BRPI0908406A2 - Derivados de quinoxalinona como estimulantes da secreção de insulina, métodos para obtenção dos mesmos e uso dos mesmos para tratamento do diabetes - Google Patents
Derivados de quinoxalinona como estimulantes da secreção de insulina, métodos para obtenção dos mesmos e uso dos mesmos para tratamento do diabetesInfo
- Publication number
- BRPI0908406A2 BRPI0908406A2 BRPI0908406-1A BRPI0908406A BRPI0908406A2 BR PI0908406 A2 BRPI0908406 A2 BR PI0908406A2 BR PI0908406 A BRPI0908406 A BR PI0908406A BR PI0908406 A2 BRPI0908406 A2 BR PI0908406A2
- Authority
- BR
- Brazil
- Prior art keywords
- stimulants
- methods
- insulin secretion
- treat diabetes
- quinoxalinone derivatives
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 230000003914 insulin secretion Effects 0.000 title 1
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical class C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 title 1
- 239000000021 stimulant Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08004053 | 2008-03-05 | ||
| EP08004053.8 | 2008-03-05 | ||
| PCT/EP2009/000209 WO2009109258A1 (en) | 2008-03-05 | 2009-01-15 | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0908406A2 true BRPI0908406A2 (pt) | 2015-08-11 |
| BRPI0908406B1 BRPI0908406B1 (pt) | 2019-04-09 |
| BRPI0908406B8 BRPI0908406B8 (pt) | 2023-02-07 |
Family
ID=40547943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908406A BRPI0908406B8 (pt) | 2008-03-05 | 2009-01-15 | Derivados de quinoxalinona, processo para a preparação dos mesmos, seu uso e composição farmacêutica |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8415352B2 (pt) |
| EP (1) | EP2247580B1 (pt) |
| JP (1) | JP5618837B2 (pt) |
| KR (1) | KR101637387B1 (pt) |
| CN (1) | CN101952258B (pt) |
| AR (1) | AR070797A1 (pt) |
| AU (1) | AU2009221327B2 (pt) |
| BR (1) | BRPI0908406B8 (pt) |
| CA (1) | CA2717718C (pt) |
| DK (1) | DK2247580T3 (pt) |
| EA (1) | EA021904B1 (pt) |
| ES (1) | ES2548583T3 (pt) |
| HU (1) | HUE027811T2 (pt) |
| IL (1) | IL207720A (pt) |
| MX (1) | MX2010009576A (pt) |
| PT (1) | PT2247580E (pt) |
| WO (1) | WO2009109258A1 (pt) |
| ZA (1) | ZA201007059B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9296701B2 (en) | 2012-04-24 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
| CA2904641C (en) | 2013-03-12 | 2021-07-20 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| WO2015058067A1 (en) | 2013-10-17 | 2015-04-23 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
| CN104628661A (zh) * | 2015-02-05 | 2015-05-20 | 北京理工大学 | 一类喹喔啉酮衍生物作为醛糖还原酶抑制剂的结构、制备方法及用途 |
| KR102723194B1 (ko) | 2015-12-24 | 2024-10-28 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용 방법 |
| JP6938510B2 (ja) | 2015-12-24 | 2021-09-22 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｃｆｔｒ制御因子及びこの使用方法 |
| BR112018012934B1 (pt) * | 2015-12-24 | 2023-11-07 | The Regents Of The University Of California | Reguladores cftr e métodos de uso dos mesmos |
| CN105769870A (zh) * | 2016-04-09 | 2016-07-20 | 李曼 | 一种治疗糖尿病的药物 |
| EP3518931A4 (en) | 2016-09-27 | 2020-05-13 | Vertex Pharmaceuticals Incorporated | METHOD FOR TREATING CANCER WITH A COMBINATION OF DNA-DAMAGING SUBSTANCES AND DNA-PK INHIBITORS |
| AU2018321926B2 (en) | 2017-08-24 | 2023-09-21 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| CN109796417A (zh) * | 2019-01-14 | 2019-05-24 | 北京理工大学 | 一系列喹喔啉酮衍生物的结构、制备方法及用途 |
| CN109793739A (zh) * | 2019-01-14 | 2019-05-24 | 北京理工大学 | 一种喹喔啉酮衍生物的结构、制备方法及用途 |
| CN114957222B (zh) * | 2022-05-31 | 2023-08-15 | 内蒙古民族大学 | 化合物及其制备方法和用途 |
| CN114907323B (zh) * | 2022-05-31 | 2023-08-15 | 内蒙古民族大学 | 喹喔啉酮类化合物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU410015A1 (pt) * | 1971-06-22 | 1974-01-05 | ||
| SU616955A1 (ru) * | 1977-03-02 | 2006-12-27 | Пермский ордена Трудового Красного Знамени государственный университет им.А.М.Горького | 2-(α-бромфенацил)-хиноксалон-3, проявляющий противовоспалительную активность |
| US4181724A (en) * | 1978-09-11 | 1980-01-01 | The Upjohn Company | Quinoxalinone compounds useful for expanding the lumina or air passages in mammals |
| FR2653430B1 (fr) | 1989-10-23 | 1991-12-20 | Pf Medicament | Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique. |
| BR9810456A (pt) | 1997-06-27 | 2001-09-25 | Fujisawa Pharmaceutical Co | Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico |
| KR100588247B1 (ko) * | 1997-09-01 | 2006-06-13 | 교린 세이야꾸 가부시키 가이샤 | 6,7-비대칭 이치환된 퀴녹살린카복실산 유도체와 이의부가염 및 이들의 제조방법 |
| KR20010042298A (ko) | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 인자 Ｘａ 및 트롬빈과 같은 세린 프로테아제억제제로서의 퀴녹살리논 |
| DE10343098A1 (de) | 2003-09-18 | 2005-04-14 | Bayer Healthcare Ag | Tetrahydrochinoxaline und ihre Verwendung |
| ES2290782T3 (es) * | 2004-01-06 | 2008-02-16 | Janssen Pharmaceutica N.V. | Derivados de (3-oxo-3,4-dihidro-quinoxalin-2-il-amino)-benzamida y compuestos aferentes como inhibidores de la glucogeno fosforilasa en el tratamiento de la diabetes y de la obesidad. |
| DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| WO2007135527A2 (en) * | 2006-05-23 | 2007-11-29 | Pfizer Products Inc. | Benzimidazolyl compounds |
-
2009
- 2009-01-15 WO PCT/EP2009/000209 patent/WO2009109258A1/en not_active Ceased
- 2009-01-15 AU AU2009221327A patent/AU2009221327B2/en active Active
- 2009-01-15 US US12/920,736 patent/US8415352B2/en active Active
- 2009-01-15 CA CA2717718A patent/CA2717718C/en active Active
- 2009-01-15 PT PT97181184T patent/PT2247580E/pt unknown
- 2009-01-15 CN CN200980105428.XA patent/CN101952258B/zh active Active
- 2009-01-15 KR KR1020107022236A patent/KR101637387B1/ko not_active Expired - Fee Related
- 2009-01-15 HU HUE09718118A patent/HUE027811T2/en unknown
- 2009-01-15 DK DK09718118.4T patent/DK2247580T3/en active
- 2009-01-15 ES ES09718118.4T patent/ES2548583T3/es active Active
- 2009-01-15 JP JP2010549024A patent/JP5618837B2/ja active Active
- 2009-01-15 MX MX2010009576A patent/MX2010009576A/es active IP Right Grant
- 2009-01-15 BR BRPI0908406A patent/BRPI0908406B8/pt not_active IP Right Cessation
- 2009-01-15 EA EA201001407A patent/EA021904B1/ru not_active IP Right Cessation
- 2009-01-15 EP EP09718118.4A patent/EP2247580B1/en active Active
- 2009-03-05 AR ARP090100781A patent/AR070797A1/es unknown
-
2010
- 2010-08-19 IL IL207720A patent/IL207720A/en active IP Right Grant
- 2010-10-04 ZA ZA2010/07059A patent/ZA201007059B/en unknown
-
2013
- 2013-01-04 US US13/734,288 patent/US8835634B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR101637387B1 (ko) | 2016-07-07 |
| BRPI0908406B8 (pt) | 2023-02-07 |
| HUE027811T2 (en) | 2016-11-28 |
| ES2548583T3 (es) | 2015-10-19 |
| ZA201007059B (en) | 2011-06-29 |
| MX2010009576A (es) | 2010-09-24 |
| EP2247580A1 (en) | 2010-11-10 |
| AR070797A1 (es) | 2010-05-05 |
| EA201001407A1 (ru) | 2011-06-30 |
| IL207720A (en) | 2014-12-31 |
| WO2009109258A1 (en) | 2009-09-11 |
| EP2247580B1 (en) | 2015-07-08 |
| JP2011513343A (ja) | 2011-04-28 |
| CA2717718A1 (en) | 2009-09-11 |
| CN101952258A (zh) | 2011-01-19 |
| DK2247580T3 (en) | 2015-10-05 |
| IL207720A0 (en) | 2010-12-30 |
| JP5618837B2 (ja) | 2014-11-05 |
| PT2247580E (pt) | 2015-10-19 |
| BRPI0908406B1 (pt) | 2019-04-09 |
| EA021904B1 (ru) | 2015-09-30 |
| AU2009221327B2 (en) | 2014-03-27 |
| KR20100123899A (ko) | 2010-11-25 |
| CA2717718C (en) | 2016-05-31 |
| US20130123257A1 (en) | 2013-05-16 |
| US20110015194A1 (en) | 2011-01-20 |
| US8835634B2 (en) | 2014-09-16 |
| US8415352B2 (en) | 2013-04-09 |
| AU2009221327A1 (en) | 2009-09-11 |
| CN101952258B (zh) | 2014-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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