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BRPI0821302A8 - Composição farmacêutica, método para prevenir ou tratar doenças do intestino inflamatórias, e, uso de um composto - Google Patents

Composição farmacêutica, método para prevenir ou tratar doenças do intestino inflamatórias, e, uso de um composto

Info

Publication number
BRPI0821302A8
BRPI0821302A8 BRPI0821302A BRPI0821302A BRPI0821302A8 BR PI0821302 A8 BRPI0821302 A8 BR PI0821302A8 BR PI0821302 A BRPI0821302 A BR PI0821302A BR PI0821302 A BRPI0821302 A BR PI0821302A BR PI0821302 A8 BRPI0821302 A8 BR PI0821302A8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
inflammatory bowel
bowel diseases
compound
prevent
Prior art date
Application number
BRPI0821302A
Other languages
English (en)
Inventor
Ninomiya Tomohisa
Uchida Mitsuhiro
Takahata Sho
Hoshina Yukari
Kawano Ken-Ichi
Shishikura Takashi
Original Assignee
Meiji Seika Kaisha
Meiji Seika Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Meiji Seika Pharma Co Ltd filed Critical Meiji Seika Kaisha
Publication of BRPI0821302A2 publication Critical patent/BRPI0821302A2/pt
Publication of BRPI0821302A8 publication Critical patent/BRPI0821302A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSIÇÃO FARMACÊUTICA, E, USO DE UM COMPOSTO. A invenção diz respeito a uma composição farmacêutica para prevenir ou tratar uma doença do intestino inflamatória que compreende 7,8-dimetóxi-4(5H), 10-dioxo-1 H-1,2,3-triazol [4,5-c][1]-benzoazepina, uma pró-droga do mesmo, preferivelmente 2-(1-isopropóxi-carbonilóxi-2-metilpropil)-7,8-dimetóxi-4(5H), 10-dioxo-2H-1,2,3-triazol [4,5-c][1] benzoazepina como a pró-droga, ou um sal deste farmacologicamente aceitável. A composição farmacêutica de acordo com a invenção é eficaz na prevenção e tratamento de uma doença do intestino inflamatória e tem poucos efeitos colaterais. Em particular, a composição farmacêutica de acordo com a invenção pode exibir um efeito preventivo e efeito terapêutico potentes também em um caso grave que mostre resistência aos agentes terapêuticos existentes.
BRPI0821302A 2007-12-18 2008-12-17 Composição farmacêutica, método para prevenir ou tratar doenças do intestino inflamatórias, e, uso de um composto BRPI0821302A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007326543 2007-12-18
PCT/JP2008/072999 WO2009078444A1 (ja) 2007-12-18 2008-12-17 炎症性腸疾患の予防または治療剤

Publications (2)

Publication Number Publication Date
BRPI0821302A2 BRPI0821302A2 (pt) 2015-06-16
BRPI0821302A8 true BRPI0821302A8 (pt) 2015-12-08

Family

ID=40795557

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821302A BRPI0821302A8 (pt) 2007-12-18 2008-12-17 Composição farmacêutica, método para prevenir ou tratar doenças do intestino inflamatórias, e, uso de um composto

Country Status (16)

Country Link
US (1) US7858612B2 (pt)
EP (1) EP2123277B1 (pt)
JP (1) JP4343268B2 (pt)
KR (1) KR101216756B1 (pt)
CN (1) CN101903027B (pt)
AT (1) ATE497386T1 (pt)
AU (1) AU2008339393A1 (pt)
BR (1) BRPI0821302A8 (pt)
CA (1) CA2709119C (pt)
DE (1) DE602008004820D1 (pt)
DK (1) DK2123277T3 (pt)
ES (1) ES2360461T3 (pt)
PL (1) PL2123277T3 (pt)
PT (1) PT2123277E (pt)
RU (1) RU2469724C2 (pt)
WO (1) WO2009078444A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7332167B2 (ja) 2018-07-28 2023-08-23 スージョウ・ファルマヴァン・カンパニー・リミテッド 抗炎症性腸疾患の作用を有する医薬、その調製方法および使用
AU2019322564A1 (en) * 2018-08-15 2021-03-25 Pharmacyl Ab A new medical treatment for pathologic inflammation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH637654A5 (en) * 1977-02-18 1983-08-15 Takeda Chemical Industries Ltd Triazolobenzazepine derivatives, process for their preparation and pharmaceutical preparations containing them
ES2156933T3 (es) 1993-12-28 2001-08-01 Meiji Seika Co Derivados triciclicos de benzazepina y benzotiazepina.
US6093714A (en) * 1995-06-15 2000-07-25 Meiji Seika Kaisha, Ltd. Tricyclic benzazepine compounds
WO1999016770A1 (en) 1997-09-29 1999-04-08 Meiji Seika Kaisha, Ltd. Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic
PE20001566A1 (es) * 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
MXPA03004832A (es) * 2000-12-01 2004-05-04 Guilford Pharm Inc Compuestos y sus usos.
ATE410427T1 (de) * 2001-12-26 2008-10-15 Meiji Seika Kaisha Neues kristallines tricyclisches triazolobenzazepinderivat
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
JP2007326543A (ja) 2006-06-07 2007-12-20 Giichi Ishikura 排気ガス利用による保温ダンプ

Also Published As

Publication number Publication date
WO2009078444A1 (ja) 2009-06-25
DE602008004820D1 (de) 2011-03-17
CA2709119C (en) 2013-08-06
ATE497386T1 (de) 2011-02-15
EP2123277A4 (en) 2010-01-06
RU2469724C2 (ru) 2012-12-20
ES2360461T3 (es) 2011-06-06
JPWO2009078444A1 (ja) 2011-04-28
US20100130475A1 (en) 2010-05-27
KR101216756B1 (ko) 2012-12-28
US7858612B2 (en) 2010-12-28
PT2123277E (pt) 2011-04-20
PL2123277T3 (pl) 2011-08-31
KR20100094576A (ko) 2010-08-26
CA2709119A1 (en) 2009-06-25
RU2010129447A (ru) 2012-01-27
EP2123277A1 (en) 2009-11-25
JP4343268B2 (ja) 2009-10-14
BRPI0821302A2 (pt) 2015-06-16
EP2123277B1 (en) 2011-02-02
DK2123277T3 (da) 2011-03-14
CN101903027A (zh) 2010-12-01
AU2008339393A1 (en) 2009-06-25
CN101903027B (zh) 2013-06-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B25D Requested change of name of applicant approved

Owner name: MEIJI SEIKA PHARMA CO., LTD. (JP)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.