BRPI0919135A2 - compostos inéditos como ligantes do receptor canabinóide. - Google Patents
compostos inéditos como ligantes do receptor canabinóide.Info
- Publication number
- BRPI0919135A2 BRPI0919135A2 BRPI0919135A BRPI0919135A BRPI0919135A2 BR PI0919135 A2 BRPI0919135 A2 BR PI0919135A2 BR PI0919135 A BRPI0919135 A BR PI0919135A BR PI0919135 A BRPI0919135 A BR PI0919135A BR PI0919135 A2 BRPI0919135 A2 BR PI0919135A2
- Authority
- BR
- Brazil
- Prior art keywords
- novel compounds
- receptor ligands
- cannabinoid receptor
- cannabinoid
- ligands
- Prior art date
Links
- 102000018208 Cannabinoid Receptor Human genes 0.000 title 1
- 108050007331 Cannabinoid receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9737808P | 2008-09-16 | 2008-09-16 | |
| US22420009P | 2009-07-09 | 2009-07-09 | |
| PCT/US2009/057088 WO2010033543A2 (en) | 2008-09-16 | 2009-09-16 | Novel compounds as cannabinoid receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0919135A2 true BRPI0919135A2 (pt) | 2015-12-08 |
Family
ID=41210849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919135A BRPI0919135A2 (pt) | 2008-09-16 | 2009-09-16 | compostos inéditos como ligantes do receptor canabinóide. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8188135B2 (pt) |
| EP (3) | EP2428507B1 (pt) |
| JP (1) | JP2012502917A (pt) |
| KR (1) | KR20110061619A (pt) |
| CN (1) | CN102216277A (pt) |
| AR (2) | AR073599A1 (pt) |
| AU (1) | AU2009293319A1 (pt) |
| BR (1) | BRPI0919135A2 (pt) |
| CA (1) | CA2737199A1 (pt) |
| CL (1) | CL2011000544A1 (pt) |
| CO (1) | CO6361998A2 (pt) |
| DO (1) | DOP2011000081A (pt) |
| EC (1) | ECSP11010974A (pt) |
| ES (1) | ES2556752T3 (pt) |
| IL (1) | IL211406A0 (pt) |
| MX (1) | MX2011002811A (pt) |
| PA (1) | PA8842501A1 (pt) |
| PE (1) | PE20110804A1 (pt) |
| RU (1) | RU2011115087A (pt) |
| TW (1) | TW201016692A (pt) |
| UY (1) | UY32125A (pt) |
| WO (1) | WO2010033543A2 (pt) |
| ZA (1) | ZA201101590B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| EP2024349B1 (en) * | 2006-05-31 | 2017-08-02 | AbbVie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| AU2007266535A1 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
| CA2681586A1 (en) | 2007-03-28 | 2008-10-09 | Abbott Laboratories | 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands |
| US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| MX2009012374A (es) * | 2007-05-18 | 2009-12-01 | Abbott Lab | Compuestos novedosos como ligandos del receptor de canabinoides. |
| US9193713B2 (en) * | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| WO2009114566A1 (en) | 2008-03-11 | 2009-09-17 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
| US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| RU2011115087A (ru) * | 2008-09-16 | 2012-10-27 | Эбботт Лэборетриз (Us) | Замещенные бензамиды в качестве лигандов каннабиноидного рецептора |
| PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
| EP2411371B1 (en) | 2009-03-27 | 2015-05-20 | AbbVie Inc. | Compounds as cannabinoid receptor ligands |
| US8586596B2 (en) | 2010-06-15 | 2013-11-19 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
| WO2015177063A1 (en) * | 2014-05-19 | 2015-11-26 | Syngenta Participations Ag | Insecticidally active amide derivatives with sulfur-substituted phenyl or pyridine groups |
| CN106795121A (zh) * | 2014-10-27 | 2017-05-31 | 豪夫迈·罗氏有限公司 | 放射性标记大麻素受体2配体 |
| CN106749078B (zh) * | 2015-11-23 | 2019-01-04 | 中国科学院大连化学物理研究所 | 一种2-亚胺基恶唑的合成方法 |
Family Cites Families (120)
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| DE1522361A1 (de) | 1966-03-08 | 1969-07-24 | Agfa Gevaert Ag | Sensibilisierung lichtempfindlicher Polymerer |
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| DE1772867A1 (de) | 1968-07-15 | 1971-06-16 | Agfa Gevaert Ag | Sensibilisierung von Schichten aus lichtvernetzbaren Polymeren |
| JPS5089367A (pt) | 1973-12-14 | 1975-07-17 | ||
| JPS57171986A (en) | 1981-04-14 | 1982-10-22 | Taiho Yakuhin Kogyo Kk | Heterocylic ring compound containing sulfur |
| DE3333450A1 (de) | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt |
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-
2009
- 2009-09-16 RU RU2011115087/04A patent/RU2011115087A/ru not_active Application Discontinuation
- 2009-09-16 EP EP11192134.2A patent/EP2428507B1/en active Active
- 2009-09-16 TW TW098131294A patent/TW201016692A/zh unknown
- 2009-09-16 US US12/560,897 patent/US8188135B2/en not_active Expired - Fee Related
- 2009-09-16 MX MX2011002811A patent/MX2011002811A/es not_active Application Discontinuation
- 2009-09-16 AR ARP090103558A patent/AR073599A1/es not_active Application Discontinuation
- 2009-09-16 PE PE2011000626A patent/PE20110804A1/es not_active Application Discontinuation
- 2009-09-16 ES ES11192134.2T patent/ES2556752T3/es active Active
- 2009-09-16 CN CN2009801455637A patent/CN102216277A/zh active Pending
- 2009-09-16 US US12/560,893 patent/US8859596B2/en not_active Expired - Fee Related
- 2009-09-16 PA PA20098842501A patent/PA8842501A1/es unknown
- 2009-09-16 EP EP15151451.0A patent/EP2896615A1/en not_active Withdrawn
- 2009-09-16 WO PCT/US2009/057088 patent/WO2010033543A2/en not_active Ceased
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- 2009-09-16 BR BRPI0919135A patent/BRPI0919135A2/pt not_active IP Right Cessation
- 2009-09-16 KR KR1020117008389A patent/KR20110061619A/ko not_active Withdrawn
- 2009-09-16 EP EP09792591A patent/EP2334646A2/en not_active Withdrawn
- 2009-09-16 UY UY0001032125A patent/UY32125A/es not_active Application Discontinuation
- 2009-09-16 JP JP2011527056A patent/JP2012502917A/ja active Pending
- 2009-09-16 CA CA2737199A patent/CA2737199A1/en not_active Abandoned
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2010
- 2010-07-14 AR ARP100102555A patent/AR077664A2/es not_active Application Discontinuation
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2011
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- 2011-03-23 CO CO11035303A patent/CO6361998A2/es not_active Application Discontinuation
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|---|---|
| CN102216277A (zh) | 2011-10-12 |
| ES2556752T3 (es) | 2016-01-20 |
| US20100069348A1 (en) | 2010-03-18 |
| PA8842501A1 (es) | 2010-04-21 |
| JP2012502917A (ja) | 2012-02-02 |
| US20100069349A1 (en) | 2010-03-18 |
| CL2011000544A1 (es) | 2011-06-17 |
| US8188135B2 (en) | 2012-05-29 |
| AR077664A2 (es) | 2011-09-14 |
| EP2428507A3 (en) | 2012-06-13 |
| UY32125A (es) | 2010-04-30 |
| US8859596B2 (en) | 2014-10-14 |
| AU2009293319A1 (en) | 2010-03-25 |
| WO2010033543A3 (en) | 2010-11-18 |
| DOP2011000081A (es) | 2011-07-15 |
| EP2428507A2 (en) | 2012-03-14 |
| CO6361998A2 (es) | 2012-01-20 |
| MX2011002811A (es) | 2011-04-12 |
| RU2011115087A (ru) | 2012-10-27 |
| AR073599A1 (es) | 2010-11-17 |
| EP2428507B1 (en) | 2015-10-21 |
| KR20110061619A (ko) | 2011-06-09 |
| CA2737199A1 (en) | 2010-03-25 |
| EP2334646A2 (en) | 2011-06-22 |
| WO2010033543A2 (en) | 2010-03-25 |
| ECSP11010974A (es) | 2011-05-31 |
| EP2896615A1 (en) | 2015-07-22 |
| ZA201101590B (en) | 2012-08-29 |
| IL211406A0 (en) | 2011-05-31 |
| TW201016692A (en) | 2010-05-01 |
| PE20110804A1 (es) | 2011-11-30 |
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