BRPI0903187B1 - method for predicting the clinical response of a dengue virus infected patient during the first days after symptom onset, a method for diagnosing dengue virus infection, and a kit for determining the prognosis of the clinical response of a dengue infected patient - Google Patents

Abstract

Clinical response prognostic markers of dengue virus infected patients The invention relates to a method for providing prognosis of clinical response of dengue virus infected patients conducted by analyzing the expression of a gene group as well as allelic polymorphism and protein levels encoded by them by the following methods: dna microarray, nortbern blot, pcr, quantitative pcr, western blot, elisa and flow cytometry, the use of any of the above or related methods is the basis for development of predictive clinical response kits, thus facilitating clinical management.

Description

METHOD OF PREDICTING THE CLINICAL RESPONSE OF THE PATIENT INFECTED DENGUE VIRUS DURING THE FIRST DAYS AFTER THE START OF SYMPTOMS, DIAGNOSTIC METHOD OF INFECTING THE DENGUE VIRUS, AND, KIT TO DETERMINE THE PROGNOSTIC OF THE PROGNOSIS

This invention relates to prognoses for the clinical response of patients infected with the dengue virus, based on the level of expression of the genes listed in Tables 2-7, or on their encoded proteins, as well as allelic polymorphism, in biological samples.

BACKGROUND OF THE INVENTION

The dengue virus is a member of the family Flaviviridae, a genus flavivirus with four antigenically distinct serotypes (DENV-1 to DENV-4). Dengue virus infection is a worldwide public health problem, with an estimated incidence of 50-100 million cases of dengue fever (FD or classic dengue), resulting in 500,000 life-threatening clinical cases of dengue hemorrhagic fever (DHF or hemorrhagic dengue) and 24,000 deaths per year (Green and Rothman 2006). DHF is characterized by vasculopathy, which leads to a sudden plasma leak which reduces blood volume and can result in hypovolemic chog, which is known as Dengue Chog Syndrome (SCD). There is no antiviral therapy for the treatment of dengue infection and no means to prevent the development of DHF.

During the acute phase of infection, patients with DF and DHF have very similar clinical guidelines. However, defervescence (2 to 7 days after the onset of symptoms) is accompanied by signs of circulatory disturbances in patients with DHF (WHO 1999). Therefore, we believe that the genetic signature differentiates the two different forms

Petition 870180125506, of 9/3/2018, p. 7/13 dengue clinics could be a powerful tool to be used in endemic areas to predict the patient's response, facilitating clinical management.

The concept currently accepted as underlying the immunopathology of DHF is based on the infection and induction of non-neutralizing antibodies (Endy, Nisalak et al. 2004; Pang, Cardosa et al. 2007), as well as on the activation of T cell clones. cross-reactive (MANGADA, Endy et al. 2002; Mongkolsapaya, Dejnirattisai et al. 2003; MANGADA Rothman and 2005; Mongkolsapaya, Duangchinda et al. 2006) both acquired after primary infection. Some of the severity markers found in peripheral blood, which have been correlated with plasma leakage in DHF include inflammatory cytokines, chemokines and adhesion molecules expressed at high levels (Green, Vaughn et al. 1999; Juffrie, van der Meer et al. 2000 ; Mustafa, Elbishbishi

et al '. 2001; Suharti, van Gorp et al. 2002; Hatfield, Hung et al. 2003; Nguyen, Lei et al. 2004; Cardier, Marino et al. 2005; Tseng, Lo et al. 2005) , a add-on activation (Avirutnan, Punyadee et al. 2006) , in addition to increasing

frequency of activated cells (Green, Vaughn et al. 1999; Azeredo, De Oliveira-Pinto et al. 2006) and occurrence of apoptosis (Mongkolsapaya, et al Dejnirattisai. 2003; Myint, Endy et al. 2006). These findings contributed to the advancement of the understanding of the immunological mechanisms involved in the development of DHF, but none of them has been proven to be reliable or useful as a biological marker for clinical use.

The DNA microarray has been used as a tool to locate genetic signatures and successfully predict the clinical response of the cancer patient (van de

Vijver, He et al. 2002; Chen, bacterial and viral infections

Scherer, Magness et al. 2007)

Yu et al. 2007), good how to > (Ramilo, Allman et al. 2007; . Van's Vijver et al (2002)

prognosis of 70 genes, reported the use of a profile previously associated with the risk of distant early metastasis in young patients with breast cancer whose lymph nodes were negative for the presence of cancer cells, as an instrument of guidance for adjuvant therapy in these patients (van in

In this way, the selection is improved

Vijver, He et al. 2002).

of patients who would benefit from systemic adjuvant treatment, reducing rates of both overtreatment and undertreatment.

In the dengue infection model, the pattern of gene expression was characterized along with the stage of infection in people affected with the most severe form of the disease, in two different dengue cohorts: Simmons et al. (2007) showed a molecular signature in Peripheral Blood Mononuclear Cells (PBMCs), representing the acute and convalescent phases of Dengue Shock Syndrome and they reported that gene transcripts for 24 IFN-stimulated genes were less abundant in adults (6 patients ) with dengue shock syndrome than in 8 dengue patients without SCD, while genes involved in apoptosis were expressed in greater quantities (Simmons, Popper et al. 2007). Recently Ubol et al (2008) in a cohort of children from Thailand conceptually confirmed the results shown in this report and in the Vietnamese study, associating the decrease in the innate immune response and the increase in apoptosis with the development of DHF (Ubol, Masrinoul et al. 2008), but the genetic pattern differs from the 5 we show here. A possible reason may be the age group used, as it is known that the repertoire of the immune response is phenotypically different during the first years, where the innate response predominates, compared to adults (Pettiford, Jason et al. 2002). In contrast, Kruif 10 et al. (2008) reported a general association of the severity of dengue and a greater amount of expression of the genes involved in the innate immune response (de Kruif, Setiati et al. 2008).

Several laboratory tests for dengue based on serology or viral detection are available and are capable of confirming the diagnosis of dengue infection. When used separately, each of these tests has limitations, however, when used in the correct combinations, it is possible to safely confirm or rule out the diagnosis of dengue virus infection. However, the biggest limitation in the clinical management of dengue cases is the clinician's ability to assess the risk of a particular dengue infected patient developing their fatal symptoms and their real need to be hospitalized. The incidence of DHF is approximately 1% and is fatal if it is not treated quickly 25. Even under medical assistance, the mortality rate due to DHF can reach 10 to 20%. Unfortunately, most of these deaths could be prevented with proper medical care. One of the main culprits of the lack of adequate assistance is the chaos caused by the large outbreaks. The World Health Organization (WHO) has established clinical criteria to define cases of DHF, but the difficulties both in meeting these criteria and in identifying serious cases early, make the clinical management of severe forms of the disease a challenge. even greater (Bandyopadhyay, Lum et al. 2006; Deen, Harris et al. 2006). Therefore, the search for new tools to predict the patient's clinical response is essential to facilitate the assessment of the need for medical interventions.

SUMMARY OF THE INVENTION

The present invention consists of a method of evaluating the clinical response of the patient infected with the dengue virus during the acute phase of the infection and before the signs of vasculopathy appear. The method consists of analyzing the 15 levels of expression of a group of genes (Tables 2-7), or proteins encoded by them, as well as allelic polymorphisms.

In one aspect of the invention, the prediction of the clinical response of patients infected with the dengue virus is based on the expression analysis of the 73 genes shown in Table 6, originated by the combination of the best 200 most significant genes (lowest p value) and 200 largest differences in expression (magnitude fold change) between classic dengue and hemorrhagic dengue.

In another aspect of the invention, the genes in Table 2 are used to characterize and differentiate gene expression in people infected with dengue virus (FD + FHD) from other causes of febrile illnesses (not dengue or ND).

Still an aspect of the invention, concerns the use of Linear Discrimination Analysis, as a classification rule, and bolstered resubstitution, as an error estimator, of genes in isolated, double, trio or more genes to predict clinical response of patients infected with dengue virus.

In another aspect of the invention, the expression of gene pairs based on the 1981 gene list (Table 7) is used as a classifier to predict the clinical response of patients infected with dengue virus.

In another aspect of the invention, the expression of a trio of genes based on the 1981 gene list (Table 7) is used as a classifier to predict the clinical response of patients infected with dengue virus.

In another aspect of the invention, the expression of a quartet of genes based on the 1981 gene list (Table 7) is used as a classifier to predict the clinical response of patients infected with dengue virus.

In yet another aspect of the invention, the evaluation of gene expression can be performed by any of the techniques designed to detect RNA, cDNA, cRNA (PCR, RT-PCR, quantitative PCR, DNA microarray, Northern biotting and others).

In yet another aspect of the invention, the levels of protein products encoded by the genes shown in Table 7 can be evaluated by any technique designed to detect denatured and native forms of proteins (ELISA, Western biotting, dot-blotting, flow cytometry) and others).

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BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 shows measures of noise and efficiency. The arrow indicates the only arrangement in the non-dengue group, which showed a reduced both signal / noise ratio and percentage of calls present.

FIG. 2 is a graph of RNA degradation.

FIG. 3 shows the exploratory analysis of the data based on the 1981 selected genes. (A) hierarchical clustering dendrogram. (B) MDS 2-D chart. (C) MDS 3-D chart. THE

ellipse in (B) represents the two largest groups of samples. FIG. 4 shows the 40 best genes differentially express between samples FD and FHD. (A) Map in expression with annotation of GeneBank. (B) Dendrogram in grouping

hierarchical (only the best 40 genes). (C) 3D MDS chart (only the 40 best genes).

FIG. 5 shows the classifier for the PSMB9 and MT2A gene pair, in the discrimination of FD against FHD. Lesser expression of both genes is characteristic of FHD, while greater expression of both genes is characteristic of FD. The estimated probability of error for this classifier is only 5.38%.

FIG. 6 shows levels of gene expression for discrimination between FD and FHD patients. (A) for all genes tested, the pPCR assays were performed using a mixture of 8 FD and 8 FHD patients used in the microarray assay. (B) For all genes, qPCR assays were performed for a group of 8 FD and 8 FHD samples used in the microarray assay (white column), or a group of 8 independent FD and 8 FHD samples (gray column). The experiment was carried out twice and each group was analyzed in triplicate.

FIG. 7 provides Volcanoes graphs showing the p-values correlated with the magnitude of the difference of expression (fold change) in patients FD versus FHD and cases of dengue (FD + FHD) versus non-dengue. The genes highlighted in red and blue represent the 40 best genes according to the p values and magnitude of difference of expression respectively.

DETAILED DESCRIPTION OF THE INVENTION

DNA microarray technology is an important tool to study the expression of mRNA simultaneously from genes in a genome. This technology consists of thousands of different sequences of

DNA representing different genes adsorbed in known regions of a solid matrix, such as a glass slide.

The slides can be hybridized with probes derived from cell or tissue mRNA. Oligonucleotide arrays (composed of DNA from

25-mers) is based on the probe's perfect match / mismatch

DNA, where probes that match perfectly are used and probes that differ from the first by a base in its center (mismatch) and that therefore do not hybridize to the DNA chip. In this type of microarray, only one fluorochrome is used to mark the complementary RNA (cRNA) and the signal is detected using optical scanning equipment. Quantification of the hybridized probe is carried out by comparing the signals of the oligos mismatch (hybridization not specified) and the oligos that look perfectly (match).

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DNA microarrays have been used as a tool to find gene signatures and successfully predict the clinical response of cancer patients (van de Vijver, He et al. 2002; Chen, Yu et al. 2007) as well as for bacterial and viral infections ( Ramilo, Allman et al. 2007; Scherer, Magness et al. 2007). van de Vijver et al (2002) reported the use of a prognostic profile using 70 genes as a tool to guide adjuvant therapy in these patients by selecting those patients who would really benefit from this systemic adjuvant treatment and reducing both the rate of overtreatment or undertreatment. The 70 genes used by these authors were previously associated with a risk of distant metastasis in young patients with breast cancer and whose lymph nodes were negative for the presence of cancer cells (van de Vijver, He et al. 2002).

There is much evidence that genetic factors, involved in susceptibility / resistance to infectious diseases, influence the immune response in humans. These factors are complex and genetically controlled and do not follow a Mendelian inheritance profile (Clementi and Di Gianantonio 2006). Some of these factors identified by DNA microarrays are involved with alteration of gene regulation and sometimes due to polymorphisms that interfere with gene expression in various ways, either directly binding to the promoter, or interfering with the signal cascade that interferes with gene activation . Host genetic polymorphism related to immune response has been shown to be correlated with altered gene expression and susceptibility to developing DHF, such as the TNF-308 allele, associated with high levels of TNFa, has been correlated with increased risk of developing the most severe form disease (Fernandez-Mestre, Gendzekhadze et al. 2004; Soundravally and Hoti 2007). An association has recently been reported between the wild genotype ΆΆ MBL2, high levels of MBL and high risk of developing thrombocytopenia associated with dengue virus infection (Acioli-Santos, Segat et al. 2008). On the other hand, polymorphism in the CD209 promoter (Sakuntabhai, Turbpaiboon et al. 2005), was associated with reduced expression of DC-SIGN and, possibly, reduced susceptibility of dendritic cells to infection by the dengue virus. Therefore, the search for alteration in gene expression among different dengue clinical conditions using DNA microarrays can elucidate on a large scale the genetic factors and immunopathological mechanisms related to dengue severity.

Using this technology, the gene expression profile was characterized in people who developed DHF in two different cohorts:

Simmons at al. (2007) showed a molecular signature in peripheral blood mononuclear cells (PBMC) representing the acute convalescent phases of patients who developed dengue shock syndrome (SCD). In this work they reported that gene transcripts for 24 interferon-stimulated genes were less abundant in adults (6 patients) with SCD than and 8 patients with DHF patients who did not develop shock, whereas those genes involved in apoptosis were expressed in greater numbers Recently Ubol et al (2008) in a cohort of Thai children also observed a reduction ι

in the expression of innate immunity genes and increased expression of genes involved in apoptosis with severity of dengue virus infection (Ubol, Masrinoul et al. 2008).

During the acute phase of the infection, patients affected with the benign (FD) and malignant (FHD) forms of the disease develop the same clinical picture. However, during the defervescence period (4 to 7 days from the onset of symptoms) it is accompanied by circulatory disorders, the magnitude of which is directly proportional to the severity of the disease (WHO 1999). Thus, the events that precede defervescence are decisive for the patient's clinical response.

The present invention provides the use of the differential expression of a group of genes as a prognostic tool to predict clinical response of patients infected with dengue based on the gene expression data obtained, before the circulatory symptoms begin, using oligonucleotide microarrays. Heparinized blood samples (sodium citrate or EDTA can also be used as an anticoagulant) collected from patients (Table 1), whose infection with the dengue virus was confirmed by serology for IgM as well as viral isolation or detection of viral RNA using RT- PCR; was used. Isolation of PBMC using density gradient can be used to minimize noise caused by granulocytes. Consequently, moderate to small changes in gene expression between the different clinical manifestations of dengue can be readily detected. Once the samples containing the cells are obtained, the messenger or total RNA can be extracted and amplified to evaluate gene expression. The amplified RNA is then marked so that it can be hybridized in a microarray of DNA, which in turn is scanned and the obtained data are processed to obtain the gene expression profile data.

The quality of the DNA microarray data is assessed using several criteria:

visual inspection, measurement of the noise / efficiency ratio, built-in control genes (spiked in) for amplification (dap, thr, phe, lys) and hybridization (bioB, bioC, bioD, cre), expression of constitutive genes (GAPDH - glyceraldehyde-

Human 3-phosphatase dehydrogenase- and beta actin), and graphs of RNA degradation.

Visual inspection based on high definition DAT files should not reveal signs of scratches or stains and the oligos B2 probes must be visible (chessboard profile as well as the name of the arrangement).

The noise / efficiency ratio is measured using the MAS 5.0 program. Noise Q factor, background, scaling factor and percentage of probes present should be similar between microarrays.

The selection of genes that predict the clinical response of patients infected with dengue virus, as well as those characteristic of dengue virus infection regardless of clinical manifestation [comparison between dengue cases (FD + FHD) and non-dengue group or ND, whose etiology of febrile disease was unknown but the possibility of being due to the dengue virus was ruled out], it was based on 26 microarrays of oligonucleotides distributed as follows:

from patients with FD, 10 from FHD patients and 8 from ND patients. These microarrays were analyzed using the Affymetrix MAS 5.0 program (Hubbell, Liu et al. 2002) to standardize the data and produce signals and detect the probes present among the 54,675 gene transcripts in each microarray. Of these, 12,299 transcripts were considered present (p <0.04) in all microarrays, while 20,365 transcripts were considered absent in any of the microarrays.

In order to keep only the most promising genes for future analyzes, two nonspecific filters were used: (i) detection filter to eliminate unexpressed genes, which kept only the genes considered to be present in at least 24 of the 26 microarrays, resulting in a total of 15,848 genes. Thus, 3,549 genes (15,848 - 12,299 = 3,549) were tolerated, which were considered absent in one or two microarrays; (ii) variance filter to eliminate genes of constitutive expression, which kept the largest 1/8 of the 15,848 previously cited genes, resulting in 1981 genes with prognostic potential (Table 7). These genes were confirmed as potential prognoses when hierarchical grouping and multidimensional scaling were performed in 2D and 3-D (Figure 3), revealing the formation of two large groups, one group containing ND samples and half of the FD samples; and another group containing DHF patients, two ND samples and the other half of DH patients. The measure of dissimilarity used was 1 - r, where r is Pearson's correlation of the values transformed into log. The microorganisms were colored according to the diagnostic class. It is noted that FHD samples constitute a more cohesive group than the ND group, represented by patients with febrile diseases of unknown etiology. While the FD samples can be divided into two groups, a similar and a different one from the FHD samples, the latter being closer to the ND samples. The small amount of stress (13.52% in Graph 2-D and 7.32% in Graph 3-D), particularly in Graph 3-D means that the structure that the data represents is intrinsically small, which indicates that a small number of gene signatures can represent the discriminatory content of the data.

Then, a statistical test was performed between the means (Welch two-sample t-tests) to find the genes that were differentially expressed between the different groups analyzed. Two comparisons were considered: FD versus FHD and Dengue (FD + FHD) versus ND. Volcano graphs in Figure 4 show that the p values were well correlated with the magnitude of the difference in expression (fold change) in both comparisons. The list of genes with the greatest fold-change shown in the volcano charts are shown in Tables 2 and 3

Figure 5 shows the expression map for the 40 most significant (lowest p-values) genes that discriminate FD FHD groups according to the Welch t test criteria, as well as the hierarchical grouping and MDS graphs for the same 40 genes.

Among the 200 most significant genes differentially expressed between FD and FHD according to Welch two-sample ttests was compared with 200 genes with greater fold-change in the average expression of mRNA levels, there are 7 3 genes in common (Table 6) , which represents the best most significant genes and with the greatest difference in the magnitude of expression (fold-change) between FD and FHD.

Among the genes differentially expressed between FD and FHD, 19 are part of the immune response category, including HLA-ΏΡαβ genes, complement factor D, CX3CR, MyD88, TNFSF17 (BCMA), TNFSF13 (APRIL). Seven genes were included in the defense response group, among them we have the myxovirus resistance gene (Mx), 2 ', 5'-oligoadenylate synthase (OAS1 and OAS2) and factors stimulated by IFN. These were expressed to a lesser extent in people who later developed DHF. These genes have been implicated in an innate immune response, confirming that this arm of the immune response may be crucial to the clinical response of patients infected with the dengue virus. In addition, 6 genes (PDCD4, PACAP, Tumor protein D52, MAGED1, proapoptotic caspase adapter protein and TNF ligand super family) associated with apoptosis are expressed in greater numbers in FHD patients. In addition, CD53, a tetraspanin produced by monocytes and B lymphocytes and prevents these cells from undergoing apoptosis (Yunta and Lazo 2003) was expressed to a lesser extent in the FHD group, reinforcing the premise that an increase in apoptosis-associated cells is associated with development the most severe form of the disease.

Comparing with the study conducted by Simmons et al (2007) (Simmons, Popper et al. 2007), there is a consistency in the genes proposed as being prognostic for the development of DHF. In this study, some genes stimulated by IFN, whose expression was reduced in patients developing SCD, such as MX, IFIT, and OAS, as well as high levels of pro-apoptotic caspase adapter protein and

PDCD5 (programmed cell death 5) are part of our list of prognostic genes.

Thus, based on the 1981 identified genes, groups of FHD marker genes were selected to be used in simpler assays, such as quantitative PCR. For this, an exhaustive selection was carried out with all possible combinations of genes isolated or combined in the form of a pair or trio, through linear discriminant analysis as a classification method, implemented by direct estimation of sample means and covariance matrices for each diagnostic class. (Braga-Neto 2005); and classification accuracy estimated by the potentiated resubstitution method (bolstead resubstitution, Braga-Neto 2004), which is ideal for selecting a group of genes in a situation with a smaller sample size (Sima, Attoor et al. 2005; Sima, Braga-Neto et al. 2005).

Table 5 shows the best genes in isolated (40) or combined [double (40) or trio (100)], ranked by the estimated error. There are 37 unique genes among the best 40 pairs, while there are 86 unique genes in the best 100 trios. The list of trios is dominated by the PSMB9, MT2A and LOC400368 genes. The average estimated error for the best classifiers containing 1 gene (40) = 0.1639 ± 0.0286, 2 genes (40) = 0.0686 ± 0.0096, 3 genes (100) = 0.0395 ± 0.0040, which indicates that the classification using pairs of genes it is more accurate than 1 gene, while classification using 3 genes is more accurate than 2 genes (the margin of error above refers to a 95% confidence interval). The selection method described above with 2 or 3 genes has the potential to select genes that are not possible to be found using univariate methods, such as t-test. This can be seen in the list of the best classifier pairs. For example, the HLA-F gene (whose expression is reduced in FHD compared to FD) Figure 6 shows the graph containing one of the classifier genes based on the PSMB9 and MT2A gene pair. The probability of error in future data for this classifier is 5.38%. In this case, reduced expression of both genes is characteristic of FHD, while increased expression is characteristic of FD. To confirm the potential of these genes as predictors of dengue severity, we selected some (PSMB9, MT2A, HLA-F and C3aRl) to develop quantitative RT-PCR assays with FD and FHD samples. The genes were amplified and detected using the TaqMan® gene expression assay with commercially available primers and probes (Applied Biosystems). The RNA was extracted with the aid of the RNeasy kit (Qiagen). The total RNA was reverse transcribed using the first SuperScript III strand synthesis system for quantitative PCR using random primers and quantitative PCR was performed on the ABI PRISM 7500 (Applied Biosystems). Beta actin was used as an endogenous control and all data were normalized based on this constitutive gene. The samples used in this assay are described in Table 1 (samples from ND patients, as well as patients FHD 105 and 112 were not used). The results of quantitative RT-PCR were comparable to those obtained in the microarray assays (Figure 7). In addition, using a group of samples independent of those samples used in the microarray assays, the above levels were also confirmed results of the PCR assay expression of the mentioned genes (Figure 7). In this way, the quantitative ones confirmed the expression of the selected genes in samples collected in the first medical visit of a patient infected with dengue virus, being able to predict whether a person infected with the dengue virus may or may not develop DHF. Therefore, the object of this invention represents a useful means of guiding the clinical management of patients with dengue.

Methods of choice for establishing levels of gene expression for predicting the clinical response of patients with dengue include DNA microarrays, RT-PCR, northern blot, competitive RT-PCR, real-time RT-PCR, differential display RT-PCR. While it is possible to conduct these techniques using individual PCR reactions, it is best to amplify the complementary DNA (cDNA) and analyze it via quantitative PCR and then normalize the results using the expression of some constitutive gene. Then, the analyzes can be done using both absolute and relative quantification so that the gene expression profile can be determined.

Levels of proteins encoded by dengue severity predictive genes, quantified from any body fluid (blood, plasma, serum, exudates) can be used for prognosis of dengue severity. However, plasma samples are preferred. For these types of samples, any immunological assay (ELISA, immunofluorescence, western blot, dot blot etc.) can be used. Furthermore, protein levels can be indirectly assessed by analyzing cell frequency (PBMC, for example) expressing a given protein in any cell compartment by flow cytometry.

The use of any of the aforementioned and related methods is a source for the development of kits for predicting dengue severity during the acute phase of infection and before plasma leakage occurs in DHF patients.

The invention is illustrated by the following examples which are not to be considered as limiting the scope of protection.

EXAMPLES

The genes analyzed according to this invention are typically related to the complete sequence of nucleic acids that code for the production of a protein or peptide. However, the identification of the complete sequence is not analytically necessary. That is, portions of the sequence or ESTs can be selected according to the well-known principles for which the probes can be designed to assess gene expression for the corresponding gene.

Example 1 - Design of the dengue cohort and strategy for functional genomics studies

A cohort of feverish cases of suspected dengue virus infection treated at 3 hospitals in the city of Recife, Pernambuco, Brazil, was established and described (Cordeiro, Schatzmayr et al. 2007; Cordeiro, Silva et al. 2007). Briefly, only a complete explanation of the study objectives, each participant of this cohort (or guardian) was asked to sign the consent form and a sequential blood donation was requested within a period of 30 days after the onset of symptoms. Serum, plasma and PBMC were separated and cryopreserved. The diagnosis of dengue was made through viral isolation in C6 / 36 cells (Igarashi 1978) and RT-PCR (Lanciotti, Calisher et al. 1992) in the samples collected on the day of admission (first sample) as well as through serology for identification IgM (Bio-Manguinhos, Oswaldo Cruz Foundation, Brazil or PanBio, Pty., Ltd., Brisbane, Australia) and IgG (PanBio, Pty., Ltd., Brisbane, Australia) anti-dengue in the first and subsequent samples. The type of infection was characterized based on the kinetics of IgM / IgG production and antibody titers in hemagglutination inhibition (HI) assay (Clarke and Casais 1958).

Dengue cases (confirmed by serology, RT-PCR or viral isolation) were clinically classified according to the criteria of the World Health Organization into two classes: dengue fever (FD or classic dengue) and dengue hemorrhagic fever (DHF) (PAHO 1995). FD cases were characterized by fever (39 ° C to 40 ° C) lasting up to 7 days accompanied by at least 2 of the symptoms, such as head odor, retrorbital pain, myalgia, arthralgia and rash. DHF cases were defined with the same symptoms found in DH, but with evidence of hemorrhage, thrombocytopenia (platelets <1000,000 / mm3) and plasma leakage following defervescence.

This study was reviewed and approved by the ethics committee of the Brazilian Ministry of Health CONEP: 4909; Process No. 25000.119007 / 2002-03; CEP: 68/02. In addition, the institutional review committee at Johns Hopkins University (USA) also reviewed and approved this study as a JHM-IRB-3 protocol:

03-08-27-01.

Functional genomics studies were performed with PBMC samples collected at the time of the first medical visit. Samples from 18 confirmed dengue cases (RT-PCR, viral isolation and / or IgM positive), genotype III, and 8 control samples from febrile cases that were negative for dengue in all tests performed on 3 or more samples (here called non-dengue or ND) were used in this assessment. The samples were divided into three groups: FD, FHD and ND. The samples for these three groups were selected to avoid a significant difference in relation to age, gender, history of dengue virus infection and symptom days. None of the patients had symptoms of DHF at the time the samples used in this evaluation were collected. At the time of sample collection, patients reported having symptoms for less than 8 days (average of 5.3 days). Among confirmed dengue cases, 8 were characterized as FD and 10 were classified as DHF (Table 1). Bold in Table 1 are the samples used exclusively in the qPCR assays. DF: dengue fever; DHF: dengue hemorrhagic fever; ND: Non-Dengue; M: male; F: female; Pos: positive; Neg: negative; -: no information.

Example 2 - Processing of samples for hybridization in gene chips

Blood samples collected from patients enrolled in this evaluation were collected in heparinized vacutainer tubes (BD Vacutainer) and within 2 hours of collection, PBMC samples were separated by density gradient using Ficoll-Paque (Amersham Biosciences) and cryopreserved at 10% (v / v) dimethyl sulfoxide (DMSO; Sigma-Aldrich) in inactivated fetal bovine serum (FBS; Hyclone). Four million cells were thawed and immediately lysed with Trizol (Invitrogen) to extract total RNA with chloroform and precipitation with isopropyl alcohol according to the manufacturer's instructions [the expression using fresh or frozen samples 10 was compared and shown to be similar, which is why frozen cells were chosen for functional genomics studies (data not shown)].

The total RNA was then purified using the RNeasy 15 MinElute Cleanup kit (Qiagen) according to the manufacturer's protocol and quantified by spectrophotometry at 260nm and 280nm (ultraviolet spectrum). Total RNA was used for the synthesis of complementary RNA (cRNA) through the targeting kit in two cycles (Affymetrix). Briefly, RNA isolated from PBMC was labeled with biotin and hybridized to microarrays of oligonucleotides (Affymetrix) using a two-cycle cDNA synthesis method. In the first cycle, the first cDNA strand was prepared using a T7- (dT) primer and Superscript II reverse transcriptase (Invitrogen) from 10-100ng cellular RNA. The second strand synthesis was performed using Escherichia coli DNA polymerase I and double stranded cDNA was used in the in vitro transcription assay (IVT) for cRNA amplification using the Megascript T7 kit (Ambion). The product of this first reaction cycle was used for reverse cDNA transcription as described for the first cycle. This cDNA was used for IVT for the synthesis of biotin-labeled cRNA, which was fragmented and sent to the Microarray Core Facility at Johns Hopkins University to hybridize the cRNA to the U133 Plus 2.0 human DNA chip (Affymetrix), tagging and scanning.

Example 3 - Quality control of microarrays

The quality of the microarray data was assessed using the following criteria: visual inspection, measures of the noise / efficiency ratio, built-in controls, expression of constitutive genes, and graphs of RNA degradation. Visual inspection based on high-resolution DAT files revealed no scratches or stains, and the B2-oligo probes (in a chessboard format and the name of the microarray) were also visible. Noise / efficiency measurements were made using the Affymetrix MAS 5.0 program, which can be used to assess the quality of the microarrays (Figure 1). Noise Q factors, background, scaling factors and percentage of genes present were similar in all microarrays. The average background values were below 100 for 20 of the 26 micro arrays; the scaling factors were within the order of 3x for 2 5 of the 2 6 micro arrays; and the percentage of genes present was around 40% or more for 25 of the 26 microarrays. None of the 6 microarrays that had a high background had a gene rate present significantly below 40%. All 3 'probes and intermediate probes for all embedded control genes (dap, thr, phe, lys) were present in all microarrays, as well as for the group of prokaryotic genes used to control hybridization (bioB, bioC, bioD, cre) and constitutive genes

GAPDH (human glyceraldehyde-3-phosphatase dehydrogenase) and beta-actin.In addition, the RNA degradation graph showing the average intensity of the probes in the same numerical position in all probe groups (for all genes) demonstrates a consistent tendency to increase in signal intensity from the 5 'end to the 3' end, which is expected due to the decrease in efficiency in cDNA synthesis (Figure 2).

Example 5 - Validation of DNA Microarray data through quantitative real-time PCR

Four genes differentially expressed between DF and FHD (MT2A, PSMB9, C3aRl and HLA-F) were selected for quantification by quantitative real-time PCR (qPCR). The genes were amplified and detected using TaqMan® gene expression assays with commercially available primers and probes (Applied Biosystems). Extraction of

RNA was performed using the RNease kit (Qiagen) according to the manufacturer's instructions. Total RNA was reverse transcribed to cDNA using the Superscript first-strand synthesis system

III (Invitrogen) for qPCR using random primers (radom primers) according to the manufacturer's suggestion.

qPCR was performed on the ABI device

PRISM 7500 (Applied Biosystems). The beta actin gene was selected as an endogenous control and all data were normalized against it. The reaction was carried out in triplicate and included 2 μΐ of cDNA, primers (20 μΜ each) and 6.25 μΜ of the specific or commercially pre-designed probe mixture for gene expression assay (Applied Biosystems), human beta-actin (Applied Biosystems), universal mix for TaqMan PCR (Applied Biosystems) and water added to a final volume of 25 μΐ. Triplicates of non-template controls (NTC) were included each time qPCR was performed. The reaction cycles were: after 2min incubation at 50 ° C and 10 minutes at 95 ° C, the samples went through 40 cycles of 95 ° C for 15 seconds and 60 ° C per lmin. The baseline and threshold used to determine the Cycle threshold were manually adjusted using the Sequence Detection Software, version 1.4 (Applied Biosystems). The amplification efficiency (E) of the target molecule was calculated from the formula (E = 10 ^Λ (-1 / Slope) - 1) where slope is the slope of the line generated by the Cts obtained from the standard curve, given automatically by the program. For the calculations of relative quantification, the method based on Delta Ct values was used [ABI PRISM® 7000 Sequence Detection System and AppliedBiosystems 7500 Real-Time PCR System - User Bulletin, Applied Biosystems] since the tests show efficiency of amplification of 100% ± 10% [Application Note 127AP05-02]. The samples used in the qPCR assays are described in Table 1 (samples from ND patients and FHD patients numbers 105 and 112 were not used).

Example 6 - Statistical Analysis

Quality control of patient data, statistical analysis and graphs were performed using the Affymetrix MAS 5.0 program (Hubbell, Liu et al. 2002) and the open access R statistical package, version 2.5.0 (Ihaka 1996) and additional library, in particular the BioConductor library, version 1.16 (Gentleman, Carey et al. 2004). Dendograms and MDS graphics were produced with the functions R hclust and isoMDS, respectively, while the expression maps (heatmaps) were obtained with the functions hset.emap and heatmap. The p-values corresponding to two-tailed Welch's two-sample t test were obtained with the t-test function. Functional category analysis was performed with the EASE program (Expression Analysis Systematic Explorer) on the DAVID Bioinformatic website (http://david.abcc.ncifcrf.gov) (Dennis, Sherman et al. 2003). The classification method used a discriminant linear analysis implemented by directly estimating the average of samples and covariance matrices for each diagnostic class (Braga-Neto 2005). The classification accuracy was estimated by the potentiated resubstitution method (bolsted resubstitution, Braga-Neto 2004), which is suitable for selection of gene groups when the sample number is low (Sima, Attoor et al. 2005; Sima, Braga- Neto et al. 2005).

Example 7 - Processing of Microarray DNA data

Affymetrix MAS 5.0 program was used to scale the data and produce signal and detection calls for the 54,675 genes in each of the 26 micro arrays. Of these, 12,2999 were considered present (p <0.04) in all microarrays, while 20,365 were not present in any of the microarrays. To keep only the promising genes for future analyzes, two non-specific filters were used: (i) detection filter to eliminate unexpressed genes, which kept only the genes considered to be present in at least 24 of the 26 microarrays, resulting in a total of 15,848 genes. Thus, 3,549 genes (15,848 - 12,299 = 3,549) were tolerated, which were considered absent in one or two microarrays; (ii) variance filter to eliminate genes of constitutive expression, which kept the largest 1/8 of the 15,848 previously cited genes, resulting in 1981 genes with prognostic potential (Table 7).

Example 8 - Exploratory analysis

Figure 3A shows the dendrogram for the hierarchical grouping of the 26 microarrays according to the expression of the 1981 genes selected in the pre-processing stage. Average linkage and Pearson's correlation of expression values transformed into log were used. It was observed that the samples fell into two large groups: the one on the right containing ND samples and half of the FD samples; while the group on the left contains all FHD samples, two ND samples (including outlier ND_199) and the other half of FD patients. This fact is in agreement with the intuition that ND and FHD are the most different groups and FD samples forming an intermediate group. This is confirmed by the multidimensional scaling graphs (MDS) in 2-D and 3-D for the 1981 genes, shown in Figure 3B and C. The dissimilarity measure used was 1 - r, where r is the Pearson correlation of the values logged. Microarrays were colored according to the diagnostic class. It can be seen that FHD samples constitute a more cohesive group than ND samples, as expected since the ND group was obtained from individuals with febrile illness of unknown etiology, while FD samples can be divided into two groups, a similar and another one different from DHF, the latter being closer to the ND group (these are the two groups marked in Figure 5). The low stress value (13.52% in the 2-D graph and 7.32% in the 3-D case), particularly in the 3-D graph, means that the delineating structure of the data is intrinsically low in size, which indicates that the small number of gene signatures is capable of representing discriminatory content in the data.

Example 9 - Differential expression analysis

Statistical tests of the differences between the means (Welch two-sample t-tests) were performed to find genes differentially expressed between the different diagnostic groups. Two main comparisons were considered: FD versus FHD and dengue (FD + FHD) versus ND. The first comparison corresponds to the 18 samples from patients proven to be infected with dengue virus and is the most important comparison for the present invention, since it discriminates between the benign (FD) and malignant (FHD) forms of the disease. Important genes used to characterize these two clinical manifestations as well as those specific for dengue virus infection are shown in Tables 2 and 3. The volcano graph in Figure 4 and the corresponding list of genes (Tables 2 and 3) show that the p values correlate well with magnitude of difference of expression (fold-change) in both situations analyzed.

Figure 5 shows the heatmap for the best 40 genes that discriminate FD samples from FHD, according to Welch t-test criteria, as well as the hierarchical grouping and MDS graphs for the 40 best discriminatory genes among FD and FHD. Table 4 shows the results of the analysis of the functional category representation of the list of the best 40 discriminatory genes between FD and FHD with the EASE program as described in Example 6. The analysis indicated the enrichment of certain categories of genes. Five categories had significant scores (p <0.05) after Benferroni's correction for multiple tests, including those involved in immune and defense responses, response to biotic stimuli, binding to copper / cadmium and home ionization of copper ion (Table 4).

Example 10 - Identification of classifying genes

In addition to the univariate selection carried out by t-tests, exhaustive selection (all possible combinations) of isolated genes was carried out, as well as doubles and trios from the 10981 genes, using linear discrimination analysis and potentiated resubstitution. Table 5 shows the classifiers based on 1, 2 or 3 genes, ranked by the estimated classification error. There are 37 unique genes among the best 40 pairs, while there are 87 unique genes among the best 100 classifying trios. The list of the gene trios is dominated by the PSMB9, MT2A, and LOC400368 genes. In fact, only one trio does not contain any of these three, this is SFRS5, PDCD4, MKNK2, whose estimated error is 0.0383. The averages for the estimated error of the best classifiers are:

classifier with 1 gene (40) = 0.1639 ± 0.0286, classifier with 2 genes (40) = 0.0686 ± 0.0096, classifier with 3 genes (100) = 0.0395 ± 0.0040, what

indicates that classification with pairs of genes is more accurate than individual genes, while classification with triple genes is more accurate than with pairs (the above margin of error refers to the 95% confidence interval). Selection with two and three genes has the potential to retrieve genes that using univariate methods (such as t-test) cannot be retrieved. This can be seen in the list of the best classifiers with 2 genes, for example, the HLA-F gene (which is less expressed in FHD than FD). Figure 6 shows the graph for the classifier with 2 genes PSMB9 and MT2A. The estimated probability of error in future data is 5.38%. In this case, the lowest expression of both genes is FHD signature, while the highest expression of both genes is characteristic of FD.

Example 11 - Validation of micro array data using quantitative real-time PCR

Quantitative real-time PCR (qPCR) assays were performed to validate the results obtained in the microarray assays. The following genes were selected: PSMB9, MT2A, HLA-F and C3aRl, whose expression was predominant in FD samples compared to FHD samples. qPCRs of the aforementioned genes were performed using eight FD and eight FHD samples obtained from the same patients tested in the microarray assays. According to Figure 7A, quantification by qPCR showed a good correlation with the microarray data. In addition, qPCR was also performed on a sample group independent of the samples used in the microarray assays, collected within 11 days of the onset of symptoms and before the onset of symptoms of vasculopathy. The results of qPCR also indicated that the expression levels of the selected genes were more reduced in FHD than in FD, corroborating the results obtained with the 2D model shown in Figure 3. With this, each of the four genes were expressed in lesser quantity in

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Table 2. List of genes shown in the Dengue volcano graph (FD + FHD) vs. ND according to fold change and p-value.

Symbol description p-val fc med sig CD52 CD52 antigen (CAMPATH-1 antigen) 0.000039 -1,9724 8,12979 ZFP36L1 zinc finger protein 36, C3H typelike 1 0.000059 -1,9941 7.26806 HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.000117 -2.5446 6.93612 HDLBP high density lipoprotein binding protein (vigilin) 0.000131 +2.7809 7.39547 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.000133 -1.8424 7.20502 MAGED1 melanoma antigen family D, 1 0.000153 +2.1404 6.85927 SPCS3 signal peptidase complex subunit 0.000207 3 homolog (S. cerevisiae) +2.2348 7.35861 FLJ20701 ... 0.000423 -2.0834 6.04034 SEC23B Sec23 homolog B (S. cerevisiae) 0.000480 +1.8829 7.10342 TRIM25 tripartite motif-containing 25 0.000612 +1.9769 7.63673 TRAI tumor rejection antigen (gp96) 1 0.000664 +4.3968 6.42347 ... ... 0.000687 -2.0036 7.61945 LOC440667 ... 0.000687 -2.3399 7,88564 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.000702 -2.3344 6.54292 CD83 CD83 antigen (activated B lymphocytes, surface immunoglobulin 0.000844 -2.8956 7.65248 MAN1A1 mannosidase, alpha, class IA, member 1 0.001023 +2.4278 7.25466 PDIA6 protein disulfide isomerase family A, member 6 0.001064 +2.8677 6.78112 IGLC2 immunoglobulin lambda constant 2 (Kem-Oz-marker) 0.001162 +5,5892 6.50222 TARDBP TAR DNA binding protein 0.001218 +1.8105 7,54527 PDIA4 protein disulfide isomerase family A, member 4 0.001223 +2.7304 6.94884 MGC11256 ... 0.001435 +2.4209 7.81936 LOC91353 ... 0.001704 +4.5913 8.19856 GMPPB GDP-mannose pyrophosphorylase B 0.001715 +2,7956 6.78685 DERL1 Derl-like domain family, member 1 0.001716 +1.9988 7.78196 PDIA6 protein disulfide isomerase family A, member 6 0.001844 +2.5145 7,19699 PDIA6 protein disulfide isomerase 0.001923 +2.5691 7,10724

family A, member 6

SPCS2 DC36 signal peptidase complex subunit 0.002134 +2.0393 +2.2111 2 homolog (S. cerevisiae) 0.002190 TRD @ T cell delta locus receiver 0.002300 -1.8996 LOC400741 ... 0.002411 -2.0124 CD38 CD38 antigen (p45) 0.002578 +3.3724 IGKV1D-13 immunoglobulin kappa variable 1D-13 0.002587 +3.6265 IGLC2 immunoglobulin lambda constant 2 (Kem-Oz-marker) 0.002701 +4.3190 PRC1 protein regulator of cytokinesis 1 0.002702 +2,6800 KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.003008 -2.2458 MMD monocyte to macrophage differentiation-associated 0.003105 +1.9302 EGR1 early growth response 1 0.003240 -2.3419 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.003294 -3.7052 C19orfl0 chromosome 19 open reading frame 10 0.003448 +1.8677 ITM2C integral membrane protein 2C 0.003476 +2.6957 DUSP2 dual specificity phosphatase 2 0.003588 -1.7949 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa 0.003715 +2.2640 BTG1 B-cell translocation gene 1, antiproliferative 0.004162 -2.0340 EGR1 early growth response 1 0.004223 -1,803 TIFA ... 0.004504 +1.7820 IFI16 interferon, gamma-inducible protein 16 0.004681 +1.9522 SAMD9L sterile alpha motif domain containing 9-like 0.004820 +2.6353 PLAUR plasminogen activator, urokinase 0.005299 receptor -2.2833 UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 0.005315 +2.0183 IGKC kappa constant immunoglobulin 0.005329 +2,44514 KIAA0746 ... 0.005694 +2.3672 CRR9 ... 0.005779 +2.1834 C5orfl4 chromosome 5 open reading frame 14 0.005805 +1.7734 KLHL14 kelch-like 14 (Drosophila) 0.005924 +4.4604 SIGLEC10 sialic acid binding Ig-like lectin 10 arginine-rich, mutated in early stage tumors 0.005997 -2.7531 ARMET 0.006618 +1.9474 TRD @ T cell delta locus receiver 0.006991 -1.8322 TXNDC5 thioredoxin domain containing 5 0.007668 +2.3417 C7orf24 chromosome 7 open reading 0.007762 +1.9157

frame 24

7.45086

7,45736

7.40155

7.25052

7.38196

7.14328

5,94850

6.27996

7.32421

6,80604

6.41955

6.71183

7.41872

6,33080

7,53773

7.04440

6.83080

6,36035

7,28424

8.22690

6,35057

6.42455

7.46490

7.86119

6.84767

7,12743

7.30565

6,19582

6.48276

7.23923

6.98857

8.67580

6.78388

LOC339562 ... 0.008089 0.008115 +2.6159 +2,5068 6,33496 8.17149 SMC4L1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 0.008325 +2.9479 6.25656 UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 0.008359 +1.8638 6,94727 NT5C3 5'-nucleotidase, cytosolic III 0.008360 +1.8688 6.91759 DF D component of complement (adipsin) 0.008687 -2.7181 6.85144 P4HB procollagen-proline, 2oxoglutarate 4-dioxygenase (proline 4 0.008716 +1.7954 8.04407 PALM2- ΑΚΑΡ ... 0.008921 +2,2190 7.14109 RASGEF1B RasGEF domain family, member 0.009825 1 r> -3.0515 5.90641 SEC13L1 SEC13-like 1 (S. cerevisiae) 0.010184 +1.8486 7.24982 TUBB tubulin, beta polypeptide 0.010994 +2,1076 6.89461 SEC11L3 SECll-like 3 (S. cerevisiae) 0.011247 +2.1820 6,70416 PRDX4 peroxiredoxin 4 0.011364 +1.9468 7.18909 SSR3 signal sequence receiver, gamma 0.011751 (translocon-associated prote +1.9620 7.69621 ZWINT ZW10 interactor 0.011795 +2.8555 7.04377 IER3 immediate early response 3 0.012348 -2,1041 7.27412 MGC27165 ... 0.012667 +4.0779 6.48172 NC0A3 nuclear receptor coactivator 3 0.012749 +2.2970 6,70409 IL8 interleukin 8 0.012961 -1.8904 7.50247 HIST1H3H histone 1, H3h 0.013216 +2.4035 6.20241 G0S2 GO / Glswitch 2 0.013273 -2.6994 6.11488 PPIB peptidylprolyl isotnerase B (cyclophilin B) 0.013490 +2,0063 8.39863 IGLC2 immunoglobulin lambda constant 2 (Kem-Oz-marker) 0.013786 +3.3635 7.22352 RORA RAR-related orphan receptor A 0.013877 -1.7492 7,79580 PRDX3 peroxiredoxin 3 0.014354 +1.9203 6.97942 BST2 bone marrow stromal cell antigen 2 0.014571 +1.7981 6.98131 FYN FYN oncogene related to SRC, FGR, YES 0.014649 -1.8662 6.81907 CLEC7A C-type lectin domain family 7, member A 0.014745 -2.2778 6.56259

Table 3. List of genes shown in the FD vs. volcano graph.

FHD according to fold change and p-value.

Symbol description p value Fold-change Average signal UBE2J1 ubiquitin-conjugating enzyme E2, 0.000119 0.000119 0.000419 2.3447 2.3447 -2.3147 6.7868 6.7868 7,37628 UBE2J1 J1 (UBC6 homolog, yeast) ubiquitin-conjugating enzyme E2, 0.000419 -2,3147 7,37628 CD300A J1 (UBC6 homolog, yeast) CD300A antigen 0.000864 2.1544 7.07896 CD300A CD300A antigen 0.000864 2.1544 7.07896 IGLC2 lambda constant immunoglobulin 0.001172 -3.0718 6,38877 IGLC2 2 (Kem-Oz-marker) immunoglobulin lambda constant 0.001172 -3.0718 6,38877 MT1X 2 (Kem-Oz-marker) metallothionein IX 0.001294 2.2122 7,5485 MT1X metallothionein IX 0.001294 2.2122 7,5485 MAGED1 melanoma antigen family D, 1 0.001644 -2.0342 7.06166 MAGED1 melanoma antigen family D, 1 0.001644 -2.0342 7.06166 GBP1 guanylate binding protein 1, 0.00216 1.9967 7,83435 VAMP3 interferon-inducible, 67kDa vesicle-associated membrane 0.002351 1.8814 7.11909 C3AR1 protein 3 (cellubrevin) complement component 3 a 0.002707 4.5817 6.08138 C3AR1 receiver 1 complement component 3 a 0.002707 4.5817 6.08138 MYD88 receiver 1 myeloid differentiation primary 0.002823 1.8194 8.06109 FCGR3B response gene (88) Fc fragment of IgG, low affinity 0.002868 4.1952 6.1543 FCGR3B Illb, receptor (CD 16b) Fc fragment of IgG, low affinity 0.002868 4.1952 6.1543 SAMHD1 Illb, receiver (CD 16b) S AM domain and HD domain 1 0.003019 2,44624 5,77873 SAMHD1 SAM domain and HD domain 1 0.003019 2,44624 5,77873 UBE2G1 ubiquitin-conjugating enzyme 0.003307 -2,1036 6.92056 UBE2G1 E2G 1 (UBC7 homolog, yeast) ubiquitin-conjugating enzyme 0.003307 -2,1036 6.92056 EGR1 E2G 1 (UBC7 homolog, yeast) early growth response 1 0.00334 3,22916 6.10353 EGR1 early growth response 1 0.00334 3,22916 6.10353 MT1H metallothionein 1H 0.003445 2.0475 6,750503 MT1H metallothionein 1H 0.003445 2.0475 6,750503 TPD52 tumor protein D52 0.003567 -2.2114 7,0498 IPD52 tumor protein D52 0.003567 -2.2114 7,0498 POU2AF1 POU domain, class 2, associating 0.00391 -2.7707 8.05215

factor 1

POU2AF1 POU domain, class 2, associating factor 1 0.00391 -2.7707 8.05215 PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B 0.004347 -2.3491 7.07497 PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B 0.004347 -2.3491 7.07497 LOC441168 ··· 0.004813 2,33726 8.08179 LOC441168 • · · 0.004813 2,33726 8.08179 SIDT2 SID1 transmembrane family, member 2 0.00485 1.9548 8,34325 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 0.004938 2.3334 7.01359 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 0.004938 2.3334 7.01359 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 0.005006 2,48888 7,58986 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 0.005006 2,48888 7,58986 IGLC2 lambda constant immunoglobulin 2 (Kem-Oz-marker) 0.005057 -2.9244 7.02255 IGLC2 lambda constant immunoglobulin 2 (Kem-Oz-marker) 0.005057 -2.9244 7.02255 TRAI tumor rejection antigen (gp96) 1 0.005488 -1,9074 8.2753 CRR9 ... 0.006054 -1.8843 7.36728 NDUFB6 NADH déydrogenase (ubiquinone) 1 beta subcomplex, 6.17kDa 0.006174 -1,828 7.27376 RNASET2 ribonuclease T2 0.006686 2,0165 7.81902 RNASET2 ribonuclease T2 0.006686 2,0165 7.81902 GBP2 guanylate binding protein 2, interferon-inducible 0.007125 1.8139 7.64193 EGR1 early growth response 1 0.007242 4.6155 6.04876 EGR1 early growth response 1 0.007242 4.6155 6.04876 CD97 CD97 antigen 0.007485 2,2044 6.8153 CD97 CD97 antigen 0.007485 2,2044 6.8153 TYROBP TYRO protein tyrosine kinase binding protein 0.007507 2,88639 7.71104 TYROBP TYRO protein tyrosine kinase binding protein 0.007507 2,88639 7.71104 LOC91353 ... 0.007524 -2,578 8.63641 LOC91353 ... 0.007524 -2,578 8.63641 SERPIN Al serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, 0.00763 2,463 7,455 SERPIN Al serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, 0.00763 2,463 7,455 FGL2 fibrinogen-like 2 0.007811 2,673 7.57893 FGL2 fibrinogen-like 2 0.007811 2,673 7.57893 TUBA3 ... 0.008598 1.8686 8.62436 TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.009406 -2.7543 7,26921 TNFRSF17 tumor necrosis receptor factor 0.009406 -2.7543 7,26921

superfamily, member 17

GMNN geminin, DNA replication inhibitor 0.009426 -2.2142 7.19724 GMNN geminin, DNA replication inhibitor 0.009426 -2.2142 7.19724 SMC4L1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 0.009866 -2.2396 6.61279 SMC4L1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 0.009866 -2.2396 6.61279 FGR Gardner-Rasheed feline viral sarcoma (v-fgr) oncogene homolo 0.009879 2.1941 7,25545 FGR Gardner-Rasheed feline viral sarcoma (v-fgr) oncogene homolo 0.009879 2.1941 7,25545 TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.010068 2,352 6,33822 IGLC2 lambda constant immunoglobulin 2 (Kem-Oz-marker) 0.010428 -2.6368 6,33398 ... ... 0.011066 -2.6563 7.40797 IGKV1D-13 immunoglobulin kappa variable 1D-13 0.011292 -2.3235 7,51906 ... ... 0.011735 2,152 7.57258 SEC11L3 SECll-like 3 (S. cerevisiae) 0.011854 -2.0503 6.92968 CX3CR1 chemokine (C-X3-C motif) receiver 1 0.012371 2.3472 7.89988 DF D component of complement (adipsin) 0.013175 2,7446 6,51822 FN5 ... 0.013342 2.1468 6.62795 SAMD9L sterile alpha motif domain containing 9-like 0.01406 2,393 7.12239 LOC441168 ... 0.014525 3,265 6.68643 PACAP ... 0.015153 -2.4229 7.03573 KIAA0746 ... 0.015464 -2.0754 7.06113 HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.015645 2.4265 7.80659 ... ... 0.016187 -2.6756 7,03496 ... ... 0.01639 -2,3461 6,36245 PACAP ... 0.016535 -2,367 7,80789 S100A9 SI00 calcium binding protein A9 (calgranulin B) 0.017515 2.0885 8.32804 S100A6 SI 00 calcium binding protein A6 0.019028 2,0002 7.28308

(calcyclin)

Table 4. EASE analysis of functional abundance from the list of

40 most significant discriminatory genes between FD and FHD. Statistically significant functional categories (p <0.05) after correction p => 2? 3 miί Ί + - ί rxΊ i ci riodc clS. Response Genes Response Genes Response to Genes of Binding genes Homcostr.si genes Immunoiologics Defense Biotic Etimule Cobrr / Cadmium Copper Iron EASE _D. Bonferrom EASE _D , Bonferrom EASE „, Bonferrom EASE _D. Bonferrom EASE „, Bonferrom score score score score score 3.91 E-06 1.19E-03 1.11E-05 3.38E-03 2.26E-05 6.89E-03 3.12E-05 9.53E-03 1.52E-04 4.64E-02 CD300A CD300A CD300A CD97 CD97 CD97 MT1H MTIH CX3CR1 CX3CR1 CX3CR1 C3AR1 C3AR1 C3AR1 MT1X CFD CFD CFD FCGR3B FCGR3B FCGR3B GBP1 GBP1 GBP1 GBP2 GBP2 GBP2 IGKV1D-13 IGKV1D-13 IGKV1D-13 HLA-DPA1 HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 HLA-DPB1 MYD88 MYD88 MYD88 POU2AF1 POU2AF1 POU2AFI S100A9 S100A9 S100A9 TNFSF12-TNFSF13 TNFSF12-TNFSF13 TNFSF12-TNFSF13 TNFSF13 TNFSF13 TNFSF13 TNFRSF17 TNFRSFI7 TNFRSF17 TYROBP TYROBP TYROBP FGR

4Ί

Table 5. Classifiers based on individual, double or triple genes ranked by the estimated error.

Gene 1 Gene 2 1-Gene Classifieds ΜΤ2Λ PSMB9 IGLC2 TO GIVE LOC400368 FCGR3B HLA-F CD53 VAMP3 CXXC5 DKFZP586 LOC91353 LRRFIP1 MT1H SAMHD1 UBE2J1 PDCD4 PACAP POU2AF1 KLHL14 FYB PACAP (no symbol) SEC11L3 NDUFB6 MT1X NCL C1QBP HIST1H4C SAMHD1 TNFRSF17 IFITM1 IGKC CHSY1 MRLC2 CXXC5 LOC400741 ATP6V0E HSPA5 TPD52 2-Classified Genes PSMB9 LRRFIP1 H3F3B MT2A SFRS5 PDCD4

Gene 3 Estimated Error

0.0870

0.0927

0.1182

0.1202

0.1277

0.1301

0.1314

0.1365

0.1389

0.1443

0.1477

0.1513

0.1555

0.1604

0.1626

0.1634

0.1669

0.1674

0.1688

0.1695

0.1708

0.1729

0.1734

0.1749

0.1767

0.1772

0.1793

0.1821

0.1850

0.1881

0.1885

0.1893

0.1910

0.1920

0.1933

0.1941

0.1956

0.1963

0.1966

0.1970

0.0351

0.0496

0.0501

LRRFIPI LOC400368 0.0504 PSMB9 MT2A - 0.0538 MT2A TMBIM4 0.0589 HA-1 LOC400368 0.0602 RHOA MT2A 0.0603 MT2A XRN1 0.0635 MRLC2 LOC400368 0.0661 NCL PSMB9 0.0665 DKFZP586 LOC400368 0.0666 MT2A CNOT2 0.0669 ITM2B LOC400368 0.0687 PSMB9 HA-1 0.0688 CD52 LOC400368 0.0702 TO GIVE ΜΤ2Λ 0.0708 MT2A HIPK3 0.0709 SELL MT2A 0.0710 PSMB9 ATP6V0E 0.0713 PSMB9 MRLC2 0.0715 NCL MT2A 0.0721 RAP1B MT2A 0.0730 MT2A LOC400368 0.0733 PSMB9 HLA-C 0.0736 TO GIVE PSMB9 0.0740 PSMB9 FNBP3 0.0742 MT2A ACTR3 0.0743 PSMB9 ARHGEF6 0.0744 UBE2J1 LOC400368 0.0752 SFRS5 MT2A 0.0762 RPS25 PSMB9 0.0765 TMSB4X LOC400368 0.0766 PSMB9 RPL14 0.0766 RPS15A LOC400368 0.0769 PSMB9 GNA13 0.0769 EIF5A LOC400368 0.0769 ARPC1B 0.0770 PSMB9 MYL6 0.0772 RPL9 LOC400368 0.0773 '-Genes Classified HNRPA1 PSMB9 MT2A 0.0256 LRRFIPI MRLC2 LOC400368 0.0302 PSMB9 SAP18 LRRFIPI 0.0316 PSMB9 LRRFIPI LOC400368 0.0319 TO GIVE PSMB9 ARHGEF6 0.0321 PSMB9 HLA-B MT2A 0.0323 LRRFIPI RPS21 LOC400368 0.0324 DEK LRRFIPI LOC400368 0.0326 EIF4A2 PSMB9 LRRFIPi 0.0326 DEK TO GIVE PSMB9 0.0329 PSMB9 HLA-C MT2A 0.0331 MT2A ACTB LOC400368 0.0332 CAPi LRRFIPI LOC400368 0.0339

PSMB9 MT2A HLA-C 0.0339 PSMB9 MT2A HNRPA1 0.0340 PSMB9 MT2A RPL14 0.0344 PSMB9 DDX17 MT2A 0.0344 PSMB9 MT2A HLA-A 0.0353 ΜΤ2Α ARHGEF10 LOC400368 0.0353 HNRPA1 MT2A LOC400368 0.0353 TO GIVE PSMB9 LRRFIPI 0.0358 HLA-E PSMB9 MT2A 0.0362 PSMB9 MT2A EEF1D 0.0362 LRRFIPI ITM2B LOC400368 0.0364 PSMC1 PSMB9 LRRFIPI 0.0367 LRRFIPI PTMA LOC400368 0.0374 SKP1A LRRFIPI LOC400368 0.0374 PSMB9 H3F3B MT2A 0.0378 PSMB9 MT2A PTPRC 0.0381 LRRFIPI TMSB4X LOC400368 0.0382 SFRS5 PDCD4 MKNK.2 0.0383 PSMB9 MT2A RAC2 0.0384 PSMB1 PSMB9 LRRFIPI 0.0385 DEK PSMB9 LRRFIPI 0.0389 LRRFIPI MRFAP1 LOC400368 0.0389 LRRFIPI ARPC2 LOC400368 0.0390 EIF4A2 LRRFIPI LOC400368 0.0392 PSMB9 DDX17 LRRFIPI 0.0394 PSMB9 MT2A MRLC2 0.0395 TO GIVE PSMB9 MT2A 0.0397 PSMB9 MT2A RPS19 0.0397 MT2A HNRPA1 LOC400368 0.0402 TMEM66 PSMB9 MT2A 0.0402 LRRFIPI GLTSCR2 LOC400368 0.0403 PSMB9 MT2A HLA-A 0.0403 I DDCTu 1 CD47 LOC400368 0.0403 LRRFIPI KPNB1 LOC400368 0.0404 PSMB9 CKTVí MT2A Λ A4A.4 v ^ v-rv-r PSMB9 LRRFIPI Clorf43 0.0405 UBE2J1 IVi ^ V T 4 AAm íCQ GRANDFATHER A Λ4ΛΛ v.v-r w PSMB9 LRRFIPI IFITM1 0.0407 PSMB9 uTXr> λ ut i. LRRFIPI A A.4AQ v.v — w UCP2 LRRFIPI LOC400368 0.0408 SAP 18 t DDCTD1 There i Γ WtíM: Kv OR Γι Γ1.4 1 1 U.U “1 1 LRRFIPI HA-1 LOC400368 0.0411 U1M E> DA z zz x ÍS. i n.i HA-I T ΓλΓ'ΜΠΑ ι τ v w A A4 t v-v-r s í UBE2J1 IGKC LOC400368 0.0411 XI A O? í 3 i tn-íí. í i i i go you A A .4 i O v.v-r i z. LRRFIPI MORF4L1 LOC400368 0.0413 LRRFIPI MT2A LOC40C «> 68 0.0413 ARL6IP5 LRRFIPI LOC400368 0.0415 í DDDIDÍ ii 1 GGAl íájLAÍíííj 68 0.0416 STK24 LRRFIPI LOC400368 0.0416 PSMB10 LRRFIPI LOC400368 0.0417

PSMB9 EEF1A1 MT2A 0.0417 PSMB9 MT2A LOC440055 0.0418 RPL35 LRRFIP1 LOC400368 0.0420 - LRRFIP1 LOC400368 0.0420 RPS29 PSMB9 MT2A 0.0420 ΜΤ2Α RPL14 LOC400368 0.0423 ACTB MT2A LOC400368 0.0425 RPS27 PSMB9 MT2A 0.0425 LRRFIP1 H3F3B LOC400368 0.0425 HA-1 HNRPA1 LOC400368 0.0425 NCL MT2A RAC2 0.0427 ARPC1B PSMB9 BTN3A3 0.0428 LRRFIP1 PSMB1 LOC400368 0.0429 TOMM7 LRRFIP1 LOC400368 0.0429 MT2A HLA-A LOC400368 0.0430 COX4I1 LRRFIP1 LOC400368 0.0430 CAP1 TO GIVE PSMB9 0.0430 LRRFIP1 SEPT9 LOC400368 0.0431 - UBE2J1 LOC400368 0.0431 PSMB9 LRRFIP1 - 0.0432 TXNL4A PSMB9 LRRFIP1 0.0433 - UBE2J1 LOC400368 0.0433 - UBE2J1 LOC400368 0.0434 TO GIVE PSMB9 CD52 0.0435 NCL RAP1B MT2A 0.0435 TPD52 IGKC LOC400368 0.0436 ACTB MT2A LOC400368 0.0436 EIF4A2 PSMB9 MT2A 0.0436 LRRFIP1 YWHAB LOC400368 0.0436 PTMA LRRF1P1 LOC400368 0.0437 HLA-B MT2A LOC400368 0.0438 PSMB9 LRRFIP1 KPNB1 0.0439 LRRFIP1 TMSB10 LOC400368 0.0439 LAMP1 PSMB9 MT2A 0.0440 LRRFIP1 - LOC400368 0.0440 MT2A DAZAP2 LOC400368 0.0440 HNRPA1 PSMB9 MT2A 0.0256 LRRFIP1 MRLC2 LOC400368 0.0302

Table 6. List of 73 genes differentially expressed between cases of FD and DHF that were common among those 200 most significant genes according to the Welch's t-test and the

200 genes with greater fold-change in the average expression of mRNA levels.

Symbol Gene Title p-val rank fc med_sig RNF36 ring finger protein 36 0.000119 2 2.3447 6.7868 UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 0.000419 4 -2,3147 7.3763 CD300A CD300a molecule 0.000864 8 2.1544 7,079 IGL @ Immunoglobulin lambda locus 0.001172 9 -3.0718 6,3888 MT1X metallothionein IX 0.001294 11 2.2122 7,5485 MAGED 1 GBP1 melanoma antigen family D, 1 0.001644 14 -2.0342 7.0617 guanylate binding protein 1, interferon- 0.00216 20 1.9967 7,8344

inducible, 67kDa /// guanylate binding protein 1, interferon-inducible, 67kDa

VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.002351 22 1.8814 7.1191 C3AR1 complement component 3 to receiver 1 0.002707 27 4.5817 6.0814 MYD88 myeloid differentiation primary response gene (88) 0.002823 30 1.8194 8.0611 FCGR3B Fc fragment of IgG, low affinity Illb, receptor (CD 16b) 0.002868 31 4.1952 6.1543 SAMHD 1 UBE2G1 S AM domain and HD domain 1 0.003019 32 2,44624 5,77873 ubiquitin-conjugating enzyme E2G 1 0.003307 33 -2,1036 6,9206

(UBC7 homolog, yeast)

EGR1 early growth response 1 0.00334 35 3,22916 6,1035 MT1H metallothionein 1H 0.003445 37 2.0475 6,755 TPD52 tumor protein D52 0.003567 38 -2.2114 7,0498 POU2AF 1 POU domain, class 2, associating factor 1 0.00391 40 -2.7707 8.0521

PPAPDC Phosphatidic acid phosphatase type 2 0.004347 45 -2.3491 7,075 IB domain containing 1B RP193H18.5 hypothetical protein LOC441168 0.004813 51 2,33726 8.0818 SIDT2 SID1 transmembrane family, member 2 0.00485 52 1.9548 8.3433 GBP1 guanylate binding protein 1, interferoninducible, 67kDa /// guanylate binding protein 1, interferon-inducible, 67kDa 0.004938 54 2.3334 7.0136 GBP1 guanylate binding protein 1, interferoninducible, 67kDa 0.005006 55 2,48888 7.5899 LOC966 Hypothetical protein similar to 0.005057 56 -2.9244 7.0226 10 /// KIAA0187 gene product /// IGL @ Immunoglobulin lambda locus HSP90B heat shock protein 90kDa beta (Grp94), 0.005488 59 -1,9074 8.2753 1 member 1 CRR9 cisplatin resistance related protein CRR9p 0.006054 64 -1.8843 7,3673 NDUFB NADH déydrogenase (ubiquinone) 1 beta 0.006174 66 -1,828 7.2738 6 subcomplex, 6, 17kDa RNASE T2 ribonuclease T2 0.006686 70 2,0165 7,819 GBP2 guanylate binding protein 2, interferoninducible /// guanylate binding protein 2, interferon-inducible 0.007125 76 1.8139 7.6419 EGR1 Early growth response 1 0.007242 77 4.6155 6,0488 CD97 CD97 molecule 0.007485 79 2,2044 6.8153 TYROB TYRO protein tyrosine kinase binding 0.007507 80 2,88639 7,711 P protein CTA- 246H3.1 similar to omega protein 0.007524 81 -2,578 8.6364 SERPIN serpin peptidase inhibitor, clade A (alpha- 0.00763 83 2,463 7,455 Al 1 antiproteinase, antitrypsin), member 1 FGL2 fibrinogen-like 2 0.007811 87 2,673 7.5789 TUBA3 tubulin, alpha 3 0.008598 93 1.8686 8.6244 TNFRSF tumor necrosis receptor factor 0.009406 98 -2.7543 7,2692 17 superfamily, member 17 GMNN geminin, DNA replication inhibitor 0.009426 99 -2.2142 7.1972 SMC4L1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 0.009866 102 -2.2396 6.6128 FGR Gardner-Rasheed feline viral sarcoma (vfgr) oncogene homolog 0.009879 103 2.1941 7.2555 TNFSF1 tumor necrosis factor (ligand) 0.010068 105 2,352 6,3382 3 /// superfamily, member 13 /// tumor

TNFSF1 necrosis factor (ligand) superfamily,

2- member 12-member 13

TNFSF1

IGL @ Immunoglobulin lambda locus 0.010428 106 -2.6368 GNAS GNAS complex locus 0.010903 111 -1.8682 UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1 0.010949 112 -1.9816 ARMET arginine-rich, mutated in early stage tumors 0.011018 113 -1.8831 Immunoglobulin kappa light chain (IGKV) mRNA variable region, joining region, and constant region /// Immunoglobulin kappa light chain (IGKV) mRNA variable region, joining region, and constant region 0.011066 114 -2.6563 HLA- DPA1 major histocompatibility complex, class II, DP alpha 1 0.011235 115 1,9378 IGKV 1D -13 /// LOC649 876 immunoglobulin kappa variable 1D-13 /// similar to Ig kappa chain V-I region HK102 precursor 0.011292 116 -2.3235 PYCAR n PYD and CARD domain containing 0.011531 117 1,904 A_7 KIAA15 05 KIAA1505 protein 0.011735 118 2,152 SEC11L SECll-like 3 (S. cerevisiae) 0.011854 120 -2.0503 CX3CR1 chemokine (C-X3-C motif) receiver 1 0.012371 124 2.3472 MT1E metallothionein 1E (fiinctional) 0.012654 125 1.8414 CFD complement factor D (adipsin) 0.013175 130 2,7446 Cllorf7 5 chromosome 11 open reading frame 75 0.013342 133 2.1468 SRPRB signal recognition particle receiver, B subunit 0.01398 139 -1.8251 SAMD9 L sterile alpha motif domain containing 9like 0.01406 142 2,393 RP193H18.5 hypothetical protein LOC441168 0.014525 151 3,265 PACAP proapoptotic caspase adapter protein 0.015153 156 -2.4229 KIAA07 KIAA0746 protein 0.015464 162 -2.0754

6,334

8.2788

6,8578

7.4254

7,408

7.2184

7.5191

7.3968

7.5726

6,9297

7.8999

6.5549

6.5182

6,628

7,2025

7,124

6.6864

7.0357

7.0611

HLA- major histocompatibility complex, class 0.015645 166 2.4265 7.8066 DPB1 II, DP beta 1 PRDX4 peroxiredoxin 4 0.01571 167 -1.8982 7.3706 - Transcribed locus 0.016136 171 -1.9733 6,722 LOC652 similar to Ig kappa chain V-I region 0.016187 172 -2.6756 7,035 745 Walker precursor TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.016262 174 1.8697 8.0753 —— Immunoglobulin kappa chain, V-region (SPK.3) 0.01639 176 -2,3461 6.3625 PACAP proapoptotic caspase adapter protein 0.016535 178 -2,367 7.8079 ITM2C integral membrane protein 2C /// integral membrane protein 2C 0.016602 179 -1.9904 6.6164 C9orfl9 chromosome 9 open reading trame 19 0.0169 182 1.9849 6,9941 LRRC59 leucine rich repeat containing 59 0.017101 185 -1.8304 7.1703 S100A9 SI 00 calcium binding protein A9 (calgranulin B) 0.017515 189 2.0885 8,328 SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.017518 190 1.9835 7.0682 PARP12 poly (ADP-ribose) polymerase family, member 12 0.017657 193 1.9566 7.7735 S100A6 SI00 calcium binding protein A6 0.019028 199 2,0002 7.2831

(calcyclin)

Table 7. List of 1981 genes after processing microarray data.

Symbol GenBank description Médjsig p-val Fold change RPS16 AA583817 ribosomal protein S16 9.72102 0.277282 1,0953 RPS20 BF184532 ribosomal protein S20 9.68353 0.148291 1,11517 ... NM 173704 9.63312 0.143144 1.1571 RPL37A NM 000998 ribosomal protein L37a 9.63014 0.235864 1,124 HUWE1 NM_017627 HECT, UBA and WWE domain containing 9,59332 0.263327 1,11138 IGL @ AA680302 immunoglobulin lambda locus 9,59311 0.26474 -1.2208 RPS6 NM 001010 ribosomal protein S6 9,58439 0.448575 1.0543 RPS2 AI183766 ribosomal protein S2 9.58222 0.203036 1.1329 RPL5 BF214492 ribosomal protein L5 9.58055 0.60019 1,0277 TPT1 BG498776 tumor protein, translationally-cont 9.57284 0.250297 1,1063 RPL10A BG231561 ribosomal protein LlOa 9,57011 0.183032 1.1372 RPLP1 NM 001003 ribosomal protein, large, PI 9.56849 0.355849 1.0739 ... AFFXHUM A ... 9,5606 0.222693 1.1384 RPS11 NM 001015 ribosomal protein SI 1 9,55964 0.158163 1.1408 TMSB10 NM 021103 thymosinbeta 10 9.55496 0.071749 1.1801 RPS3A NM 001006 ribosomal protein S3A 9.55158 0.532298 1.0521 EEF1A1 NM 001403 eukaryotic translation elongation f 9.55085 0.188962 1.1368 ... NM 173710 ... 9,5493 0.116896 1.1738 OAF NM 173705 OAF homolog (Drosophila) 9.54913 0.370259 1,0809 B2M NM 004048 beta-2-microglobulin 9.54197 0.090167 1.1779 RPS10 AA320764 ribosomal protein S10 9,53284 0.235061 1,118 RPS19 NM 001022 ribosomal protein S19 9.53197 0.202512 1,121 UNC5B AF253979 unc-5 homolog B (C. elegans) 9.51965 0.362171 1,084 RPL41 NM 021104 ribosomal protein L41 9.51841 0.204405 1.1252 ACTB AA809056 actin, beta 9,51448 0.042627 1.2607 RPS19 BE259729 ribosomal protein S19 9.5107 0.284201 1.0841 RPS23 NM 001025 ribosomal protein S23 9.51007 0.594312 1.0499 EEF1A1 AL515273 eukaryotic translation elongation f 9.50998 0.15173 1,11471 ACTB AK025873 actin, beta 9.50928 0.044908 1,22484 OAF NM 173705 OAF homolog (Drosophila) 9.50312 0.288608 1.1074 RPL15 NM 002948 ribosomal protein LI 5 9.50277 0.386678 1.0834 RPL23A BF125158 ribosomal protein L23a 9,50045 0.388508 1.0715 RPS3A AI925635 ribosomal protein S3A 9.49856 0.553253 1,0479 RPL31 NM 000993 ribosomal protein L31 9.49816 0.313692 1,086 FAU NM 001997 Finkel-Biskis-Reilly murine sarcoma 9.49129 0.2122 1,096 RPL23A U43701 ribosomal protein L23a 9.49081 0.331343 1.0855 RPL23A BC001865 ribosomal protein L23a 9,48737 0.312354 1.0872 EEF1D AI613383 eukaryotic translation elongation f 9.48636 0.213286 1.1055 RPS4X NM 001007 ribosomal protein S4, X-linked 9.48595 0.408488 1.0624 RPS29 NM 001032 ribosomal protein S29 9.48084 0.150919 1.1499 TPT1 AI721229 tumor protein, translationally-cont 9.47991 0.285558 1,1002 RPL39 BC001019 ribosomal protein L39 9.47553 0.096318 1.1696

ACTB NM 001101 actin, beta 9.47114 0.0697 1.1949 RPS15 NM 001018 ribosomal protein S15 9.46707 0.196897 1,11154 ... AFFX-R2-P1 ... 9,46578 0.089216 1,22245 RPS9 BE348997 ribosomal protein S9 9.46084 0.253801 1.1066 IGL @ M87790 immunoglobulin lambda locus 9,4486 0.593009 -1,1058 UBB NM 018955 ubiquitin B 9.44118 0.220373 1,11155 RPL3 NM 000967 ribosomal protein L3 9.43772 0.671052 -1.0755 RPL7 NM 000971 ribosomal protein L7 9,436 0.801954 1.0063 EEF1A1 BE786672 eukaryotic translation elongation f 9.43375 0.427973 1.0545 RPLPO BC005863 ribosomal protein, large, P0 9.42602 0.763185 1,0109 HNRNPA1 NM_002136 heterogeneous nuclear ribonucleopro 9.41967 0.406989 1.0617 RPS27 NM 001030 ribosomal protein S27 (metallopanst 9.41628 0.336861 1.0765 RPS1O BC004334 ribosomal protein S10 9.41607 0.712702 1.0426 HLA-C M63438 major histocompatibility complex, c 9.41477 0.750739 -1.0047 RPS1O NM 001014 ribosomal protein S10 9.41418 0.75229 1.0432 RPS21 NM 001024 ribosomal protein S21 9.40759 0.429942 1,0654 HLA-C BC005332 major histocompatibility complex, c 9.40659 0.785125 -1.0054 RPLPO BC003655 ribosomal protein, large, P0 9.40178 0.4799 1,0697 UNC5B AF253979 unc-5 homolog B (C. elegans) 9.40113 0.582518 1,044 HLA-C AK024836 major histocompatibility complex, c 9.39887 0.024909 1.2349 RPS13 NM 001017 ribosomal protein S13 9.39684 0.459016 1,0558 ... AI799007 ... 9.39384 0.197631 1,1377 S100A8 NM 002964 S100 calcium binding protein A8 9.39086 0.015169 1.5466 RPLPO NM 001002 ribosomal protein, large, P0 9.38461 0.485979 1,0669 EEF1A1 BE964125 eukaryotic translation elongation f 9.37992 0.13346 1,11524 RPL3 BG339228 ribosomal protein L3 9.37871 0.839669 -1,044 RPL28 NM 000991 ribosomal protein L28 9,3748 0.39936 1,0608 RPL9 NM 000661 ribosomal protein L9 9.37473 0.258157 1,11118 RPL3 BC006483 ribosomal protein L3 9.36888 0.737559 -1,068 RP11- 78J2 AL568186 heterogeneous nuclear ribonucleopro 9.36012 0.367155 1.0744 RPL24 AI560573 ribosomal protein L24 9.35859 0.501768 1,0478 RPL27 NM 000988 ribosomal protein L27 9.3577 0.503576 1,0509 ACTB AFFX-HSACO actin, beta 9.3571 0.01343 1.3012 EEF1A1 NM 001402 eukaryotic translation elongation f 9.35146 0.240016 1,11134 RPSA AW304232 ribosomal protein SA 9.35114 0.471434 1,0593 RPL30 L05095 ribosomal protein L30 9.35061 0.243352 1,092 RPS4X AW132023 ribosomal protein S4, X-linked 9.35047 0.581757 1.0265 RPS2 NM 002952 ribosomal protein S2 9.34567 0.439845 1.0667 EIF1 BF246436 eukaryotic translation initiation f 9.34057 0.631992 1.0154 GAPDH AFFXHUMGA glyceraldéyde-3-phosphate déydrog 9.33581 0.89193 -1.0392 ACTG1 AW190090 actin, gamma 1 9.33579 0.445738 1,0586 FTL BG53719O ferritin, light polypeptide 9.33422 0.071832 1.2664 RPS16 AI200589 ribosomal protein S16 9.33387 0.391346 1,0779 HLA-C AW575927 major histocompatibility complex, c 9.32293 0.355996 1,084 ACTG1 BE741683 actin, gamma 1 9.32133 0.44021 1,0587 RPS3 U14990 ribosomal protein S3 9.32019 0.477698 1.0542 HLA-C BC004489 major histocompatibility complex, c 9.31866 0.033383 1.2311 RPS2 AA630314 ribosomal protein S2 9.31738 0.4672 1.0644

... NM 173709 ... 9.31716 0.46121 1.1032 RPL37 BF216701 ribosomal protein L37 9.31715 0.311818 1.0865 RPL13A BC001675 ribosomal protein LI3a 9.30846 0.850195 1.0084 RPL7A NM 000972 ribosomal protein L7a 9.30744 0.98087 -1.0241 HLA-A AA573862 major histocompatibility complex, c 9.30649 0.039143 1,22435 FTHP1 J04755 ferritin, heavy polypeptide pseudog 9.30328 0.153458 1,2082 RPS6 BC000524 ribosomal protein S6 9.30218 0.76263 1.0115 HLA-E NM 005516 major histocompatibility complex, c 9.29981 0.005682 1.3252 ... AFFX-R2-P1 ... 9.29925 0.141108 1.1733 HSP90AA 1 ACTG1 R01140 heat shock protein 90kDa alpha (cyt 9,29619 0.472471 1.0427 BG026805 actin, gamma 1 9.28695 0.481606 1.0628 RPL34 NM 000995 ribosomal protein L34 9,28618 0.345932 1.0919 HMGB1 AF283771 high-mobility group box 1 9,28533 0.420569 1,0493 RPL12 AK026491 ribosomal protein LI 2 9.28392 0.529619 1.0438 PPIA AI708767 peptidylprolyl isomerase A (cycloph 9.28151 0.801456 1.0087 HLA-C M12679 major histocompatibility complex, c 9.27185 0.006432 1.3952 UBC AB009010 ubiquitin C 9.26849 0.179327 1.1239 HLA-A AI923492 major histocompatibility complex, c 9,26464 0.066598 1.2639 PPIA BC001224 peptidylprolyl isomerase A (cycloph 9.26039 0.73387 1,0166 RPL17 NM 000985 ribosomal protein LI7 9.25929 0.590458 1.0354 IGLJ3 X57812 immunoglobulin lambda joining 3 9.2531 0.852679 -1.0772 LAMP1 NM 005561 lysosomal-associated membrane prote 9.2518 0.02758 1.2336 IGHA1 S55735 immunoglobulin heavy constant alpha 9.24575 0.161432 -1.2587 RPL13A BF942308 ribosomal protein LI 3a 9,24495 0.907602 -1,019 RPS7 AI970731 ribosomal protein S7 9.24089 0.394691 1,0693 IGHG3 M87789 immunoglobulin heavy constant gamma 9.23447 0.118872 -1.4418 PPIA BE731738 peptidylprolyl isomerase A (cycloph 9.23348 0.914791 -1.0103 PPIA NM 021130 peptidylprolyl isomerase A (cycloph 9.23292 0.774203 1,0124 IFITM2 AA749101 interferon induced transmembrane pr 9.22991 0.010733 1.3418 RPL12 AA281332 ribosomal protein L12 9.22863 0.442312 1,059 PPIA BC005982 peptidylprolyl isomerase A (cycloph 9.22852 0.766783 1.0121 ACTG1 BC001920 actin, gamma 1 9.22635 0.391136 1,0697 TMSB4X AL133228 thymosin beta 4, X-linked 9.22436 0.09178 1.1714 TXNIP NM 006472 thioredoxin interacting protein 9.22385 0.017551 1.3428 RPS18 NM 022551 ribosomal protein S18 9.22347 0.640855 1.0232 B2M AW188940 beta-2-microglobulin 9.22284 0.064391 1,11544 CFL1 NM 005507 cofilin 1 (non-muscle) 9.22219 0.209578 1.1488 HLA-B L42024 major histocompatibility complex, c 9.22158 0.060992 1.2255 Z98200 similar to ribosomal protein L3 9.22142 0.462473 -1.1381

LOC64274

LOC65400 7 BE963164 similar to Elongation factor 1-gamm 9.21894 0.893903 1,0008 / ACTGl AA703939 actin, gamma 1 9.21769 0.478674 1.0512 ACTG1 NM 001614 actin, gamma 1 9,215 0.624088 1.0412 ACTGl AL515810 actin, gamma 1 9.21184 0.445591 1,0659 RPL12 NM 000976 ribosomal protein LI 2 9.20909 0.583603 1,0366

ACTG1 AU145192 actin, gamma 1 9.20749 0.830784 1,0105 ATP13A5 NM 173702 ATPase type 13A5 9.19998 0.345577 1,0798 RPS28 BC000354 ribosomal protein S28 9.19855 0.381597 1,0702 RPL17 BE733979 ribosomal protein LI 7 9.19503 0.70165 1.0193 CXCR4 AJ224869 chemokine (C-X-C motif) receiver 4 9.19395 0.356133 1,0951 GAPDH BE561479 glyceraldéyde-3 -phosphate déydrog 9.19303 0.95088 -1.0228 RPLPO AI953822 ribosomal protein, large, P0 9.1842 0.76663 -1.0503 RPL27A NM 000990 ribosomal protein L27a 9.18373 0.344058 -1,138 RPL8 NM 000973 ribosomal protein L8 9.18043 0.859466 -1.0191 RPL1O NM 006013 ribosomal protein L10 9.17945 0.36895 1.0721 TPT1 AL565449 tumor protein, translationally-cont 9,16944 0.678257 1,0367 RPL13 AA961748 ribosomal protein LI 3 9.16757 0.501828 1.0519 RPL17 BG168283 ribosomal protein LI7 9.16715 0.586324 1,0361 CALM1 NM 006888 calmodulin 1 (phosphorylase kinase, 9.16373 0.124191 1.1384 RPL23A NM 000984 ribosomal protein L23a 9.15434 0.316639 1.0878 RPL32 NM 000994 ribosomal protein L32 9,14479 0.452238 1.0551 PARK7 NM 007262 Parkinson disease (autosomal recess 9.13486 0.868402 -1.0256 RPL14 AA838274 ribosomal protein LI4 9.13319 0.249666 1.1051 RPL14 AV698647 ribosomal protein L14 9,124 0.203838 -1,304 EEF1G AF119850 eukaryotic translation elongation f 9.11523 0.926845 -1.0024 MYL6 BE734356 myosin, light chain 6, alkali, smoo 9.11311 0.039513 1,22264 TPT1 AI888178 tumor protein, translationally-cont 9,1127 0.254352 1.1035 RPL13 AI186735 ribosomal protein LI 3 9.11066 0.871378 1.0094 OAZ1 D87914 omithine decarboxylase antizyme 1 9.10971 0.084005 1.1848 RPL7A BE559788 ribosomal protein L7a 9.10954 0.454251 -1,136 ACTR3 Z78330 ARP3 actin-related protein 3 homolo 9.10385 0.267007 1.0904 RPL13A NM 012423 ribosomal protein LI 3a 9,10061 0.631542 -1.0628 FTH1 NM 002032 ferritin, heavy polypeptide 1 9.09524 0.297546 1.2596 RPL7 BG3 89744 ribosomal protein L7 9.09364 0.515805 -1,086 TUBA1B BC006379 tubulin, alpha lb 9.08109 0.841614 1,0253 RPL13A BC000514 ribosomal protein LI 3a 9,077 0.864916 1,0343 ACTG1 AL567820 actin, gamma 1 9.07471 0.831466 -1.0315 H3F3A AI955655 H3 histone, family 3A 9.07186 0.425505 1,0604 EEF1G NM 001404 eukaryotic translation elongation f 9.07124 0.915188 1,0009 HLA- DRB4 NM 021983 major histocompatibility complex, c 9.07049 0.004755 1,615 RPL13 BC004954 ribosomal protein LI 3 9.06753 0.987902 -1.0063 RPS14 AF116710 ribosomal protein S14 9.06718 0.829329 1.0027 RPLP2 NM 001004 ribosomal protein, large, P2 9.06705 0.96404 1.0063 IGHM BC001872 immunoglobulin heavy constant mu 9.06679 0.060332 -1.5376 LDHB BE042354 lactate déydrogenase B 9.06533 0.254782 -1.1837 RPL6 NM 000970 ribosomal protein L6 9.06527 0.763928 -1.0322 GAPDH AK026525 glyceraldéyde-3-phosphate déydrog 9.06447 0.691828 -1.0585 HMGB1 NM 002128 high-mobility group box 1 9.06167 0.634429 -1.0681 ... AFFXHUMRG ... 9.05778 0.754369 1.0464 PSAP NM 002778 prosaposin (variant Gaucher disease 9.0513 0.014358 1,493 PGK1 NM 000291 phosphoglycerate kinase 1 9.04979 0.708498 1,0253 RPL13 AA789278 ribosomal protein LI 3 9.04579 0.705579 -1.0621 RPS17 BC004886 ribosomal protein SI 7 9.04447 0.86706 -1.0172 IFITM2 NM 006435 interferon induced transmembrane pr 9.0441 0.008667 1.4253

ΑΤΡ5Α1 AI587323 ATP synthase, H + transporting, myth 9.04128 0.343458 -1.1345 VDAC3 BC002456 voltage-dependent anion channel 3 9.04039 0.855195 -1,038 RPS6 BE741754 ribosomal protein S6 9.03922 0.87524 1,011 GAPDH BF689355 glyceraldéyde-3-phosphate déydrog 9.03653 0.721786 -1.0612 AL356115 similar to v-fos transformation eff 9.03645 0.469549 -1.0701

LOC43999

RPS15A NM 001019 ribosomal protein SI5a 9.03616 0.703533 1.0195 H3F3B Z48950 H3 histone, family 3B (H3.3B) 9.03523 0.018645 1,22441 CCDC72 BG167522 coiled-coil domain containing 72 9.03313 0.558874 1.0339 ... AFFX-CREX- ... 9.03182 0.11733 1.1922 GLTSCR2 NM 015710 glioma tumor suppressor candidate r 9.03081 0.321885 1,095 RPS17 NM 001021 ribosomal protein S17 9.02791 0.677306 1,0101 LDHB NM 002300 lactate déydrogenase B 9.02343 0.142411 -1.2633 PTP4A2 U48297 protein tyrosine phosphatase type I 9.0221 0.290558 1.09 RPL38 NM 000999 ribosomal protein L38 9.01145 0.463186 1.0524 RPL4 AI953886 ribosomal protein L4 9.00683 0.291573 -1.1686 RPL4 BC005817 ribosomal protein L4 9.00391 0.291551 -1.1778 CALM2 NM 001743 calmodulin 2 (phosphorylase kinase, 9.00315 0.061735 1.2351 HLA- M27487 major histocompatibility complex, c 8.99731 0.116661 1.3641 DPA1 RPS16 NM 001020 ribosomal protein SI6 8.98755 0.504482 -1.0885 SUBI BG231551 SUBI homolog (S. cerevisiae) 8.98712 0.785248 -1.0771 SRGN NM 002727 serglycin 8.98252 0.021124 1.2154 NPM1 BC002398 nucleophosmin (nucleolar phosphopro 8.97804 0.942268 -1.0452 GZMB J03189 granzyme B (granzyme 2, cytotoxic T 8,9728 0.839811 1,0587 ... AFFX- ... 8.97248 0.927282 -1.0267 RPS25 HUMRG AA888388 ribosomal protein S25 8,968 0.451603 1,0507 RAC2 BE138888 ras-related C3 botulinum toxin subs 8.96722 0.04496 1,2077 RPL19 NM 000981 ribosomal protein LI 9 8.96643 0.984973 -1.02 IFITM3 BF338947 interferon induced transmembrane pr 8.95608 0.004324 1.5349 TUBA1B BC006481 tubulin, alpha lb 8.9533 0.82065 1.0221 H3F3A AA477655 H3 histone, family 3A 8.95196 0.779353 1.0034 YBX1 BC002411 Y box binding protein 1 8.94972 0.491025 -1,085 FTL BG538564 ferritin, light polypeptide 8.94766 0.038142 1,318 TXNDC5 NM 030810 thioredoxin domain containing 5 8.94106 0.030516 -1,748 SFRS11 NM 004768 splicing factor, arginine / serine-ri 8,93673 0.153725 -1.1644 YWHAZ NM 003406 tyrosine 3-monooxygenase / tryptophan 8.93617 0.4536 1.0417 LDHA NM 005566 lactate déydrogenase A 8.93369 0.229237 -1.2105 TUBA1B AL581768 tubulin, alpha lb 8.93318 0.700624 -1,052 UBA52 AF348700 ubiquitin A-52 ribosomal residue pr 8.93116 0.191727 1,11365 BF026595 similar to SI ribosomal protein 40S 8.93012 0.569538 -1,101 LOC40205 7 / BE043477 ATPase, H + transporting, lysosomal 8.92881 0.00176 1.3477 ATP6V0E 1 SAT1 NM 002970 spermidine / spermine N1-acetyltransf 8,92734 0.052755 1,253 PSMB1 W86293 proteasome (prosome, macropain) sub 8.92652 0.290971 1,065 EIF1 AL537707 eukaryotic translation initiation f 8.92356 0.225941 1.1509

RPL4 NM 000968 ribosomal protein L4 8.92326 0.231891 -1,2041 HMGN2 BC003689 high-mobility group nucleosomal bin 8,91576 0.995282 -1.0087 CUGBP2 U69546 CUG triplet repeat, RNA binding pro 8,91464 0.12645 1,11179 ΑΝΡ32Β NM 006401 acidic (leucine-rich) nuclear phosp 8.91131 0.75023 -1.0683 LAPTM5 NM 006762 lysosomal associated multispanning 8.89919 0.01393 1.3365 ARHGDIB NM_001175 Rho GDP dissociation inhibitor (GDI 8.89875 0.147922 1.1675 HLA- DRB5 NM_002125 major histocompatibility complex, c 8.89872 0.024751 1,392 EIF1 W67644 eukaryotic translation initiation f 8.89125 0.286604 1,11281 MCL1 AI275690 myeloid cell leukemia sequence 1 (B 8.8908 0.010518 1.4101 ETS1 BE218980 v-ets erythroblastosis virus E26 on 8.89057 0.337203 1.0935 PGAM1 NM 002629 phosphoglycerate mutase 1 (brain) 8.88869 0.404531 1,057 TPT1 AF072098 tumor protein, translationally-cont 8.88478 0.351409 -1.0899 EIF1 AF083441 eukaryotic translation initiation f 8.88283 0.190526 1.1643 RPLPO-lik AA555113 ribosomal protein P0-like 8.88164 0.224729 -1.2465 JTB NM 006694 jumping translocation breakpoint 8.87785 0.181525 -1.1605 PPIB NM 000942 peptidylprolyl isomerase B (cycloph 8.87774 0.179995 -1,1752 HMGB2 BC000903 high-mobility group box 2 8.87201 0.630332 -1,058 DDX5 NM 004396 DEAD (Asp-Glu-Ala-Asp) box polypept 8.87179 0.071368 1,11292 STK24 AF083420 serine / threonine kinase 24 (STE20 h 8.87093 0.745207 1.0089 NBPF12 AI800419 neuroblastoma breakpoint family, me 8.87085 0.019139 1.3092 KARS NM 005548 lysyl-tRNA synthetase 8.86896 0.184249 1.2056 GAPDH AFFXHUMGA glyceraldéyde-3-phosphate déydrog 8.86808 0.422229 -1,1047 RAP1B NM 015646 RAP1B, member of RAS oncogene famil 8.86544 0.201436 1,11411 NCOA4 AL162047 nuclear receptor coactivator 4 8.85785 0.080125 1,202 LYZ AV711904 lysozyme (renal amyloidosis) 8.85778 0.037997 1.4136 NACA NM 005594 nascent polypeptide-associated comp 8.85536 0.424115 -1.0899 NACA BF976260 nascent polypeptide-associated comp 8.85465 0.43483 -1.0977 HSPA8 AA704004 heat shock 70kDa protein 8 8.85434 0.562599 1,0674 TUBA1B BE300252 tubulin, alpha lb 8.85365 0.791074 -1.04 RPL29 BF683426 ribosomal protein L29 8.85113 0.981075 -1.0072 JTB AF151056 jumping translocation breakpoint 8.85066 0.360407 -1,149 HLA- DRB1 U65585 major histocompatibility complex, c 8.84778 0.004772 1,674 H3F3A BF312331 H3 histone, family 3A 8.84764 0.948572 -1.0226 RPL22 BG152979 ribosomal protein L22 8.84735 0.21061 -1.1931 RPL18 NM 000979 ribosomal protein LI 8 8.84354 0.603153 -1.0798 COX7A2 NM 001865 cytochrome c oxidase subunit Vila p 8.84329 0.862977 -1,056 CALM1 BC000454 calmodulin 1 (phosphorylase kinase, 8.84239 0.491245 1,0676 SEPT9 AB023208 septin 9 8.83562 0.318261 1.0829 RPL21 NM 000982 ribosomal protein L21 8.83217 0.491557 -1.0984 LOC39018 AL121916 similar to Ribosomal protein S4, X- 8.82901 0.320864 -1.1639 D TMEM66 NM 016127 transmembrane protein 66 8.82831 0.449138 1.0411 SFRS10 NM 004593 splicing factor, arginine / serine-ri 8.82767 0.722992 1,0123 MRFAP1 BG435643 Mof4 family associated protein 1 8.82497 0.009441 1.2186

PABPC1 AI734929 poly (A) binding protein, cytoplasmi 8.82396 0.788552 -1.0244 YWHAB NM 014052 tyrosine 3-monooxygenase / tryptophan 8.82329 0.042936 1.2248 USMG5 BG291685 upregulated during skeletal muscle 8.82282 0.40484 -1.0995 SNX3 AB047360 sorting nexin 3 8.82178 0.081311 1.1552 DUSP1 NM 004417 dual specificity phosphatase 1 8.81961 0.074007 1.5588 HNRPM AL713781 heterogeneous nuclear ribonucleopro 8.81197 0.333136 -1,198 PTPRC Y00062 protein tyrosine phosphatase, recep 8.81028 0.030575 1.1735 EIF4G2 NM 001418 eukaryotic translation initiation f 8.80702 0.496202 -1,072 FKBP11 NM 016594 FK506 binding protein 11.19 kDa 8.80684 0.031309 -1.5631 EIF3EIP NM 016091 eukaryotic translation initiation f 8.80043 0.244783 -1,2092 RPL5 NM 000969 ribosomal protein L5 8.79898 0.115551 -1.2494 ARL6IP5 NM 006407 ADP-ribosylation-like factor 6 inte 8,79615 0.008646 1.2454 RPS9 NM 001013 ribosomal protein S9 8,7888 0.649216 1.0829 LRRFIP1 AF130054 leucine rich repeat (in FLII) inter 8.7862 0.001476 1,44494 CD53 NM 000560 CD53 molecule 8.78328 0.00198 1.3513 SELL NM 000655 selectin L (lymphocyte adhesion mol 8.78176 0.017184 1,252 TNFAIP3 NM 006290 tumor necrosis factor, alpha-induce 8.77338 0.310663 1.1847 RPS5 NM 001009 ribosomal protein S5 8.77137 0.261117 -1.2117 SEC11A NM 014300 SEC11 homolog A (S. cerevisiae) 8.77122 0.671295 1.0215 NDUFS6 NM 004553 NADH déydrogenase (ubiquinone) Fe- 8,7707 0.487406 -1.0913 H3F3B NM 005324 H3 histone, family 3B (H3.3B) 8.77049 0.006003 1.2459 RPL22 D17652 ribosomal protein L22 8.76953 0.224893 -1.1997 IFI30 NM 006332 interferon, gamma-inducible protein 8.76733 0.006894 1.7446 ITM2B NM 021999 integral membrane protein 2B 8.76641 0.018103 1,239 SNHG5 BG339050 small nucleolar RNA host gene (non- 8.76076 0.686548 1.0655 ANXA2 BE908217 annexin A2 8,789 0.112224 1.1966 LBR NM 002296 laminate B receiver 8,73636 0.49024 1.0725 DAZAP2 NM 014764 DAZ associated protein 2 8.73274 0.040265 1,192 CAP1 AA806142 CAP, adenylate cyclase-associated p 8.73267 0.095262 1.1986 MORF4L2 NM 012286 mortality factor 4 like 2 8.73006 0.983915 -1.0086 DAZAP2 N34846 DAZ associated protein 2 8.7283 0.015479 1.3032 PSME2 NM 002818 proteasome (prosome, macropain) act 8.72604 0.344588 1,11192 LOC15266 α AJ224080 similar to ribosomal protein L7a 8.7241 0.427953 -1,137 j RPL15 AF279903 ribosomal protein LI 5 8.72273 0.776328 -1.0353 IGJ AV733266 immunoglobulin J polypeptide, link 8.71951 0.543791 -1.0706 COPB1 NM 016451 coatomer protein complex, subunit b 8.71621 0.955809 -1.0384 TRAM1 BC000687 translocation associated membrane p 8.71566 0.215917 -1.1522 HSPA8 AF217511 heat shock 70kDa protein 8 8,71414 0.887456 1,0461 OAZ1 AF090094 omithine decarboxylase antizyme 1 8.71171 0.16295 1.1394 TUBA1C BC004949 tubulin, alpha lc 8.70601 0.690914 -1.0738 CDV3 AK025647 CDV3 homolog (mouse) 8.70557 0.416355 -1.1748 NFKBIZ AB037925 nuclear factor of kappa light polyp 8.70271 0.184594 1.2322 JTB BC004239 jumping translocation breakpoint 8.70164 0.147036 -1.1991 MRLC2 U26162 myosin regulatory light chain MRLC2 8.69791 0.001244 1.2847 CBX3 NM_016587 chromobox homolog 3 (HP1 gamma homo 8.6959 0.626431 -1.0583 NBPF1 BF740216 neuroblastoma breakpoint family, me 8.69552 0.020385 1,307 RPL14 U16738 ribosomal protein LI 4 8.69417 0.733336 -1.0329

SLC25A6 AI961224 solute carrier family 25 (mitochond 8.69288 0.411253 -1.0783 SNRPG NM 003096 small nuclear ribonucleoprotein pol 8.69182 0.564187 -1.0556 NBPF11 BE299495 neuroblastoma breakpoint family, me 8.69027 0.027597 1.2842 EIF4A2 NM 001967 eukaryotic translation initiation f 8.68518 0.27169 1.0921 GNAS NM 000516 GNAS complex locus 8.68128 0.136389 -1.2194 HIF1A NM 001530 hypoxia-inducible factor 1, alpha s 8.68125 0.55657 1,096 ANXA2 NM 004039 annexin A2 8.67919 0.198595 1.1553 LOC38834 Λ AW574664 similar to RPL13 protein 8.67576 0.510046 -1,1066 ANXA2 BC001388 annexin A2 8.67456 0.150184 1.1769 TUBA1B NM 006082 tubulin, alpha lb 8.67401 0.649176 -1.0709 HNRPD D55672 heterogeneous nuclear ribonucleopro 8.67246 0.109788 -1.2204 GNAS AI591100 GNAS complex locus 8.6705 0.21107 -1.1814 RPL13A BF979419 ribosomal protein LI 3a 8.67017 0.656611 -1.0468 H2AFZ BF718636 H2A histone family, member Z 8.66877 0.128288 -1.2753 RABIA BC000905 RABIA, member RAS oncogene family 8.66619 0.265013 1,084 YWHAQ BF033313 tyrosine 3-monooxygenase / tryptophan 8.66619 0.548594 -1.0615 SUMO2 AI971724 SMT3 suppressor of mif two 3 homolo 8.66018 0.264149 1,11115 NDUFB8 NM 005004 NADH déydrogenase (ubiquinone) 1 b 8.65785 0.457879 -1.0677 C0X4I1 NM 001861 cytochrome c oxidase subunit IV iso 8.65772 0.993453 1.0122 CD47 BG230614 CD47 molecule 8.65507 0.197202 1.0755 RPS26 NM 001029 ribosomal protein S26 8.65078 0.128958 -1.3425 HNRPH1 NM 005520 heterogeneous nuclear ribonucleopro 8.64889 0.11545 1.1881 C20orfll8 AA603344 chromosome 20 open reading frame 11 8.6481 0.001997 1.5776 GNAS NM 016592 GNAS complex locus 8.64755 0.216701 -1.1834 ... AFFX-M2783 ... 8.64732 0.329731 -1,112 NBPF1 N32025 neuroblastoma breakpoint family, me 8.64711 0.040338 1.2668 PPIB NM 000942 peptidylprolyl isomerase B (cycloph 8.64481 0.061964 -1.3924 HNRPA3 BC012090 heterogeneous nuclear ribonucleopro 8.64043 0.213013 1.1624 DDX17 Z97056 DEAD (Asp-Glu-Ala-Asp) box polypept 8.63854 0.19513 1,1077 SKP1 AA927664 S-phase kinase-associated protein 1 8.63829 0.272737 1,0682 GDI2 NM 001494 GDP dissociation inhibitor 2 8.63786 0.502036 1.0918 IGLL3 AL022324 lambda-like immunoglobulin polypept 8.63641 0.007524 -2,578 SPCS2 NM 014752 signal peptidase complex subunit 2 8.63436 0.211341 -1,2067 ADD3 NM 019903 adducin 3 (gamma) 8.63106 0.883335 1.0068 TPM3 BC000771 tropomyosin 3 8.62948 0.006796 1.2679 TUBA1A AF141347 tubulin, alpha la 8.62436 0.008598 1.8686 RRM2 BE966236 ribonucleotide reductase M2 polypep 8.62408 0.07486 -1.5518 SULT1C4 NM 006588 sulfotransferase family, cytosolic, 8.62073 0.607141 -1.0942 YWHAQ AA854017 tyrosine 3-monooxygenase / tryptophan 8.62006 0.83803 -1.0346 MATR3 AA129420 matrin 3 8.61975 0.947878 -1.0071 FNTA BG168896 famesyltransferase, CAAX box, alph 8.61832 0.420763 1,0906 CIRBP NM 001280 cold inducible RNA binding protein 8.61794 0.667038 1,0242 PSMC2 NM 002803 proteasome (prosome, macropain) 26S 8.61788 0.768603 -1.0291 ... AFFX-CREX- ... 8.61406 0.120663 1,203 SPCS1 NM 014041 signal peptidase complex subunit 1 8.61253 0.03051 -1.4228 NM 006791 mortality factor 4 like 1 8.61235 0.438021 1,0409

M0RF4L1

TO GIVE NM 001111 adenosine deaminase, RNA-specific 8.61157 0.002492 1.3729 HNRPK BC000355 heterogeneous nuclear ribonucleopro 8.61084 0.826012 1,0163 ... AV756161 ... 8.61014 0.8532 -1,045 ChlorflO NM 014206 chromosome 11 open reading frame 10 8,60968 0.051991 -1.2891 PTMA NM 002823 prothymosin, alpha (gene sequence 2 8,6087 0.658373 1,021 BTN3A3 NM 006994 butyrophilin, subfamily 3, member A 8.60384 0.005682 1.3936 IFITM1 NM 003641 interferon induced transmembrane pr 8.60378 0.001576 1.5969 TUBA1C BC005946 tubulin, alpha lc 8.60342 0.694183 -1.0727 SEC61B NM 006808 Sec61 beta subunit 8.60329 0.063735 -1.3585 PABPC3 NM 030979 poly (A) binding protein, cytoplasmi 8.60118 0.388877 -1,104 CYCS BC005299 cytochrome c, somatic 8.60042 0.075356 -1.2815 PTMA AF348514 prothymosin, alpha (gene sequence 2 8.5994 0.144158 1.2109 ARPC2 BG034239 actin related protein 2/3 complex, 8.59816 0.127318 1,11544 RPL36AL NM 001001 L36a-like ribosomal protein 8,59726 0.229918 -1,236 PRICKLE THE NM 017601 prickle homolog 4 (Drosophila) 8.59693 0.728453 -1.0464 H· STAT1 NM 007315 signal transducer and activator of 8.59651 0.022135 1,44528 C20orfll8 BF437747 chromosome 20 open reading frame 11 8.5961 0.001886 1.6089 RPS27A NM 002954 ribosomal protein S27a 8.59553 0.070705 -1.4124 TMEM123 BG538627 transmembrane protein 123 8.59401 0.349258 1,1005 RHOA BC001360 ras homolog gene family, member A 8.59283 0.016069 1.1702 RPS24 BC000523 ribosomal protein S24 8.59161 0.393334 -1,115 TMBIM4 AF161526 transmembrane B AX inhibitor motif c 8,58976 0.310843 1,1017 SERBP1 AF131807 SERPINE1 mRNA binding protein 1 8,58742 0.385759 -1.1135 CD52 N90866 CD52 molecule 8.58717 0.032139 1.3885 C20orf24 NM 018840 chromosome 20 open reading frame 24 8.58661 0.023381 1,1904 SAT1 M55580 spermidine / spermine N1 -acetyltransf 8.5846 0.077824 1.5407 SLC25A5 NM 001152 solute carrier family 25 (mitochond 8,58375 0.198028 -1.1865 ITGB1 BG500301 integrin, beta 1 (fibronectin recep 8.58222 0.847869 1,0179 DHX15 NM_001358 DEAH (Asp-Glu-Ala-His) box polypept 8.57962 0.983785 -1.0249 HMGN1 NM 004965 high-mobility group nucleosome bind 8,57611 0.373303 -1.0987 NPM1 AA191576 nucleophosmin (nucleolar phosphopro 8.57503 0.040137 -1.5236 ... AFFX- HUMRG ... 8.57265 0.788727 -1.0247 ATP5E NM 006886 ATP synthase, H + transporting, myth 8.57105 0.962371 -1.0062 SFPQ AL558875 splicing factor proline / glutamine-r 8.57035 0.708656 -1.0445 SLC25A3 NM 002635 solute carrier family 25 (mitochond 8.56151 0.267652 -1.1243 FCN1 NM 002003 ficolin (collagen / fibrinogen domain 8,55761 0.059741 1.9616 GNA13 AI928136 guanine nucleotide binding protein 8.55261 0.160771 1,141 PRF1 AI445650 perforin 1 (pore forming protein) 8.55224 0.146867 1.3625 EIF3F NM 003754 eukaryotic translation initiation f 8.55096 0.087846 -1.2208 SSR4 NM 006280 signal sequence receiver, delta (tr 8,5484 0.039545 -1.3429 ACTR3 NM 005721 ARP3 actin-related protein 3 homolo 8.54681 0.299654 1,11411 GZMA NM 006144 granzyme A (granzyme 1, cytotoxic T 8,54675 0.861827 1,0809 PPP1CC NM 002710 protein phosphatase 1, catalytic su 8.54295 0.14502 -1,1641 SERP1 NM 014445 stress-associated endoplasmic retic 8.54186 0.289653 -1.1623 ATP5B NM 001686 ATP synthase, H + transporting, myth 8.54112 0.256857 -1,1449 NACAP1 AF315951 nascent-polypeptide-associated comp 8.53938 0.48654 1,11192

OGT AF070560 O-linked N-acetylglucosamine (GlcNA 8.53847 0.383879 -1,115 SNX3 AL078596 sorting nexin 3 8.53255 0.025265 1,1466 MRCL3 NM 006471 myosin regulatory light chain MRCL3 8.5315 0.021295 1.2678 CARS AI769685 cysteinyl-tRNA synthetase 8.53135 0.559251 1.0334 BTG1 AL535380 B-cell translocation gene 1, anti-p 8.53125 0.66227 1,0778 TFRC BC001188 transferrin receptor (p90, CD71) 8.52902 0.258864 1,11189 GLRX NM 002064 glutaredoxin (thioltransferase) 8.52836 0.363547 1.2252 SFRS3 BC000914 splicing factor, arginine / serine-ri 8.52745 0.196148 -1.2157 NDUFB2 NM 004546 NADH déydrogenase (ubiquinone) 1 b 8.52523 0.808646 1,0203 CAPZA1 NM 006135 capping protein (actin filament) mu 8.52204 0.563771 1,0601 EIF4A1 BC006210 eukaryotic translation initiation f 8.52195 0.319129 -1,174 HINT1 AK054976 histidine triad nucleotide binding 8.51944 0.801409 -1.0371 ARPC2 NM 005731 actin related protein 2/3 complex, 8.51808 0.382069 1.1455 ENO1 NM 001428 enolase 1, (alpha) 8.51426 0.78052 -1.0508 Cllorf31 AA526939 chromosome 11 open reading frame 31 8.51262 0.885715 -1,0008 RPL22 NM 000983 ribosomal protein L22 8.5116 0.064639 -1,3701 RPN2 AL514285 ribophorin II 8.50781 0.026513 -1,3485 H3F3B BC001124 H3 histone, family 3B (H3.3B) 8.50458 0.008086 1.2685 RRM2 BC001886 ribonucleotide reductase M2 polypep 8,49655 0.075038 -1,603 WAC AL135461 WW domain containing adapter with c 8,49213 0.470841 1.0736 XAF1 AA142842 XIAP associated factor 1 8.4916 0.026902 1.8594 RPL35 NM 007209 ribosomal protein L35 8.49106 0.953744 -1,017 AQP3 N74607 aquaporin 3 (Gill blood group) 8,48628 0.041547 -1,5061 SLC38A2 AF298897 solute carrier family 38, member 2 8.4831 0.724251 1.0312 SEPT2 NM 004404 septin 2 8.48295 0.601425 -1.0528 PNRC2 NM 017761 proline-rich nuclear coact receiver 8.48146 0.529099 1.0428 SERBP1 BC002488 SERPINE1 mRNA binding protein 1 8.48085 0.074077 -1.2827 RPN2 AI560720 ribophorin II 8.48047 0.020623 -1.3683 HNRNPA1 X79536 heterogeneous nuclear ribonucleopro 8.48 0.109978 -1.1823 PSME1 NM 006263 proteasome (prosome, macropain) act 8,47861 0.020071 1.1923 ATP5C1 AV711183 ATP synthase, H + transporting, myth 8,47568 0.35253 -1.0916 VCAN BF218922 versican 8.47389 0.379926 1.2321 PSMB4 NM 002796 proteasome (prosome, macropain) sub 8.47364 0.347902 -1.0981 RPL11 NM 000975 ribosomal protein Ll 1 8,47332 0.879096 -1.0063 GTF3A NM 002097 general transcription factor IIIA 8.47227 0.126196 -1,195 EEF1B2 NM 001959 eukaryotic translation elongation f 8.47175 0.074916 -1.3207 HLA-C BG536224 major histocompatibility complex, c 8.46867 0.028967 -1.7709 PTP4A2 AF208850 protein tyrosine phosphatase type I 8.46819 0.626678 -1.0479 PLAC8 NM 016619 placenta-specific 8 8.46743 0.160626 1.4257 PSMA6 BC002979 proteasome (prosome, macropain) sub 8,46112 0.745441 1,0126 ATP5F1 BC005960 ATP synthase, H + transporting, myth 8,46058 0.306271 -1.11 GTF3A BE542815 general transcription factor IIIA 8.45894 0.185403 -1.1777 HIST1H4C NM_003542 histone cluster 1, H4c 8.45875 0.040247 -1.7231 PSMB9 NM 002800 proteasome (prosome, macropain) sub 8,45623 0.00005 1.5788 HSPD1 NM 002156 heat shock 60kDa protein 1 (chapero 8,455,522 0.014228 -1,602 CANX M94859 calnexin 8,448 0.06167 -1.3139 GPX1 NM 000581 glutathione peroxidase 1 8,44558 0.551288 1.1574 PABPC1 U64661 poly (A) binding protein, cytoplasmi 8,44432 0.43789 -1.0964

YWHAZ NM 003406 tyrosine 3-monooxygenase / tryptophan 8.44163 0.973987 -1.0225 SNRPD3 NM 004175 small nuclear ribonucleoprotein D3 8.44146 0.098063 -1.2019 GNLY M85276 granulysin 8.44141 0.369248 1.3198 UBC M26880 ubiquitin C 8.44112 0.036395 1.2383 HNRNPR BC001449 heterogeneous nuclear ribonucleopro 8.44106 0.215056 -1,1047 CROP NM 006107 cisplatin resistance-associated ove 8.44072 0.549831 -1,1129 IFI16 AF208043 interferon, gamma-inducible protein 8.43852 0.126521 1,388 HLA-F AW514210 major histocompatibility complex, c 8.43622 0.000621 1.43 RTN4 AF320999 reticulon 4 8.43528 0.00766 1,22524 KLF2 NM 016270 Kruppel-like factor 2 (lung) 8.43483 0.382317 1.1502 HLA-B L07950 major histocompatibility complex, c 8.43407 0.03959 1.3362 CLIC1 AF034607 intracellular chloride channel 1 8.43405 0.194511 1.1505 RANBP9 AF306510 RAN binding protein 9 8.42932 0.148105 -1.1877 HSP90AA 1 C20orf24 BG420237 heat shock protein 90kDa alpha (cyt 8.42928 0.464569 1,0409 BC004446 chromosome 20 open reading frame 24 8.4271 0.038037 1,2048 MAPRE1 NM 012325 microtubule-associated protein, RP / 8.4262 0.931121 -1.0322 H3F3A BE869922 H3 histone, family 3A 8.42557 0.937962 -1.08 RPL3 L22453 ribosomal protein L3 8.4254 0.098997 -1,3361 KLF6 BU683415 Kruppel-like factor 6 8.42156 0.046383 1.5129 YME1L1 NM 014263 YMEl-like 1 (S. cerevisiae) 8.42027 0.8865 -1.0083 SUBI BE784583 SUBI homolog (S. cerevisiae) 8.41998 0.039766 -1,331 CAPN2 M23254 calpain 2, (m / II) large subunit 8.4195 0.411411 1.0755 IL23A AL559122 interleukin 23, alpha subunit pl9 8.41855 0.904095 1.0529 ATP5C1 BC000931 ATP synthase, H + transporting, myth 8.41843 0.375003 -1.0987 IRF2BP2 AW242432 interferon regulatory factor 2 bind 8.4171 0.227106 1,2063 IL7R BE217880 interleukin 7 receiver 8.41659 0.973402 1,0126 TRIB1 NM 025195 tribbles homolog 1 (Drosophila) 8.41559 0.796679 1.0818 RPL35A AW402660 ribosomal protein L35a 8.41197 0.872273 -1,029 SSR1 NM 003144 signal sequence receiver, alpha (tr 8.41137 0.00612 -1.5507 PRPF40A NM_017892 PRP40 pre-mRNA processing factor 40 signal recognition particle 14kDa ( 8,40789 0.276653 1.0767 SRP14 NM 003134 8.40329 0.403397 -1.0662 HSP90AA 1 NINTH AF028832 heat shock protein 90kDa alpha (cyt 8,40219 0.38341 -1.0762 NM 007363 non-POU domain containing, octamer- 8,40037 0.631831 -1.0413 ALDOA AK026577 aldolase A, fructose-bisphosphate 8.40029 0.405992 1.1089 ZC3HAV1 AI133727 zinc finger CCCH-type, antiviral 1 8.39856 0.49176 1,0454 NFKBIA AI078167 nuclear factor of kappa light polyp 8.39693 0.723447 1,0851 HLADRB1 AJ297586 major histocompatibility complex, c 8.39671 0.017874 1.7361 PRDX1 L19184 peroxiredoxin 1 8,39621 0.233972 -1.1572 DNAJC1 BF591419 DnaJ (Hsp40) homolog, subfamily C, 8.3948 0.295562 -11586 FAM120A BE963765 family with sequence similarity 120 8,39418 0.86461 1.0183 NM_002137 heterogeneous nuclear ribonucleopro 8.39305 0.128769 -1.1834

HNRNPA2 BI

HNRPDL D89092 heterogeneous nuclear ribonucleopro 8.3923 0.849824 -1.0149 LAP3 NM 015907 leucine aminopeptidase 3 8.39046 0.092932 1.4073 XRN1 BG534738 5-3 'exoribonuclease 1 8.3903 0.007922 1.3637 IKZF1 AI741188 IKAROS family zinc finger 1 (Ikaros 8.38925 0.1615 1,11392 PTPRO U20489 protein tyrosine phosphatase, recep 8.38858 0.45852 -1.0965 ... AI475680 ... 8,38786 0.73979 1.0292 YY1 NM 003403 YY1 transcription factor 8.38742 0.894068 1,006 EIF4A1 NM 001416 eukaryotic translation initiation f 8,38655 0.411834 -1.0963 ATP5L AF070655 ATP synthase, H + transporting, myth 8.38536 0.130216 -1.1949 MKNK2 NM 017572 MAP kinase interacting serine / threo 8,38535 0.007243 1,374 CD99 NM 002414 CD99 molecule 8.38057 0.768741 1,0809 GLUL AL161952 glutamate-ammonia ligase (glutamine 8.38042 0.026311 1.7408 SFRS2 NM 003016 splicing factor, arginine / serine-ri 8.37976 0.549051 -1.1154 BAT2D1 AL096857 BAT2 domain containing 1 8.37657 0.65826 1.0339 SSR2 NM 003145 signal sequence receiver, beta (tra 8.37371 0.053499 -1,3037 RASSF5 BC004270 Ras association (RalGDS / AF-6) domai 8.37363 0.425454 1.0467 HNRPA3P 1 NDUFA12 BG505670 heterogeneous nuclear ribonucleopro 8.37123 0.337738 -1,1205 AF217092 NADH déydrogenase (ubiquinone) 1 a 8.37103 0.540797 -1.0946 ATF4 NM 001675 activating transcription factor 4 ( 8.37068 0.038601 -1.2466 PDLA6 BE910010 protein disulfide isomerase family 8.37012 0.020271 -1,4064 UCP2 U94592 uncoupling protein 2 (mitochondrial 8.37008 0.034364 1.3434 COX6B1 NM 001863 cytochrome c oxidase subunit Vib po 8.36865 0.526681 1.0611 KPNB1 BG249565 karyopherin (importin) beta 1 8.36813 0.6602 -1.0783 CD 164 NM 006016 CD 164 molecule, sialomucin 8,36798 0.03153 1.1897 C14orf2 AF116639 chromosome 14 open reading frame 2 8.36406 0.324647 -1.0952 HIATL1 AF130099 hippocampus abundant transcript-lik 8,36375 0.140116 -1.1371 MX1 NM 002462 myxovirus (influenza virus) resist 8.36328 0.520428 1.3424 ARF4 NM 001660 ADP-ribosyiation factor 4 8.36192 0.385816 -1,148 RPL35A BE968801 ribosomal protein L35a 8,3604 0.165992 -1,1602 COX7B NM 001866 cytochrome c oxidase subunit Vllb 8.35879 0.552375 -1.0948 CUTA AF230924 cutA divalent cation tolerance homo 8.35867 0.068731 -1,241 GGA1 AW009695 golgi associated, gamma adaptin ear 8.35687 0.629857 1,0509 SFRS5 NM 006925 splicing factor, arginine / serine-ri 8.35184 0.027215 1.2557 MSN NM 002444 moesin 8.35141 0.181786 1.1855 DUT U62891 deoxyuridine triphosphatase 8.35055 0.188521 -1.2369 ATP5L AL050277 ATP synthase, H + transporting, myth 8.34504 0.083496 -1.2366 NARS NM 004539 asparaginyl-tRNA synthetase 8,34449 0.635304 -1.0749 SIDT2 AA150165 SID1 transmembrane family, member O 8,34325 0.00485 1.9548 GHITM AF131820 z growth hormone inducible transmembr 8,34322 0.106941 -1,2067 DEK NM 003472 DEK oncogene (DNA binding) 8,34219 0.098052 1.1739 ISG20 U88964 interferon stimulated exonuclease g 8.34132 0.524488 1,1466 TP53INP1 AW341649 nuclear protein p53 inducible tumor 8,33664 0.013329 -1.4612 RPL23 NM 000978 ribosomal protein L23 8.33294 0.947883 -1.0515 EEF1D NM 001960 eukaryotic translation elongation f 8.33234 0.745396 -1,037 DDX3X NM_001356 DEAD (Asp-Glu-Ala-Asp) box polypept 8.33229 0.953913 -1.0772 RPL36 NM015414 ribosomal protein L36 8.32832 0.321675 -1,097

S100A9 NM 002965 SI 00 calcium binding protein A9 8.32804 0.017515 2.0885 GCH1 NM 000161 GTP cyclohydrolase 1 (dopa-responsi 8.32697 0.002631 1.6161 ALDOA NM 000034 aldolase A, fructose-bisphosphate 8.32541 0.537656 1.0768 ATP5C1 NM 005174 ATP synthase, H + transporting, myth 8.32478 0.402435 -1.0772 HNRNPC AV725195 heterogeneous nuclear ribonucleopro 8.32323 0.619889 -1.0633 MT2A NM 005953 metallothionein 2A 8.32201 0.000184 1.7931 RABGGT B CEBPB U49245 Rab geranylgeranyltransferase, beta 8.32127 0.727953 -1.0337 AL564683 CCAAT / enhancer binding protein (C / E 8.3206 0.041769 1,753 C2orf25 NM 015702 chromosome 2 open reading frame 25 8.31939 0.118611 -1.1739 HLA-E X56841 major histocompatibility complex, c 8.31854 0.026943 1,44724 BTF3 X74070 basic transcription factor 3 8.31805 0.081674 -1,1602 FGD2 NM_173558 FYVE, RhoGEF and PH domain containi 8.31601 0.048059 1.9222 S100A4 NM 002961 SI00 calcium binding protein A4 8,314 0.020537 1,66863 CTSS AK024855 cathepsin S 8.31386 0.052636 1,5002 XPO1 D89729 exportin 1 (CRM1 homolog, yeast) 8.31266 0.714281 1,0576 COX4I1 AA854966 cytochrome c oxidase subunit IV iso 8.31042 0.337784 1.1079 RGS1 S59049 regulator of G-protein signaling 1 8,30962 0.667615 -1.1409 BTG1 NM 001731 B-cell translocation gene 1, anti-p 8,30697 0.347294 1,097 EIF3E BC000734 eukaryotic translation initiation f 8.30594 0.229759 -1,144 RBM39 NM 004902 RNA binding motif protein 39 8.30573 0.621206 1,0377 ... AFFX-R2-EC ... 8,30493 0.136681 1,188 IL23A M15564 interleukin 23, alpha subunit pl9 8.30309 0.613798 -1.0291 TMEM50 THE AL550722 transmembrane protein 50A 8.30289 0.50782 -1.0896 r \ ERH NM 004450 enhancer of rudimentary homolog (Dr 8.30258 0.964687 -1.0172 CKAP4 NM 006825 cytoskeleton-associated protein 4 8.29994 0.229647 -1.2417 HNRPD M94630 heterogeneous nuclear ribonucleopro 8.29747 0.160675 -1.1848 GGA1 AW001443 golgi associated, gamma adaptin ear 8.29674 0.586356 1.0567 URG4 BF970023 up-regulated gene 4 8.29555 0.306455 -1.1575 ARPC2 AF279893 actin related protein 2/3 complex, 8.29498 0.249624 1,1009 STARD7 NM 020151 StAR-related lipid transfer (START) 8,29465 0.954305 -1.0062 RPS27L NM 015920 ribosomal protein S27-like 8.29376 0.540076 1.0992 SMCR8 N25727 Smith-Magenis syndrome chromosome r 8.29287 0.088141 1.2924 RPL24 NM 000986 ribosomal protein L24 8.29274 0.506332 -1.0651 LOC64689 0 SEPT7 W72220 hypothetical LOC646890 8.29227 0.24446 1.0969 AU157515 septin 7 8.29012 0.615907 1.0426 RAC1 BG292367 ras-related C3 botulinum toxin subs 8.28598 0.142416 1,11527 SDCBP NM 005625 syndecan binding protein (syntenin) 8.2835 0.062812 1.3584 GNLY NM 006433 granulysin 8,28235 0.383517 1.3033 FOXP1 AK026898 forkhead box Pl 8,28233 0.950153 -1,039 KHDRBS1 NM 006559 KH domain containing, RNA binding, 8,282 0.880587 -1.0146 ISG15 NM_005101 ISG15 ubiquitin-like modifier 8.28172 0.083812 1,913

CAP1 NM 006367 CAP, adenylate cyclase-associated p 8.28066 0.057672 1,22419 FTH1 AA083483 ferritin, heavy polypeptide 1 8.28056 0.360314 1.4026 GNAS AF088184 GNAS complex locus 8,27878 0.010903 -1.8682 GNB2L1 NM 006098 guanine nucleotide binding protein 8.27566 0.157792 -1,2041 HSP90B1 NM 003299 heat shock protein 90kDa beta (Grp9 8.2753 0.005488 -1,9074 ANXA1 NM 000700 annexin Al 8.27519 0.121859 1,247 SNRPA1 NM 003090 small nuclear ribonucleoprotein pol 8.27426 0.266829 -1.0958 COX8A NM 004074 cytochrome c oxidase subunit 8A (ub 8.27069 0.766653 -1.0428 RPS8 NM 001012 ribosomal protein S8 8.27038 0.160062 -1,168 PPP6C NM 016294 protein phosphatase 6, catalytic su 8.2644 0.335491 -1.1229 MAPK1IP 1L S100A10 AI671747 mitogen-activated protein kinase 1 8.26426 0.590003 -1.0544 NM 002966 SI00 calcium binding protein A10 8.26219 0.064505 1.2626 HNRPDL NM 005463 heterogeneous nuclear ribonucleopro 8.25823 0.180024 -1.1425 DBI NM 020548 diazepam binding inhibitor (GABA re 8.25394 0.284601 1.0937 PTGES3 BC003005 prostaglandin E synthase 3 (cytosol 8.25277 0.892391 -1.0057 PTMA BF686442 prothymosin, alpha (gene sequence 2 8.25224 0.652471 1.0518 MAP3K5 NM 005923 mitogen-activated protein kinase ki 8.25208 0.25101 1.1085 CCT2 NM 006431 chaperonin containing TCP1, subunit 8.24577 0.063573 -1,3234 CD3D NM_000732 CD3d molecule, delta (CD3-TCR compl 8.24324 0.9706 1,0481 KCMF1 NM 020122 potassium channel modulatory factor 8.23504 0.155602 -1.1713 TNPO1 AI307759 transportin 1 8.23501 0.339538 -1,1128 HMGB1 BF673940 high-mobility group box 1 8.23251 0.474802 -1,072 GAPDH AFFXHUMGA glyceraldéyde-3-phosphate déydrog 8.2321 0.169197 -1,258 P4HB J02783 procollagen-proline, 2-oxoglutarate 8.23102 0.086088 -1,3641 NDUFA1 NM 004541 NADH déydrogenase (ubiquinone) 1 a 8.2212 0.626282 -1.2111 SUMO3 NM 006936 SMT3 suppressor of mif two 3 homolo 8.2195 0.437147 1.0869 LGALS1 NM 002305 lectin, galactoside-binding, solubl 8.21919 0.572261 1.1837 EDF1 AB002282 endothelial differentiation-related 8.21902 0.526316 -1.1349 RAN AF054183 RAN, member RAS oncogene family 8.21807 0.065397 -1,3724 FBXO9 AL031178 F-box protein 9 8.21739 0.409716 1,0657 ATP6V0E 1 UBE2L6 NM 003945 ATPase, H + transporting, lysosomal 8.21734 0.002317 1.3355 NM 004223 ubiquitin-conjugating enzyme E2L 6 8.21408 0.008367 1.6999 YPEL5 NM 016061 yippee-like 5 (Drosophila) 8.21168 0.904653 1.0332 ATP5O NM 001697 ATP synthase, H + transporting, myth 8.21023 0.242888 -1.1563 EEF2 NM 001961 eukaryotic translation elongation f 8.20901 0.058201 -1.4298 MTCH1 AF189289 mitochondrial carrier homolog 1 (C. 8.20823 0.655524 1.1502 PSMA1 BC005932 proteasome (prosome, macropain) sub 8,20799 0.076977 -1.1429 BTF3 R83000 basic transcription factor 3 8,20789 0.738831 -1.0181 ATP6V1A AF113129 ATPase, H + transporting, lysosomal 8.2055 0.524883 1.1079 DDX47 NM_016355 DEAD (Asp-Glu-Ala-Asp) box polypept 8.20268 0.432305 -1,1056 CHCHD2 NM 016139 coiled-coil-helix-coiled-coil-helix 8.20227 0.116734 -1.2208 DICER1 BF590131 dicer 1, ribonuclease type III 8.19873 0.448877 1,0573 VAPA AF154847 VAMP (vesicle-associated membrane 8.19855 0.484614 -1.0647

Ρ

IFI16 NM 005531 interferon, gamma-inducible protein 8.19783 0.083394 1.3594 C0X5B AI557312 cytochrome c oxidase subunit Vb 8.19555 0.386195 1.05 BTF3 NM 001207 basic transcription factor 3 8,19465 0.369525 -1,074 GSPT1 BE906054 G1 to S phase transition 1 8,18832 0.121258 -1.2841 RPL36A NM 021029 ribosomal protein L36a 8,18795 0.106761 -1,3204 HNRNPC NM 004500 heterogeneous nuclear ribonucleopro 8.1878 0.804821 -1.0209 DYRK1A D86550 dual-specificity tyrosine- (Y) -phosp 8.18478 0.898476 -1.0302 ANAPC5 T33068 anaphase promoting complex subunit 8.18364 0.295651 -1.1779 WARS NM 004184 tryptophanyl-tRNA synthetase 8.18244 0.104168 2.0094 COX7C NM 001867 cytochrome c oxidase subunit VIIc 8.18229 0.443055 -1.0968 ARMCX6 AK000818 armadillo repeat containing, X-link 8.18138 0.798858 -1.0141 IQGAP1 NM 003870 IQ motif containing GTPase activati 8.18103 0.141181 1,11429 SH3KBP1 AF230904 SH3-domain kinase binding protein 1 8.18004 0.40147 1.0527 C0X6A1 NM 004373 cytochrome c oxidase subunit Via po 8.17859 0.109778 -1.2556 CCT8 NM 006585 chaperonin containing TCP1, subunit 8.17805 0.205106 -1.1569 UQCRC2 AV727381 ubiquinol-cytochrome c reductase co 8,17547 0.229933 -1,1033 TMED2 AK024976 transmembrane emp24 domain traffick 8.17265 0.15154 -1,2146 HLA-B D83043 major histocompatibility complex, c 8,16695 0.07086 1,366 ISG20 NM 002201 interferon stimulated exonuclease g 8,16677 0.867817 1.0728 STK17B N51102 serine / threonine kinase 17b 8,16663 0.099987 1,172 CMTM6 NM 017801 CKLF-like MARVEL transmembrane doma 8.16611 0.217529 1,2073 PHC3 AI042019 polyhomeotic homolog 3 (Drosophila) 8.16489 0.217167 -1.1318 H2AFY NM 004893 H2A histone family, member Y 8,16429 0.469588 1,0658 HNRPH1 AV753392 heterogeneous nuclear ribonucleopro 8.16164 0.650321 -1.0907 CHMP4A NM 014169 chromatin modifying protein 4A 8.16139 0.244815 1,1012 ATP5L NM 006476 ATP synthase, H + transporting, myth 8,16055 0.097009 -1.2291 GMFG NM 004877 glia maturation factor, gamma 8,1584 0.107106 1,199 IL23A AF043179 interleukin 23, alpha subunit pl9 8,15722 0.828678 1,0446 HSPA8 AF352832 heat shock 70kDa protein 8 8.15684 0.898128 1.0527 ZFP36L2 U07802 zinc finger protein 36, C3H type-li 8.1533 0.699391 1.0579 CDIPT NM 006319 CDP-diacylglycerol — inositol 3-phos 8.15137 0.193167 1.1208 NDUFA11 AI743115 NADH déydrogenase (ubiquinone) 1 a 8,15083 0.455681 -1.0867 USP7 AI160440 ubiquitin specific peptidase 7 (her 8,15075 0.774305 1,0109 EIF3K AW083133 eukaryotic translation initiation f 8,14838 0.387202 -1,101 CROWN1A U34690 coronin, actin binding protein, 1A 8.1448 0.662056 1.1124 BUB3 AF047473 BUB3 budding uninhibited by benzimi 8.14397 0.223256 -1,142 IFI44 NM 006417 interferon-induced protein 44 8.14365 0.216154 1.3768 Clorf41 AV702994 chromosome 1 open reading frame 41 8.14335 0.234725 -1.2484 RAC1 BC004247 ras-related C3 botulinum toxin subs 8.1431 0.053696 1,22382 ATP1B3 U51478 ATPase, Na + / K + transporting, beta 3 8.14151 0.722562 -1.0507 USP3 AF077040 ubiquitin specific peptidase 3 8.14094 0.975649 1,0204 RTN4 ABO 15639 reticulon 4 8.14039 0.118429 1,1444 RPL10A NM 007104 ribosomal protein LlOa 8.14036 0.079958 -1,403 NADK AI334128 NAD kinase 8,13858 0.303548 1.2529 HLA-C BG485135 major histocompatibility complex, c 8.13812 0.039267 -1,6007 TMBIM4 AF182414 transmembrane BAX inhibitor motif c 8.13702 0.331949 1,1777 PHF11 BF055474 PHD finger protein 11 8,13442 0.013218 1.4247 UQCR NM 006830 ubiquinol-cytochrome c reductase, 6 8,1329 0.532081 1.1853 PRKCB1 M13975 protein kinase C, beta 1 8.13205 0.232981 1.1366

ΊΟ

CCT4 NM 006430 chaperonin containing TCP1, subunit 8.13147 0.16879 -1.1908 SF3B1 NM 012433 splicing factor 3b, subunit 1, 155k 8.13137 0.098079 -1.1353 NDUFB9 AF261090 NADH déydrogenase (ubiquinone) 1 b 8,13045 0.040803 -1,254 NAP1L1 AW148801 nucleosome assembly protein 1-like 8.12871 0.429853 -1.0828 TNFSF13 Β S0D1 AF134715 tumor necrosis factor (ligand) supe 8.12797 0.060071 1,9273 NM 000454 superoxide dismutase 1, soluble (am 8.12528 0.613424 -1.0658 AFG3L2 AA905788 AFG3 ATPase family gene 3-like 2 (y 8.12264 0.309957 -1,194 KLF6 BG250721 Kruppel-like factor 6 8.12184 0.047534 1.5436 CCL5 NM 002985 chemokine (C-C motif) ligand 5 8.11657 0.7246 1.4152 ACTR3 Z78330 ARP3 actin-related protein 3 homolo 8.11364 0.059794 1.2148 SNRPB AL049650 small nuclear ribonucleoprotein pol 8.11331 0.303023 -1,131 HNRPD AA865357 heterogeneous nuclear ribonucleopro 8.11085 0.733618 -1.0929 JAK1 AL039831 Janus kinase 1 (a protein tyrosine 8.11071 0.530372 1.0315 HMHA1 BE349017 histocompatibility (minor) HA-1 8,1093 0.092012 1.2394 HSPC152 NM 016404 hypothetical protein HSPC152 8.10919 0.326201 -1.1359 GSTO1 NM 004832 glutathione S-transferase omega 1 8.10821 0.090006 1.3182 CCL5 M21121 chemokine (C-C motif) ligand 5 8.1054 0.620439 1,3123 ATP5J2 NM 004889 ATP synthase, H + transporting, myth 8.1041 0.63643 -1.0692 JUND NM 005354 jun D proto-oncogene 8,10089 0.272302 1.1922 PAG1 AK000680 phosphoprotein associated with glyc 8,10064 0.643176 -1,113 SLC38A1 BF247552 solute carrier family 38, member 1 8.09983 0.292745 -1.1328 HIPK3 AV693403 homeodomain interacting protein kin 8,098 0.014359 1.2149 GABARA p NM 007278 GABA (A) receptor-associated protein 8.09673 0.099454 1,394 ICAM3 NM 002162 intercellular adhesion molecule 3 8.09583 0.024752 1,22527 CRELD2 NM 024324 cysteine-rich with EGF-like domains 8.0945 0.073672 -1.4127 FDFT1 AA872727 famesyl-diphosphate famesyltransf 8.09397 0.849569 -1,001 CD48 NM 001778 CD48 molecule 8.0936 0.073903 1.1852 ASAH1 AI934569 N-acylsphingosine amidohydrolase (a 8.09224 0.149826 1.3797 CHST6 NM 021615 carbohydrate (N-acetylglucosamine 6 8.09216 0.216899 1.5145 TRAF3IP3 AL022398 TRAF3 interacting protein 3 8.09147 0.717668 1.0645 SET NM 003011 SET translocation (myeloid leukemia 8.09111 0.497269 -1.1402 STOM M81635 stomatin 8.09103 0.020133 1.4155 GZMH M36118 granzyme H (cathepsin G-like 2, pro 8.0882 0.163366 1.7024 NDUFS5 NM 004552 NADH déydrogenase (ubiquinone) Fe- 8.08662 0.012009 -1,3304 ZNF207 NM 003457 zinc finger protein 207 8.08452 0.11384 -1.1966 PECAM1 AW574504 platelet / endothelial cell adhesion 8.08292 0.492454 1,11582 PIP4K2A BE878277 phosphatidylinositol-5-phosphate 4- 8.08197 0.181779 1,11271 FAM26F AV734646 family with sequence similarity 26, 8.08179 0.004813 2,33726 IER2 NM 004907 immediate early response 2 8.08119 0.103088 1.2748 I CAME AI922599 vimentin 8.08044 0.373999 -1,1106 PSMB2 NM 002794 proteasome (prosome, macropain) sub 8.07895 0.083045 -1,367 NUCKS1 AW515443 nuclear casein kinase and cyclin-de 8.07748 0.443498 -1,117 SCO2 NM 005138 SCO cytochrome oxidase deficient 8.07667 0.039569 1.8079 SLC25A6 AA916851 solute carrier family 25 (mitochond 8.07578 0.415097 -1.0743 NLRC5 AA005023 NLR family, CARD domain containing 8.07544 0.004076 1.7472

TCF7L2 AI949687 transcription factor 7-like 2 (T-ce 8.07535 0.016262 1.8697 GNS BE880245 glucosamine (N-acetyl) -6-sulfatase 8.07425 0.158787 1,6006 NDUFA6 NM 002490 NADH déydrogenase (ubiquinone) 1 a 8.07369 0.741775 1.0076 KPNA2 NM 002266 karyopherin alpha 2 (RAG cohort 1, 8.06967 0.057832 -1.3577 ... AFFX-BIODN ... 8.06934 0.11027 1,212 ARF1 AF052179 ADP-ribosylation factor 1 8.06919 0.517062 1,0392 FBX09 AF176704 F-box protein 9 8.06764 0.353218 1,1014 ARGLU1 NM 018011 arginine and glutamate rich 1 8.06662 0.68851 -1.0125 STAT1 BC002704 signal transducer and activator of 8.06656 0.131885 1.4237 H2AFZ NM 002106 H2A histone family, member Z 8.06542 0.051489 -1.5297 RPL29 NM 000992 ribosomal protein L29 8.06512 0.55845 -1,119 Cllorf58 NM 014267 chromosome 11 open reading frame 58 8.06336 0.314178 -1,1069 MYD88 U70451 myeloid differentiation primary res 8.06109 0.002823 1.8194 WSB1 NM_015626 WD repeat and SOCS box-containing 1 TROVE domain family, member 2 8.06062 0.00276 1,44536 TROVE2 AL538601 8.06052 0.265045 -1,107 HLA-E M31183 major histocompatibility complex, c 8.05639 0.055986 1,263 PLEKHA2 BF968578 pleckstrin homology domain containi 8.05497 0.194794 1,11324 HNRNPU NM 004501 heterogeneous nuclear ribonucleopro 8.05472 0.7649 -1.0324 P0U2AF1 NM 006235 POU class 2 associating factor 1 8.05215 0.00391 -2.7707 UQCRFS1 BC000649 ubiquinol-cytochrome c reductase, R 8.05026 0.191958 -1.1716 ... AF112222 ... 8.04967 0.920772 -1.0059 WIPF1 AW058622 WAS / WASL interacting protein family 8.04929 0.66926 -1.0195 MAX BC003525 MYC associated factor X 8.04404 0.210946 1.1229 PSMG2 NM 020232 proteasome (prosome, macropain) ass 8.04348 0.428247 -1.0691 XRCC6 NM 001469 X-ray repair complementing defectiv 8.04347 0.249394 -1.1711 NDUFB1 NM 004545 NADH déydrogenase (ubiquinone) 1 b 8.0421 0.846981 1.0042 TACC1 NM 006283 transforming, acidic coiled-coil co 8.04071 0.549207 1,0396 CD55 AI679555 CD55 molecule, decay accelerating f 8.04067 0.784258 1.1724 FAM46C AL046017 family with sequence similarity 46, 8.03968 0.096586 -1.4895 NOMO2 AL512687 NODAL modulator 2 8.03869 0.098951 -1.3523 PAN3 AI970788 PAN3 polyA specific ribonuclease su 8.03825 0.89689 1.0132 VCAN NM 004385 versican 8.03597 0.385148 1,292 PPA1 NM 021129 pyrophosphatase (inorganic) 1 8.03509 0.069984 -1.3591 MBNL1 AW296451 muscleblind-like (Drosophila) 8.0338 0.486855 1,0128 PSMA1 NM 002786 proteasome (prosome, macropain) sub 8.03335 0.014331 -1,314 PSMB8 U17496 proteasome (prosome, macropain) sub 8.03203 0.186064 1.1656 NOP5 / NO P5 SLC38A1 AF161469 nucleolar protein NOP5 / NOP58 8.03187 0.093332 -1.3236 NM 030674 solute carrier family 38, member 1 8.0278 0.025016 -1,4021 Clorf43 BC000152 chromosome 1 open reading frame 43 8.02721 0.059845 -1.1982 LNPEP AA156754 leucyl / cystinyl aminopeptidase 8.02703 0.026253 1.2604 GYG1 AF087942 glycogenin 1 8.02642 0.534641 -1,2035 CYBA NM 000101 cytochrome b-245, alpha polypeptide 8.02426 0.053699 1,277 TRIM22 AA083478 tripartite motif-containing 22 8.0224 0.030426 1,66719 SNHG1 AL530869 small nucleolar RNA host gene (non- 8.02118 0.004411 -1.4879 MRPL3 BC003375 mitochondrial ribosomal protein L3 8.0203 0.015573 -1,3782

BE260771 keratinocyte associated protein 2 8.01882 0.136134 -1.2214 KRTCAP2 RPS20 NM 001023 ribosomal protein S20 8.0188 0.565374 -1.0488 ΙΤΜ2Β AF092128 integral membrane protein 2B 8.01825 0.242755 1.1838 EPSTI1 AA781795 epithelial stromal interaction 1 (b 8.01662 0.077436 1,644 SRP72 BE856385 signal recognition particle 72kDa 8.01516 0.006937 -1.4357 SNHG6 BG169443 small nucleolar RNA host gene (non- 8.01504 0.308839 -1.0917 DDX21 NM 004728 DEAD (Asp-Glu-Ala-Asp) box polypept 8.01428 0.485314 -1.0679 TDG NM 003211 thymine-DNA glycosylase 8.01252 0.40529 -1.0824 NC0A7 AL035689 nuclear receptor coactivator 7 8.01191 0.071178 1,57739 PTMA AL121585 prothymosin, alpha (gene sequence 2 8.01149 0.471739 -1,1039 TOP1 J03250 topoisomerase (DNA) I 8.00829 0.525123 -1.0487 CSDE1 AA167775 cold shock domain containing El, RN 8.00733 0.520295 -1.1743 C14orfl66 NM 016039 chromosome 14 open reading trame 16 8.00683 0.041707 -1.2839 AP3S1 NM 001284 adapter-related protein complex 3, 8.00663 0.970597 -1.0021 DERL1 NM 024295 Derl-like domain family, member 1 8.00362 0.082843 -1.3332 ... AFFX-R2-EC ... 8.00211 0.085496 1,22493 TIMM23 AI804075 translocase of inner mitochondrial 8.0019 0.095141 -1,225 PCNA NM 002592 proliferating cell nuclear antigen 8,00098 0.085038 -1.4205 LGALS3 BC001120 lectin, galactoside-binding, solubl 7.99569 0.552808 -1.1585 NTN2L AW404894 netrin 2-like (chicken) 7.99496 0.019948 -1,9949 RNASEK BE744389 ribonuclease, RNase K 7.99337 0.321241 1.0922 EPC1 AK024117 enhancer of polycomb homolog 1 (Dro 7.99307 0.896893 -1.0439 SNX5 AA131508 sorting nexin 5 7.99189 0.025089 -1,3304 ARHGEF6 D25304 Rac / Cdc42 guanine nucleotide exchanges 7.99103 0.161681 1,1065 TEGT NM 003217 testis enhanced gene transcript (BA 7,99026 0.370488 1.0665 MYADM BE908995 myeloid-associated differentiation 7,98985 0.448536 1,1444 ARPC1B NM 005720 actin related protein 2/3 complex, 7,98766 0.024046 1,272 TRMT5 AB037814 TRM5 tRNA methyltransferase 5 homol 7,98761 0.391108 -1.0948 PGM2 BF512139 phosphoglucomutase 2 7,98617 0.724018 1.0917 DDX39 NM 005804 DEAD (Asp-Glu-Ala-Asp) box polypept 7,98519 0.211137 -1.2886 USP1 NM 003368 ubiquitin specific peptidase 1 7,98427 0.103234 -1.3175 TBCA NM 004607 tubulin folding cofactor A 7.98365 0.195429 -1,178 NKG7 NM 005601 natural killer cell group 7 sequenc 7.98363 0.530321 1.2459 C0X5A NM 004255 cytochrome c oxidase subunit Va 7.97854 0.106624 -1,267 R0D1 AI735576 ROD1 regulator of differentiation 1 7,97738 0.049041 1.1834 SH3BGRL NM 003022 SH3 domain binding glutamic acid-ri 7,97732 0.043681 1.2939 UQCRH NM 006004 ubiquinol-cytochrome c reductase hi 7,97623 0.010479 -1.5162 HCLS1 NM 005335 hematopoietic cell-specific Lyn sub 7,9739 0.394064 1,0679 ANAPC5 BC006301 anaphase promoting complex subunit 7.97301 0.285519 -1,176 CYFIP2 AL161999 cytoplasmic FMR1 interacting protei 7,97235 0.608979 1,0753 C7orf30 BG397444 chromosome 7 open reading trame 30 7.97118 0.09616 -1,1582 TALDO1 NM 006755 transaldolase 1 7.97109 0.472856 1.1701 PSMB1 NM 002793 proteasome (prosome, macropain) sub 7,96981 0.055941 -1.1383 ATP5I BC003679 ATP synthase, H + transporting, myth 7,96511 0.120927 -1.4173 PPT1 NM 000310 palmitoyl-protein thioesterase 1 (c 7,96429 0.409818 1.1569

RPS14 AF116710 ribosomal protein S14 7,96324 0.326332 -1.2222 ... AL031589 ... 7.96259 0.071552 -1.4326 BG107203 RAB GTPase activating protein 1-lik 7.96179 0.1958 1.2853 RABGAP1 τ L · SET M93651 SET translocation (myeloid leukemia 7,96036 0.329404 -1,1751 PSMB3 NM 002795 proteasome (prosome, macropain) sub 7,9592 0.464727 -1,1011 SRI L12387 sorcin 7,9591 0.041935 1,25353 ACLY NM 001096 ATP citrate lyase 7.95858 0.588659 -1.0694 NDUFA4 NM 002489 NADH déydrogenase (ubiquinone) 1 a 7,95513 0.218428 -1,1443 PSMB10 NM 002801 proteasome (prosome, macropain) sub 7.95506 0.008457 1.4388 NAP1L1 AI888672 nucleosome assembly protein 1-like 7.95473 0.429714 -1,1087 CECR1 NM 017424 cat eye syndrome chromosome region, 7.9532 0.054082 1,47717 EIF3H NM 003756 eukaryotic translation initiation f 7,953 0.13323 -1.1329 PSMC1 NM 002802 proteasome (prosome, macropain) 26S 7,95027 0.028256 -1,2037 IFI44L NM 006820 44-like interferon-induced protein 7,94977 0.31081 1.5435 PFDN5 AB055804 prefoldin subunit 5 7.94688 0.148682 1.2697 NAP1L1 AI985751 nucleosome assembly protein 1-like 7,93972 0.423449 -1.0898 IFI27 NM 005532 interferon, alpha-inducible protein 7,93893 0.948533 1.3222 IFNGR1 NM 000416 gamma interferon receptor 1 7,9384 0.291485 1.2536 LIMS1 AL110164 LIM and senescent cell antigen-like 7.93759 0.888499 -1.0143 HLA-G M90684 major histocompatibility complex, c 7,93684 0.137039 1.2659 C15orfl5 AF165521 chromosome 15 open reading frame 15 7,93433 0.869033 1.0055 TINP1 NM 014886 TGF beta-inducible nuclear protein 7.93385 0.118064 -1,2099 TYMS NM 001071 thymidylate synthetase 7.93346 0.043902 -1.7356 CLTC NM 004859 clathrin, heavy chain (Hc) 7.93169 0.262781 -1,1206 D ADI NM 001344 defend against cell death 1 7.93131 0.084036 -1,303 ARPC5 AL516350 actin related protein 2/3 complex, 7,93019 0.023254 1.3929 MESDC2 AK026606 mesoderm development candidate 2 7.92901 0.271806 -1.1771 EIF4E2 BF516289 eukaryotic translation initiation f 7,9273 0.215405 1.1607 RNF213 AA233374 iing finger protein 213 7,92579 0.004581 1,553 DKC1 NM 001363 congenital dyskeratosis 1, dyskerin 7.92572 0.057177 -1.2269 NM_004493 hydroxysteroid (17-beta) déydrogen 7,92345 0.608285 -1.0662 HSD17B1 Λ U FKBP5 ΑΓ753747 FK506 binding protein 5 7,9231 0.057854 1.4185 CD52 NM 001803 CD52 molecule 7.91932 0.524059 1,11436 RBMS1 AL517946 RNA binding motif, single stranded 7.91705 0.046484 1.2965 MIF NM 002415 macrophage migration inhibitory fac 7,91423 0.106448 -1,3398 SAT1 BE326919 spermidine / spermine N1 -acetyltransf 7,91179 0.264597 1.8175 CSTA NM 005213 cystatin A (stefm A) 7.90955 0.072264 1,88634 HLA-F NM 018950 major histocompatibility complex, c 7.90836 0.017175 1.3924 ECOP NM 030796 EGFR-coamplified and overexpressed 7,9055 0.07665 -1,3057 MCM6 NM 005915 minichromosome maintenance 7.90157 0.038118 -1,602 complex PPTC7 AW300598 PTC7 protein phosphatase homolog (S 7,90069 0.356898 -1.0665 ... AFFX-R2-BS ... 7,90066 0.884237 -1.2344 SSR3 AW087870 signal sequence receiver, gamma (tr 7,90011 0.014039 -1.7728 CX3CR1 U20350 chemokine (C-X3-C motif) receiver 1 7.89988 0.012371 2.3472 SFRS7 BF033354 splicing factor, arginine / serine-ri 7,89544 0.436289 -1.1439 RBM39 AI890947 RNA binding motif protein 39 7,89424 0.448342 -1.0918

SFT2D1 ΤΙΜΜ8Β BF975327 NM 012459 SFT2 domain containing 1 translocase of inner mitochondrial 7.89083 0.798093 7.88921 0.681191 -1.0423 -1.0325 FBXL5 AF142481 F-box and leucine-rich repeat prote 7,88865 0.016196 1.3524 YWHAZ BC003623 tyrosine 3-monooxygenase / tryptophan 7.8884 0.698486 -1.1792 0DC1 NM 002539 omithine decarboxylase 1 7,88718 0.09129 -1.3131 LSM14A BG054966 LSM14A, SCD6 homolog A (S. cerevisi 7.88606 0.059241 -1,179 CDC42SE O AF131831 CDC42 small effector 2 7,88516 0.198825 -1.15 SFRS9 NM 003769 splicing factor, arginine / serine-ri 7.8827 0.667166 -1.0837 HNRPA3 AA528233 heterogeneous nuclear ribonucleopro 7,88217 0.37059 -1,1008 SAP18 U78303 Sin3A-associated protein, 18kDa 7.88139 0.150022 -1,1034 ZFAND5 AF062347 zinc finger, ANl-type domain 5 7.88095 0.063681 1.4311 H3F3B AW138159 H3 histone, family 3B (H3.3B) 7,87842 0.377711 1,161 PEBP1 AF130103 phosphatidylethanolamine binding pr 7,87794 0.019274 -1.5278 CCT7 NM 006429 chaperonin containing TCP1, subunit 7.87698 0.076044 -1.3172 RBM15 NM 022768 RNA binding motif protein 15 7.87652 0.407893 -1,177 PHB2 NM 007273 prohibitin 2 7.87581 0.140475 -1.2495 SFRS6 AL031681 splicing factor, arginine / serine-ri 7,87558 0.051458 -1.2458 TPI1 NM 000365 triosephosphate isomerase 1 7.8746 0.487514 -1,1066 AO AO AO 101 NM 014736 KIAA0101 7,87436 0.049651 -1,6844 SERF2 BE568651 small EDRK-rich factor 2 7,87325 0.421448 1.0767 ADD3 BE545756 adducin 3 (gamma) 7.87255 0.392151 -1.0707 CROP NM 016424 cisplatin resistance-associated ove 7,87218 0.567651 -1.1491 CFLAR AF005775 CASP8 and FADD-like apoptosis regul 7.87209 0.169911 -1,255 ATP5J NM 001685 ATP synthase, H + transporting, myth 7.87151 0.023635 -1,3658 TCF7 NM 003202 transcription factor 7 (T-cell spec 7,87083 0.340212 -1.1737 LAPTM5 AI589086 lysosomal associated multispanning 7,87044 0.168989 1.1309 RAP2B AW005535 RAP2B, member of RAS oncogene famil 7,86988 0.363821 1,0953 ... AW084125 ... 7,86975 0.545528 -1.2461 COP1 NM 052889 caspase-1 dominant-negative inhibit 7,86974 0.015776 1,77438 EVI2B BC005926 ecotropic viral integration site 2B 7,86582 0.361829 1.1354 ARPP-19 AF084555 cyclic AMP phosphoprotein, 19 kD 7,86548 0.500026 -1,1665 NDUFC2 NM 004549 NADH déydrogenase (ubiquinone) 1, 7,86547 0.022416 -1,3152 CLEC2B BC005254 C-type lectin domain family 2, memb 7,86529 0.427371 1,174 UFC1 NM 016406 ubiquitin-fold modifier conjugating 7,86429 0.14366 -1,171 HDAC1 NM 004964 histone deacetylase 1 7.86357 0.695006 -1.0059 CBFB NM 001755 core-binding factor, beta subunit 7.86157 0.302277 -1,185 ADSL NM 000026 adenylosuccinate lyase 7.86154 0.115159 -1,2038 NDUFB8 NM 005004 NADH déydrogenase (ubiquinone) 1 b 7,861 0.268462 -1,1956 DENR AB014731 density-regulated protein 7,86099 0.405568 -1.09 CSNK1A1 AW268585 casein kinase 1, alpha 1 7.8604 0.96556 -1.0223 PSCDBP L06633 pleckstrin homology, Sec7 and coile 7,85981 0.561005 -1,094 HMGN1 NM 004965 high-mobility group nucleosome bind 7,85924 0.068964 -1.5046 NM 003730 ribonuclease T2 7,85874 0.055491 1.5828

RNASET2

STAT1 LOC72817 ο AFFX-HUMIS AL136226 signal transducer and activator of similar to LOC100037086 protein 7.85697 7.85677 0.024373 0.164486 1.6813 -1.3105 NOLC1 D21262 nucleolar and coiled-body phosphopr 7.85496 0.086744 -1.2281 PABPC1 ΑΓ760366 poly (A) binding protein, cytoplasmi 7.85478 0.94926 1,0167 NMI NM 004688 N-myc (and STAT) interactor 7.8532 0.006946 1.5219 EIF3G BC000733 eukaryotic translation initiation f 7,85094 0.730483 1,0383 COX6C NM 004374 cytochrome c oxidase subunit VIc 7.85042 0.051302 -1.2906 FLJ22662 NM 024829 hypothetical protein FLJ22662 7.84999 0.053703 2,112 SLC2A3 NM 006931 solute carrier family 2 (facilitate 7,84894 0.186639 1.3041 ANP32E AW612574 acidic (leucine-rich) nuclear phosp 7,84885 0.081693 -1,3476 TRIM25 BE563152 tripartite motif-containing 25 7.8476 0.016936 1,44518 EIF3K AF085358 eukaryotic translation initiation f 7.84658 0.270938 -1.1342 GNG5 NM 005274 guanine nucleotide binding protein 7.84483 0.61179 -1.1253 HINT1 U27143 histidine triad nucleotide binding 7,84463 0.157242 -1.2225 C22orf32 AV751709 chromosome 22 open reading ffame 32 7,84213 0.500757 -1.0839 Clorf63 AF267856 chromosome 1 open reading frame 63 7.84158 0.439394 1,0608 EEF2 AI004246 eukaryotic translation elongation f 7.84131 0.207484 -1,4015 SET AV702810 SET translocation (myeloid leukemia 7.84122 0.085839 -1.5046 CHSY1 NM 014918 chondroitin sulfate synthase 1 7.84111 0.001841 1.4027 CD74 K01144 CD74 molecule, major histocompatibi 7.84047 0.046954 1.6994 NPC2 NM 006432 Niemann-Pick disease, type C2 7,84034 0.081141 1.6014 MTHFD2 NM 006636 methylenetetrahydrofolate déydroge 7.84011 0.637543 1.0358 STAT2 H98105 signal transducer and activator of 7,83876 0.032873 1.7502 KIAA0746 AB018289 KIAA0746 protein 7.83845 0.103401 -1,486 TRAC M12959 T cell alpha constant receiver 7.83803 0.637512 1.0284 CD63 NM 001780 CD63 molecule 7,838 0.071032 1.3863 SON X63071 SON DNA binding protein 7,83641 0.545264 -1.0938 RPL22 AW071997 ribosomal protein L22 7,8349 0.526305 -1.0577 GBP1 NM 002053 guanylate binding protein 1, interf 7,83435 0.00216 1.9967 TncRNA BE675516 trophoblast-derived noncoding RNA 7.83321 0.053576 1.5296 KLC1 AF222691 kinesin light chain 1 7,83289 0.651812 1.0619 NR3C1 AI432196 nuclear receiver subfamily 3, group 7.83164 0.121456 1.1614 BCLAF1 NM 014739 BCL2-associated transcription facto 7.83153 0.063633 -1,1958 NOSIP NM 015953 nitric oxide synthase interacting p 7.83121 0.78545 1,146 ARL8B NM 018184 ADP-ribosylation factor-like 8B 7.83004 0.925295 1,0273 SNRPE NM 003094 small nuclear ribonucleoprotein pol 7.82908 0.114942 -1.3543 LOC44035 4 AF271775 ΡΙ-3-kinase-related kinase SMG-1 ps 7.82841 0.641383 1,0778 ATP6V0E 1 TNFAIP8 AI862255 ATPase, H + transporting, lysosomal 7,82795 0.103392 1,22433 NM 014350 tumor necrosis factor, alpha-induce 7,82731 0.782193 -1.0404 C16orf72 AA526970 chromosome 16 open reading frame 72 7.82672 0.772311 1.0845 HINT1 N32864 histidine triad nucleotide binding 7.82349 0.193143 -1.17 D80006 MOB1, Mps One Binder kinase activat 7,82278 0.08179 1,191

M0BKL1 Β

ZNF313 AF090934 zinc finger protein 313 7,82269 0.007947 1.2929 SFRS9 NM 003769 splicing factor, arginine / serine-ri 7.82236 0.545666 -1.1601 AL0X5 NM 000698 arachidonate 5-lipoxygenase 7.82228 0.158777 1.7109 HLA-G M90685 major histocompatibility complex, c 7.82127 0.038981 1.3489 CD69 L07555 CD69 molecule 7.82017 0.687162 1.0872 NM 003730 ribonuclease T2 7.81902 0.006686 2,0165 RNASET2 BZW1 NM 014670 basic leucine zipper and W2 domains 7.81898 0.177089 -1.1269 DYNLT1 NM 006519 dynein, light chain, Tctex-type 1 7.81805 0.061789 1.3837 N0LA2 BC000009 nucleolar protein family A, member 7,81794 0.117219 -1.2346 HNRPK AI701949 heterogeneous nuclear ribonucleopro 7,81234 0.63527 -1.0982 SFRS5 AW084582 splicing factor, arginine / serine-ri 7.81152 0.311355 1.1523 TLE4 NM 007005 transducin-like enhancer of split 4 7.81145 0.132057 1.3109 TPI1 BF116254 triosephosphate isomerase 1 7.81126 0.534216 -1.0895 CUL3 AF062537 cullin 3 7.81014 0.134901 -1,152 LCK NM 005356 lymphocyte-specific protein tyrosin 7.80984 0.620879 1,0406 AK021514 hypothetical protein LOC 152719 7,80935 0.322153 1,22531 LOC15271 y NMO16459 hypothetical protein MGC29506 7,80789 0.016535 -2,367 MGC2950 0 HLA- NM 002121 major histocompatibility complex, c 7.80659 0.015645 2.4265 DPB1 CHD2 AV756026 chromodomain helicase DNA binding 7,80599 0.443294 -1,133 CTSB NM 001908 P cathepsin B 7.80529 0.034551 1,723 DNAJC9 BE551340 DnaJ (Hsp40) homolog, subfamily C, 7.80528 0.056206 -1.4413 PPTC7 AA521311 PTC7 protein phosphatase homolog (S 7.80492 0.477164 1.1038 GUSB NM 000181 glucuronidase, beta 7.80487 0.894855 1.0117 TEGT AF033095 testis enhanced gene transcript (BA 7.80374 0.094836 -1,2708 PIK3AP1 AW575754 phosphoinositide-3-kinase adapter p 7.80278 0.002432 1,784 EIF3B U78525 eukaryotic translation initiation f 7.80229 0.08966 -1,206 CNPY2 NM 014255 canopy 2 homolog (zebrafish) 7.80183 0.036005 -1,348 TXNL1 NM 004786 thioredoxin-like 1 7.8013 0.30414 -1,2076 RHEB NM 005614 Ras homolog enriched in brain 7.79979 0.145509 1,11426 TPP1 NM 000391 tripeptidyl peptidase I 7,79764 0.105129 1.3029 SRGN J03223 serglycin 7,79742 0.27782 1.1307 ARS2 AI523895 arsenate resistance protein 2 7.79677 0.169276 -1.1821 MYLIP AW292746 myosin regulatory light chain inter 7.79607 0.365412 1.1535 C20orf24 AF274948 chromosome 20 open reading frame 24 7.79507 0.074121 1,2021 ELOVL5 AL136939 ELOVL family member 5, elongation Λ 7.79473 0.203901 -1.1545 SATB1 NM 002971 U SATB homeobox 1 7.79286 0.53287 -1.1779 CD38 NM 001775 CD38 molecule 7.79243 0.03203 -1.7441 IL10RA NM 001558 interleukin 10 receptor, alpha 7.79042 0.075688 1.2713 TNFAIP8 BC005352 tumor necrosis factor, alpha-induce 7.78993 0.841802 -1.0513 PLSCR3 AI783924 phospholipid scramblase 3 7,78967 0.405584 1,0809 ISCU AY009128 iron-sulfur cluster scaffold homolo 7.78952 0.012091 -1.3315 SQRDL NM 021199 quinone reductase-like sulfide (yea 7.78824 0.003312 1,44912 UQCRC1 NM 003365 ubiquinol-cytochrome c reductase co 7.7878 0.622634 -1.0617

MAFF AL021977 v-maf musculoaponeurotic fibrosarco 7,78766 0.738139 1,145 TMED8 AK025695 transmembrane emp24 protein transpo 7.78137 0.508269 -1.0791 IRAK1 NM 001569 interleukin-1 receptor-associated k 7.78133 0.214125 -1,476 NAT13 NM 025146 N-acetyltransferase 13 7.78116 0.065522 -1,291 PDE4C NM 000923 phosphodiesterase 4C, cAMP-specific 7.78109 0.25063 1.1866 MRPL20 NM 017971 mitochondrial ribosomal protein L20 7.78045 0.016396 -1.2407 NDUFAB1 NM 005003 NADH déydrogenase (ubiquinone) 1, 7,7794 0.219845 -1,2044 SNX18 AU146771 sorting nexin 18 7.77704 0.15195 1,22225 HERPUD1 AF217990 homocysteine-inducible, endoplasmic 7,77613 0.234465 -1,1203 SEPW1 AW514401 selenoprotein W, 1 7.77532 0.110662 1,2029 RBPJ AL513759 recombination signal binding protei 7,77514 0.739594 1.0815 C6orf32 NM 015864 chromosome 6 open reading frame 32 7,77475 0.048169 1.4238 PARP12 NM 022750 poly (ADP-ribose) polymerase family 7.77347 0.017657 1.9566 ACBD3 NM_022735 acyl-Coenzyme A binding domain cont heterogeneous nuclear ribonucleopro 7.77159 0.205912 -1,1597 HNRPM AF061832 7.76851 0.189384 -1,159 BUB3 AF081496 BUB3 budding uninhibited by benzimi 7.76831 0.065539 -1,3456 AW006185 hypothetical LOC283666 7,76594 0.44857 -1.1251

LOC28366

LRRFIP1 BF965566 leucine rich repeat (in FLII) inter 7.76381 0.084756 1,22432 ... AV755522 ... 7,76233 0.165238 1.3526 MDH2 BC001917 malate déydrogenase 2, NAD (mitoch 7.76125 0.068119 -1.3197 HP1BP3 AK023129 heterochromatin protein 1, binding 7,761 0.039728 1.2879 ZNF706 NM 016096 zinc fínger protein 706 7.76023 0.089784 -1.2373 AAK1 AW451954 AP2 associated kinase 1 7.75954 0.703591 -1.0683 NCL NM 005381 nucleolin 7.75885 0.000569 -1,5782 TM9SF2 NM 004800 transmembrane 9 superfamily member 7.75885 0.027909 -1,4065 BF209337 hypothetical LOC541471 7,75746 0.298291 -1.1599

LOC54147

MICB NM 005931 MHC class I polypeptide-related seq 7.75672 0.772778 1,0784 MYCBP2 AA488899 MYC binding protein 2 7,75577 0.995848 -1.0321 TXNDC1 AL080080 thioredoxin domain containing 1 7.75221 0.485506 -1.0883 FAM91A2 AW340595 family with sequence similarity 91, 7.74928 0.182376 1.1404 FAM107B BC004872 family with sequence similarity 107 7.74756 0.499811 -1.0544 ARPC3 AF004561 actin related protein 2/3 complex, 7.74657 0.084024 1.3605 CD2 NM 001767 CD2 molecule 7.74656 0.362389 1.3499 MYCBP2 NM 015057 MYC binding protein 2 7.74341 0.908252 -1.0037 YWHAQ NM 006826 tyrosine 3-monooxygenase / tryptophan 7.74296 0.17355 -1.1902 COX7C AF042165 cytochrome c oxidase subunit VIIc 7.74258 0.807011 -1,039 AP1S2 AA551090 adapter-related protein complex 1, 7.74165 0.064008 1.5971 LOC64797 Q AV729406 hypothetical protein LOC647979 7.74088 0.949464 -1.0534 RAB8B AI807023 RAB8B, member RAS oncogene family 7.73834 0.041937 1.1996 PCMT1 NM 005389 protein-L-isoaspartate (D-aspartate 7,73767 0.045632 1.2617

ΤΑΡ1 NM 000593 transporter 1, ATP-binding cassette 7.73755 0.013995 1,462 CGGBP1 BF979809 CGG triplet repeat binding protein 7,7372 0.690437 -1.0409 PSMB7 NM 002799 proteasome (prosome, macropain) sub 7.73632 0.159487 -1.1414 TARDBP NM 007375 TAR DNA binding protein 7.73201 0.609571 -1.0645 PDE4B NM 002600 phosphodiesterase 4B, cAMP-specific 7.73163 0.399776 -1.1585 SNX3 BE962615 sorting nexin 3 7.73033 0.134193 1.1233 TXNDC4 BC005374 thioredoxin domain containing 4 (en 7.72965 0.2594 -1,1368 CRTC3 NM 022769 CREB regulated transcription coacti 7,7277 0.27079 -1,1452 NUSAP1 NM 016359 nucleolar and spindle associated pr 7.72637 0.064059 -1.5978 FYN M14333 FYN oncogene related to SRC, FGR, Y voltage-dependent anion channel 2 7,7257 0.567563 1,0851 VDAC2 L08666 7.72313 0.089074 -1,2089 NDUFB4 NM 004547 NADH déydrogenase (ubiquinone) 1 b 7.72166 0.125707 -1.1992 VPS35 NM 018206 vacuolar protein sorting 35 homolog 7.72133 0.18938 1.2765 PPHLN1 NM 016488 periphilin 1 7.72121 0.668043 -1.0863 PRR11 AK000296 proline rich 11 7.72094 0.110951 1,11819 PPP1CB AI700962 protein phosphatase 1, catalytic su 7.71929 0.535542 -1.1476 VPS4B AF195514 vacuolar protein sorting 4 homolog 7,7165 0.24156 1,174 EIF3C BC000533 eukaryotic translation initiation f 7,71464 0.576111 -1.1357 FBL M30448 fibrillarin 7.71345 0.062648 -1.3937 PSMA5 NM 002790 proteasome (prosome, macropain) sub 7.71335 0.326924 -1.1319 TYROBP NM 003332 TYRO protein tyrosine kinase bindin 7.71104 0.007507 2,88639 HNRNPC AA664258 heterogeneous nuclear ribonucleopro 7.71058 0.387002 -1.1427 SERPINB9 AI986192 serpin peptidase inhibitor, clade B 7.71009 0.189443 1,581 EIF5 AK026933 eukaryotic translation initiation f 7.70884 0.735741 1.0475 MALAT1 BE708432 metastasis associated lung adenocar 7.70861 0.039277 1.5142 CBWD5 AV709992 COBW domain containing 5 7,7071 0.020212 -1.5882 BLVRA NM 000712 biliverdin reductase A 7.70582 0.03669 1.5987 PFDN5 NM 002624 prefoldin subunit 5 7.70578 0.53748 1.1262 TMED10 BE780075 transmembrane emp24-like traffickin 7.70531 0.011932 -1.3384 PTGER4 AA897516 prostaglandin AND receptor 4 (subtype 7.70461 0.358765 1,11919 ... AFFX-DAPX- ... 7.70305 0.926458 -1.3185 PTEN AK024986 phosphatase and tensin homolog (mut 7.70196 0.125612 1,22289 DUSP22 NM 020185 dual specificity phosphatase 22 7.70104 0.143362 1.1578 CLINT1 NM 014666 clathrin interactor 1 7,70064 0.055364 -1.2644 SETD2 AI761110 SET domain containing 2 7.69961 0.591759 -1.0521 SAMD9L BE966604 sterile alpha motif domain containi 7.69861 0.126238 1.8851 CAB39 NM 016289 calcium binding protein 39 7.69848 0.427307 1.0981 NAP1L1 NM 004537 nucleosome assembly protein 1-like 7.69746 0.365014 -1.1487 TGFBR3 AW193698 transforming growth factor, beta re 7.69733 0.918318 1.1724 ANP32B AV712577 acidic (leucine-rich) nuclear phosp 7.69711 0.237782 -1.2431 ESD AU145746 esterase D / formylglutathione hydrol 7.6957 0.760036 1.0544 PSMA4 NM 002789 proteasome (prosome, macropain) sub 7.69483 0.020933 1.2925 TXNL4A NM 006701 thioredoxin-like 4A 7.69333 0.01074 -1.3401 SGK1 NM 005627 serum / glucocorticoid regulated kina 7.69052 0.709699 1.1343 TIMM17A AK023063 translocase of inner mitochondrial 7.69006 0.038309 -1,291 REXO2 NM_015523 REX2, RNA exonuclease 2 homolog ^(S : biliverdin reductase A 7.68937 0.094987 -1.3334 BLVRA BC005902 7.68887 0.042683 1.5364

KBTBD2 AF161402 kelch repeat and BTB (POZ) domain c 7.65478 0.332791 -1.1842 CAPZB U03271 capping protein (actin filament) mu 7.65426 0.063275 1.2362 C8orf59 BF674436 chromosome 8 open reading frame 59 7.65366 0.330133 -1.13 SNRPB J04564 small nuclear ribonucleoprotein pol 7.65286 0.787873 -1.0088 ITGB2 NM 000211 integrin, beta 2 (complement components 7.6523 0.031817 1.4305 CCT3 NM 005998 chaperonin containing TCP1, subunit 7.65149 0.094926 -1.2758 LITAF AB034747 lipopolysaccharide-induced TNF fact 7.65111 0.892974 -1.0235 LITAF NM 004862 lipopolysaccharide-induced TNF fact 7.65038 0.748136 -1.0584 GRN NM 002087 granulin 7.6487 0.095302 1,66698 CNDP2 NM 018235 CNDP dipeptidase 2 (metallopeptides 7.64763 0.018839 1.5663 HNRPAB NM 004499 heterogeneous nuclear ribonucleopro 7.6475 0.026283 -1,5461 TCIRG1 NM 006019 T-cell, immune regulator 1, ATPase, 7.64672 0.11177 1,44449 HADHA AI972144 hydroxyacyl-Coenzyme A déydrogenas 7.64496 0.227576 -1.2751 HDLBP AA515560 high density lipoprotein binding pr 7.64419 0.113027 -1.8803 DPM1 NM 003859 dolichyl-phosphate mannosyltransfer 7.64394 0.045461 -1.2781 PDCD10 BC002506 programmed cell death 10 7.64317 0.929259 1,0005 HCST AF285447 hematopoietic cell signal transduce 7.64258 0.066254 1.4105 GBP2 NM 004120 guanylate binding protein 2, interf 7.64193 0.007125 1.8139 KIAA0528 AB011100 KIAA0528 7.64193 0.557386 1.0826 PGK1 NM 000291 phosphoglycerate kinase 1 7.64048 0.824762 -1.0473 S0RL1 AV728268 sortilin-related receptor, L (DLR cl 7.64047 0.699823 -1.0597 EIF4A3 NM 014740 eukaryotic translation initiation f 7.64006 0.077666 -1,3463 ACTB AFFX-HSACO actin, beta 7.63897 0.83752 -1.0353 LYN NM 002350 v-yes-1 Yamaguchi viral sarcoma king 7.63878 0.148443 1.6308 ITSN2 U61167 intersectin 2 7.63774 0.151286 -1.1829 PSMD2 NM 002808 proteasome (prosome, macropain) 26S 7.63759 0.489536 -1,115 ARHGAP9 BC006107 Rho GTPase activating protein 9 7.63661 0.142569 1.1795 PRKCH NM 024064 protein kinase C, eta 7.6348 0.950108 1.0768 LOC64244 1 MRPL47 AA532655 hypothetical LOC642441 7.63466 0.526681 1.0626 ΑΙ189156 mitochondrial ribosomal protein L47 7.63417 0.411821 -1.1572 SUBI AV715940 SUBI homolog (S. cerevisiae) 7.63286 0.026136 -1,3039 RBM5 NM 005778 RNA binding motif protein 5 7.63107 0.768865 -1.0712 RORA BC040965 RAR-related orphan receptor A 7.6292 0.837724 -1,189 CTSH NM 004390 cathepsin H 7.62474 0.484803 1.5466 LOC40115 O AL571684 HCV F-transactivated protein 1 7.6246 0.179093 1,174 £ LOC44145 Λ NM_016171 hypothetical gene supported by BC01 7.6242 0.280802 1,243 TARP M27331 TCR gamma altemate reading frame p 7.62325 0.206759 1.4124 ARPC5L AU158936 actin related protein 2/3 complex, 7.62292 0.980358 1,0329 EIF3C NM 003752 eukaryotic translation initiation f 7.61952 0.297822 -1.2262 ARHGEF3 NM-019555 Rho guanine nucleotide exchange fac 7.61652 0.016341 1.3373 SUMO2 AK024823 SMT3 suppressor of mif two 3 homolo 7.61631 0.992351 1,0376

CRTAP BQ876971 cartilage associated protein 7.61515 0.303588 1.2446 ECHDC1 AL109939 enoyl Coenzyme A hydratase domain c 7.61129 0.619859 -1.0557 MGEA5 AF307332 meningioma expressed antigen 5 (hya 7.60983 0.765516 1,0303 CDKN1B BC001971 cyclin-dependent kinase inhibitor 1 7.60896 0.781614 -1.0792 CIRBP NM 001280 cold inducible RNA binding protein 7.60839 0.747999 -1.2397 SP110 NM 004509 SP110 nuclear body protein 7.60812 0.00872 1.7371 USP14 NM 005151 ubiquitin specific peptidase 14 (tR 7.60677 0.021071 -1.4681 RBM25 AV757384 RNA binding motif protein 25 7.60566 0.504875 1.1059 IGL @ AJ249377 immunoglobulin lambda locus 7.60489 0.024751 -2,276 OCIAD1 H09533 OCIA domain containing 1 7.60459 0.139441 1,11284 SFRS1 BC006181 splicing factor, arginine / serine-ri 7.60329 0.202276 -1,207 CCND3 NM 001760 cyclin D3 7,60316 0.03019 1.3374 METTL7A NM_014033 methyltransferase like 7 A 7.60293 0.002606 -1,585 RCSD1 AI659418 RCSD domain containing 1 7.60286 0.02614 1.2837 PTBP1 BC002397 polypyrimidine tract binding protei 7.60284 0.566035 -1,1155 RAB8A BC002977 RAB8A, member RAS oncogene family 7,6024 0.232362 1,182 RBL2 X76061 retinoblastoma-like 2 (pl30) 7.60119 0.63202 1.0944 TOMM7 NM 019059 translocase of outer mitochondrial 7.60107 0.683046 1,0374 UHRF2 BF511410 ubiquitin-like, containing PHD and 7.59971 0.643307 1,0558 LOC64712 1 CDC25B W84421 embigin homolog (mouse) pseudo gene 7,59742 0.801185 -1.0343 NM 021873 cell division cycle 25 homolog B (S 7.59643 0.527043 -1.0346 SP11O AF280095 SP110 nuclear body protein 7,59548 0.0269 1.8226 CHMP5 NM 015961 chromatin modifying protein 5 7,59535 0.190712 1.3799 SEPT6 D50918 septin 6 7.59449 0.642472 -1.0339 UBL5 NM 024292 ubiquitin-like 5 7.59393 0.558221 1,11465 JOSD3 AF275800 Josephin domain containing 3 7.59186 0.19658 1.1678 ETS1 AA702930 v-ets erythroblastosis virus E26 on 7.59159 0.683206 -1.1849 UQCRQ NM 014402 ubiquinol-cytochrome c reductase, c 7.59127 0.052296 -1,3784 SPCS3 AL136660 signal peptidase complex subunit 3 7,59062 0.020842 -1.6207 GBP1 AWO14593 guanylate binding protein 1, interf 7,58986 0.005006 2,48888 TXNIP AA812232 thioredoxin interacting protein 7,58879 0.139682 1.4068 CREG1 NM 003851 cellular repressor of El A-stimulate 7,58617 0.06744 1.7291 ACTR2 NM 005722 ARP2 actin-related protein 2 homolo 7,58578 0.336164 -1.1813 MNDA NM 002432 myeloid cell nuclear differentiatio 7,58475 0.044113 1,846 C19orfl0 AL524093 chromosome 19 open reading frame 10 7.58374 0.013063 -1.7683 EIF3K AF119846 eukaryotic translation initiation f 7.58167 0.186686 -1.1911 ID2 AI819238 inhibitor of DNA binding 2, dominan 7,58066 0.284787 1.3264 CD47 AL118798 CD47 molecule 7,58055 0.571242 1.1101 ANKRD10 BC001727 ankyrin repeat domain 10 7,58047 0.617954 -1.0351 WTAP AU147416 Wilms tumor 1 associated protein 7,57985 0.125873 -1.2422 APBB1IP AI093231 amyloid beta (A4) precursor protein 7.57972 0.029023 1.3843 FGL2 NM 006682 fibrinogen-like 2 7.57893 0.007811 2,673 CMPK2 AI742057 cytidine monophosphate (UMP-CMP) ki 7,57862 0.299205 1.3557 AA526907 7.57802 0.255906 1,2036 IFI35 BC001356 interferon-induced protein 35 7.57709 0.063075 1.7289

C14orf2 NM 004894 chromosome 14 open reading frame 2 7,57518 0.627111 -1.0523 PF4 NM 002619 platelet factor 4 (chemokine (C-X-C 7.57337 0.75131 -1,2073 FGL2 AW135176 fibrinogen-like 2 7.57258 0.011735 2,152 PACSIN2 NM 007229 protein kinase C and casein kinase 7,57082 0.199546 1.3663 NM 014761 KIAA0174 7,56978 0.038297 1.4021 KIAA0174 RPL22L1 BE274422 L22-like ribosomal protein 1 7,56951 0.009481 -1,621 ZFAND5 AW471220 zinc finger, ANl-type domain 5 7,56933 0.586264 1.2604 C19orf22 W07773 chromosome 19 open reading frame 22 7,56927 0.931835 -1.0658 PSMD14 NM 005805 proteasome (prosome, macropain) 26S 7.56905 0.123876 -1,3085 GOLPH3 NM 022130 golgi phosphoprotein 3 (coat-protei 7,56816 0.584915 -1,066 EVI2A NM 014210 ecotropic viral integration site 2A 7,5677 0.086504 1,275 NUB1 AF300717 negative regulator of ubiquitin-lik 7,56685 0.015278 1,6007 CTNNB1 AW362945 catenin (cadherin-associated protei 7.56606 0.145529 1,5022 AI708524 OK / SW-cl.16 7.56507 0.426833 -1.1241

LOC44055

CD44 BE903880 CD44 molecule (Indian blood group) 7,56473 0.558221 -1.0431 MARCH6 BF000409 membrane-associated ring finger (C3 7,56463 0.013467 -1,3494 DYNLL1 NM 003746 dynein, light chain, LC8-type 1 7.56367 0.253683 -1.2446 ARRB2 AL832061 arrestin, beta 2 7.56323 0.062545 1.7626 APLP2 NM 001642 amyloid beta (A4) precursor-like pr 7.56241 0.133196 1.4098 MRPL53 AV726817 mitochondrial ribosomal protein L53 7,56013 0.34919 -1.1371 CMBL BE537881 carboxymethylenebutenolidase homolo 7.56006 0.333511 1.0747 XRCC5 AA205834 X-ray repair complementing defectiv 7.56003 0.048827 -1.3751 MRPL9 BC004517 mitochondrial ribosomal protein L9 7.55995 0.094155 -1.2938 CTSC NM 001814 cathepsin C 7,55947 0.096722 1,247 MX2 NM 002463 myxovirus (influenza virus) resist 7,55943 0.041424 2.1826 FBXO10 BF969806 F-box protein 10 7.55907 0.105034 -1,3277 PIM1 M24779 pim-1 oncogene 7,5587 0.330076 1.1246 NAMPT NM 005746 nicotinamide phosphoribosyltransfer 7,5582 0.401092 1,371 TSC22D3 AL110191 TSC22 domain family, member 3 7.55805 0.270426 1,239 RNF213 AI523817 ring finger protein 213 7.55698 0.021716 1.7133 LOC91316 AA398569 similar to bK246H3.1 (immunoglobuli 7.55684 0.053479 -1.3375 PDCD4 N92498 programmed cell death 4 (neoplastic 7,55561 0.000465 -1.4445 ASAH1 AI379338 N-acylsphingosine amidohydrolase (a 7,55424 0.251223 1.3524 ERP29 NM 006817 endoplasmic reticulum protein 29 7.5541 0.135128 -1.2378 NHP2L1 AF155235 NHP2 non-histone chromosome protein 7.55201 0.014327 -1.3928 KRAS W80678 v-Ki-ras2 Kirsten rat viral sarcoma 7.55122 0.401921 -1,1013 PRKACB AA130247 protein kinase, cAMP-dependent, cat 7,55067 0.47977 -1.0582 YTHDF2 BC002559 YTH domain family, member 2 7,5503 0.159619 -1.1997 SCOTIN BC001463 scotin 7,54927 0.008933 1,44562 MT1X NM 005952 metallothionein IX 7,5485 0.001294 2.2122 IL6ST AL049265 interleukin 6 signal transducer (gp 7.54659 0.172712 -1.1861 SP 100 NM 003113 SP 100 nuclear antigen 7,5456 0.76144 1,0909 SORL1 NM 003105 sortilin-related receptor, L (DLR cl 7.54378 0.648127 -1,1037 PTTG1IP NM 004339 pituitary tumor-transforming 1 inte 7.54347 0.022243 1,57717 KLRF1 NM 016523 killer cell lectin-like receiver su 7,54219 0.362944 1.2632 MPEG1 T64884 macrophage expressed gene 1 7,54219 0.109901 1,77748

Λ »

HLA- M60334 major histocompatibility complex, c 7,53958 0.074368 1.7024 DRA TncRNA AV699657 trophoblast-derived noncoding RNA 7,53898 0.469198 1.1495 ... AI355441 ·· ♦ 7,53775 0.487568 1,5091 ATG3 AF202092 ATG3 autophagy related 3 homolog (S 7.5331 0.104555 1.2959 SCP2 NM 002979 sterol carrier protein 2 7,53261 0.689884 -1,091 0LA1 NM 013341 Obg-like ATPase 1 7.53169 0.098121 -1.3585 TAF10 NM 006284 TAF10 RNA polymerase II, TATA box b 7,53086 0.789107 -1.0356 SNRPD2 NM 004597 small nuclear ribonucleoprotein D2 7,52668 0.284636 -1,246 PTPRJ AI631833 protein tyrosine phosphatase, recep 7.52601 0.167334 1.2153 SMAP2 AL137764 stromal membrane-associated GTPase- 7.5256 0.195852 1,291 LEF1 AF288571 lymphoid enhancer-binding factor 1 7.5253 0.346488 -1.2846 MAGT1 BG292405 magnesium transporter 1 7,52387 0.057105 -1,3367 KLF4 BF514079 Kruppel-like factor 4 (gut) 7,52317 0.028447 2,1705 SAMD9 AA741307 sterile alpha motif domain containi 7.52251 0.045497 2.2987 SMCHD1 AV699744 structural maintenance of chromosom 7,52033 0.506626 -1.0667 ARL4C BG435404 ADP-ribosylation factor-like 4C 7.51949 0.803521 1.0818 IGKV1D- 13 CBX4 AW408194 immunoglobulin kappa variable 1D-13 7,51906 0.011292 -2.3235 AI570531 chromobox homolog 4 (Pc class homol 7.51868 0.1376 -1.2016 PRNP NM 000311 prion protein (p27-30) (Creutzfeldt 7.5181 0.190006 1.1833 PRELID1 AF153607 PRELI domain containing 1 7,51744 0.755179 1.0634 MAN1A1 BG287153 mannosidase, alpha, class 1 A, membe 7,51738 0.016691 -1.7464 TUBB BC001002 tubulin, beta 7,51425 0.164881 -1.2605 NUP153 NM 005124 153kDa nucleoporin 7,51356 0.290198 -1.1644 MTDH AI886796 metadherin 7,51177 0.034911 -1.4497 EIF2S1 NM 004094 eukaryotic translation initiation f 7.50966 0.063345 -1.3382 CTBP1 BF337195 C-terminal binding protein 1 7.50955 0.206279 1.1575 TLOC1 BE866511 translocation protein 1 7.50919 0.364502 -1.3357 GOLGA8 G TUFM AI620911 golgi autoantigen, golgin subfamily 7.50826 0.036389 1.2952 NM 003321 Tu translation elongation factor, m 7.50771 0.089252 -1,3499 TAGLN2 NM 003564 transgelin 2 7.50657 0.801935 -1.0711 NME2 NM 002512 non-metastatic cells 2, protein (NM 7.50512 0.079858 -1,3013 DNAJA1 AL534104 DnaJ (Hsp40) homolog, subfamily A, 7.50394 0.093258 1,254 CSGALN ACT NM_018590 chondroitin sulfate N-acetylgalacto 7.50278 0.032418 1.4213 PLCG2 NM 002661 phospholipase C, gamma 2 (phosphati 7.50223 0.259505 -1,3438 ICAM2 AA126728 intercellular adhesion molecule 2 7.49956 0.108815 1.3548 HINT1 NM 005340 histidine triad nucleotide binding 7.49859 0.236295 -1,172 SLC7A7 NM 003982 solute carrier family 7 (cationic a 7.49659 0.024929 1.9475 LOC20205 1 CNOT2 AK098740 hypothetical protein LOC202051 7.49571 0.824139 -1.0248 BG105204 CCR4-NOT transcription complex, cnh 7.49562 0.911068 -1.0029 DBT NM 001918 dihydrolipoamide branched chain tra 7.49442 0.012876 1.3057 C5orf26 BF314746 chromosome 5 open reading frame 26 7,494 0.267609 -1.1904

ZMIZ2 AA868332 zinc finger, ΜΙΖ-type containing 2 7.49286 0.413808 1.0621 IL18RAP NM 003853 interleukin 18 receptor accessory p 7.49267 0.799441 -1.0059 RAB27A AF125393 RAB27A, member RAS oncogene family 7.49264 0.152316 -1.2575 ... H15073 ... 7.4892 0.561536 -1.0862 RBMX AI452524 RNA binding motif protein, X-linked 7.48838 0.11949 -1.2771 PDLA6 NM 005742 protein disulfide isomerase family 7.48819 0.020639 -1.6636 AB046820 KIAA1600 7,48724 0.918689 -1.0282 KIAA1600 MTDH AI972475 metadherin 7.48459 0.087143 -1,483 P2RY8 AI436587 purinergic P2Y receptor, G-protein 7,48332 0.781117 1,0328 NOL7 AF130102 nucleolar protein 7, 27kDa 7,48322 0.003969 -1.4731 ITGAM NM 000632 integrin, alpha M (complement compo 7.48256 0.220182 1.2548 CNOT6L AW514857 CCR4-NOT transcription complex, sub dolichyl-diphosphooligosaccharide-p 7.48203 0.206903 -1.2963 DDOST BC002594 7.48163 0.006695 -1,6168 PTTG1 NM 004219 tumor-transforming pituitary 1 7.48147 0.061812 -1.6711 C6orf62 AL136632 chromosome 6 open reading frame 62 7.47929 0.221789 1.1691 SLAMF7 AL121985 SLAM family member 7 7.47911 0.617842 1.0548 RPS21 AW024383 ribosomal protein S21 7,47875 0.701514 1.0728 USP4 NM 003363 ubiquitin specific peptidase 4 (pro 7.47733 0.231369 1.2597 MAP3K2 AI125541 mitogen-activated protein kinase ki 7.47715 0.786999 -1.0287 MPEG1 BF590697 macrophage expressed gene 1 7.47382 0.039243 2,0856 AKAP2 BG540494 Kinase (PRKA) anchor protein 2 7.47092 0.175072 -1.2104 MDM4 AA961420 Mdm4, transformed 3T3 cell double m 7.47089 0.732265 -1.0289 CENTD1 AB011152 centaurin, delta 1 7.47025 0.108507 1.3393 WIPF1 BF446719 WAS / WASL interacting protein family 7.4694 0.655506 -1.0311 KPNB1 AA861608 karyopherin (importin) beta 1 7.46879 0.105199 1,11363 YME1L1 AF070656 YMEl-like 1 (S. cerevisiae) 7.46872 0.014474 -1,4003 SELPLG AI741056 selectin P ligand 7.46846 0.002757 1.5125 RHOG NM 001665 ras homolog gene family, member G ( 7.46808 0.032551 1.4664 PRR11 NM 018304 proline rich 11 7.46652 0.863727 -1.0063 MCM5 AA807529 minichromosome maintenance complex 7.46633 0.084716 -1.4164 TXNIP AI439556 thioredoxin interacting protein 7.46546 0.206057 1.3365 C20orfll8 AV715309 chromosome 20 open reading frame 11 7.46429 0.005605 1.7538 YME1L1 AJ295618 YMEl-like 1 (S. cerevisiae) 7.46389 0.16034 -1,245 IARS NM 013417 isoleucyl-tRNA synthetase 7.46337 0.016927 -1.7784 IMPDH2 NM 000884 IMP (inosine monophosphate) déydro 7.46123 0.049026 -1,5509 CSK NM 004383 c-src tyrosine kinase 7.46116 0.029042 1.3099 C6orf48 NM_016947 chromosome 6 open reading frame 48 7.46101 0.913713 -1.0409 SMC1A D80000 structural maintenance of chromosom 7.46013 0.220713 -1.1873 EDF1 AB002282 endothelial differentiation-related 7.45753 0.28854 -1.1791 GRN AK023348 granulin 7.45646 0.105118 1,6091 AW516297 Notch homolog 2 (Drosophila) N-term 7,45595 0.300512 1.3554 NOTCH2 NL MDH1 NM 005917 malate déydrogenase 1, NAD (solubl 7,455,588 0.077683 -1.2739 AF119873 serpin peptidase inhibitor, clade A 7,455 0.00763 2,463

SERPINA

TIFA AA195074 TRAF-interacting protein with forkh 7,45438 0.025884 -1.5536 MRCL3 NM 006471 myosin regulatory light chain MRCL3 7.45291 0.346892 1.1996 TXNDC15 NM_024715 thioredoxin domain containing 15 7,418 0.021086 -1.6983 MBNL1 AI697540 muscleblind-like (Drosophila) 7.45172 0.796887 -1.0028 CXXC5 AK001782 CXXC fmger 5 7.44996 0.005124 -1.4299 IRF8 AI073984 interferon regulatory factor 8 7.44988 0.17711 1,44919 SERPINB9 BC002538 serpin peptidase inhibitor, clade B 7.44743 0.747091 1.1748 GARS D30658 glycyl-tRNA synthetase 7.4472 0.014336 -1.4931 ANXA5 NM 001154 annexin A5 7.44647 0.992456 -1.0378 ILF3 AF141870 interleukin enhancer binding factor 7.44341 0.033018 -1.3358 EFHD2 NM 024329 EF-hand domain family, member D2 7.44186 0.160768 1.3945 RPL18A NM 000980 ribosomal protein LI 8a 7.43716 0.723726 -1,176 TES NM 015641 testis derived transcript (3 LIM of 7.43591 0.015809 1.3989 MTDH AV700332 metadherin 7.43543 0.00632 -1,619 ... AW392551 ... 7.43535 0.086173 1.7432 ZEB2 AF086037 zinc finger E-box binding homeobox 7.43467 0.611448 1,2008 RSAD2 AW189843 radical S-adenosyl methionine domai 7.43424 0.112533 3,146 FAM45A BE565675 family with sequence similarity 45, 7.43319 0.25883 1.3032 C22orf9 AK025608 chromosome 22 open reading frame 9 7.43169 0.029455 1.5386 SEC13 NM 030673 SEC13 homolog (S. cerevisiae) 7.43053 0.044417 -1,517 TAP2 AA573502 transporter 2, ATP-binding cassette 7.42979 0.282417 1.4458 KRAS BF673699 v-Ki-ras2 Kirsten rat viral sarcoma 7.42914 0.420004 1,11519 LTB NM 002341 lymphotoxin beta (TNF superfamily, 7.4288 0.692661 1,099 NPM1 AB042278 nucleophosmin (nucleolar phosphopro 7.42798 0.012864 -1.5668 EPSTI1 AA633203 epithelial stromal interaction 1 (b 7.42772 0.024256 1.8602 ZRANB2 AF065391 zinc finger, RAN-binding domain con 7.42648 0.263617 -1,159 MAFB NM 005461 v-maf musculoaponeurotic fibrosarco 7.42634 0.270495 1,846 CENPL BF316352 centromere protein L 7.4262 0.244093 -1.2485 SHMT2 AW190316 serine hydroxymethyltransferase 2 ( 7.42611 0.086216 -1,449 ARMET NM 006010 arginine-rich, mutated in early sta 7.42537 0.011018 -1.8831 SRPR NM 003139 signal recognition particle recepto 7.42306 0.022959 -1,4447 ID2 NM 002166 inhibitor of DNA binding 2, dominan 7.42165 0.088197 1,4365 CDC16 AF164598 cell division cycle 16 homolog (S. 7.41847 0.396208 1.0932 METTL9 NM 016025 methyltransferase like 9 7.4176 0.801467 -1.0204 LRRFIP1 BE674143 leucine rich repeat (in FLII) inter 7.4172 0.511552 1.1306 RUNX3 AA541630 runt-related transcription factor 3 7.41682 0.555748 1,2072 CDC2L2 AI767436 cell division cycle 2-like 2 (PITSL 7.41653 0.824159 -1.0472 CACYBP AF057356 calcyclin binding protein 7.4165 0.122575 -1,3223 UTRN N66570 utrophin 7.41403 0.047842 1,44964 BTBD1 NM 025238 BTB (POZ) dòmain containing 1 7.41175 0.792259 1,127 ACSL1 NM 021122 acyl-CoA synthetase long-chain fami 7.41119 0.350623 1,63535 TUBB BC005838 tubulin, beta 7.41074 0.066409 -1.4973 PDLA6 BC001312 protein disulfide isomerase family 7.40816 0.035045 -1.5616 ... M85256 ... 7.40797 0.011066 -2.6563 Cllorf2 NM 013265 chromosome 11 open reading frame2 7.40774 0.53236 -1.0565 EIF3CL AA679705 eukaryotic translation initiation f 7.40692 0.470087 -1.1872 PALM2- AKA NM 007203 PALM2-AKAP2 7.40378 0.177918 -1.3389

UFM1 NM 016617 ubiquitin-fold modifier 1 7.40251 0.398044 -1.16 VCL NM 014000 vinculin 7.40223 0.082591 1.4216 WFP NM 000919 peptidylglycine alpha-amidating mon 7.40209 0.135836 1.3469 SAMM50 NM 015380 sorting and assembly machinery comp 7.40034 0.243735 -1.2337 SMC4 AL136877 structural maintenance of chromosom 7.39896 0.094838 -1.4237 PYCARD BC004470 PYD and CARD domain containing 7.39683 0.011531 1,904 BE616972 DKFZP434B0335 protein 7,39624 0.757367 -1.0095 DKFZP43 4B RNF19A AB029316 ring finger protein 19A 7.39262 0.522571 -1.0718 PTPRC AI809341 protein tyrosine phosphatase, recep 7.39148 0.052605 1,371 ARHGEF1 8 C1QBP AB011093 rho / rac guanine nucleotide exchange 7.39039 0.291828 1.1023 AU151801 complement component 1, q 7,38926 0.01763 -1.5754

subcompon

UBE2G1 AW299555 ubiquitin-conjugating enzyme E2G 1 7.38718 0.007798 -1.6871 SFPQ NM 005066 splicing factor proline / glutamine-r 7.38689 0.195069 -1,4149 TFRC NM 003234 transferrin receptor (p90, CD71) 7.38343 0.806645 -1.0436 GIMAP2 AI431931 GTPase, IMAP family member 2 7,38245 0.014479 1.4662 TCEB2 NM 007108 transcription elongation factor B ( 7.38243 0.814389 -1.0055 TRIP12 AI149880 thyroid hormone receptor interactor 7.38147 0.535201 1,1087 AL121871 similar to rCG57659 7.38132 0.311524 -1.1384

LOC39250

EIF5 AL080102 eukaryotic translation initiation f 7.38014 0.036975 -1,481 EPRS NM 004446 glutamyl-prolyl-tRNA synthetase 7,37844 0.22597 -1,241 CCNI AF135162 cyclin I 7,37819 0.514545 -1,161 SLC35E1 NM 024881 solute carrier family 35, member El 7.37691 0.105694 1.3175 UBE2J1 AF161502 ubiquitin-conjugating enzyme E2, J1 7,37628 0.000419 -2,3147 GZMK NM_002104 granzyme K (granzyme 3 tryptase II 7.37496 1402 1402 MFSD1 NM 022736 major facilitator superfamily domai 0.092063 1.4239 STAT6 BC004973 signal transducer and activator of 7.37457 0.014624 1,583 TSPAN13 NM 014399 tetraspanin 13 7.37428 0.280816 -1,2046 NOTCH2 AA291203 Notch homolog 2 (Drosophila) 7.37239 0.048744 1.3852 LOC33875 8 DSTN AI377324 hypothetical protein LOC338758 7.37209 0.140501 1,886 NM 006870 destrin (actin depolymerizing facto 7.37099 0.80006 -1.0207 PRDX4 NM 006406 peroxiredoxin 4 7.3706 0.01571 -1.8982 SP3 AU144413 Sp3 transcription factor 7,36925 0.590485 -1.0834 ALG5 NM 013338 asparagine-linked glycosylation 5 h 7.36738 0.004891 -1,6276 CUL1 AA682674 cullin 1 7.36732 0.255345 1.3226 CLPTM1L AB045223 CLPTMl-like 7.36728 0.006054 -1.8843 PPP2R5C AL834350 protein phosphatase 2, regulatory n 7.36255 0.864325 1.0222 TRAPPC4 NM 016146 trafficking protein particle comple 7.3612 0.315876 -1.1929 EIF5B BG261322 eukaryotic translation initiation f 7.36103 0.046033 -1,6475 SF3B5 NM 031287 splicing factor 3b, subunit 5, 10kD 7.36094 0.126615 -1.2765 IER5 NM 016545 immediate early response 5 7,35968 0.147159 1.3095

TMPO AL566034 thymopoietin 7,35949 0.274761 -1.1248 GNG2 AU146329 guanine nucleotide binding protein 7,35845 0.789904 1,0497 FAM101B BG036514 family with sequence similarity 101 7.35813 0.322931 -1.1424 ARPC5L NM 030978 actin related protein 2/3 complex, 7.35652 0.143945 -1.2524 ZWINT NM 007057 ZW10 interactor 7,35345 0.059843 -1.5759 ... AI678013 ... 7.35134 0.388349 1,767 RUNX3 NM 004350 runt-related transcription factor 3 7,34961 0.527132 1.1439 ADA NM 000022 adenosine deaminase 7,3489 0.276034 -1.2502 ITGAE NM 002208 integrin, alpha E (antigen CD 103, h 7.34825 0.028698 -1,437 FAM35A NM 019054 family with sequence similarity 35, 7.34824 0.313082 -1.2523 KIAA0999 AW590838 KIAA0999 protein 7.3457 0.695174 1.0339 GOLGA8 THE AF204231 golgi autoantigen, golgin subfamily 7.34547 0.710158 -1.0178 FNDC3B NM 022763 fibronectin type III domam contain 7.34525 0.108133 -1.3457 CTBP1 NM 001328 C-terminal binding protein 1 7,34475 0.237025 1,11919 KCTD12 AI718937 potassium channel tetramerisation d 7.33935 0.067832 1,6988 BCL6 NM 001706 B-cell CLL / lymphoma 6 (zinc finger 7.33849 0.384674 1.2629 CCDC84 BF446390 coiled-coil domain containing 84 7.33821 0.8569 -1.0274 CFLAR U97075 CASP8 and FADD-like apoptosis regul 7.33561 0.205271 -1.2368 DDIT4 NM 019058 DNA-damage-inducible transcript 4 7,33493 0.460119 1.3483 TNFSF1O AW474434 tumor necrosis factor (ligand) supe 7.33489 0.034056 2.1349 DNAJB9 AL080081 DnaJ (Hsp40) homolog, subfamily B, 7.33431 0.121042 -1,3201 CSDA AL556190 cold shock domain protein A 7.33318 0.868653 1.0345 C17orf91 AF070569 chromosome 17 open reading frame 91 7.33291 0.649458 1,11213 DUSP2 NM 004418 dual specificity phosphatase 2 7.3312 0.837541 1,11135 SURF4 AK026646 surfing 4 7.33035 0.478109 -1.0955 LAT AF036906 linker for activation of T cells 7.33018 0.541589 1.2306 HNRPD W74620 heterogeneous nuclear ribonucleopro 7.32906 0.046949 -1,404 DDX6 BF129093 DEAD (Asp-Glu-Ala-Asp) box polypept 7,32766 0.204121 -1.2211 CENPL BG329175 centromere protein L 7.3258 0.684594 -1.1379 MYLIP AF212221 myosin regulatory light chain inter 7.32522 0.384416 1.1556 RNASE2 NM 002934 ribonuclease, RNase A family, 2 (li 7.32392 0.159557 1,886 SF3A1 BF129339 splicing factor 3 a, subunit 1, 120k 7.32298 0.139399 -1,3486 NFKBIZ BE646573 nuclear factor of kappa light polyp 7.3168 0.062552 1.5799 PPBP R64130 pro-platelet basic protein (chemoki 7,31478 0.884264 1,0208 P2RX5 U49396 purinergic P2X receiver, ligand-gat 7.31217 0.185142 -1.2985 ATP6V0D 1 SP11O AL566172 ATPase, H + transporting, lysosomal 7.31157 0.307694 1.0931 AF280094 SP110 nuclear body protein 7.31119 0.011853 1.7032 SNRPA1 AA872471 small nuclear ribonucleoprotein pol 7.31014 0.517405 1,0701 HSPA5 AF216292 heat shock 70kDa protein 5 (glucose 7.3077 0.012754 -1.7213 ASH1L AI806500 ashl (absent, small, or homeotic) -l 7.30676 0.548217 1,0246 ... AV687517 ... 7,3061 0.575499 -1.2606 FAM133B AK000119 family with sequence similarity 133 7.30573 0.248908 1,5029 COPS8 BC003090 COP9 constitutive photomorphogenic 7.30543 0.893859 -1.0822 RHOH BE676335 ras homolog gene family, member H 7.3021 0.023192 -1.3712

CAPZA2 AV685920 capping protein (actin filament) mu 7.30208 0.200162 1.22 APLP2 BC000373 amyloid beta (A4) precursor-like pr 7,30058 0.11537 1.4335 RAB11FIP 1 CKS2 NM 025151 RAB11 family interacting protein 1 7.29837 0.137782 1.4148 NM 001827 CDC28 protein kinase regulatory sub 7.29782 0.05086 -1.6631 KPNA2 BC005978 karyopherin alpha 2 (RAG cohort 1, 7.29757 0.020279 -1,714 NDUFA13 NM 015965 NADH déydrogenase (ubiquinone) 1 a 7.29716 0.849285 1.0985 SEC23B BC005032 Sec23 homolog B (S. cerevisiae) 7,29611 0.55733 -1.0956 ANP32E NM 030920 acidic (leucine-rich) nuclear phosp 7.29143 0.028548 -1.5776 LARS D84223 leucyl-tRNA synthetase 7.28708 0.547248 -1.2256 CD83 NM 004233 CD83 molecule 7,28581 0.758757 -1.1233 NLN AK026655 neurolysin (metallopeptidase M3 fam 7.28481 0.045965 1,22729 NCF1 AW072388 neutrophil cytosolic factor 1, (chr 7.28401 0.135512 2.0212 S100A6 NM 014624 SI 00 calcium binding protein A6 7.28308 0.019028 2,0002 LYN AI356412 v-yes-1 Yamaguchi viral sarcoma king 7.28236 0.135674 1.6915 PLSCR1 AI825926 phospholipid scramblase 1 7.28196 0.069662 1.5452 NEK9 AL117502 NIMA (never in mitosis gene a) - rei 7.28137 0.524007 1,077 US01 NM 003715 USO1 homolog, vesicle docking protein 7.27916 0.264755 -1,182 ... N25986 ... 7,27813 0.262853 -1.3216 RAP1A AW793677 RAP1A, member of RAS oncogene famil 7.27715 0.716187 -1,1077 C1QBP L04636 complement component 1, q subcompon 7.27666 0.014995 -1.7889 NDUFB6 NM 002493 NADH déydrogenase (ubiquinone) 1 b 7.27376 0.006174 -1,828 FOXP1 AF146696 forkhead box PI 7.27194 0.552374 -1.18 HSBP1 AK026575 heat shock factor binding protein 1 7.27088 0.160599 1.4323 TNFRSF1 7 NM001192 tumor necrosis supe receptor factor 7,26921 0.009406 -2.7543 / HERC5 NM 016323 hect domain and RLD 5 7.26865 0.122196 1,985 RP11- 345P AL031282 similar to solute carrier family 35 7.26626 0.691802 -1.0472 HLADMA X76775 major histocompatibility complex, c 7.2657 0.057443 1,605 AIM1 U83115 absent in melanoma 1 7,26495 0.400738 1.1912 CTSS NM 004079 cathepsin S 7,2641 0.163119 1,3006 DC2 AF201937 DC2 protein 7.26335 0.031519 -1,701 KIAA1267 AL137317 KIAA1267 7.26008 0.660292 1,0498 AHNAK BG287862 AHNAK nucleoprotein 7.25701 0.5372 1.0405 S100A12 NM 005621 S100 calcium binding protein A12 7.25689 0.283587 1.5395 CD8A AW006735 CD8a molecule 7.25626 0.912661 1,459 BE675995 CDC42 small effector 2 7.25621 0.517273 -1.1396

CDC42SE

FGR NM 005248 Gardner-Rasheed feline sarcoma turns 7,25545 0.009879 2.1941 HLA- NM 002118 major histocompatibility complex, c 7.25493 0.039745 1,66869 DMB PDIA4 BC006344 protein disulfide isomerase family 7.25466 0.088648 -1.4799

ΟΡΤΝ NM 021980 optineurin 7.25407 0.750935 1,0696 JARID2 BG029530 jumonji, AT rich interactive domain 7.25247 0.255552 1.1914 RICTOR W49629 rapamycin-insensitive companion of 7.25181 0.784326 1.0186 PFKFB3 NM 004566 6-phosphofructo-2-kinase / fructose-2 7,24874 0.703927 1.2746 •. * AW151360 ... 7,24431 0.046937 1.7632 NOL5A NM 006392 nucleolar protein 5A (56kDa with KK 7.24373 0.144876 -1.2938 PCBP2 NM 005016 poly (rC) binding protein 2 7.2433 0.320261 -1,1694 RGS2 NM 002923 regulator of G-protein signaling 2, 7.24252 0.151817 1.6989 TNFSF10 NM 003810 tumor necrosis factor (ligand) supe 7.24195 0.044441 2.3425 LOC40150 Λ BG170478 hypothetical gene supported by AK09 7.24133 0.83899 -1,078 4 MCM7 D55716 minichromosome maintenance complex 7.23949 0.112466 -1.3777 DTX3L AA577672 deltex 3-like (Drosophila) 7.23914 0.004459 1,734 TGFBR2 D50683 transforming growth factor, beta re 7.23882 0.930821 -1,1678 HRB AI989512 HIV-1 Rev binding protein 7.23788 0.658439 1,2047 TAGAP BF591040 T-cell activation RhoGTPase activat 7.23547 0.146357 1,279 PGF AK023843 placental growth factor 7.23391 0.413203 1,0952 ... AFFX-R2-BS ... 7.23137 0.611685 -1.7638 FCER1G NM 004106 Fe fragment of IgE, high affinity I 7.2292 0.020635 2.5666 RASA2 AI888503 RAS p21 protein activator 2 7.22599 0.868336 -1.0089 NUCKS1 NM 022731 nuclear casein kinase and cyclin-de 7.22519 0.55243 -1.0862 FEN1 BC000323 structure-specific flap endonucleas 7.22509 0.092411 -1,4038 ... AC004544 ... 7.22353 0.609314 -1.0597 LOC72885 ç AA863228 hypothetical protein LOC728855 7.22337 0.066898 1.2586 0 GIMAPl NM 130759 GTPase, IMAP family member 1 7.22249 0.006328 1.7139 AIF1 BF213829 allograft inflammatory factor 1 7.22048 0.041111 2,44635 RAB24 AK021761 RAB24, member RAS oncogene family 7.21845 0.043692 1.5203 HLA- DPA1 M27487 major histocompatibility complex, c 7.21841 0.011235 1,9378 UBE2L3 BG531983 ubiquitin-conjugating enzyme E2L 3 7.21706 0.13575 -1.2806 IL7R NM 002185 interleukin 7 receiver 7.2168 0.624437 1.1379 CXXC5 BC006428 CXXC finger 5 7.21492 0.003382 -1.6791 MAP3K1 AA211369 mitogen-activated protein kinase ki 7.21372 0.356893 1,148 GLTP AI052020 glycolipid transfer protein 7.20911 0.601343 1.0788 ADFP BC005127 adipose differentiation-related pro 7,2073 0.153079 1.3121 CCND2 NM 001759 cyclin D2 7.20479 0.174284 -1,3075 SRPRB NM 021203 signal recognition particle recepto 7.20248 0.01398 -1.8251 HIST1H2B K KIAA1702 BC000893 histone cluster 1, H2bk 7,2021 0.928604 -1.0368 AK027074 KIAA1702 protein 7,20059 0.453221 -1,1038 CAMK2G NM 001222 calcium / calmodulin-dependent protei 7.19942 0.357869 -1.2771 CD36 M98399 CD36 molecule (thrombospondin recep 7.19905 0.24264 1.4246 PRDX3 NM_006793 peroxiredoxin 3 7.19854 0.204156 -1.2433

NM_005739 RAS guanyl releasing protein 1 (lime 7.19784 0.624123 1.0989 RASGRP1 GMNN NM 015895 geminin, DNA replication inhibitor 7.19724 0.009426 -2.2142 ZBTB20 NM 015642 zinc finger and BTB domain containi 7.19694 0.69319 -1.0781 PLXNC1 AF035307 plexin Cl 7.19673 0.015321 1.5884 SLC38A2 NM 018573 solute carrier family 38, member 2 7.19504 0.07105 -1,2892 PRKCH AL512701 protein kinase C, eta 7.1924 0.98413 -1.0181 HLADRA M60333 major histocompatibility complex, c 7.18903 0.076158 1.9596 ITGB2 AW303397 integrin, beta 2 (complement components 7,18675 0.017817 1,658 CLEC7A AF313468 C-type lectin domain family 7, memb 7.18478 0.220047 1.4178 LAMP1 NM 005561 lysosomal-associated membrane prote 7,18225 0.371746 1,11169 APLP2 BC004371 amyloid beta (A4) precursor-like pr 7,18219 0.082365 1.5294 TRIM14 NM 014788 tripartite motif-containing 14 7.18179 0.007725 1.5941 SFRS11 AW241752 splicing factor, arginine / serine-ri 7.18168 0.194301 -1,3656 GBP5 BG545653 guanylate binding protein 5 7,17838 0.022718 2,77614 DR1 AW516932 down-regulator of transcription 1, 7,17832 0.855321 1,0704 NOLA3 NM 018648 nucleolar protein family A, member 7.17454 0.742457 -1.0845 NCF2 BC001606 neutrophil cytosolic factor 2 (65kD 7.17178 0.093362 2,0307 LOC15116 o AL134724 hypothetical LOC151162 7.17144 0.924836 -1.0157 TNFAIP3 AI738896 tumor necrosis factor, alpha-induce 7.17131 0.594602 1.1375 ANKRD44 AA744636 ankyrin repeat domain 44 7.17126 0.597802 1.0351 LIPA NM 000235 lipase A, lysosomal acid, cholester 7.17109 0.153066 1,315 SOCS3 AI244908 suppressor of cytokine signaling 3 7.17045 0.283484 1.3454 LRRC59 AK025328 leucine rich repeat containing 59 7.17028 0.017101 -1.8304 GLCCI1 AI761989 glucocorticoid induced transcript 1 7.16872 0.063945 -1.4757 C6orf62 BE465032 chromosome 6 open reading frame 62 7.16704 0.886 1,0798 MAFB AW135013 v-maf musculoaponeurotic fibrosarco 7.16636 0.175796 2.1682 CSE1L AF053640 CSE1 chromosome segregation 1-like 7.16629 0.085477 -1.4435 CCR2 NM 000647 chemokine (C-C motif) receptor 2 7.16298 0.855911 1,0397 TRD © X06557 T cell delta locus receiver 7.16241 0.252075 1.2233 SAT1 BE971383 spermidine / spermine Nl-acetyltransf 7.16209 0.11076 2,22781 RANBP9 BE674964 RAN binding protein 9 7.16204 0.46828 -1,3041 RUFY1 NM 025158 RUN and FYVE domain containing 1 7.16193 0.986618 1.0282 TIPARP AL556438 TCDD-inducible poly (ADP-ribose) in limb bud and heart development homo 7,1581 0.156938 1.1786 LBH NM 030915 7.15752 0.80578 1,11163 BST2 NM 004335 bone marrow stromal cell antigen 2 7.15713 0.102735 1.5857 IL8 NM 000584 interleukin 8 7.15616 0.3474 1.0429 PRO 1073 NM 014086 PRO1073 protein 7.1561 0.595472 -1.0439 TSPO NM 000714 translocator protein (18kDa) 7,15465 0.046167 1,77312 GADD45B NM_015675 growth arrest and DNA-damage-induci 7.15422 0.379925 1.4345 STMN1 NM 005563 stathmin 1 / oncoprotein 18 7.15282 0.050935 -1.5726 GRN BC000324 granulin 7,14984 0.071057 1.7539 BAD NM 002371 evil, T-cell differentiation protein 7.14856 0.359485 -1.2609 NM 004125 hypothetical protein LOC552891 7.14835 0.356859 1.2888

LOC55289

ICOS AB023135 inducible T-cell co-stimulator 7.14686 0.557642 -1.0967 CDV3 AV646549 CDV3 homolog (mouse) 7.14654 0.127723 -1,42626 PFN1 NM 005022 profilin 1 7.14346 0.946311 -1.0757 CST7 AF031824 cystatin F (leukocystatin) 7.14178 0.192562 1,6091 SLC7A1 AA148507 solute carrier family 7 (cationic a 7.14149 0.014555 -1.6575 RRM1 NM 001033 ribonucleotide reductase Ml 7.14092 0.084178 -1.4211 JMJD6 AK021780 jumonji domain containing 6 7.14044 0.897614 1,0674 NM 003516 histone cluster 2, H2aa3 7.13839 0.164608 1.5113 HIST2H2 AA TCF4 BF592782 transcription factor 4 7.13586 0.381035 -1,181 GSPT1 AA580082 G1 to S phase transition 1 7,13564 0.568937 -1.0317 CDCA7L AK022955 cell division cycle associated 7-li 7.1356 0.143749 -1,348 BHLHB2 NM 003670 basic helix-loop-helix domain account 7.13462 0.604043 1,0804 YAF2 AA651631 YY1 associated factor 2 7.13239 0.555127 1,11112 CYFIP1 BC005097 cytoplasmic FMR1 interacting protei 7.13211 0.172208 1,542 RPN1 NM 002950 ribophorin I 7.1321 0.023576 -1.5921 DKFZp586 I RB1CC1 AL050378 hypothetical protein DKFZp58611420 7.13198 0.579265 1.1509 AI801666 RB1-inducible coiled-coil 1 7.1292 0.467613 -1,1598 CDC42 BC002711 cell division cycle 42 (GTP binding 7.12828 0.590256 -1,1013 GIMAP5 NM 018384 GTPase, IMAP family member 5 7,12764 0.639744 1.2795 DCN NM 001920 decorin 7.12744 0.034471 -1.5559 EIF4A1 U79273 eukaryotic translation initiation f 7.12535 0.156318 1.2588 TKT L12711 transketolase (Wemicke-Korsakoff s 7.12473 0.222755 1.2949 MS4A6A AF253977 membrane-spanning 4-domains, subfam 7.12424 0.073503 1.8167 LCP2 AI123251 lymphocyte cytosolic protein 2 (SH2 7.12395 0.025919 1.6107 TRGC2 M13231 T cell gamma constant 2 receiver 7.12357 0.372068 1.3134 SAMD9L BE669858 sterile alpha motif domain containi 7.12239 0.01406 2,393 UBE2J1 AF151039 ubiquitin-conjugating enzyme E2, J1 7.12047 0.016637 -1.7689 TUBB AF141349 tubulin, beta 7,11976 0.064298 -1,5503 VAMP3 BC003570 vesicle-associated membrane protein 7.11909 0.002351 1.8814 MALAT1 AI446756 metastasis associated lung adenocar 7.11904 0.23813 1,44949 APLP2 AI525212 amyloid beta (A4) precursor-like pr 7.11836 0.073467 1,69494 JUN BG491844 jun oncogene 7,11786 0.995998 -1.0078 IDH2 U52144 isocitrate déydrogenase 2 (NADP +), 7,11618 0.163975 -1.2185 PTPLAD1 AL573951 protein tyrosine phosphatase-like A 7.11593 0.083071 -1,369 FGFBP2 AB021123 fibroblast growth factor binding pr 7.11442 0.580816 1.8223 CCL5 AF043341 chemokine (C-C motif) ligand 5 7.11339 0.671914 1.2602 ... AI092770 ... 7,10964 0.390894 1.2454 ACTR2 BE566290 ARP2 actin-related protein 2 homolo 7.10953 0.759885 -1.0509 CNIH4 AL136930 itching homolog 4 (Drosophila) 7.10846 0.032449 1.5332 PDIA6 AK026926 protein disulfide isomerase family 7.10777 0.046214 -1,6005 NT5C3 AF312735 5'-nucleotidase, cytosolic III 7.10744 0.42022 1.3836 SEC22B AA890010 SEC22 vesicle trafficking protein h 7,10737 0.217271 -1.2908 GIMAP5 AI435089 GTPase, IMAP family member 5 7.10544 0.574153 1.1821 DEGS1 BC000961 degenerative spermatocyte homolog 1 7.10495 0.104756 1.4108 C9orf72 BC020851 chromosome 9 open reading frame 72 7.10325 0.148838 1.8555

ΖΕΒ2 AI623184 zinc finger E-box binding homeobox 7.10254 0.492952 1.5442 MGAT4A AW006441 mannosyl (alpha-l, 3 -) - glycoprotein 7.0993 0.625945 -1.1936 PRDX2 L19185 peroxiredoxin 2 7.09884 0.11358 -1.4173 NM 024901 DENN / MADD domain containing 2D 7.09818 0.329203 1.3884 DENND2 D VAMP1 AU150319 vesicle-associated membrane protein 7.09782 0.294172 -1,3303 WDR42A AI208342 WD repeat domain 42A 7,09521 0.946306 1.0427 AI554300 serpin peptidase inhibitor, clade B 7.09301 0.015523 1,488 SERPINB1 AA502643 platelet-activating factor acetylhy 7.09227 0.110366 -1.5971 PAFAH1B 1 NM_012197 RAB GTPase activating protein 1 7.09226 0.089805 1.4141 RABGAP1 DPYSL2 NM 001386 dihydropyrimidinase-like 2 7.09196 0.046244 1.6057 IFIT2 AA131041 interferon-induced protein with tet 7,09145 0.079307 2.3699 OCC-1 BF969397 overexpressed in colon carcinoma-1 7.09021 0.074651 -1,4051 TCF4 AI927067 transcription factor 4 7.08771 0.131507 -1.4672 KLRB1 NM 002258 killer cell lectin-like receiver su 7,08637 0.522235 1,0554 GMPPB NM 021971 GDP-mannose pyrophosphorylase B 7.08461 0.02346 -1.8817 ATP5G1 AL080089 ATP synthase, H + transporting, myth 7,08317 0.035607 -1.5588 SET W26593 SET translocation (myeloid leukemia 7.08154 0.512452 -1,2066 AP0BEC3 B CHD1 NM 004900 apolipoprotein B mRNA editing enzym 7.08014 0.150737 -1.4155 NM_001270 chromodomain helicase DNA binding 7.07912 0.834607 1.0789 CD300A AF020314 P CD300a molecule 7.07896 0.000864 2.1544 0AS1 NM 016816 2 ', 5'-oligoadenylate synthetase 1, 7.07526 0.227757 1,66868 BF111651 phosphatidic acid phosphatase type 7.07497 0.004347 -2.3491 PPAPDC1 B NTN2L AF103529 netrin 2-like (chicken) 7,07069 0.027016 -2.0572 CD27 NM 001242 CD27 molecule 7.07025 0.112686 -1,3892 DDX60L AK023743 DEAD (Asp-Glu-Ala-Asp) box polypept 7,06917 0.053039 1.6755 SPTLC2 BC005123 serine palmitoyltransferase, long c 7.06817 0.017518 1.9835 RPL22 BE250348 ribosomal protein L22 7.06653 0.309923 -1.2338 ITPK1 AF279372 inositol 1,3,4-triphosphate 5/6 kin 7,06589 0.013765 1,46969 BCL11B AA918317 B-cell CLL / lymphoma 11B (zinc pretend 7.06482 0.767873 -1.0564 NDRG1 NM 006096 N-myc downstream regulated gene 1 7.06288 0.007598 1,44415 HLA- AI583173 major histocompatibility complex, c 7.06267 0.046951 1.8401 DQB1 IRF1 NM 002198 interferon regulatory factor 1 7.06259 0.046606 1.6269 MAGED1 AF217963 melanoma antigen family D, 1 7.06166 0.001644 -2.0342 AA522514 KIAA0746 protein 7.06113 0.015464 -2.0754 KIAA0746 STAG3L1 AA554827 stromal antigen 3-like 1 7.06066 0.511692 1.1105 SYK AW467357 spleen tyrosine kinase 7.05962 0.587708 -1.0093 MS4A6A NM 022349 membrane-spanning 4-domains, 7,05799 0.024153 2.4807

subfam ELF4 U32645 E74-like factor 4 (ets domain trans 7.05752 0.004034 1,66688 FAM46A AW246673 family with sequence similarity 46, 7,05721 0.052725 2,382 NR3C1 AI934556 nuclear receiver subfamily 3, group 7.0552 0.765834 -1.0115 AL353759 histone cluster 1, H2ac 7.05419 0.789519 -1.0609 HIST1H2 B.C S0D2 W46388 superoxide dismutase 2, mitochondri 7.05353 0.861515 -1.3685 TPD52 AA524023 tumor protein D52 7,0498 0.003567 -2.2114 AI859834 transcriptional adapter 2 (ADA2 hom 7.0496 0.77299 1,0361 MGC2187 CXCR4 L01639 chemokine (C-X-C motif) receiver 4 7.04848 0.714744 -1.2804 CCR5 NM 000579 chemokine (C-C motif) receptor 5 7.04793 0.227199 1.4096 ZFP36L1 BG250310 zinc finger protein 36, C3H type-li 7.04767 0.163363 1.3606 ABLIM1 NM 006720 actin binding LIM protein 1 7.04749 0.253045 -1,397 NUDT5 BC000025 nudix (nucleoside diphosphate linke 7.04507 0.044097 -1.6975 ... BE865517 ... 7.04074 0.003804 1.5431 POLR2L BC005903 polymerase (RNA) II (DNA directed) 7.04022 0.030649 -1.7389 HLA-C U62824 major histocompatibility complex, c 7.03785 0.231917 1,346 AF151024 hypothetical protein MGC29506 7.03573 0.015153 -2.4229 MGC2950 O AJ408433 7,03496 0.016187 -2.6756 C6orf32 AB002384 chromosome 6 open reading frame 32 7.03424 0.22556 1.3397 ZEB1 NM 030751 zinc finger E-box binding homeobox 7.03309 0.972692 -1.04 CTLA4 AI733018 cytotoxic T-lymphocyte-associated p 7,03276 0.470188 -1.1414 KLF10 NM 005655 Kruppel-like factor 10 7.03208 0.833274 1,0774 MYO1G BE646398 myosin IG 7.03128 0.027158 1.5904 CTSS BC002642 cathepsin S 7.03103 0.121835 1,44725 DPYD NM 000110 dihydropyrimidine déydrogenase 7.03016 0.169686 1.3614 PLEK NM 002664 pleckstrin 7.02538 0.070595 1.5824 IGLV1-44 U96394 immunoglobulin lambda variable 1-44 7.02255 0.005057 -2.9244 WAS UI 2707 Wiskott-Aldrich syndrome (eczema-th 7.02112 0.689594 1.0171 RNF135 BC005084 ring finger protein 135 7.02051 0.041324 1.9632 FLJ11286 AI862559 hypothetical protein FLJ11286 7.01933 0.027339 1,99741 FYB AF198052 FYN binding protein (FYB-120/130) 7.01908 0.023791 1,441 RANBP1 NM 002882 RAN binding protein 1 7.01866 0.042887 -1,5489 L48784 hypothetical gene supported by AB08 7.01833 0.05133 -1.8554 LOC40096 2 O BE500942 7.0169 0.503995 1.1605 PITPNC1 NM 012417 phosphatidylinositol transfer prote 7.0165 0.783095 -1.0205 FPR1 NM 002029 formyl peptide receptor 1 7.01379 0.07639 2.3093 GBP1 BC002666 guanylate binding protein 1, interf 7.01359 0.004938 2.3334 U03891 apolipoprotein B mRNA editing 7.0133 0.116343 2.1383 APOBEC3 A enzym AI510829 Rho GTPase activating protein 15 7.01185 0.331165 -1.4751

ARHGAP1

NC0A3 NM 006534 nuclear receptor coactivator 3 7.01173 0.671273 -1.1932 N0TCH2 AU158495 Notch homolog 2 (Drosophila) 7.0107 0.094728 1.4133 MS4A6A AF237908 membrane-spanning 4-domains, subfam 7.00974 0.085451 1.8192 RPS11 BF680255 ribosomal protein Sl 1 7.00798 0.442837 -1.0779 GCA NM 012198 grancalcin, EF-hand calcium binding 7.00743 0.138807 1.4326 NCF1 NM 000265 neutrophil cytosolic factor 1, (chr 7.00541 0.104483 2.0763 LOC72861 BC020552 programmed cell death 6 pseudogene 7.00517 0.131366 -1.9796 CSF2RB AV756141 colony stimulating factor 2 reception 6.99579 0.39196 1.4117 C9orfl9 H92988 chromosome 9 open reading frame 19 6,9941 0.0169 1.9849 IL8 BG340548 interleukin 8 6.99336 0.019738 -2.2463 TRAPPC5 BF433657 trafficking protein particle comple 6.99303 0.152229 1,44736 FOXO3 N25732 forkhead box 03 6.99217 0.100346 1.3492 PDE4D AI082004 phosphodiesterase 4D, cAMP-specific 6,98535 0.238967 -1,3065 TGFBR3 NM 003243 transforming growth factor, beta re 6,98469 0.732594 1,11537 IFI6 NM 022873 interferon, alpha-inducible protein 6.98176 0.213753 1,605 Clorfl62 AW662189 chromosome 1 open reading frame 162 6.98117 0.033182 2.1046 NAGK NM 017567 N-acetylglucosamine kinase 6.98114 0.044515 2.1669 LACTB BE892574 lactamase, beta 6.98027 0.158193 1.4705 GBP2 BF509371 guanylate binding protein 2, interf 6.97688 0.173086 1,467 MMD NM 012329 monocyte to macrophage differentiat 6.9765 0.342755 -1.2891 CTSB NM 001908 cathepsin B 6,97419 0.075968 1.6974 PHF1 AL021366 PHD finger protein 1 6.96878 0.45642 -1.0607 PIK3R1 AI680192 phosphoinositide-3-kinase, regulate 6.96826 0.979601 -1.0663 CTSB W47179 cathepsin B 6.96701 0.08545 1.8221 IRF7 NM 004030 interferon regulatory factor 7 6.96633 0.068472 1.7286 QKI AA935633 quaking homolog, KH domain RNA bind 6,96561 0.97386 1,0798 TRIM8 NM 030912 tripartite motif-containing 8 6,96477 0.377591 1.2891 PIK3IP1 AL540260 phosphoinositide-3-kinase interacti 6.96192 0.378665 -1.3307 C7orf24 AK021779 chromosome 7 open reading frame 24 6.95869 0.113088 -1.4106 C0TL1 AL565621 coactosin-like 1 (Dictyostelium) 6.95562 0.429298 1.3715 RNF149 AW969703 ring finger protein 149 6.95284 0.149306 1,673 EIF4B BF247371 eukaryotic translation initiation f 6,94954 0.07694 -1.5107 VPS35 BG537579 vacuolar protein sorting 35 homolog 6.94857 0.159665 1.3425 SEPX1 NM 016332 selenoprotein X, 1 6.94571 0.026552 1,77838 ISCAI BG387555 iron-sulfur cluster assembly 1 homo 6.94407 0.317862 -1.1999 NFATC2 AA489681 nuclear factor of activated T-cells 6.94069 0.758079 1.3427 IER3 NM 003897 immediate early response 3 6.93712 0.709751 -1.1538 CCR1 AI421071 chemokine (C-C motif) receptor 1 6.93654 0.050617 2.4401 KLF10 AW292830 Kruppel-like factor 10 6.93556 0.385597 1.3605 OAS2 NM 016817 2'-5'-oligoadenylate synthetase 2, 6.93337 0.081678 1.7448 SEC11C AF212233 SEC11 homolog C (S. cerevisiae) 6.92968 0.011854 -2.0503 ANKRD10 AV724266 ankyrin repeat domain 10 6.92755 0.478365 -1.1314 RYBP W84482 RING1 and YY1 binding protein 6.92684 0.177661 -1.2562 VCAN BF590263 versican 6.92446 0.416176 1,11818 CHD1 AU155298 chromodomain helicase DNA binding 6.92423 0.727865 -1,1054

Ρ

AFFX-R2-BS ... 6.92351 0.830122 -1.7299 RBM39 BE466173 RNA binding motif protein 39 6.92228 0.77089 1,0609 UBE2G1 BC002775 ubiquitin-conjugating enzyme E2G 1 6.92056 0.003307 -2,1036 HSD17B1 η NM016142 hydroxysteroid (17-beta) déydrogen 6.91876 0.358301 -1.3522 Ζ RAB31 BE789881 RAB31, member RAS oncogene family 6,91495 0.141937 1,77572 CCL3 NM 002983 chemokine (C-C motif) ligand 3 6.91345 0.541792 1.0035 G0T2 NM 002080 glutamic-oxaloacetic transaminase 2 6.91156 0.231453 -1.5351 IFNGR1 AI458949 gamma interferon receptor 1 6.91041 0.654853 1.3743 IGHM X17115 immunoglobulin heavy constant mu 6,908 0.971852 1.0089 PAICS AA902652 phosphoribosylaminoimidazole carbox 6.90641 0.032405 -1.7396 FLJ43663 AA417078 hypothetical LOC378805 6.90546 0.445461 -1.1995 ARL4C BC001051 ADP-ribosylation factor-like 4C 6.90423 0.39386 1,2068 SYNCRIP NM 006372 synaptotagmin binding, cytoplasmic 6.90175 0.088592 -1.4881 ΑΚΑΡ13 M90360 The kinase (PRKA) anchor protein 13 6.8983 0.045386 1.7568 GLCCI1 AA058770 glucocorticoid induced transcript 1 6.89694 0.234472 -1.3977 C16orf33 NM 024571 chromosome 16 open reading frame 33 6,89628 0.127879 -1.2984 CDC42 N92917 cell division cycle 42 (GTP binding 6.88917 0.799504 1.1011 CD8B NM 004931 CD8b molecule 6.88606 0.538535 1.1676 GBP5 BG271923 guanylate binding protein 5 6,885 0.065443 1.8802 HLA- DQB1 M17565 major histocompatibility complex, c 6,88466 0.079155 1,9154 UPP1 NM 003364 uridine phosphorylase 1 6.88143 0.017462 1.7345 IL1RN U65590 interleukin 1 antagonist receptor 6.88109 0.340721 1.5453 MAML2 AI148006 mastermind-like 2 (Drosophila) 6.88 0.613849 1,0164 LOC93349 AK023116 hypothetical protein BC004921 6.87802 0.023226 1.5507 FABP5 NM 001444 fatty acid binding protein 5 (psori 6.87515 0.037904 -1,617 CSNK1G2 AL530441 casein kinase 1, gamma 2 6.87398 0.111173 1.2173 PCTK2 AA436887 PCTAIRE protein kinase 2 6.86625 0.251535 -1.2816 ... AFFX-LYSX- ... 6.86246 0.915527 -1.5547 ... BF512254 ... 6.86092 0.894648 -1.1871 HSP90B1 AI582238 heat shock protein 90kDa beta (Grp9 6.85808 0.095424 -1,8055 UAP1 S73498 UDP-N-acteylglucosamine pyrophospho 6,85782 0.010949 -1.9816 NADK BC001709 NAD kinase 6.85706 0.015096 1.7331 AP1S2 NM 003916 adapter-related protein complex 1, 6.85641 0.061417 1.5901 FBX011 NM 018693 F-box protein 11 6.85565 0.725629 1.0217 ZFP36 NM 003407 zinc finger protein 36, C3H type, h 6.85557 0.133838 1,66744 JARID2 NM 004973 jumonji, AT rich interactive domain 6.85296 0.675705 1,0684 MCM2 NM 004526 minichromosome maintenance complex 6.8511 0.077386 -1.4297 HSPA1A NM 005345 heat shock 70kDa protein 1A 6.8511 0.093623 2.02 AZIN1 AI742383 antizyme inhibitor 1 6.85109 0.703535 -1.1644 LY86 NM 004271 lymphocyte antigen 86 6,8442 0.060639 1.7259 RAB31 AF183421 RAB31, member RAS oncogene family 6.84267 0.117838 1.7087 GLIPR1 AI912583 GLI pathogenesis-related 1 (glioma) 6.84013 0.148953 1.3332

KCTD12 AA551O75 potassium channel tetramerisation d 6.83789 0.025993 1.8453 PTPLAD1 AJ271091 protein tyrosine phosphatase-like A 6.83371 0.142372 -1.3359 ... ΑΓ707896 ... 6.83035 0.053332 1.7104 RAP2B N20927 RAP2B, member of RAS oncogene famil 6.8283 0.048376 1,417 SFRS3 BE927772 splicing factor, arginine / serine-ri 6.82812 0.27746 -1.3711 GARNL4 AK000478 GTPase activating Rap / RanGAP domain 6.82692 0.113182 1.7985 STK17A AW194730 serine / threonine kinase 17a 6.82643 0.139806 -1.3344 IL12RB1 NM 153701 interleukin 12 receptor, beta 1 6.82551 0.144978 1.2185 GABARA PL3 AF180519 GABA (A) receptors associated protei 6.82548 0.247472 1,77786 STK4 AI763206 serine / threonine kinase 4 6.82347 0.956478 -1.0819 ... AW512196 ... 6.81886 0.010007 1.5776 CD97 NM 001784 CD97 molecule 6.8153 0.007485 2,2044 TSC22D1 AK027071 TSC22 domain family, member 1 6,80768 0.693231 1.1615 ETV6 AF147300 ets variant gene 6 (TEL oncogene) 6.8066 0.58475 1.2642 BCL2 AU146384 B-cell CLL / lymphoma 2 6,80617 0.512082 1.0624 PTPRE AA775177 protein tyrosine phosphatase, recep 6,80604 0.180328 1.3884 ELL2 AW057518 elongation factor, RNA polymerase I 6,80324 0.192568 -1,7096 KLRK1 NM 007360 killer cell lectin-like receiver su 6.80258 0.802833 1.2847 CTBP2 AF222711 C-terminal binding protein 2 6.80118 0.02151 1.8254 MALAT1 AF001540 metastasis associated lung adenocar 6,79622 0.142517 1.2835 KRT10 M19156 keratin 10 (epidermolytic hyperkera 6,79566 0.090969 -1.6333 BRWD2 BF062828 bromodomain and WD repeat domain 6.79355 0.721716 -1,037 TRIM69 BM976092 CO tripartite motif-containing 69 6.7868 0.000119 2.3447 TRA @ AW007751 T cell alpha locus receiver 6.78564 0.199719 1,22429 DUSP6 BC003143 dual specificity phosphatase 6 6.78413 0.055966 2.5524 SLC2A3 AW197431 solute carrier family 2 (facilitate 6.78371 0.128836 1,433 AP1S2 AF251295 adapter-related protein complex 1, 6.78003 0.129304 1,457 CXCR4 AF348491 chemokine (C-X-C motif) receiver 4 6.77836 0.61256 -1.2641 CAMKK2 AK024748 calcium / calmodulin-dependent protei 6.77194 0.192387 1,44644 CCL4 NM 002984 chemokine (C-C motif) ligand 4 6.76722 0.490448 -1.1534 GIMAP4 NM 018326 GTPase, IMAP family member 4 6.76541 0.048545 1,799 BASP1 NM 006317 brain abundant, membrane attached n 6.76512 0.258315 -1,3442 ΡΑΚΙ AU154408 p21 / Cdc42 / Racl-activated kinase 1 ( 6,76026 0.020967 1,9259 MT1H NM 005951 metallothionein 1H 6,750503 0.003445 2.0475 ANP32E AI697657 acidic (leucine-rich) nuclear phosp 6,75217 0.016136 -1.9733 PSAP M32221 prosaposin (variant Gaucher disease 6.74555 0.076822 1,44875 TncRNA AI042152 trophoblast-derived noncoding RNA 6.74254 0.066395 1,5084 BACH2 AI052447 BTB and CNC homology 1, basic leuci 6.73005 0.041431 -1.6115 SEC14L1 AIO17770 SEC14-like 1 (S. cerevisiae) 6.72301 0.020707 -2.0975 TLR2 NM 003264 toll-like receiver 2 6.71644 0.304005 1,76565 FBXO5 NM 012177 F-box protein 5 6,7028 0.054797 -1.5874 FOSL2 AI670862 FOS-like antigen 2 6.70192 0.612354 1.1101 CTNNB1 AF130085 catenin (cadherin-associated protei 6.69747 0.346638 1.3935 CD44 NM 000610 CD44 molecule (Indian blood group) 6.69603 0.643084 -1.0849 MAML2 BF358386 mastermind-like 2 (Drosophila) 6,69589 0.559976 -1,068 FAM26F AV734646 family with sequence similarity 26, 6.68643 0.014525 3,265

ΑΙ655467 6.68015 0.02401 2,22238 SLA U44403 Src-like-adapter 6.67936 0.086301 1,66713 FER1L3 NM 013451 fer-l-like 3, myoferlin (C. elegans 6.67763 0.037863 2.3014 ... AFFX-PHEX- ... 6.67115 0.930535 -1,8022 BRI3 AB055977 brain protein 13 6.67018 0.06886 1.6603 MS4A1 AW474852 membrane-spanning 4-domains, subfam 6.66725 0.332659 1.1704 WARS M61715 tryptophanyl-tRNA synthetase 6.66474 0.035392 2.6189 DUSP6 BC003143 dual specificity phosphatase 6 6.66131 0.035796 2.5553 ELL2 AW960145 elongation factor, RNA polymerase I 6.65868 0.433958 -1,458 NLRP3 NM 004895 NLR family, pyrin domain containing 6.65751 0.305145 1.1479 FLJ45445 AL040396 hypothetical LOC399844 6.65652 0.20665 1.6106 NR4A2 NM 006186 nuclear receiver subfamily 4, group 6.65413 0.69775 -1.1243 CD58 R64696 CD58 molecule 6.65187 0.581994 1.2954 CD36 AW299226 CD36 molecule (thrombospondin recep 6.65103 0.127415 1.6703 RPL38 BC000603 ribosomal protein L38 6.65076 0.423418 1.0077 ... AA393940 ... 6.64943 0.392231 1.1523 ... AI351653 ... 6,64939 0.965783 1,1026 TUBB1 N63244 tubulin, beta 1 6,64426 0.56416 -1.1933 SAMD9L AI064690 sterile alpha motif domain containi 6,643 0.124245 1,66462 GINS2 BC003186 GINS complex subunit 2 (Psf2 homolo 6.64092 0.057406 -1,8078 FYN BG222258 FYN oncogene related to SRC, FGR, v 6.63635 0.483944 1.2341 Cllorf75 NM 020179 chromosome 11 open reading frame 75 6.62795 0.013342 2.1468 TYMP NM 001953 thymidine phosphorylase 6.62316 0.133613 1.7705 HLA-C M20812 major histocompatibility complex, c 6.61859 0.024304 -1,9034 HLA- DPA1 AI 128225 major histocompatibility complex, c 6.61738 0.37239 1,66745 ITM2C NM 030926 integral membrane protein 2C 6.61644 0.016602 -1.9904 SMC4 NM 005496 structural maintenance of chromosom 6.61279 0.009866 -2.2396 ... BG165011 ... 6.60993 0.080853 -1.5291 tcag7.907 AW006934 hypothetical LOC402483 6,60869 0.138441 1.8472 VPS37C BM452172 vacuolar protein sorting 37 homolog 6.60687 0.111928 1.8702 MBNL2 BE328496 muscleblind-like 2 (Drosophila) 6,58821 0.124987 -1.7822 FAM128A BG332462 family with sequence similarity 128 6,58645 0.639565 -1.0216 KLHL14 AB037805 kelch-like 14 (Drosophila) 6.58278 0.019275 -2.3468 ... AI343473 ... 6.58177 0.883977 -1.1807 WDR61 BF791874 WD repeat domain 61 6.58015 0.479318 1,66652 LOC28366 AI926479 hypothetical protein LOC283663 6,5797 0.600396 -1.5841 TLR8 AW872374 toll-like receiver 8 6,57962 0.034218 2.0356 ... AV717590 ... 6,56834 0.041413 -1,855 BAT2D1 BF110903 BAT2 domain containing 1 6.56237 0.51209 -1.7216 PRC1 NM 003981 protein regulator of cytokinesis 1 6.56227 0.052759 -1.7871 ... BF510692 ... 6.56005 0.218008 -1.3941 C13orfl5 NM 014059 chromosome 13 open reading frame 15 6.55673 0.815108 1,3007 MT1E BF217861 metallothionein 1E 6.5549 0.012654 1.8414 NFKB1 R37337 nuclear factor of kappa light polyp 6,54436 0.719548 -1.0463

HCK NM 002110 hemopoietic cell kinase 6.54265 0.060487 2,1608 RNF144B AI953847 144B ring finger 6,53878 0.042506 2.9791 MALAT1 AA827878 metastasis associated lung adenocar 6,53835 0.943034 -1.1608 WTAP BE464729 Wilms tumor 1 associated protein 6,53738 0.403701 -1.4199 EZR AA670344 ezrin 6,52246 0.213627 -1.2624 CFD NM 001928 complement factor D (adipsin) 6,51822 0.013175 2,7446 PHF19 BE544837 PHD finger protein 19 6,51192 0.109919 -1.5748 HERC6 NM 017912 hect domain and RLD 6 6.51025 0.240036 1.5461 ... AFFX-THRX- ... 6.50818 0.997535 -1,727 ADM NM 001124 adrenomedullin 6.50619 0.111558 2.0849 CEBPD NM_005195 CCAAT / enhancer binding protein (CZE 6.50223 0.042689 2.2678 EMILIN2 AF270513 elastin microfibril interfacer 2 6.50221 0.136331 1.8051 ARF6 AA243143 ADP-ribosylation factor 6 6.49979 0.885069 -1.3269 CLEC4A NM 016184 C-type lectin domain family 4, memb 6.48539 0.070909 1.5993 LY96 NM 015364 lymphocyte antigen 96 6,47833 0.028722 1.8432 FOS BC004490 v-fos FBJ murine viral osteosarcoma 6.47306 0.117172 1.7601 NELL2 NM 006159 NEL-like 2 (chicken) 6.47135 0.160413 -1.8655 LST1 NM 007161 leukocyte specific transcript 1 6.46765 0.038581 2,77433 RSBN1 AK022166 round spermatid basic protein 1 6.45176 0.737834 1,0279 ... AFFX-R2-BS ... 6.4452 0.967272 -1.3919 SERPINA 1 CTSL1 NM 000295 serpin peptidase inhibitor, clade A 6.44127 0.025155 2,617 NM 001912 cathepsin Ll 6.44026 0.075111 2,0229 FCGR1B L03419 Fc fragment of IgG, high affmity I 6,43791 0.034844 2,66418 NR4A2 S77154 nuclear receiver subfamily 4, group 6.43655 0.615487 -1.2521 KYNU D55639 kynureninase (L-kynurenine hydrolas 6.43563 0.050925 2,0858 C4orfl8 AF260333 chromosome 4 open reading frame 18 6.42955 0.132761 1.5552 SMCHD1 AA336502 structural maintenance of chromosom 6,42658 0.130073 1.3682 NM 003536 histone cluster 1, H3h 6.42655 0.158024 -1,577

HIST1H3 Η

GAS7 BE439987 growth arrest-specific 7 6.42452 0.181941 1,8954 ARGLU1 R53084 arginine and glutamate rich 1 6.41881 0.862775 -1.7157 H2AFY BE503981 H2A histone family, member Y 6,39933 0.486676 1.3278 HMMR NM 012485 hyaluronan-mediated motility recept 6,39826 0.092274 -1,5011 CREM D14826 cAMP responsive element modulator 6,39628 0.373941 -1,563 AIF1 AF299327 allograft inflammatory factor 1 6.39356 0.202238 1,603 IGL @ H53689 immunoglobulin lambda locus 6,38877 0.001172 -3.0718 CCNB2 NM 004701 cyclin B2 6,377 0.02646 -2.2304 ... AV764378 ... 6.37123 0.494228 1,049 ... AF1O353O ... 6,36245 0.01639 -2,3461 DTL AK001261 denticleless homolog (Drosophila) 6,36065 0.04699 -1.8529 TIMP1 NM 003254 TIMP metallopeptidase inhibitor 1 6.35391 0.318715 1.5269 CST3 NM 000099 cystatin C (amyloid angiopathy and 6,34496 0.077443 1,88675 ... BE739287 ... 6,34092 0.706553 1.1033 TNFSF13 AF114013 tumor necrosis factor (ligand) supe 6,33822 0.010068 2,352 RPL14 AF103591 ribosomal protein L14 6,33398 0.010428 -2.6368 IL1B M15330 interleukin 1, beta 6,33362 0.985823 -2.1685 CENTA2 NM 018404 centaurin, alpha 2 6.33111 0.087184 2,22723

RGL1 EPSTI1 LILRB2 AF186779 BE645480 AF004231 ral guanine nucleotide dissociation epithelial stromal interaction 1 (b leukocyte immunoglobulin-like recep 6,31839 6,31463 6,31411 0.202314 0.0678 0.049719 2.1334 2,013 2,66937 MS4A7 AI301935 membrane-spanning 4-domains, subfam 6.30867 0.035119 2,5679 BLVRB NM 000713 biliverdin reductase B (flavin redu 6.30777 0.040453 1.8995 FLJ11903 AU120130 similar to hypothetical protein MGC 6.29959 0.316305 1,22428 LILRB1 AI681260 immunoglobulin-like leukocyte recep 6.29676 0.052061 2.2342 LST1 AI735692 leukocyte specific transcript 1 6.29361 0.037098 2.8309 CLEC7A BC013385 C-type lectin domain family 7, memb 6,29216 0.162446 1.8897 CDCA7 AY029179 cell division cycle associated 7 6,27819 0.204965 -1,1017 HLA- DQB1 M32577 major histocompatibility complex, c 6,27559 0.525221 1.2395 HLA- DQA1 BG397856 major histocompatibility complex, c 6.2684 0.270192 2.0622 S100A11 NM 005620 SI00 calcium binding protein Al 1 6,256 0.024816 1.8793 DLG7 NM 014750 discs, large homolog 7 (Drosophila) 6.25423 0.033649 -2.0616 ZCCHC2 BE676543 zinc finger, CCHC domain containing 6,24429 0.075008 1.8192 ... BF724558 ... 6.24224 0.106534 2,182 SLC31A2 NM 001860 solute carrier family 31 (copper tr 6.23459 0.035495 2.4407 CLEC12A NM 138337 C-type lectin domain family 12, mem 6.23324 0.279177 1.35 BANK1 NM 017935 B-cell scaffold protein with ankyri 6.21968 0.53668 -1,1604 CHURC1 BE568660 churchill domain containing 1 6,18873 0.391562 1.2923 ZNF600 AI620827 zinc finger protein 600 6,18727 0.155702 1.2628 ZNF331 NM 018555 zinc finger protein 331 6,18617 0.231555 -1,3646 OASL NM 003733 2'-5'-oligoadenylate synthetase-lik 6.18186 0.029524 2.7191 FCGR3B J04162 Fc fragment of IgG, low affinity II 6.1543 0.002868 4.1952 TNFSF10 U57059 tumor necrosis factor (ligand) supe 6,14789 0.052835 2,325 ANKRD22 AI097229 ankyiin repeat domain 22 6,14069 0.042713 2,66953 ... AW016812 ... 6.13308 0.369829 1,905 SIGLEC10 AF301007 sialic acid binding Ig-like lectin 6,12976 0.025479 3.3761 CD44 BE467023 CD44 molecule (Indian blood group) 6,12947 0.539482 -1,4378 NCAPG NM 022346 non-SMC condensin I complex, subuni 6.12877 0.042418 -2.2595 PLAUR U08839 plasminogen activator, urokinase re 6.1285 0.637177 1.0997 LST1 AF000424 leukocyte specific transcript 1 6.12233 0.041172 2.2944 ... AFFX-DAPX- ... 6,11575 0.843948 -1,4703 EGR1 NM 001964 early growth response 1 6.10353 0.00334 3,22916 C3AR1 U62027 complement component 3 to receiver 1 6.08138 0.002707 4.5817 ... AFFX-R2-BS ... 6.06704 0.944989 -1.6537 EGR1 AI459194 early growth response 1 6.04876 0.007242 4.6155 LYZ U25677 lysozyme (renal amyloidosis) 6.04567 0.097348 2,0446 LGALS2 NM 006498 lectin, galactoside-binding, solubl 5.99647 0.053018 1,66653 ANKRD22 AI925518 ankyrin repeat domain 22 5.97178 0.037611 2,5852 CREM AI800640 cAMP responsive element modulator 5,94068 0.458181 -1.4787 LILRA2 NM 006866 immunoglobulin-like leukocyte recep 5.90652 0.045384 2.2348 FOSB NM 006732 FBJ murine viral osteosarcoma oncog 5.90285 0.144303 1,66763 LILRB2 NM 005874 immunoglobulin-like leukocyte recep 5.88697 0.02635 3,289 ... AFFX-R2-BS ... 5.87851 0.932598 -1.7862

100

... AFFX-PHEX- ... 5.84298 0.781562 -2.0474 IFIT3 NM 001549 interferon-induced protein with tet 5.81069 0.077607 2.9505 G0S2 NM 015714 GO / jGlswitch 2 5.78858 0.787938 1,22464 BCL2A1 NM 004049 BCL2-related protein Al 5.7881 0.231424 1.5545 SAMHD1 AF147427 SAM domain and HD domain 1 5,77873 0.003019 2,44624 IDB1 AL080280 phosphotyrosine interaction domain 5.62461 0.807122 1.9415 BF110534 ... ·: ·. 5,58112 0.500238 1.6184 HBA1 T50399 hemoglobin, alpha 1 5.34606 0.441238 1,9256 CDKN1C N33167 cyclin-dependent kinase inhibitor 1 5.33359 0.038424 7,9145 C15orf48 AF228422 chromosome 15 open reading frame 48 5.00893 0.729228 -1.3972

/ 5

CLAIM

Claims (30)

1. Method of predicting the clinical response of the patient infected with the dengue virus during the first days after the onset of symptoms, characterized by the identification of the differential expression of genes selected from a group of 1981 genes listed in Table 7, or their allelic polymorphisms, as well as by analyzing the expression levels of its encoded proteins. 2. Method of diagnosing dengue virus infection, differentiating it from other febrile diseases, during the first days after the onset of symptoms, characterized by the identification of the differential expression of genes selected from a group of 1981 genes listed in Table 7, or its allelic polymorphisms, as well as by analyzing the expression levels of its encoded proteins. 3. Method according to claim 1, characterized by the fact that the identification of the differential expression of selected genes comprises the identification of isolated nucleic acid sequences, their complements, parts, or allelic polymorphism, as well as the analysis of the expression levels of the encoded product of said isolated nucleic acids. 4. Method according to claim 1, characterized by the fact that the identification of the differential expression of selected genes comprises the identification of isolated nucleic acid sequences, their complements, parts, or allelic polymorphism, as well as the analysis of the expression levels of the encoded products of genes in pairs. Petition 870180125506, of 9/3/2018, p. 8/13 2/5 5. Method according to claim 1, characterized in that the identification of the differential expression of selected genes comprises the identification of isolated nucleic acid sequences, their complements, parts, or allelic polymorphism, as well as the analysis of the expression levels of the encoded proteins of trio genes. 6. Method according to claim 1, characterized in that the identification of the differential expression of selected genes comprises identification of isolated nucleic acid sequences, their complements, parts, or allelic polymorphism, as well as the analysis of the expression levels of the encoded proteins of genes in quartet or larger groups. 7. Method according to claim 1, characterized by the fact that it is conducted with nucleic acids extracted from Peripheral Blood Mononuclear Cells (PBMC), as well as any of their cellular contents selected from B cells, T cells, Monocytes, Macrophages, cells NK and dendritic. 8. Method according to claim 1, characterized by the fact that it is conducted in any cell compartment, as well as any body liquid, such as blood, plasma, serum, exudate and others. 9. Method according to claim 1, characterized by the use of Linear Discrimination Analysis as a classification rule, and the bolstered resubstitution as an error estimator, for the exhaustive selection of groups of predictive genes of Petition 870180125506, of 9/3/2018, p. 9/13 3/5 clinical response of patients infected with dengue virus, using one, two or three or more differentially expressed genes. 10. Method according to claim 1, characterized in that the group of genes includes the 73 genes listed in Table 6. 11. Method according to claim 1, characterized by the fact that the group of genes includes the classifiers listed in Table 5. 12. Method according to claim 2, characterized by the fact that the group of genes includes the genes listed in Table 2. 13. Method according to claim 1, characterized by the fact that the p-value indicating differential modulation is less than 0.05. 14. Method according to claim 1, characterized by the fact that there is at least one difference in 2 times in the expression of the modulated genes. 15. Method according to claim 1, characterized by the fact that the infectious serotypes of the dengue virus are DENV1, DENV2, DENV3 or DENV 4, as well as multiple infections with any combination of them. 16. Method according to claim 1, characterized by the fact that it comprises patients affected by primary infection. 17. Method according to claim 1, characterized by the fact that it comprises patients affected by secondary infection. 18. Kit to determine the prognosis of the response Petition 870180125506, of 9/3/2018, p. 10/13 4/5 clinic of the dengue infected patient, characterized by comprising materials to detect nucleic acid sequences, their complements, parts, allelic polymorphism of a gene or combination of genes to be selected from the 1981 list transcribed or to detect proteins encoded by said nucleic acid sequences or cells containing said proteins. 19. Kit for diagnosis of dengue, characterized by comprising materials to detect nucleic acid sequence, its complements, parts, allelic polymorphism of a gene or combination of genes to be selected from the 1981 transcribed list or to detect proteins encoded by said sequences nucleic acids or cells containing said proteins. 20. Kit according to claim 18 or 19, characterized in that the combination includes all genes individually. 21. Kit according to claim 18 or 19, characterized in that the combination includes all genes in pairs. 22. Kit according to claim 18 or 19, characterized in that the combination includes all genes in triples. 23. Kit according to claim 18 or 19, characterized in that the combination includes all genes in quartets or more. 24. Kit according to claim 18 or 19, characterized in that it occurs in a microarray matrix to identify the differential expression of genes. Petition 870180125506, of 9/3/2018, p. 11/13 5/5 25. Kit according to claim 18 or 19, characterized in that it occurs in a quantitative PCR reaction to identify the differential expression of genes. 26. Kit wake up with the claim 18 or 19, characterized by to occur in a reaction of RT-PCR for identify the differential expression of the genes. 27. Kit wake up with the claim 18 or 19, characterized by occurring in a Northern blotting reaction to identify the differential expression of genes. 28. Kit according to claim 18 or 19, characterized in that it occurs in a PCR reaction to identify the differential expression of the allelic polymorphism of genes. 29. Kit according to claim 18 or 19, characterized in that it occurs in an ELISA test to identify the differential production of protein encoded by genes. 30. Kit according to claim 18 or 19, characterized in that it occurs in a Western blotting test to identify the differential production of protein encoded by genes. 31. Kit according to claim 18 or 19, characterized in that it occurs in a Dot-blotting test to identify the differential production of protein encoded by genes. 32. Kit according to claim 18 or 19, characterized in that it occurs in a flow cytometry test to identify the differential production of protein encoded by genes or any cell compartment.