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BRPI0906478B8 - anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende - Google Patents

anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende

Info

Publication number
BRPI0906478B8
BRPI0906478B8 BRPI0906478A BRPI0906478A BRPI0906478B8 BR PI0906478 B8 BRPI0906478 B8 BR PI0906478B8 BR PI0906478 A BRPI0906478 A BR PI0906478A BR PI0906478 A BRPI0906478 A BR PI0906478A BR PI0906478 B8 BRPI0906478 B8 BR PI0906478B8
Authority
BR
Brazil
Prior art keywords
antibody
pharmaceutical composition
present
antibodies
treating
Prior art date
Application number
BRPI0906478A
Other languages
English (en)
Inventor
Shiraiwa Hirotake
Tsunoda Hiroyuki
Esaki Keiko
Kasutani Keiko
Ohyama Souhei
Kuramochi Taichi
Tachibana Tatsuhiko
Igawa Tomoyuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2008/072152 external-priority patent/WO2009072604A1/ja
Priority claimed from PCT/JP2009/054941 external-priority patent/WO2010064456A1/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0906478A2 publication Critical patent/BRPI0906478A2/pt
Publication of BRPI0906478B1 publication Critical patent/BRPI0906478B1/pt
Publication of BRPI0906478B8 publication Critical patent/BRPI0906478B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Liquid Crystal (AREA)

Abstract

anticorpo anti-nr10 r uso do mesmo. a presente invenção refere-se a anticorpos anti-nr 10 tendo uma atividade de neutralização eficaz contra nr10. os anticorpos anti-nr10 providos pela presente invenção são úteis como,por exemplo, agentes farmacêuticos para tratamento ou prevenção de doenças inflamatórias.
BRPI0906478A 2008-12-05 2009-12-04 anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende BRPI0906478B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPPCT/JP2008/072152 2008-12-05
PCT/JP2008/072152 WO2009072604A1 (ja) 2007-12-05 2008-12-05 抗nr10抗体、およびその利用
PCT/JP2009/054941 WO2010064456A1 (ja) 2008-12-05 2009-03-13 抗nr10抗体、およびその利用
JPPCT/JP2009/054941 2009-03-13
PCT/JP2009/070376 WO2010064697A1 (ja) 2008-12-05 2009-12-04 抗nr10抗体、およびその利用

Publications (3)

Publication Number Publication Date
BRPI0906478A2 BRPI0906478A2 (pt) 2015-11-24
BRPI0906478B1 BRPI0906478B1 (pt) 2020-02-11
BRPI0906478B8 true BRPI0906478B8 (pt) 2021-05-25

Family

ID=42233344

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906478A BRPI0906478B8 (pt) 2008-12-05 2009-12-04 anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende

Country Status (10)

Country Link
EP (2) EP2949672A1 (pt)
JP (1) JP2010210772A (pt)
KR (1) KR101271323B1 (pt)
BR (1) BRPI0906478B8 (pt)
DK (1) DK2354161T3 (pt)
ES (1) ES2552690T3 (pt)
PL (1) PL2354161T3 (pt)
PT (1) PT2354161E (pt)
RU (1) RU2487136C2 (pt)
WO (1) WO2010064697A1 (pt)

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US20220411518A1 (en) 2021-04-07 2022-12-29 Galderma Holding S.A. Treatments for prurigo nodularis
CN117999035A (zh) 2021-08-30 2024-05-07 高德美控股有限公司 异位性皮肤炎的治疗
CN118613503A (zh) 2021-12-22 2024-09-06 中外制药株式会社 生物学活性降低的抗体变体
JP2025530773A (ja) 2022-09-02 2025-09-17 ガルデルマ ホールディング エスエー 結節性痒疹のための治療

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Also Published As

Publication number Publication date
RU2010126078A (ru) 2013-01-10
WO2010064697A1 (ja) 2010-06-10
JP2010210772A (ja) 2010-09-24
EP2949672A1 (en) 2015-12-02
PL2354161T3 (pl) 2016-01-29
ES2552690T3 (es) 2015-12-01
BRPI0906478B1 (pt) 2020-02-11
KR20100091245A (ko) 2010-08-18
EP2354161A1 (en) 2011-08-10
BRPI0906478A2 (pt) 2015-11-24
EP2354161B1 (en) 2015-08-12
KR101271323B1 (ko) 2013-06-04
RU2487136C2 (ru) 2013-07-10
PT2354161E (pt) 2015-10-22
EP2354161A4 (en) 2013-01-02
DK2354161T3 (en) 2015-09-14

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