BRPI0916973A2 - anticorpos para ccr2 - Google Patents

anticorpos para ccr2

Info

Publication number: BRPI0916973A2
Authority: BR; Brazil
Prior art keywords: ccr2; antibodies
Prior art date: 2008-08-18

Application number

BRPI0916973A

Other languages

English (en)

Inventor

Arvind Rajpal

Bradley T Keller

Larry L Green

Laurie A Tylaska

Meina Liang

Ronald P Gladue

Shelley Sims Belouski

Shinji Ogawa

Original Assignee

Amgen Fremont Inc

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-18

Filing date

2009-08-17

Publication date

2016-07-26

2009-08-17 Application filed by Amgen Fremont Inc, Pfizer filed Critical Amgen Fremont Inc

2016-07-26 Publication of BRPI0916973A2 publication Critical patent/BRPI0916973A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Oncology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
AIDS & HIV (AREA)

BRPI0916973A 2008-08-18 2009-08-17 anticorpos para ccr2 BRPI0916973A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18935708P	2008-08-18	2008-08-18
PCT/US2009/004711 WO2010021697A2 (en)	2008-08-18	2009-08-17	Antibodies to ccr2

Publications (1)

Publication Number	Publication Date
BRPI0916973A2 true BRPI0916973A2 (pt)	2016-07-26

Family

ID=41347729

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916973A BRPI0916973A2 (pt)	2008-08-18	2009-08-17	anticorpos para ccr2

Country Status (21)

Country	Link
US (2)	US8710191B2 (pt)
EP (1)	EP2321351B1 (pt)
JP (1)	JP5685535B2 (pt)
KR (1)	KR101772706B1 (pt)
CN (1)	CN102239180B (pt)
AU (1)	AU2009283199B2 (pt)
BR (1)	BRPI0916973A2 (pt)
CA (1)	CA2734578C (pt)
CO (1)	CO6351802A2 (pt)
DK (1)	DK2321351T3 (pt)
ES (1)	ES2658117T3 (pt)
IL (1)	IL211284A (pt)
MX (1)	MX2011001911A (pt)
MY (1)	MY160892A (pt)
NO (1)	NO2321351T3 (pt)
NZ (1)	NZ591471A (pt)
PE (1)	PE20110774A1 (pt)
RU (1)	RU2547595C2 (pt)
SG (2)	SG193216A1 (pt)
WO (1)	WO2010021697A2 (pt)
ZA (1)	ZA201101047B (pt)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011116299A2 (en) *	2010-03-18	2011-09-22	Colorado State University Research Foundation	Myeloid derived suppressor cell inhibiting agents
US20110038871A1 (en) *	2009-08-11	2011-02-17	Veena Viswanth	Ccr2 inhibitors for treating conditions of the eye
WO2012096917A1 (en)	2011-01-10	2012-07-19	Novimmune S.A.	Anti-tlr4 antibodies and methods of use thereof
CN102603649B (zh) *	2011-01-20	2016-05-25	赣南师范学院	一种以地巴唑为先导分子的荧光探针化合物及其制备方法
US20120288442A1 (en) *	2011-05-11	2012-11-15	Atomic Energy Council-Institute Of Nuclear Energy Research	Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis
US9726666B2 (en)	2011-06-13	2017-08-08	Tla Targeted Immunotherapies Ab	Diagnosing and treating inflammatory diseases
WO2012172344A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating conditions associated with sepsis
EP2717940B1 (en)	2011-06-13	2020-04-22	TLA Targeted Immunotherapies AB	Treating conditions associated with metabolic syndrome
WO2012172339A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating inflammatory arthritis
WO2012172342A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating multiple sclerosis
WO2012172336A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating inflammatory skin diseases
EP3228631B1 (en)	2011-06-13	2020-06-24	TLA Targeted Immunotherapies AB	Treating respiratory conditions
WO2012172337A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating cardiovascular disease
WO2012172343A2 (en)	2011-06-13	2012-12-20	Ith Immune Therapy Holdings	Treating primary sclerosing cholangitis
WO2013089647A1 (en) *	2011-12-16	2013-06-20	Agency For Science, Technology And Research	Binding molecules against dengue virus and uses thereof
CA2877814A1 (en) *	2012-06-22	2013-12-27	Dingqiu HUANG	Antigen binding proteins that bind ccr2
US8975290B2 (en)	2013-03-01	2015-03-10	Colorado State University Research Foundation	Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis
CU24446B1 (es) *	2013-03-13	2019-10-04	Prothena Biosciences Ltd	Un anticuerpo monoclonal humanizado que se une a tau
NL2011406C2 (en)	2013-09-06	2015-03-10	Bionovion Holding B V	Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides.
WO2016081801A1 (en) *	2014-11-21	2016-05-26	Millennium Pharmaceuticals, Inc.	Use of an anti-ccr2 antagonist in the treatment of an infectious disease
NL2014108B1 (en) *	2015-01-09	2016-09-30	Aduro Biotech Holdings Europe B V	Altered april binding antibodies.
EP3262418B1 (en)	2015-02-26	2019-05-01	Innovative Concepts in Drug Development	Diagnostic markers of cognitive impairments, kits and uses thereof
MY197413A (en)	2016-05-02	2023-06-16	Prothena Biosciences Ltd	Antibodies recognizing tau
PL3452507T3 (pl)	2016-05-02	2023-01-09	Prothena Biosciences Limited	Immunoterapia tau
BR112018072389A2 (pt)	2016-05-02	2019-02-19	Prothena Biosciences Limited	anticorpos que reconhecem tau
WO2017210526A1 (en) *	2016-06-03	2017-12-07	Chemocentryx, Inc.	Method of treating liver fibrosis
MX388165B (es)	2016-11-23	2025-03-19	Chemocentryx Inc	Método para tratar glomeruloesclerosis segmentaria focal
EP4252629A3 (en)	2016-12-07	2023-12-27	Biora Therapeutics, Inc.	Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en)	2016-12-14	2023-06-07	Biora Therapeutics, Inc.	Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
CA3058944A1 (en)	2017-04-19	2018-10-25	Elstar Therapeutics, Inc.	Multispecific molecules and uses thereof
US11851486B2 (en)	2017-05-02	2023-12-26	National Center Of Neurology And Psychiatry	Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
BR112019022906A2 (pt)	2017-05-02	2020-05-26	Prothena Biosciences Limited	Anticorpos que reconhecem tau
MX386699B (es)	2017-10-11	2025-03-19	Chemocentryx Inc	Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2
EP3698808B1 (en)	2017-10-20	2025-01-01	Hyogo College Of Medicine	Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
WO2019113464A1 (en)	2017-12-08	2019-06-13	Elstar Therapeutics, Inc.	Multispecific molecules and uses thereof
CA3085782A1 (en)	2017-12-19	2019-06-27	Surrozen, Inc.	Wnt surrogate molecules and uses thereof
CA3085785A1 (en)	2017-12-19	2019-06-27	Surrozen, Inc.	Anti-lrp5/6 antibodies and methods of use
AU2019299216A1 (en)	2018-07-03	2021-01-07	Fennec Pharmaceuticals, Inc.	Anhydrous sodium thiosulfate and formulations thereof
JP2021534101A (ja)	2018-08-09	2021-12-09	ヴェルソーセラピューティクス，インコーポレイテッド	Ｃｃｒ２及びｃｓｆ１ｒを標的とするためのオリゴヌクレオチド組成物ならびにその使用
EP3856350A1 (en)	2018-09-27	2021-08-04	Marengo Therapeutics, Inc.	Csf1r/ccr2 multispecific antibodies
US20220249814A1 (en)	2018-11-19	2022-08-11	Progenity, Inc.	Methods and devices for treating a disease with biotherapeutics
KR20210099614A (ko) *	2018-12-04	2021-08-12	노파르티스 아게	Cd3에 대한 결합 분자 및 이의 용도
JP2022515424A (ja)	2018-12-24	2022-02-18	サノフイ	突然変異ｆａｂドメインを有する多重特異性結合タンパク質
EP3911954A4 (en) *	2019-01-16	2022-11-02	Yeda Research and Development Co. Ltd	BIOMARKERS FOR MODIFICATION OF CNS DISEASES
CU20210073A7 (es)	2019-03-03	2022-04-07	Prothena Biosciences Ltd	Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs
KR20220019670A (ko) *	2019-04-17	2022-02-17	고쿠리츠다이가쿠호진 히로시마다이가쿠	Il-6 저해제 및 ccr2 저해제를 조합하여 투여하는 것을 특징으로 하는 비뇨기암의 치료제
WO2020232127A1 (en)	2019-05-13	2020-11-19	The Research Foundation For The State University Of New York	Compositions and methods to block and bind ccr2 to modulate cellular function
WO2020264208A1 (en) *	2019-06-26	2020-12-30	Amunix Pharmaceuticals, Inc.	Egfr antigen binding fragments and compositions comprising same
EP4309722A3 (en)	2019-12-13	2024-08-07	Biora Therapeutics, Inc.	Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2022006470A1 (en)	2020-07-01	2022-01-06	Vanderbilt University	Methods of treatment for a kidney disease
US12319958B2 (en) *	2020-07-21	2025-06-03	Rutgers, The State University Of New Jersey	Method and kit for CCR2 expression profiling and disease stratification
IL302390A (en)	2020-11-09	2023-06-01	Takeda Pharmaceuticals Co	Drug antibody conjugates
KR20240099211A9 (ko)	2021-10-27	2025-12-10	그라나이트 바이오 아게	Ccr2를 표적으로 하는 항체
CN114990073A (zh) *	2022-05-27	2022-09-02	河南农业大学	一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用
WO2024245988A1 (en)	2023-05-29	2024-12-05	Granite Bio Ag	Antibodies targeting ccr2
CN116510020A (zh) *	2023-06-01	2023-08-01	中国人民解放军军事科学院军事医学研究院	降低ccr2含量或活性的物质在治疗或预防发热伴血小板减少综合征中的应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8823869D0 (en)	1988-10-12	1988-11-16	Medical Res Council	Production of antibodies
US5175384A (en)	1988-12-05	1992-12-29	Genpharm International	Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US6673986B1 (en)	1990-01-12	2004-01-06	Abgenix, Inc.	Generation of xenogeneic antibodies
DK0463151T3 (da)	1990-01-12	1996-07-01	Cell Genesys Inc	Frembringelse af xenogene antistoffer
US6075181A (en)	1990-01-12	2000-06-13	Abgenix, Inc.	Human antibodies derived from immunized xenomice
US6150584A (en)	1990-01-12	2000-11-21	Abgenix, Inc.	Human antibodies derived from immunized xenomice
US5789650A (en)	1990-08-29	1998-08-04	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
US5770429A (en)	1990-08-29	1998-06-23	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
US5814318A (en)	1990-08-29	1998-09-29	Genpharm International Inc.	Transgenic non-human animals for producing heterologous antibodies
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
JP2938569B2 (ja)	1990-08-29	1999-08-23	ジェンファームインターナショナル，インコーポレイティド	異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
CA2090473A1 (en)	1990-08-29	1992-03-01	Robert M. Kay	Homologous recombinatin in mammalian cells
WO1993004169A1 (en)	1991-08-20	1993-03-04	Genpharm International, Inc.	Gene targeting in animal cells using isogenic dna constructs
ATE244571T1 (de)	1991-12-02	2003-07-15	Millennium Pharm Inc	Inhibitorische immunglobulin-polypeptide gegen den pdgf beta-rezeptor
EP0652950B1 (en)	1992-07-24	2007-12-19	Amgen Fremont Inc.	Generation of xenogeneic antibodies
US5643763A (en)	1994-11-04	1997-07-01	Genpharm International, Inc.	Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US6091001A (en)	1995-03-29	2000-07-18	Abgenix, Inc.	Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en)	1995-03-29	2000-10-10	Abgenix, Inc.	Production of antibodies using Cre-mediated site-specific recombination
CA2218489A1 (en)	1995-04-21	1996-10-24	Aya Jakobovits	Generation of large genomic dna deletions
DE69637481T2 (de)	1995-04-27	2009-04-09	Amgen Fremont Inc.	Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
AU2466895A (en)	1995-04-28	1996-11-18	Abgenix, Inc.	Human antibodies derived from immunized xenomice
SE9600820D0 (sv) *	1996-03-01	1996-03-01	Pharmacia Ab	Antibodies and their use
US5714352A (en)	1996-03-20	1998-02-03	Xenotech Incorporated	Directed switch-mediated DNA recombination
US5994619A (en)	1996-04-01	1999-11-30	University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus	Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5916771A (en)	1996-10-11	1999-06-29	Abgenix, Inc.	Production of a multimeric protein by cell fusion method
CA2273194C (en)	1996-12-03	2011-02-01	Abgenix, Inc.	Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
US6235883B1 (en)	1997-05-05	2001-05-22	Abgenix, Inc.	Human monoclonal antibodies to epidermal growth factor receptor
KR20010034554A (ko)	1998-03-03	2001-04-25	레이몬드, 엠. 위티	치료제로서의 ｃｄ147 결합 분자
US20020029391A1 (en)	1998-04-15	2002-03-07	Claude Geoffrey Davis	Epitope-driven human antibody production and gene expression profiling
US6312689B1 (en) *	1998-07-23	2001-11-06	Millennium Pharmaceuticals, Inc.	Anti-CCR2 antibodies and methods of use therefor
US6727349B1 (en) *	1998-07-23	2004-04-27	Millennium Pharmaceuticals, Inc.	Recombinant anti-CCR2 antibodies and methods of use therefor
AU770555B2 (en)	1998-08-17	2004-02-26	Abgenix, Inc.	Generation of modified molecules with increased serum half-lives
CA2356215C (en)	1998-12-23	2015-11-24	Pfizer Inc.	Human monoclonal antibodies to ctla-4
JP4398620B2 (ja)	2000-02-03	2010-01-13	ミレニアム・ファーマシューティカルズ・インコーポレイテッド	ヒト化抗ｃｃｒ−２抗体およびその使用方法
GB0016138D0 (en)	2000-06-30	2000-08-23	Novartis Ag	Organic compounds
US20030165988A1 (en) *	2002-02-08	2003-09-04	Shaobing Hua	High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
EP2298717B1 (en)	2001-11-30	2015-10-28	Biogen MA Inc.	Antibodies against monocyte chemotactic proteins
WO2003066830A2 (en) *	2002-02-08	2003-08-14	Genetastix Corporation	Human monoclonal antibodies against membrane proteins
NZ542784A (en)	2002-08-19	2008-07-31	Astrazeneca Ab	Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
AU2003262051B2 (en)	2002-09-12	2008-09-25	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Human antihuman MCP-1 antibody and antibody fragment thereof
MXPA06000176A (es)	2003-12-10	2006-06-27	Millennium Pharm Inc	Anticuerpos anti-ccr2 humanizados y sus metodos de uso.
EA010350B1 (ru)	2004-06-03	2008-08-29	Новиммун С.А.	Антитела против cd3 и способы их применения
WO2006085961A2 (en)	2004-06-30	2006-08-17	Centocor, Inc.	Anti-mcp-1 antibodies, compositions, methods and uses
KR20080044360A (ko) *	2004-07-30	2008-05-20	화이자 프로덕츠 인코포레이티드	Ｃｃｒ2 매개 질병 또는 장애의 치료방법
MX2009003762A (es)	2006-10-05	2009-07-10	Centocor Ortho Biotech Inc	Antagonistas del receptor cc-quimiocina 2 para el tratamiento de fibrosis.

2009
- 2009-08-17 CN CN200980136307.1A patent/CN102239180B/zh not_active Expired - Fee Related
- 2009-08-17 RU RU2011110169/10A patent/RU2547595C2/ru active
- 2009-08-17 US US13/059,702 patent/US8710191B2/en active Active
- 2009-08-17 SG SG2013063318A patent/SG193216A1/en unknown
- 2009-08-17 WO PCT/US2009/004711 patent/WO2010021697A2/en not_active Ceased
- 2009-08-17 MY MYPI2011000512A patent/MY160892A/en unknown
- 2009-08-17 KR KR1020117006355A patent/KR101772706B1/ko not_active Expired - Fee Related
- 2009-08-17 BR BRPI0916973A patent/BRPI0916973A2/pt not_active IP Right Cessation
- 2009-08-17 NO NO09789161A patent/NO2321351T3/no unknown
- 2009-08-17 ES ES09789161.8T patent/ES2658117T3/es active Active
- 2009-08-17 AU AU2009283199A patent/AU2009283199B2/en not_active Ceased
- 2009-08-17 CA CA2734578A patent/CA2734578C/en active Active
- 2009-08-17 EP EP09789161.8A patent/EP2321351B1/en active Active
- 2009-08-17 JP JP2011523807A patent/JP5685535B2/ja active Active
- 2009-08-17 NZ NZ591471A patent/NZ591471A/xx unknown
- 2009-08-17 DK DK09789161.8T patent/DK2321351T3/en active
- 2009-08-17 SG SG10201701323TA patent/SG10201701323TA/en unknown
- 2009-08-17 MX MX2011001911A patent/MX2011001911A/es active IP Right Grant
- 2009-08-17 PE PE2011000160A patent/PE20110774A1/es active IP Right Grant
2011
- 2011-02-09 ZA ZA2011/01047A patent/ZA201101047B/en unknown
- 2011-02-17 IL IL211284A patent/IL211284A/en active IP Right Grant
- 2011-03-11 CO CO11030038A patent/CO6351802A2/es active IP Right Grant
2014
- 2014-04-03 US US14/244,167 patent/US9238691B2/en active Active

Also Published As

Publication number	Publication date
AU2009283199A8 (en)	2011-06-16
IL211284A (en)	2017-07-31
JP2012500020A (ja)	2012-01-05
MX2011001911A (es)	2011-07-04
SG193216A1 (en)	2013-09-30
KR20110057166A (ko)	2011-05-31
US20140342450A1 (en)	2014-11-20
US20110274696A1 (en)	2011-11-10
EP2321351A2 (en)	2011-05-18
HK1163134A1 (en)	2012-09-07
US9238691B2 (en)	2016-01-19
CN102239180B (zh)	2014-12-31
AU2009283199A1 (en)	2010-02-25
ZA201101047B (en)	2012-04-25
CA2734578A1 (en)	2010-02-25
SG10201701323TA (en)	2017-04-27
AU2009283199B2 (en)	2015-08-13
MY160892A (en)	2017-03-31
RU2547595C2 (ru)	2015-04-10
CN102239180A (zh)	2011-11-09
NZ591471A (en)	2012-08-31
ES2658117T3 (es)	2018-03-08
WO2010021697A3 (en)	2010-09-16
KR101772706B1 (ko)	2017-08-29
CO6351802A2 (es)	2011-12-20
EP2321351B1 (en)	2017-11-01
US8710191B2 (en)	2014-04-29
PE20110774A1 (es)	2011-10-13
DK2321351T3 (en)	2017-12-18
WO2010021697A2 (en)	2010-02-25
CA2734578C (en)	2019-03-12
NO2321351T3 (pt)	2018-03-31
IL211284A0 (en)	2011-04-28
JP5685535B2 (ja)	2015-03-18
RU2011110169A (ru)	2012-09-27

Publication	Publication Date	Title
BRPI0916973A2 (pt)	2016-07-26	anticorpos para ccr2
CY2019004I2 (el)	2019-11-27	Τροποποιημενα αντισωματα αντι-ιl-23ρ19
EP3064512C0 (en)	2023-08-30	ANTIBODIES AGAINST CLDN6
BRPI0906877A2 (pt)	2015-07-28	Anticorpos anti-trkb aperfeiçoados
HRP20171011T1 (hr)	2017-09-22	ANTI-eMET ANTITIJELO
BRPI1014262A2 (pt)	2017-05-23	anticorpos específicos para caderina-17
PT2406284T (pt)	2016-09-29	Anticorpos anti-bcma
SMT201600288B (it)	2016-11-10	SPECIFICI ANTICORPI IgE
IL212175B (en)	2019-08-29	Muc1* antibodies
EP2337798A4 (en)	2012-10-24	SPECIFIC ANTIBODIES OF THE ASB
PT2813570T (pt)	2018-02-12	Resumo
DK2340021T3 (da)	2012-12-10	Substituerede pyrrolidin-2-carboxamider
BRPI1011005A2 (pt)	2018-03-06	anticorpos anti-epcam
EP2473531A4 (en)	2013-05-01	Anti-gitr antibodies
EP2518338A4 (en)	2015-06-10	TERMINAL
HRP20150224T1 (xx)	2015-06-05	Anti-mif protutijela
PT3045471T (pt)	2017-06-14	Resumo
DK3444343T3 (da)	2021-01-18	Polypeptider
BRPI0914743A2 (pt)	2015-10-20	estrutura
DE602008003521D1 (de)	2010-12-30	Sitzrücklehnungsmechanismus
EP2320913A4 (en)	2012-10-03	NUCLEIC ACID APTAMERS
DK2342454T3 (da)	2013-10-28	Vindkraftanlæg
BRPI0909633A2 (pt)	2015-09-22	anticorpos anti-tyrp1
EP2377648A4 (en)	2016-11-30	GRINDING MACHINE INNER TOOTH WHEEL
BRPI0819633A2 (pt)	2015-05-05	Métodos para produzir poliolefinas

Legal Events

Date	Code	Title	Description
2018-01-23	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-12-17	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-02-27	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2021-04-27	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2021-06-08	B350	Update of information on the portal [chapter 15.35 patent gazette]
2021-06-22	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 12A ANUIDADE.
2021-10-13	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2633 DE 22-06-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.