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BRPI0916702A2 - composto, uso de um composto, e, composição farmacêutica. - Google Patents

composto, uso de um composto, e, composição farmacêutica.

Info

Publication number
BRPI0916702A2
BRPI0916702A2 BRPI0916702A BRPI0916702A BRPI0916702A2 BR PI0916702 A2 BRPI0916702 A2 BR PI0916702A2 BR PI0916702 A BRPI0916702 A BR PI0916702A BR PI0916702 A BRPI0916702 A BR PI0916702A BR PI0916702 A2 BRPI0916702 A2 BR PI0916702A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
BRPI0916702A
Other languages
English (en)
Inventor
Annalisa Bonfanti
Ennio Ongini
Francesca Benedini
Rebecca Steele
Stefano Biondi
Valerio Chiroli
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of BRPI0916702A2 publication Critical patent/BRPI0916702A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0916702A 2008-07-31 2009-07-07 composto, uso de um composto, e, composição farmacêutica. BRPI0916702A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8529408P 2008-07-31 2008-07-31
US12289608P 2008-12-16 2008-12-16
PCT/EP2009/058572 WO2010012567A1 (en) 2008-07-31 2009-07-07 Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology

Publications (1)

Publication Number Publication Date
BRPI0916702A2 true BRPI0916702A2 (pt) 2015-11-10

Family

ID=41170981

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916702A BRPI0916702A2 (pt) 2008-07-31 2009-07-07 composto, uso de um composto, e, composição farmacêutica.

Country Status (20)

Country Link
US (2) US8518920B2 (pt)
EP (1) EP2318427B1 (pt)
JP (1) JP5520948B2 (pt)
KR (1) KR20110041496A (pt)
CN (1) CN102131821B (pt)
AR (1) AR075263A1 (pt)
AU (1) AU2009277381B2 (pt)
BR (1) BRPI0916702A2 (pt)
CA (1) CA2731513C (pt)
DK (1) DK2318427T3 (pt)
ES (1) ES2442720T3 (pt)
IL (1) IL210477A0 (pt)
MX (1) MX2011001119A (pt)
NZ (1) NZ590454A (pt)
PL (1) PL2318427T3 (pt)
PT (1) PT2318427E (pt)
RU (1) RU2501804C2 (pt)
SI (1) SI2318427T1 (pt)
WO (1) WO2010012567A1 (pt)
ZA (1) ZA201100636B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5791064B2 (ja) * 2009-07-17 2015-10-07 エア・ウォーター株式会社 医薬用組成物
ES2847883T3 (es) * 2010-12-17 2021-08-04 Glaxo Group Ltd Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares
WO2013133980A1 (en) * 2012-03-05 2013-09-12 Bausch & Lomb Incorporated Nitroxy derivatives of soft steroids
CN104837895B (zh) * 2013-07-01 2017-06-06 Lg化学株式会社 聚硅氧烷化合物及其制备方法以及包含它的共聚碳酸酯树脂
CN110862318B (zh) * 2019-10-24 2022-05-13 甘肃省化工研究院有限责任公司 一种叔丁基取代羟基苯甲酸酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
EP1940863B1 (en) 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy derivatives of glucocorticoids
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.

Also Published As

Publication number Publication date
CA2731513A1 (en) 2010-02-04
PT2318427E (pt) 2014-01-22
US20130303499A1 (en) 2013-11-14
US8518920B2 (en) 2013-08-27
CN102131821A (zh) 2011-07-20
JP5520948B2 (ja) 2014-06-11
CA2731513C (en) 2016-09-20
RU2011106173A (ru) 2012-09-10
AR075263A1 (es) 2011-03-23
EP2318427A1 (en) 2011-05-11
CN102131821B (zh) 2014-08-27
EP2318427B1 (en) 2013-10-23
KR20110041496A (ko) 2011-04-21
US9012435B2 (en) 2015-04-21
US20110144073A1 (en) 2011-06-16
PL2318427T3 (pl) 2014-05-30
IL210477A0 (en) 2011-03-31
MX2011001119A (es) 2011-03-02
RU2501804C2 (ru) 2013-12-20
NZ590454A (en) 2012-09-28
AU2009277381B2 (en) 2014-04-24
JP2011529461A (ja) 2011-12-08
DK2318427T3 (da) 2014-01-20
ZA201100636B (en) 2011-10-26
AU2009277381A1 (en) 2010-02-04
WO2010012567A1 (en) 2010-02-04
SI2318427T1 (sl) 2014-02-28
ES2442720T3 (es) 2014-02-13
HK1160142A1 (en) 2012-08-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]