인크.	화합물의 제조를 위한 조성물 및 방법
KR20190099396A (ko)	2016-10-28	2019-08-27	징코 바이오웍스, 인크.	화합물의 생산을 위한 조성물 및 방법
WO2021091982A1 (en)	2019-11-04	2021-05-14	Revolution Medicines, Inc.	Ras inhibitors
CN120699039A (zh)	2019-11-04	2025-09-26	锐新医药公司	Ras抑制剂
BR112022008535A2 (pt)	2019-11-04	2022-08-09	Revolution Medicines Inc	Composto, composição farmacêutica, métodos para tratar câncer e um distúrbio relativo à proteína ras
WO2021190601A1 (en)	2020-03-26	2021-09-30	Farsight Medical Technology (Shanghai) Co., Ltd.	Cyclophilin inhibitors and uses thereof
MX2023003060A (es)	2020-09-15	2023-04-05	Revolution Medicines Inc	Derivados indolicos como inhibidores de ras en el tratamiento del cancer.
CR20230558A (es)	2021-05-05	2024-01-24	Revolution Medicines Inc	Inhibidores de ras para el tratamiento del cáncer
AR127308A1 (es)	2021-10-08	2024-01-10	Revolution Medicines Inc	Inhibidores ras

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (pt)	1975-11-04	1979-12-28	Sandoz Ag
DE2819094A1 (de)	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv)	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en)	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
ATE43335T1 (de)	1980-02-14	1989-06-15	Sandoz Ag	Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
US4384996A (en)	1981-01-09	1983-05-24	Sandoz Ltd.	Novel cyclosporins
EP0290762B1 (en)	1984-10-04	1993-05-12	Sandoz Ag	Cyclosporins
EP0194972B1 (en)	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US5239057A (en)	1987-03-27	1993-08-24	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en)	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es)	1987-06-17	1994-11-16	Sandoz Ag	Ciclosporins y su uso como productos farmaceuticos.
GB2206119B (en)	1987-06-22	1990-10-31	Merck & Co Inc	A new cyclosporin derivative with modified "8-amino acid"
GB8717300D0 (en)	1987-07-22	1987-08-26	Nat Res Dev	Cyclosporins
GB8717299D0 (en)	1987-07-22	1987-08-26	Nat Res Dev	Peptides
GB2207678A (en)	1987-08-03	1989-02-08	Merck & Co Inc	Novel immunosuppressive fluorinated cyclosporin analogs
US5604092A (en)	1988-12-05	1997-02-18	The Trustees Of Columbia University In The City Of New York	Method for the detection of HIV-1 using a cyclosporine-specific monoclonal antibody that reacts with the P24 Gag protein
US5284826A (en)	1989-07-24	1994-02-08	Sandoz Ltd.	0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
FR2762843B1 (fr) *	1997-04-30	1999-12-10	Rhone Poulenc Rorer Sa	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2298572C (en)	1997-10-08	2002-04-09	Isotechnika Inc.	Deuterated cyclosporine analogs and their use as immunomodulating agents
DE69928938T2 (de) *	1998-07-01	2006-08-17	Debiopharm S.A.	Neues cyclosporin mit verbesserter wirkung
US6784156B2 (en)	2001-03-05	2004-08-31	Enanta Pharmaceuticals, Inc.	Cyclosporins for the treatment of respiratory diseases
US6809077B2 (en)	2001-10-12	2004-10-26	Enanta Pharmaceuticals, Inc.	Cyclosporin analogs for the treatment of autoimmune diseases
US20030087813A1 (en)	2001-10-12	2003-05-08	Or Yat Sun	Cyclosporin analogs for the treatment of lung diseases
DE60231570D1 (de)	2001-10-19	2009-04-23	Isotechnika Inc	Synthese von Cyclosporinanalogen
US7012065B2 (en)	2003-02-07	2006-03-14	Enanta Pharmaceuticals, Inc.	Cyclosporins for the treatment of immune disorders
US20040266669A1 (en)	2003-06-20	2004-12-30	Wu Frank X. H.	Cyclosporin derivatives for the treatment of immune disorders
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
MX2007000503A (es)	2004-07-14	2007-03-08	Novartis Ag	Uso de una combinacion de ciclosporina e interferon pegilado para el tratamiento de hepatitis c(hcv).
WO2006039164A2 (en) *	2004-09-29	2006-04-13	Amr Technology, Inc.	Novel cyclosporin analogues and their pharmaceutical uses
BRPI0515494A (pt)	2004-10-01	2008-07-29	Debiopharm Sa	uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina
ES2373450T3 (es) *	2004-10-01	2012-02-03	Scynexis, Inc.	Derivados de ciclosporina sustituidos con 3-éter y 3-tioéter para el tratamiento y la prevención de infección por hepatitis c.
JP5322647B2 (ja)	2005-09-30	2013-10-23	スシネキスインク	ウイルス感染の治療及び予防のためのシクロスポリンａのアリールアルキル及びヘテロアリールアルキル誘導体
WO2007049803A1 (en) *	2005-10-26	2007-05-03	Astellas Pharma Inc.	New cyclic peptide compounds
JP2009529059A (ja)	2006-03-08	2009-08-13	アキリオンファーマシューティカルズ，インコーポレーテッド	抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20070232532A1 (en)	2006-03-28	2007-10-04	Amr Technology, Inc.	Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7776832B2 (en) *	2006-04-21	2010-08-17	Gem Pharmaceuticals, Llc	Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
CN101687012A (zh)	2007-05-02	2010-03-31	安斯泰来制药有限公司	新的环肽化合物
WO2008143996A1 (en) *	2007-05-18	2008-11-27	Scynexis, Inc.	New chemical processes
KR101476626B1 (ko) *	2009-01-30	2014-12-26	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en)	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8685917B2 (en)	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8367053B2 (en)	2009-07-09	2013-02-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8349312B2 (en)	2009-07-09	2013-01-08	Enanta Pharmaceuticals, Inc.	Proline substituted cyclosporin analogues
US8429835B2 (en) *	2009-10-21	2013-04-30	Nike, Inc.	Composite shoe upper and method of making same
US8178531B2 (en)	2010-02-23	2012-05-15	Enanta Pharmaceuticals, Inc.	Antiviral agents
US8623814B2 (en)	2010-02-23	2014-01-07	Enanta Pharmaceuticals, Inc.	Antiviral agents
WO2012009715A2 (en)	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en)	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2015031381A1 (en) *	2013-08-26	2015-03-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis c

2010
- 2010-01-30 KR KR1020147001832A patent/KR101476626B1/ko not_active Expired - Fee Related
- 2010-01-30 NZ NZ594755A patent/NZ594755A/en not_active IP Right Cessation
- 2010-01-30 US US12/697,215 patent/US8367618B2/en not_active Expired - Fee Related
- 2010-01-30 KR KR1020117020221A patent/KR20110111321A/ko not_active Ceased
- 2010-01-30 EP EP10736507A patent/EP2391376A4/en not_active Withdrawn
- 2010-01-30 SG SG2011054715A patent/SG173180A1/en unknown
- 2010-01-30 AU AU2010208071A patent/AU2010208071C1/en not_active Ceased
- 2010-01-30 JP JP2011548361A patent/JP5406943B2/ja not_active Expired - Fee Related
- 2010-01-30 RU RU2011133900/04A patent/RU2492181C2/ru not_active IP Right Cessation
- 2010-01-30 WO PCT/US2010/022675 patent/WO2010088573A1/en not_active Ceased
- 2010-01-30 CA CA2751210A patent/CA2751210C/en not_active Expired - Fee Related
- 2010-01-30 MX MX2011008000A patent/MX2011008000A/es active IP Right Grant
- 2010-01-30 BR BRPI1007476A patent/BRPI1007476A2/pt not_active Application Discontinuation
- 2010-01-30 CN CN2010800142248A patent/CN102365094A/zh active Pending
2011
- 2011-07-25 IL IL214278A patent/IL214278A0/en unknown
2013
- 2013-01-04 US US13/734,074 patent/US9156886B2/en active Active
2015
- 2015-09-02 US US14/843,119 patent/US9603895B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN102365094A (zh)	2012-02-29
KR20110111321A (ko)	2011-10-10
AU2010208071A1 (en)	2011-09-01
EP2391376A4 (en)	2012-08-01
US8367618B2 (en)	2013-02-05
US20130183267A1 (en)	2013-07-18
US9156886B2 (en)	2015-10-13
KR20140014323A (ko)	2014-02-05
AU2010208071B2 (en)	2012-11-08
US20100196316A1 (en)	2010-08-05
SG173180A1 (en)	2011-09-29
NZ594755A (en)	2013-12-20
MX2011008000A (es)	2011-09-15
JP5406943B2 (ja)	2014-02-05
EP2391376A1 (en)	2011-12-07
RU2492181C2 (ru)	2013-09-10
RU2011133900A (ru)	2013-03-10
US9603895B2 (en)	2017-03-28
IL214278A0 (en)	2011-09-27
CA2751210A1 (en)	2010-08-05
JP2012516850A (ja)	2012-07-26
AU2010208071C1 (en)	2013-06-20
CA2751210C (en)	2015-04-21
WO2010088573A1 (en)	2010-08-05
KR101476626B1 (ko)	2014-12-26
US20160051625A1 (en)	2016-02-25

Publication	Publication Date	Title
BRPI1007476A2 (pt)	2016-02-16	análogos de ciclosporina para prevenir ou tratar infecção por hepatite c
IL271083A (en)	2020-01-30	Humanized fcgammar mice
EP2491033A4 (en)	2013-03-13	AZAINDAZOLES FOR THE TREATMENT OF FLAVIVIRIDAE VIRUS INFECTION
EP2509639A4 (en)	2015-05-20	DISINFECTION SYSTEM FOR HARD SURFACES
SMT201400056B (it)	2014-07-07	Analoghi carba-nucleosidici per trattamento antivirale
SMT201700091B (it)	2017-03-08	ANALOGHI CARBA-NUCLEOSIDlCI2'-FLUORO SOSTITUITI PER TRATTAMENTO ANTIVIRALE
EP2671451A4 (en)	2014-06-25	VIRENINAKTIVATOR
BR112012023753A2 (pt)	2016-08-23	tratamento de resíduos orgânicos
BR112013020425A2 (pt)	2017-06-13	composições e métodos para o tratamento ou prevenção de infecção por vírus da hepatite b
CR20130069A (es)	2013-09-20	Quelatos de oligonucleótidos
EP2393914A4 (en)	2012-10-17	TISSUE ENGINEERING OF THE LUNG
FI20095291L (fi)	2010-09-21	Kuitujen käsittely muovausta kestäväksi
BRPI1009275A2 (pt)	2016-03-08	manipulação de objeto virtual
BRPI0911410A2 (pt)	2015-10-06	análogos de carba-nucleosídeo para tratamento antiviral
BR112012005594A2 (pt)	2015-09-08	tratamento de câncer
DK3124610T3 (da)	2019-06-11	Hbv-behandling
BR112014010164A2 (pt)	2017-04-25	implante de tecido duro
BRPI0924425A2 (pt)	2015-08-11	"combinações de substâncias ativas sinergéticas".
IL219715A (en)	2017-04-30	Sewage treatment apparatus
BR112012002269A2 (pt)	2016-06-14	implemento para tratar superfície
EP2454085A4 (en)	2014-07-09	EQUIPMENT FOR WEBERBERENERATION IN MAMMALS
EP2442821A4 (en)	2013-07-31	SAFE ADMINISTRATION OF DESMOPRESSIN
PT2504298T (pt)	2016-12-29	Preparação e purificação de iodoxanol
EP2448627A4 (en)	2013-05-15	SAFETY CATHETER
BRPI1013985A2 (pt)	2015-08-25	Agentes de proteção

Legal Events

Date	Code	Title	Description
2018-02-27	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2018-04-17	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-29	B06I	Publication of requirement cancelled [chapter 6.9 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2468 DE 24/04/2018 POR TER SIDO INDEVIDA.
2018-06-05	B07B	Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
2018-06-12	B11E	Dismissal acc. art. 34 of ipl - requirements for examination incomplete
2020-09-24	B11T	Dismissal of application maintained [chapter 11.20 patent gazette]