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BRPI0911384A8 - Canabinóides em combinação com agentes quimioterápêuticos não canabinóides (por exemplo, agentes de alquilação ou serm) - Google Patents

Canabinóides em combinação com agentes quimioterápêuticos não canabinóides (por exemplo, agentes de alquilação ou serm)

Info

Publication number
BRPI0911384A8
BRPI0911384A8 BRPI0911384A BRPI0911384A BRPI0911384A8 BR PI0911384 A8 BRPI0911384 A8 BR PI0911384A8 BR PI0911384 A BRPI0911384 A BR PI0911384A BR PI0911384 A BRPI0911384 A BR PI0911384A BR PI0911384 A8 BRPI0911384 A8 BR PI0911384A8
Authority
BR
Brazil
Prior art keywords
agents
cannabinoids
combination
serm
cannabinoid chemotherapeutic
Prior art date
Application number
BRPI0911384A
Other languages
English (en)
Inventor
Velasco Diez Guillermo
Guzman Pastor Manuel
Lorente Mar
Torres Sofia
Original Assignee
Gw Pharma Ltd
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gw Pharma Ltd, Otsuka Pharma Co Ltd filed Critical Gw Pharma Ltd
Publication of BRPI0911384A2 publication Critical patent/BRPI0911384A2/pt
Publication of BRPI0911384A8 publication Critical patent/BRPI0911384A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

CANABINÓIDES EM COMBINAÇÃO COM AGENTES QUIMIOTERAPÊUTICOS NÃO CANABINÓIDES (POR EXEMPLO, AGENTES DE ALQUILAÇÃO OU SERM) A invenção refere-se ao uso de um ou mais canabinóides, particularmente THC e/ou CBD em combinação com um agente quimioterpêutico não canabinóide na fabricação de um medicamento para uso no tratamento de câncer, mais particularmente um glioma, mais particularmente ainda uma glioblastoma multiforme (GBM). O agente quimioterapêutico de não canabinóide pode ser um modulador de receptor de estrogênio seletivo ou um agente de alquilação.
BRPI0911384A 2008-06-04 2009-06-04 Canabinóides em combinação com agentes quimioterápêuticos não canabinóides (por exemplo, agentes de alquilação ou serm) BRPI0911384A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0810203.0A GB2460672B (en) 2008-06-04 2008-06-04 Cannabinoids in combination with non-cannabinoid chemotherapeutic agents that are alkylating agents
PCT/GB2009/050620 WO2009147438A1 (en) 2008-06-04 2009-06-04 Cannabinoids in combination with non -cannabinoid chemotherapeutic agents (e.g. serm or alkylating agents)

Publications (2)

Publication Number Publication Date
BRPI0911384A2 BRPI0911384A2 (pt) 2015-12-29
BRPI0911384A8 true BRPI0911384A8 (pt) 2018-04-03

Family

ID=39638156

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911384A BRPI0911384A8 (pt) 2008-06-04 2009-06-04 Canabinóides em combinação com agentes quimioterápêuticos não canabinóides (por exemplo, agentes de alquilação ou serm)

Country Status (24)

Country Link
US (3) US20110086113A1 (pt)
EP (2) EP3213748B1 (pt)
JP (2) JP5674649B2 (pt)
KR (1) KR20110053944A (pt)
CN (1) CN102083426B (pt)
AR (1) AR072002A1 (pt)
AU (1) AU2009254935B2 (pt)
BR (1) BRPI0911384A8 (pt)
CA (1) CA2726257C (pt)
CO (1) CO6341551A2 (pt)
DK (1) DK2320881T3 (pt)
ES (2) ES2887084T3 (pt)
GB (2) GB2460672B (pt)
IL (1) IL209739A0 (pt)
MX (1) MX2010013036A (pt)
MY (1) MY156264A (pt)
NZ (1) NZ589373A (pt)
PT (1) PT2320881T (pt)
RU (1) RU2543034C2 (pt)
SG (1) SG191643A1 (pt)
TW (1) TWI469777B (pt)
UA (1) UA104589C2 (pt)
WO (1) WO2009147438A1 (pt)
ZA (1) ZA201008558B (pt)

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Also Published As

Publication number Publication date
CN102083426A (zh) 2011-06-01
RU2010154672A (ru) 2012-07-20
US20110086113A1 (en) 2011-04-14
JP5674649B2 (ja) 2015-02-25
AR072002A1 (es) 2010-07-28
EP2320881A1 (en) 2011-05-18
AU2009254935A1 (en) 2009-12-10
DK2320881T3 (en) 2018-01-02
GB2460672B (en) 2012-01-04
CO6341551A2 (es) 2011-11-21
CA2726257C (en) 2016-09-13
EP3213748A1 (en) 2017-09-06
TWI469777B (zh) 2015-01-21
ES2887084T3 (es) 2021-12-21
MX2010013036A (es) 2011-02-18
EP3213748B1 (en) 2021-08-18
RU2543034C2 (ru) 2015-02-27
US20210069333A1 (en) 2021-03-11
MY156264A (en) 2016-01-29
GB201101072D0 (en) 2011-03-09
JP2011522028A (ja) 2011-07-28
US20190099492A1 (en) 2019-04-04
CN102083426B (zh) 2015-05-13
SG191643A1 (en) 2013-07-31
PT2320881T (pt) 2017-12-22
BRPI0911384A2 (pt) 2015-12-29
GB2475183A (en) 2011-05-11
IL209739A0 (en) 2011-02-28
ZA201008558B (en) 2014-11-26
CA2726257A1 (en) 2009-12-10
WO2009147438A1 (en) 2009-12-10
GB2460672A (en) 2009-12-09
ES2653200T3 (es) 2018-02-06
GB2475183B (en) 2011-11-23
TW201002316A (en) 2010-01-16
NZ589373A (en) 2013-05-31
JP2015057411A (ja) 2015-03-26
UA104589C2 (ru) 2014-02-25
KR20110053944A (ko) 2011-05-24
GB0810203D0 (en) 2008-07-09
EP2320881B1 (en) 2017-09-20
AU2009254935B2 (en) 2015-03-19

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