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BRPI0924081A2 - DERIVADOS DE 5- AMINO -2-(1-hIDROXI-ETIL)- TETRAHIDROPIRANO. - Google Patents

DERIVADOS DE 5- AMINO -2-(1-hIDROXI-ETIL)- TETRAHIDROPIRANO.

Info

Publication number
BRPI0924081A2
BRPI0924081A2 BRPI0924081A BRPI0924081A BRPI0924081A2 BR PI0924081 A2 BRPI0924081 A2 BR PI0924081A2 BR PI0924081 A BRPI0924081 A BR PI0924081A BR PI0924081 A BRPI0924081 A BR PI0924081A BR PI0924081 A2 BRPI0924081 A2 BR PI0924081A2
Authority
BR
Brazil
Prior art keywords
tetrahydropyrane
hydroxy
derivatives
ethyl
amino
Prior art date
Application number
BRPI0924081A
Other languages
English (en)
Inventor
Hubschwerlen Christian
Zumbrunn Acklin Cornelita
Rueedi Georg
Surivet Jean-Philippe
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0924081A2 publication Critical patent/BRPI0924081A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0924081A 2008-12-12 2009-12-11 DERIVADOS DE 5- AMINO -2-(1-hIDROXI-ETIL)- TETRAHIDROPIRANO. BRPI0924081A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008055261 2008-12-12
PCT/IB2009/055689 WO2010067332A1 (en) 2008-12-12 2009-12-11 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives

Publications (1)

Publication Number Publication Date
BRPI0924081A2 true BRPI0924081A2 (pt) 2018-03-20

Family

ID=41723046

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0924081A BRPI0924081A2 (pt) 2008-12-12 2009-12-11 DERIVADOS DE 5- AMINO -2-(1-hIDROXI-ETIL)- TETRAHIDROPIRANO.

Country Status (27)

Country Link
US (1) US8211890B2 (pt)
EP (1) EP2376497B1 (pt)
JP (1) JP4955835B2 (pt)
KR (1) KR101297450B1 (pt)
CN (1) CN102232078B (pt)
AR (1) AR074604A1 (pt)
AU (1) AU2009325902B2 (pt)
BR (1) BRPI0924081A2 (pt)
CA (1) CA2744456C (pt)
CL (1) CL2011001413A1 (pt)
CY (1) CY1114869T1 (pt)
DK (1) DK2376497T3 (pt)
ES (1) ES2435596T3 (pt)
HR (1) HRP20140010T1 (pt)
IL (1) IL213432A (pt)
MA (1) MA32956B1 (pt)
MX (1) MX2011005905A (pt)
MY (1) MY159183A (pt)
NZ (1) NZ593891A (pt)
PL (1) PL2376497T3 (pt)
PT (1) PT2376497E (pt)
RU (1) RU2525541C2 (pt)
SG (1) SG172088A1 (pt)
SI (1) SI2376497T1 (pt)
TW (1) TWI426076B (pt)
WO (1) WO2010067332A1 (pt)
ZA (1) ZA201105095B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
ES2578182T3 (es) 2011-05-31 2016-07-21 Actelion Pharmaceuticals Ltd. Procedimientos de preparación de intermediarios sintéticos que pueden usarse para la fabricación de antibióticos
EP2723737A1 (en) * 2011-06-27 2014-04-30 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
TW201313726A (zh) 2011-09-16 2013-04-01 Actelion Pharmaceuticals Ltd 製造合成之中間體之方法
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
MA49858A (fr) 2017-08-09 2021-04-28 Denali Therapeutics Inc Composés, compositions et procédés
WO2019046779A1 (en) * 2017-09-01 2019-03-07 Denali Therapeutics Inc. COMPOUNDS, COMPOSITIONS AND METHODS
AU2020223228A1 (en) 2019-02-13 2021-08-26 Denali Therapeutics Inc. Compounds, compositions and methods
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
PL170567B1 (pl) * 1991-03-28 1997-01-31 Eisai Co Ltd Sposób wytwarzania pochodnych aminy heterocykliczno-cyklicznej PL PL PL PL PL PL PL PL
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP1470125A1 (en) * 2002-01-29 2004-10-27 Glaxo Group Limited Aminopiperidine derivatives
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
TW200427688A (en) * 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
WO2006014580A1 (en) 2004-07-08 2006-02-09 Glaxo Group Limited Antibacterial agents
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
CA2608072A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2007016610A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited Antibacterial agents
ES2340531T3 (es) 2005-10-21 2010-06-04 Glaxo Group Limited Compuestos triciclos peri-condensados utiles como agentes antibacterianos.
US7732460B2 (en) 2005-12-22 2010-06-08 Glaxo Group Limited Heterocyclic compounds, their preparation and their use as antibacterials
DE102005062889A1 (de) 2005-12-29 2007-07-05 Robert Bosch Gmbh Elektrische Null-Kraft-Steckvorrichtung
JP2009524643A (ja) * 2006-01-26 2009-07-02 アクテリオン ファーマシューティカルズ リミテッド テトラヒドロピラン抗生物質
WO2007105154A2 (en) 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Antibiotic compounds
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CA2689102C (en) * 2007-06-15 2016-07-26 Actelion Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives
PL2221309T3 (pl) 2007-11-26 2013-12-31 Toyama Chemical Co Ltd Monohydrat pochodnej naftyrydyny i sposób jego wytwarzania

Also Published As

Publication number Publication date
CL2011001413A1 (es) 2011-11-11
RU2525541C2 (ru) 2014-08-20
SG172088A1 (en) 2011-07-28
AR074604A1 (es) 2011-01-26
ES2435596T3 (es) 2013-12-20
JP4955835B2 (ja) 2012-06-20
RU2011128550A (ru) 2013-01-20
KR20110086643A (ko) 2011-07-28
MX2011005905A (es) 2011-06-20
HRP20140010T1 (hr) 2014-02-14
US20110245259A1 (en) 2011-10-06
PL2376497T3 (pl) 2014-03-31
IL213432A (en) 2013-11-28
CN102232078A (zh) 2011-11-02
JP2012511566A (ja) 2012-05-24
TWI426076B (zh) 2014-02-11
CA2744456A1 (en) 2010-06-17
PT2376497E (pt) 2013-11-21
NZ593891A (en) 2013-05-31
CN102232078B (zh) 2014-07-16
WO2010067332A1 (en) 2010-06-17
MA32956B1 (fr) 2012-01-02
SI2376497T1 (sl) 2014-01-31
US8211890B2 (en) 2012-07-03
ZA201105095B (en) 2012-12-27
AU2009325902A1 (en) 2011-07-21
KR101297450B1 (ko) 2013-08-20
EP2376497A1 (en) 2011-10-19
CA2744456C (en) 2017-09-26
DK2376497T3 (da) 2013-11-18
AU2009325902B2 (en) 2015-01-29
HK1162478A1 (en) 2012-08-31
CY1114869T1 (el) 2016-12-14
MY159183A (en) 2016-12-30
IL213432A0 (en) 2011-07-31
TW201026699A (en) 2010-07-16
EP2376497B1 (en) 2013-09-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time