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GB1080994A - Injectable emulsions containing antigens - Google Patents

Injectable emulsions containing antigens

Info

Publication number
GB1080994A
GB1080994A GB42210/63A GB4221063A GB1080994A GB 1080994 A GB1080994 A GB 1080994A GB 42210/63 A GB42210/63 A GB 42210/63A GB 4221063 A GB4221063 A GB 4221063A GB 1080994 A GB1080994 A GB 1080994A
Authority
GB
United Kingdom
Prior art keywords
oil
aqueous
phase
antigenic material
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42210/63A
Inventor
W Herbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAT RES DEV
National Research Development Corp UK
Original Assignee
NAT RES DEV
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAT RES DEV, National Research Development Corp UK filed Critical NAT RES DEV
Priority to GB42210/63A priority Critical patent/GB1080994A/en
Priority to BR163510/64A priority patent/BR6463510D0/en
Priority to NL6412206A priority patent/NL6412206A/xx
Priority to SE12746/64A priority patent/SE326796B/xx
Priority to FR992566A priority patent/FR4083M/fr
Priority to FR1603312D priority patent/FR1603312A/en
Priority to BE654793D priority patent/BE654793A/xx
Priority to ES0305277A priority patent/ES305277A1/en
Priority to DK527064AA priority patent/DK114855B/en
Publication of GB1080994A publication Critical patent/GB1080994A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Injectable compositions containing antigenic material comprise a multiple oil/water emulsion in which the continuous phase is aqueous and the primary disperse phase is an oil phase in which an aqueous phase containing antigenic material is dispersed. Oils may be therapeutically acceptable mineral oils, or vegetable oils such as arachis oil. The emulsions are prepared by subjecting a mixture of a water-in-oil emulsion having antigenic material in the aqueous phase, an aqueous medium, and an oil-in-water emulsifying agent, to emulsifying conditions; e.g. ultra-sonic vibrations, or treatment in a homogeniser. The stability of the emulsions may be improved by incorporation of agar in the aqueous component. Examples are given for the preparation of vaccines for poliomyelitis, pertussis, tetanus, influenza, Newcastle disease, and a multiple vaccine for pertussis, tetanus, diphtheria, poliomyeltitis and measles.
GB42210/63A 1963-10-25 1963-10-25 Injectable emulsions containing antigens Expired GB1080994A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB42210/63A GB1080994A (en) 1963-10-25 1963-10-25 Injectable emulsions containing antigens
BR163510/64A BR6463510D0 (en) 1963-10-25 1964-10-19 PROCESSING PROCESSES FOR THE PRODUCTION OF INJECTABLE COMPOSITIONS
NL6412206A NL6412206A (en) 1963-10-25 1964-10-20
SE12746/64A SE326796B (en) 1963-10-25 1964-10-22
FR992566A FR4083M (en) 1963-10-25 1964-10-23
FR1603312D FR1603312A (en) 1963-10-25 1964-10-23 Injectable vaccine prepns
BE654793D BE654793A (en) 1963-10-25 1964-10-23
ES0305277A ES305277A1 (en) 1963-10-25 1964-10-24 Procedure for the preparation of an injectable composition containing antigen material. (Machine-translation by Google Translate, not legally binding)
DK527064AA DK114855B (en) 1963-10-25 1964-10-24 Process for the preparation of an injectable agent in emulsion form containing antigenic material.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB42210/63A GB1080994A (en) 1963-10-25 1963-10-25 Injectable emulsions containing antigens

Publications (1)

Publication Number Publication Date
GB1080994A true GB1080994A (en) 1967-08-31

Family

ID=10423339

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42210/63A Expired GB1080994A (en) 1963-10-25 1963-10-25 Injectable emulsions containing antigens

Country Status (8)

Country Link
BE (1) BE654793A (en)
BR (1) BR6463510D0 (en)
DK (1) DK114855B (en)
ES (1) ES305277A1 (en)
FR (2) FR1603312A (en)
GB (1) GB1080994A (en)
NL (1) NL6412206A (en)
SE (1) SE326796B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363806A (en) * 1980-06-19 1982-12-14 Aktiebolaget Draco Pharmaceutical composition
GB2170708A (en) * 1985-02-10 1986-08-13 Israel State Injectable vaccine system
USRE32393E (en) * 1967-09-01 1987-04-07 Kabivitrum Ab Composition for enhancing the administration of pharmacologically active agents
US9724278B2 (en) 2008-06-13 2017-08-08 Colgate-Palmolive Company Oral compositions and uses thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8301996A (en) * 1983-06-06 1985-01-02 Duphar Int Res METHOD FOR PREPARING ADVISED LIVE VACCINES AND SO OBTAINED VACCINES OBTAINED.
FR2649012B1 (en) * 1989-07-03 1991-10-25 Seppic Sa INJECTABLE MULTIPHASIC EMULSIONS
MX9204379A (en) * 1991-07-26 1993-02-01 Smithkline Beecham Corp PHARMACEUTICALLY ACCEPTABLE, STABLE, SELF-EMULSIFIABLE OIL WATER MICROEMULSIONS.
ATE147620T1 (en) * 1991-07-26 1997-02-15 Smithkline Beecham Corp W/O MICROEMULSIONS

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32393E (en) * 1967-09-01 1987-04-07 Kabivitrum Ab Composition for enhancing the administration of pharmacologically active agents
US4363806A (en) * 1980-06-19 1982-12-14 Aktiebolaget Draco Pharmaceutical composition
GB2170708A (en) * 1985-02-10 1986-08-13 Israel State Injectable vaccine system
US9724278B2 (en) 2008-06-13 2017-08-08 Colgate-Palmolive Company Oral compositions and uses thereof

Also Published As

Publication number Publication date
SE326796B (en) 1970-08-03
FR4083M (en) 1966-04-12
DK114855B (en) 1969-08-11
NL6412206A (en) 1965-04-26
FR1603312A (en) 1971-04-05
ES305277A1 (en) 1965-05-01
BE654793A (en) 1965-04-23
BR6463510D0 (en) 1973-08-02

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