BRPI0911682A2 - indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 - Google Patents

indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Info

Publication number: BRPI0911682A2
Authority: BR; Brazil
Prior art keywords: indoles; subtype; modulators; acetylcholine receptor; nicotinic acetylcholine
Prior art date: 2008-04-17

Application number

BRPI0911682A

Other languages

English (en)

Inventor

Andrew P Lightfoot

Howard Robert Marhsall

Kevin Dinnell

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-17

Filing date

2009-04-16

Publication date

2015-10-13

2008-04-17 Priority claimed from GB0807050A external-priority patent/GB0807050D0/en

2008-06-04 Priority claimed from GB0810229A external-priority patent/GB0810229D0/en

2009-04-16 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2015-10-13 Publication of BRPI0911682A2 publication Critical patent/BRPI0911682A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0911682A 2008-04-17 2009-04-16 indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71 BRPI0911682A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0807050A GB0807050D0 (en)	2008-04-17	2008-04-17	Novel compounds
GB0810229A GB0810229D0 (en)	2008-06-04	2008-06-04	Novel compounds
PCT/EP2009/054493 WO2009127678A1 (en)	2008-04-17	2009-04-16	Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71

Publications (1)

Publication Number	Publication Date
BRPI0911682A2 true BRPI0911682A2 (pt)	2015-10-13

Family

ID=40791353

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI0910585A BRPI0910585A2 (pt)	2008-04-17	2009-04-16	indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7
BRPI0911682A BRPI0911682A2 (pt)	2008-04-17	2009-04-16	indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI0910585A BRPI0910585A2 (pt)	2008-04-17	2009-04-16	indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7

Country Status (19)

Country	Link
US (2)	US8377941B2 (pt)
EP (2)	EP2279183B1 (pt)
JP (2)	JP2011516598A (pt)
KR (2)	KR20100135911A (pt)
CN (2)	CN102066357B (pt)
AR (1)	AR071203A1 (pt)
AU (2)	AU2009237650B2 (pt)
BR (2)	BRPI0910585A2 (pt)
CA (2)	CA2721630A1 (pt)
CL (1)	CL2009000916A1 (pt)
EA (2)	EA017726B1 (pt)
ES (2)	ES2392795T3 (pt)
IL (2)	IL208575A (pt)
MX (2)	MX2010011359A (pt)
PE (1)	PE20091724A1 (pt)
TW (1)	TW201004939A (pt)
UY (1)	UY31769A1 (pt)
WO (2)	WO2009127679A1 (pt)
ZA (2)	ZA201006855B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2784B1 (en)	2007-10-18	2014-03-15	شركة جانسين فارماسوتيكا ان. في	5,3,1 - Triazole substitute derivative
MX2010004177A (es)	2007-10-18	2010-05-03	Janssen Pharmaceutica Nv	1,2,4-triazoles trisustituidos.
ES2479440T3 (es)	2008-01-30	2014-07-24	Cephalon, Inc.	Derivados de piridazina sustituidos que tienen actividad antagonista de histamina H3
ES2442932T3 (es)	2008-03-19	2014-02-14	Janssen Pharmaceutica N.V.	1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina
CL2009001125A1 (es)	2008-05-09	2011-02-11	Janssen Pharmaceutica Nv	Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias.
KR20120089190A (ko) *	2009-04-16	2012-08-09	프록시머겐 리미티드	알파 7 니코틴 아세틸콜린 수용체(ｎＡＣｈＲ)의 인돌 유도체 조절체
JO3250B1 (ar)	2009-09-22	2018-09-16	Novartis Ag	إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
GB201012686D0 (en) *	2010-07-28	2010-09-15	Glaxo Group Ltd	Novel compounds
JO3078B1 (ar) *	2009-11-27	2017-03-15	Janssen Pharmaceutica Nv	مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
AU2012213086B2 (en)	2011-02-03	2016-05-05	Lupin Limited	Pyrrole derivatives used as modulators of alpha7 nAChR
BR112013021602A2 (pt)	2011-02-23	2019-09-24	Lupin Ltd	derivados de heteroarila como moduladores de nachr alfa7.
WO2012127393A1 (en) *	2011-03-18	2012-09-27	Novartis Ag	COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
EP2691368A1 (en)	2011-03-31	2014-02-05	Lupin Limited	Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
TW201245185A (en)	2011-04-01	2012-11-16	Lundbeck & Co As H	New positive allosteric modulators of nicotinic acetylcholine receptor
ES2606043T3 (es)	2011-07-05	2017-03-17	Lupin Limited	Derivados de biarilo como moduladores de nAChR
WO2013132380A1 (en)	2012-03-06	2013-09-12	Lupin Limited	Thiazole derivatives as alpha 7 nachr modulators
EP2846803B1 (en) *	2012-05-08	2017-06-21	Alpharmagen, LLC	Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
AU2013325615A1 (en) *	2012-10-02	2015-04-09	Sumitomo Dainippon Pharma Co., Ltd.	Imidazole derivative
WO2014072957A1 (en)	2012-11-12	2014-05-15	Lupin Limited	Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) *	2013-01-04	2014-10-22	中国药科大学	一类炔亚甲基吲哚-2-酮类衍生物的用途
WO2014111839A1 (en)	2013-01-16	2014-07-24	Lupin Limited	Pyrrole derivatives as alpha 7 nachr modulators
WO2014141091A1 (en)	2013-03-13	2014-09-18	Lupin Limited	Pyrrole derivatives as alpha 7 nachr modulators
US10058310B2 (en)	2013-03-13	2018-08-28	Ethicon Llc	Electrosurgical device with drum-driven articulation
TW201446243A (zh)	2013-06-03	2014-12-16	Lupin Ltd	4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
CA2913987A1 (en)	2013-06-17	2014-12-24	Lupin Limited	Pyrrole derivatives as alpha 7 nachr modulators
US20170182058A1 (en) *	2014-03-25	2017-06-29	Emicipi Llc	Treatment of rett syndrome
JP6870304B2 (ja) *	2016-12-05	2021-05-12	住友電気工業株式会社	半導体装置の製造方法
US11046683B2 (en)	2016-12-15	2021-06-29	Ono Pharmaceutical Co., Ltd.	Activator of TREK (TWIK RElated K+ channels) channels
HU231478B1 (hu)	2018-07-13	2024-02-28	Richter Gedeon Nyrt.	Szubsztituált (aza)indol származékok
HU231333B1 (hu) *	2018-07-13	2023-01-28	Richter Gedeon Nyrt	Spirokromán származékok
HU231414B1 (hu)	2018-07-13	2023-08-28	Richter Gedeon Nyrt.	Tiadiazin származékok
AU2020394867A1 (en)	2019-12-02	2022-05-26	Storm Therapeutics Limited	Polyheterocyclic compounds as METTL3 inhibitors
CN111285792B (zh) *	2020-03-23	2023-05-02	三峡大学	2-取代吲哚化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9903997D0 (sv) *	1999-11-03	1999-11-03	Astra Ab	New compounds
GB0403155D0 (en) *	2004-02-12	2004-03-17	Vernalis Res Ltd	Chemical compounds
BRPI0907492A2 (pt) *	2008-02-07	2017-06-13	Abbott Lab	derivados amida como moduladores alostéricos positivos e métodos de sua utilização

2009
- 2009-04-16 AU AU2009237650A patent/AU2009237650B2/en not_active Ceased
- 2009-04-16 MX MX2010011359A patent/MX2010011359A/es active IP Right Grant
- 2009-04-16 CN CN200980123031.3A patent/CN102066357B/zh not_active Expired - Fee Related
- 2009-04-16 JP JP2011504457A patent/JP2011516598A/ja not_active Ceased
- 2009-04-16 WO PCT/EP2009/054495 patent/WO2009127679A1/en not_active Ceased
- 2009-04-16 MX MX2010011358A patent/MX2010011358A/es active IP Right Grant
- 2009-04-16 JP JP2011504458A patent/JP2011516599A/ja not_active Ceased
- 2009-04-16 EP EP09732038A patent/EP2279183B1/en active Active
- 2009-04-16 US US12/936,431 patent/US8377941B2/en not_active Expired - Fee Related
- 2009-04-16 CN CN200980123025.8A patent/CN102066356B/zh not_active Expired - Fee Related
- 2009-04-16 BR BRPI0910585A patent/BRPI0910585A2/pt not_active IP Right Cessation
- 2009-04-16 KR KR1020107025698A patent/KR20100135911A/ko not_active Withdrawn
- 2009-04-16 PE PE2009000537A patent/PE20091724A1/es not_active Application Discontinuation
- 2009-04-16 AU AU2009237649A patent/AU2009237649B2/en not_active Ceased
- 2009-04-16 WO PCT/EP2009/054493 patent/WO2009127678A1/en not_active Ceased
- 2009-04-16 AR ARP090101342A patent/AR071203A1/es not_active Application Discontinuation
- 2009-04-16 EA EA201071202A patent/EA017726B1/ru not_active IP Right Cessation
- 2009-04-16 KR KR1020107025697A patent/KR20100133016A/ko not_active Withdrawn
- 2009-04-16 EA EA201071201A patent/EA018113B1/ru not_active IP Right Cessation
- 2009-04-16 CA CA2721630A patent/CA2721630A1/en not_active Abandoned
- 2009-04-16 UY UY031769A patent/UY31769A1/es not_active Application Discontinuation
- 2009-04-16 BR BRPI0911682A patent/BRPI0911682A2/pt not_active IP Right Cessation
- 2009-04-16 CL CL2009000916A patent/CL2009000916A1/es unknown
- 2009-04-16 TW TW098112580A patent/TW201004939A/zh unknown
- 2009-04-16 ES ES09732038T patent/ES2392795T3/es active Active
- 2009-04-16 US US12/936,408 patent/US8283365B2/en not_active Expired - Fee Related
- 2009-04-16 CA CA2725441A patent/CA2725441C/en not_active Expired - Fee Related
- 2009-04-16 ES ES09733402T patent/ES2392796T3/es active Active
- 2009-04-16 EP EP09733402A patent/EP2279184B1/en active Active
2010
- 2010-09-27 ZA ZA2010/06855A patent/ZA201006855B/en unknown
- 2010-09-27 ZA ZA2010/06856A patent/ZA201006856B/en unknown
- 2010-10-07 IL IL208575A patent/IL208575A/en not_active IP Right Cessation
- 2010-10-07 IL IL208574A patent/IL208574A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA201006855B (en)	2011-06-29
KR20100133016A (ko)	2010-12-20
AR071203A1 (es)	2010-06-02
IL208575A (en)	2014-04-30
AU2009237649A1 (en)	2009-10-22
JP2011516599A (ja)	2011-05-26
CN102066357B (zh)	2014-04-09
CL2009000916A1 (es)	2010-12-31
US8283365B2 (en)	2012-10-09
CN102066357A (zh)	2011-05-18
WO2009127679A1 (en)	2009-10-22
IL208575A0 (en)	2010-12-30
MX2010011359A (es)	2010-11-12
BRPI0910585A2 (pt)	2015-09-22
CA2725441A1 (en)	2009-10-22
EP2279184B1 (en)	2012-08-08
ES2392796T3 (es)	2012-12-13
US20110034515A1 (en)	2011-02-10
IL208574A0 (en)	2010-12-30
JP2011516598A (ja)	2011-05-26
EP2279183B1 (en)	2012-08-08
EA201071201A1 (ru)	2011-04-29
AU2009237650A1 (en)	2009-10-22
WO2009127678A1 (en)	2009-10-22
TW201004939A (en)	2010-02-01
US8377941B2 (en)	2013-02-19
EP2279183A1 (en)	2011-02-02
CA2721630A1 (en)	2009-10-22
EA017726B1 (ru)	2013-02-28
EA018113B1 (ru)	2013-05-30
EP2279184A1 (en)	2011-02-02
US20110028486A1 (en)	2011-02-03
ES2392795T3 (es)	2012-12-13
IL208574A (en)	2014-04-30
AU2009237650B2 (en)	2012-05-31
PE20091724A1 (es)	2009-12-06
MX2010011358A (es)	2010-11-10
CA2725441C (en)	2014-05-27
UY31769A1 (es)	2009-09-30
ZA201006856B (en)	2011-06-29
KR20100135911A (ko)	2010-12-27
EA201071202A1 (ru)	2011-06-30
AU2009237649B2 (en)	2012-07-26
CN102066356A (zh)	2011-05-18
CN102066356B (zh)	2014-06-11

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BRPI0911682A2 (pt)	2015-10-13	indóis como moduladores do recpetor da acetilcolina nicotínico subtipo alfa-71
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Legal Events

Date	Code	Title	Description
2017-02-21	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-06-06	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]