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BRPI0915025A2 - composição de colutório de fase dupla, e, método para melhorar saúde oral - Google Patents

composição de colutório de fase dupla, e, método para melhorar saúde oral

Info

Publication number
BRPI0915025A2
BRPI0915025A2 BRPI0915025A BRPI0915025A BRPI0915025A2 BR PI0915025 A2 BRPI0915025 A2 BR PI0915025A2 BR PI0915025 A BRPI0915025 A BR PI0915025A BR PI0915025 A BRPI0915025 A BR PI0915025A BR PI0915025 A2 BRPI0915025 A2 BR PI0915025A2
Authority
BR
Brazil
Prior art keywords
double
oral health
mouthwash composition
improving oral
phase mouthwash
Prior art date
Application number
BRPI0915025A
Other languages
English (en)
Inventor
Claude Blanvalet
Pierre Lambert
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of BRPI0915025A2 publication Critical patent/BRPI0915025A2/pt
Publication of BRPI0915025B1 publication Critical patent/BRPI0915025B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/03Liquid compositions with two or more distinct layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20Halogens; Compounds thereof
    • A61K8/21Fluorides; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
BRPI0915025A 2008-06-13 2009-06-15 composição de colutório de fase dupla, e, método para melhorar saúde oral BRPI0915025B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/138,647 US9724278B2 (en) 2008-06-13 2008-06-13 Oral compositions and uses thereof
PCT/US2009/047383 WO2009152507A2 (en) 2008-06-13 2009-06-15 Oral compositions and uses thereof

Publications (2)

Publication Number Publication Date
BRPI0915025A2 true BRPI0915025A2 (pt) 2015-10-27
BRPI0915025B1 BRPI0915025B1 (pt) 2016-12-13

Family

ID=41414992

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915025A BRPI0915025B1 (pt) 2008-06-13 2009-06-15 composição de colutório de fase dupla, e, método para melhorar saúde oral

Country Status (15)

Country Link
US (1) US9724278B2 (pt)
EP (1) EP2293849B1 (pt)
JP (1) JP2011526245A (pt)
CN (2) CN105581925A (pt)
AR (1) AR072145A1 (pt)
AU (1) AU2009257250B2 (pt)
BR (1) BRPI0915025B1 (pt)
CA (1) CA2726560C (pt)
CO (1) CO6341582A2 (pt)
MX (1) MX2010013440A (pt)
MY (1) MY157314A (pt)
RU (1) RU2483709C2 (pt)
TW (1) TWI432215B (pt)
WO (1) WO2009152507A2 (pt)
ZA (1) ZA201008887B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009049504A1 (de) * 2009-10-15 2011-04-21 Schülke & Mayr GmbH Wund- und Schleimhautantiseptikum auf der Basis von Bispyridiniumalkanen
SG185631A1 (en) 2010-06-23 2012-12-28 Colgate Palmolive Co Therapeutic oral composition
BR112013011852A2 (pt) * 2010-11-12 2016-07-26 Colgate Palmolive Co produto para cuidado oral e métodos de uso e de fabricação do mesmo
CA2821374C (en) 2010-12-20 2015-10-20 Colgate-Palmolive Company Non-aqueous oral care composition containing dental occlusion actives
MX347065B (es) 2010-12-20 2017-04-11 Colgate Palmolive Co Composicion de cuidado oral encapsulada con gelatina que contiene activos de oclusion dental, modificador hidrofobico de viscosidad y portador de aceite.
WO2012124533A1 (ja) * 2011-03-11 2012-09-20 ライオン株式会社 2層分離型液体口腔用組成物
WO2013036229A1 (en) 2011-09-08 2013-03-14 Colgate-Palmolive Company Oral and skin care compositions based on a 3, 3 ' - dialkyl - 1, 1 ' - biphenyl - 2, 2 ' - diol or a 3, 3 ' -dialkenyl- 1, 1 ' -biphenyl- 2, 2 ' -diol
US20140345648A1 (en) * 2011-12-15 2014-11-27 Ozospa Holdings Limited Oral Healthcare, Products and Methods Therefor
JP6031902B2 (ja) * 2012-09-06 2016-11-24 ライオン株式会社 2層分離型液体口腔用組成物
AU2012396916B2 (en) 2012-12-21 2015-10-01 Gaba International Holding Ag Oral care composition
US9326922B2 (en) 2014-01-15 2016-05-03 The Procter & Gamble Company Oral care compositions containing high purity barium sulfate particles
CA2953126C (en) 2014-07-25 2021-07-20 Colgate-Palmolive Company Dual phase mouthwash compositions
US10709644B2 (en) * 2014-12-26 2020-07-14 Colgate-Palmolive Company Oral care products and methods of use and manufacture therof
US9713582B2 (en) * 2015-04-13 2017-07-25 The Procter & Gamble Company Multi-layered cosmetic composition
US10874596B2 (en) 2015-07-31 2020-12-29 Gc Corporation Tooth whitening composition
CN105166835A (zh) * 2015-09-11 2015-12-23 安徽爱迪香料股份有限公司 一种水溶性复配凉味剂的制备方法
WO2018125691A1 (en) 2016-12-27 2018-07-05 Colgate-Palmolive Company Oral care product and methods of use and manufacture thereof
JP7337083B2 (ja) 2017-11-21 2023-09-01 スリーエム イノベイティブ プロパティズ カンパニー 口腔用植物系水中油型エマルジョン及び使用方法
EP3727326A2 (en) 2017-12-20 2020-10-28 3M Innovative Properties Company Oral compositions and methods of use
WO2019123171A1 (en) 2017-12-20 2019-06-27 3M Innovative Properties Company Oral compositions and methods of use
US12246098B2 (en) 2018-09-27 2025-03-11 BioPhysics Pharma, Inc. Trans-epithelial membrane drug delivery system
CA3112808A1 (en) 2018-09-27 2020-04-02 BioPhysics Pharma, Inc. Transdermal drug delivery system
CN109260102B (zh) * 2018-12-06 2022-02-11 广州舒客实业有限公司 一种多相口腔护理组合物
US12390488B2 (en) 2018-12-29 2025-08-19 Solventum Intellectual Properties Company Oral articles and methods of use
CN113950316B (zh) 2019-07-01 2024-04-16 高露洁-棕榄公司 口腔护理组合物和方法
WO2021167942A1 (en) * 2020-02-20 2021-08-26 North Atlantic Holdings LLC Transmucosal drug delivery system
CN113244155A (zh) * 2021-05-19 2021-08-13 广州冰泉化妆品科技有限公司 一种复合型抑菌防蛀奶盖漱口水及其制备方法
AU2022335358B2 (en) 2021-08-23 2025-07-31 Colgate-Palmolive Company Oral care compositions and methods
CN117084929B (zh) * 2023-08-11 2025-08-29 纳爱斯浙江科技有限公司 一种双相漱口水及其制备方法

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB641203A (en) 1947-05-19 1950-08-09 Unilever Ltd Improvements in compositions comprising an oil phase and an aqueous phase
GB837068A (en) 1957-05-13 1960-06-09 Charles Casper Yeager Improvements relating to biocidal compositions
GB1018454A (en) 1962-10-18 1966-01-26 Smith Kline French Lab Improvements in or relating to antibacterial and antifungal compositions
GB1062895A (en) 1962-12-13 1967-03-22 Wellcome Found Sulphomethyl derivatives of polymxin
GB1080994A (en) 1963-10-25 1967-08-31 Nat Res Dev Injectable emulsions containing antigens
US3697220A (en) * 1969-08-22 1972-10-10 Schwartz Chem Co Inc Bacteria growth inhibiting textiles and dry cleaning and disinfecting compositions and processes
US4154815A (en) * 1970-04-01 1979-05-15 Lever Brothers Company Zinc and enzyme toothpowder dentifrice
US3696191A (en) * 1970-11-10 1972-10-03 Monsanto Co Dental creams containing enzymes
US4058595A (en) * 1971-10-13 1977-11-15 Colgate-Palmolive Company Stabilized toothpastes containing an enzyme
US3991177A (en) * 1973-11-27 1976-11-09 Colgate-Palmolive Company Oral compositions containing dextranase
US3874870A (en) * 1973-12-18 1975-04-01 Mill Master Onyx Corp Microbiocidal polymeric quarternary ammonium compounds
GB1505069A (en) 1974-06-07 1978-03-22 Exxon Research Engineering Co Oil-in-water emulsions with bacteriaresistance
FR2313078A1 (fr) * 1975-02-07 1976-12-31 Anvar Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention
US4042679A (en) * 1975-11-07 1977-08-16 Colgate-Palmolive Company Antibacterial oral composition
US4022909A (en) * 1976-07-06 1977-05-10 Imc Chemical Group, Inc. Method of inhibiting the growth of bacteria using quaternary ammonium compounds
JPS6042764B2 (ja) 1978-01-13 1985-09-25 ライオン株式会社 クロルヘキシジン含有口腔用組成物
US4442125A (en) * 1978-06-26 1984-04-10 Oxford Hill, Ltd. Process for detaching or preventing attachment of microorganisms to a surface
GB2045241A (en) 1979-02-07 1980-10-29 Cadbury Schweppes Ltd Antimicrobial compositions
ATE6466T1 (de) * 1979-10-26 1984-03-15 Smith And Nephew Associated Companies P.L.C. Autoklavierbare emulsionen.
US4343730A (en) * 1981-03-09 1982-08-10 Petrolite Corporation Water-in-oil emulsions of polymers of quaternary ammonium compounds of the acrylamido type
US4355022A (en) * 1981-07-01 1982-10-19 Interon, Inc. Method of dental treatment
AT377436B (de) * 1982-06-08 1985-03-25 Colgate Palmolive Co Zahnpflegemittel
US4525432A (en) * 1982-06-21 1985-06-25 Fujikura Ltd. Magnetic material wire
IL68027A (en) * 1983-03-03 1986-09-30 Univ Ramot Dental preparation for preventing bacterial adherence to the tooth surface
JPS604126A (ja) * 1983-06-21 1985-01-10 Takasago Corp う蝕性菌生育阻害剤
US4693888A (en) * 1983-08-11 1987-09-15 Lion Corporation Caries-preventive composition
US5000939A (en) * 1984-06-12 1991-03-19 Colgate-Palmolive Company Dentifrice containing stabilized enzyme
JPH0772123B2 (ja) 1984-12-25 1995-08-02 ライオン株式会社 歯垢形成抑制剤組成物
JPS62145016A (ja) 1985-12-18 1987-06-29 Mitsubishi Chem Ind Ltd 抗菌剤
GB8608775D0 (en) * 1986-04-10 1986-05-14 Quantel Ltd Video editing & processing
JP2603465B2 (ja) 1986-08-29 1997-04-23 ライオン株式会社 口腔用組成物
US5180578A (en) * 1987-01-30 1993-01-19 Colgate-Palmolive Company Antibacterial antiplaque anticalculus oral composition
CH671879A5 (pt) * 1987-02-26 1989-10-13 Nestle Sa
IL85934A (en) * 1988-03-30 1992-02-16 Univ Ramot Composition for desorbing bacteria containing amphipathic cations
US5334375A (en) * 1988-12-29 1994-08-02 Colgate Palmolive Company Antibacterial antiplaque oral composition
SE512333C2 (sv) 1989-08-25 2000-02-28 Colgate Palmolive Co Antibakteriell oral komposition med plack- och tandstensbegränsande verkan
US5279813A (en) * 1989-10-26 1994-01-18 Colgate-Palmolive Company Plaque inhibition with antiplaque oral composition dispensed from container having polymeric material in contact and compatible with the composition
ES2187560T3 (es) * 1994-07-25 2003-06-16 Warner Lambert Co Dentifrico antiseptico.
IL121708A0 (en) 1997-09-04 1998-02-22 Innoscent Ltd Deodorant compositions and method
IL121709A0 (en) 1997-09-04 1998-02-22 Innoscent Ltd Antibacterial deodorizing compositions
JPH1179962A (ja) 1997-09-09 1999-03-23 Sunstar Inc 口腔用2相液体組成物
ES2134743B1 (es) * 1998-02-06 2000-05-01 Biocosmetics Sl Composicion para el tratamiento de la halitosis.
ATE249740T1 (de) 1998-04-06 2003-10-15 Innoscent Ltd Orale antimikrobielle und desodoriende zusammensetzungen
BR9804596B1 (pt) * 1998-11-10 2008-11-18 composiÇço cosmÉtica bifÁsica.
EP1173555A4 (en) 1999-04-26 2002-07-10 Innoscent Ltd METHOD AND KIT FOR DISPLAYING THE DEGREE OF SMELLING BREATH
US20040067203A1 (en) * 1999-06-23 2004-04-08 Rita Parikh Multi-benefit oral hygiene product
ATE276731T1 (de) 1999-11-12 2004-10-15 Procter & Gamble Verbesserte zweikomponente orale zusammensetzungen die zinn-derivate enthalten
WO2002034221A1 (en) 2000-10-25 2002-05-02 The Procter & Gamble Company Dental care compositions
JP2003231622A (ja) 2001-12-04 2003-08-19 Kao Corp 口腔用組成物
DE10258827A1 (de) * 2002-12-17 2004-07-08 Henkel Kgaa Zweischichtige temporör emulgierbare Zusammensetzungen
JP2006528690A (ja) * 2003-05-07 2006-12-21 ディーエムアイ バイオサイエンシズ インコーポレイテッド 口腔ケア方法および製品
US20050158349A1 (en) 2004-01-20 2005-07-21 Jampani Hanuman B. Two-phase compositions containing alcohol
US20050255072A1 (en) * 2004-01-20 2005-11-17 Jampani Hanuman B Two-phase compositions containing alcohol
US20050210615A1 (en) * 2004-03-29 2005-09-29 Ramachandra Shastry Oral care method
CN1977801A (zh) * 2005-12-05 2007-06-13 武汉慧洋生物技术有限公司 一种具有清除口臭作用的漱口水
EP1797860A1 (en) 2005-12-15 2007-06-20 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Two-phase compositions containing alcohol
BRPI0620265B8 (pt) 2005-12-21 2021-05-25 Colgate Palmolive Co composição oral anti-placa e dessensibilizante
CN1990004A (zh) 2005-12-30 2007-07-04 天津威欧斯生物科技发展有限公司 一种具有除口臭功能的漱口液
US7820758B1 (en) * 2007-11-13 2010-10-26 O'lenick Kevin A Polymeric glycerin surfactants

Also Published As

Publication number Publication date
US20090311200A1 (en) 2009-12-17
MX2010013440A (es) 2011-03-02
BRPI0915025B1 (pt) 2016-12-13
CA2726560A1 (en) 2009-12-17
AR072145A1 (es) 2010-08-11
CO6341582A2 (es) 2011-11-21
TWI432215B (zh) 2014-04-01
AU2009257250A1 (en) 2009-12-17
US9724278B2 (en) 2017-08-08
CA2726560C (en) 2015-01-06
WO2009152507A3 (en) 2011-08-11
TW201010735A (en) 2010-03-16
WO2009152507A2 (en) 2009-12-17
MY157314A (en) 2016-05-31
JP2011526245A (ja) 2011-10-06
CN105581925A (zh) 2016-05-18
AU2009257250B2 (en) 2012-08-30
RU2483709C2 (ru) 2013-06-10
RU2011100783A (ru) 2012-07-20
CN102281922A (zh) 2011-12-14
ZA201008887B (en) 2014-11-26
EP2293849B1 (en) 2017-01-04
EP2293849A2 (en) 2011-03-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/06/2009, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2727 DE 11-04-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.