BRPI0821004A2 - Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste - Google Patents

Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste

Info

Publication number: BRPI0821004A2
Authority: BR; Brazil
Prior art keywords: pharmaceutical composition; composition containing; derivative compound; aminopyrazole derivative; aminopyrazole
Prior art date: 2007-12-14

Application number

BRPI0821004-7A

Other languages

English (en)

Inventor

Daniel Bur

Olivier Corminboeuf

Corinna Grisostomi

Sylvia Richard-Bildstein

Heinz Fretz

Julien Pothier

Sylvaine Cren

Xavier Leroy

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-14

Filing date

2008-12-12

Publication date

2015-06-16

2008-12-12 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-06-16 Publication of BRPI0821004A2 publication Critical patent/BRPI0821004A2/pt

2017-12-26 Publication of BRPI0821004A8 publication Critical patent/BRPI0821004A8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0821004A 2007-12-14 2008-12-12 Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste BRPI0821004A8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2007055111		2007-12-14
IB2008053648		2008-09-10
PCT/IB2008/055251 WO2009077954A1 (en)	2007-12-14	2008-12-12	Aminopyrazole derivatives

Publications (2)

Publication Number	Publication Date
BRPI0821004A2 true BRPI0821004A2 (pt)	2015-06-16
BRPI0821004A8 BRPI0821004A8 (pt)	2017-12-26

Family

ID=40456559

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821004A BRPI0821004A8 (pt)	2007-12-14	2008-12-12	Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste

Country Status (24)

Country	Link
US (1)	US8288419B2 (pt)
EP (1)	EP2242743B1 (pt)
JP (1)	JP5435744B2 (pt)
KR (1)	KR101622413B1 (pt)
CN (1)	CN101903353B (pt)
AR (1)	AR069650A1 (pt)
BR (1)	BRPI0821004A8 (pt)
CA (1)	CA2706836C (pt)
CY (1)	CY1114793T1 (pt)
DK (1)	DK2242743T3 (pt)
ES (1)	ES2432059T3 (pt)
HR (1)	HRP20131105T1 (pt)
IL (1)	IL206296A (pt)
MA (1)	MA31988B1 (pt)
MX (1)	MX2010005827A (pt)
MY (1)	MY153921A (pt)
NZ (1)	NZ586776A (pt)
PL (1)	PL2242743T3 (pt)
PT (1)	PT2242743E (pt)
RU (1)	RU2489426C2 (pt)
SI (1)	SI2242743T1 (pt)
TW (1)	TWI430795B (pt)
WO (1)	WO2009077954A1 (pt)
ZA (1)	ZA201004939B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI434685B (zh)	2007-12-18	2014-04-21	Actelion Pharmaceuticals Ltd	胺基三唑衍生物
ES2431298T3 (es)	2009-05-18	2013-11-25	Actelion Pharmaceuticals Ltd.	Derivados de espiro[2.4]heptano puenteados como agonistas del receptor de ALX y/o FPRL2
MY161243A (en)	2009-06-09	2017-04-14	Actelion Pharmaceuticals Ltd	Fluorinated aminotriazole derivatives
CN102803237B (zh) *	2009-06-12	2014-09-24	埃科特莱茵药品有限公司	作为alx受体激动剂的噁唑和噻唑衍生物
PH12012501864A1 (en)	2010-04-07	2017-07-26	Hoffmann La Roche	Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
CA2814826C (en)	2010-11-17	2019-02-12	Actelion Pharmaceuticals Ltd	Bridged spiro[2.4]heptane ester derivatives
PT2649068E (pt) *	2010-12-07	2014-12-23	Actelion Pharmaceuticals Ltd	Derivados de éter oxazolil-metílico como agonistas do receptor de alx
JP5923108B2 (ja) *	2010-12-07	2016-05-24	アクテリオンファーマシューティカルズリミテッドＡｃｔｅｌｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ	Ａｌｘ受容体アゴニストとしてのヒドロキシル化アミノトリアゾール誘導体
ES2541531T3 (es)	2011-02-18	2015-07-21	Actelion Pharmaceuticals Ltd.	Nuevos derivados de pirazol e imidazol útiles como antagonistas de orexina
EP2707373A1 (de)	2011-05-10	2014-03-19	Bayer Intellectual Property GmbH	Bicyclische (thio)carbonylamidine
AR088061A1 (es)	2011-09-27	2014-05-07	Hoffmann La Roche	Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso
DE102011055815A1 (de)	2011-11-29	2013-05-29	Aicuris Gmbh & Co. Kg	Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
ES2596521T3 (es)	2012-05-16	2017-01-10	Actelion Pharmaceuticals Ltd.	Derivados de espiro[2.4]heptano sustituidos con puente 1-(p-tolil)ciclopropilo como agonistas de receptor de ALX
MA37618B1 (fr)	2012-05-16	2017-08-31	Actelion Pharmaceuticals Ltd	Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
DE102012016908A1 (de)	2012-08-17	2014-02-20	Aicuris Gmbh & Co. Kg	Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
AR096686A1 (es)	2013-06-25	2016-01-27	Actelion Pharmaceuticals Ltd	Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
RU2016105310A (ru)	2013-07-18	2017-08-23	Актелион Фармасьютиклз Лтд	Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора
AR097279A1 (es)	2013-08-09	2016-03-02	Actelion Pharmaceuticals Ltd	Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
SI3075726T1 (en)	2013-11-28	2018-05-31	Kyorin Pharmaceutical Co., Ltd.	DERIVATIVES OF UREA OR ITS PHARMACOLOGICAL RECRUITABLE SALTS USED AS FORMIL PEPTIDAL RECEPTOR LIKE 1 (FPRL-1) AGONISTS
AR104751A1 (es)	2015-05-27	2017-08-09	Kyorin Seiyaku Kk	Derivado de urea o una sal de este aceptable desde el punto de vista farmacológico
EP3303284B1 (en)	2015-05-27	2020-04-08	Kyorin Pharmaceutical Co., Ltd.	Urea derivative or pharmacologically acceptable salt thereof
HUE058044T2 (hu)	2018-03-05	2022-06-28	Bristol Myers Squibb Co	Fenilpirrolidinon-formil peptid 2 receptor agonisták
CA3096139A1 (en)	2018-04-06	2019-10-10	Black Belt Tx Ltd	Atf6 inhibitors and uses thereof
WO2023118434A1 (en) *	2021-12-22	2023-06-29	Globachem Nv	Pesticidally active amide compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8531019D0 (en) *	1985-12-17	1986-01-29	Beecham Group Plc	Compounds
JPS62234018A (ja)	1986-04-02	1987-10-14	Rooto Seiyaku Kk	糖尿病併発症治療剤
RU2242474C2 (ru) *	1999-03-12	2004-12-20	Бёрингер Ингельхайм Фармасьютиклз, Инк.	Соединения, пригодные в качестве противовоспалительных агентов
AU2001290258A1 (en)	2000-09-22	2002-04-02	Nihon Nohyaku Co. Ltd.	N-(4-pyrazolyl)amide derivatives, chemicals for agricultural and horticultural use, and usage of the same
JP2004526721A (ja) *	2001-03-02	2004-09-02	エフ．ホフマン−ラ　ロシュ　アーゲー	Ｉｐアンタゴニストとしてのアルコキシカルボニルアミノヘテロアリールカルボン酸誘導体
US20050164305A1 (en)	2002-04-03	2005-07-28	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
US7135575B2 (en) *	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
WO2005047899A2 (en) *	2003-11-07	2005-05-26	Acadia Pharmaceuticals Inc.	Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
GB0508472D0 (en) *	2005-04-26	2005-06-01	Glaxo Group Ltd	Compounds
JP2009514858A (ja)	2005-11-03	2009-04-09	メルクエンドカムパニーインコーポレーテッド	アリール−ピラゾリルモチーフを有するヒストンデアセチラーゼ阻害剤
GB0606876D0 (en) *	2006-04-05	2006-05-17	Glaxo Group Ltd	Compounds
AU2008289485B2 (en)	2007-08-21	2014-08-14	Senomyx, Inc.	Human T2R bitterness receptors and uses thereof
TWI434685B (zh)	2007-12-18	2014-04-21	Actelion Pharmaceuticals Ltd	胺基三唑衍生物
ES2431298T3 (es)	2009-05-18	2013-11-25	Actelion Pharmaceuticals Ltd.	Derivados de espiro[2.4]heptano puenteados como agonistas del receptor de ALX y/o FPRL2
MY161243A (en)	2009-06-09	2017-04-14	Actelion Pharmaceuticals Ltd	Fluorinated aminotriazole derivatives
CN102803237B (zh)	2009-06-12	2014-09-24	埃科特莱茵药品有限公司	作为alx受体激动剂的噁唑和噻唑衍生物

2008
- 2008-12-11 AR ARP080105380A patent/AR069650A1/es unknown
- 2008-12-12 PL PL08862120T patent/PL2242743T3/pl unknown
- 2008-12-12 WO PCT/IB2008/055251 patent/WO2009077954A1/en not_active Ceased
- 2008-12-12 CN CN2008801219752A patent/CN101903353B/zh not_active Expired - Fee Related
- 2008-12-12 KR KR1020107015524A patent/KR101622413B1/ko not_active Expired - Fee Related
- 2008-12-12 TW TW097148594A patent/TWI430795B/zh not_active IP Right Cessation
- 2008-12-12 MY MYPI2010002723A patent/MY153921A/en unknown
- 2008-12-12 HR HRP20131105AT patent/HRP20131105T1/hr unknown
- 2008-12-12 BR BRPI0821004A patent/BRPI0821004A8/pt not_active IP Right Cessation
- 2008-12-12 RU RU2010128240/04A patent/RU2489426C2/ru not_active IP Right Cessation
- 2008-12-12 ES ES08862120T patent/ES2432059T3/es active Active
- 2008-12-12 EP EP08862120.6A patent/EP2242743B1/en not_active Not-in-force
- 2008-12-12 JP JP2010537589A patent/JP5435744B2/ja not_active Expired - Fee Related
- 2008-12-12 NZ NZ586776A patent/NZ586776A/en not_active IP Right Cessation
- 2008-12-12 DK DK08862120.6T patent/DK2242743T3/da active
- 2008-12-12 PT PT88621206T patent/PT2242743E/pt unknown
- 2008-12-12 SI SI200831072T patent/SI2242743T1/sl unknown
- 2008-12-12 MX MX2010005827A patent/MX2010005827A/es active IP Right Grant
- 2008-12-12 CA CA2706836A patent/CA2706836C/en not_active Expired - Fee Related
- 2008-12-12 US US12/808,137 patent/US8288419B2/en not_active Expired - Fee Related
2010
- 2010-06-10 IL IL206296A patent/IL206296A/en not_active IP Right Cessation
- 2010-06-29 MA MA32967A patent/MA31988B1/fr unknown
- 2010-07-13 ZA ZA2010/04939A patent/ZA201004939B/en unknown
2013
- 2013-11-20 CY CY20131101025T patent/CY1114793T1/el unknown

Also Published As

Publication number	Publication date
JP5435744B2 (ja)	2014-03-05
KR20100098557A (ko)	2010-09-07
JP2011506424A (ja)	2011-03-03
IL206296A0 (en)	2010-12-30
PT2242743E (pt)	2013-10-28
KR101622413B1 (ko)	2016-05-18
AR069650A1 (es)	2010-02-10
CA2706836A1 (en)	2009-06-25
CN101903353B (zh)	2013-04-10
WO2009077954A1 (en)	2009-06-25
EP2242743A1 (en)	2010-10-27
MY153921A (en)	2015-04-15
SI2242743T1 (sl)	2013-11-29
RU2010128240A (ru)	2012-01-20
MX2010005827A (es)	2010-06-11
CN101903353A (zh)	2010-12-01
TW200924753A (en)	2009-06-16
AU2008337151A1 (en)	2009-06-25
IL206296A (en)	2015-03-31
HK1148286A1 (en)	2011-09-02
RU2489426C2 (ru)	2013-08-10
PL2242743T3 (pl)	2014-01-31
ES2432059T3 (es)	2013-11-29
CA2706836C (en)	2016-05-17
US8288419B2 (en)	2012-10-16
HRP20131105T1 (hr)	2013-12-20
NZ586776A (en)	2012-06-29
CY1114793T1 (el)	2016-12-14
US20110034516A1 (en)	2011-02-10
TWI430795B (zh)	2014-03-21
DK2242743T3 (da)	2013-10-14
ZA201004939B (en)	2012-12-27
EP2242743B1 (en)	2013-08-21
MA31988B1 (fr)	2011-01-03
BRPI0821004A8 (pt)	2017-12-26

Publication	Publication Date	Title
BRPI0821004A2 (pt)	2015-06-16	Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste
BRPI0818804A2 (pt)	2015-04-22	Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
BRPI0815190A2 (pt)	2015-03-31	Composto derivado de piridina, composição farmacêutica que o compreende e uso do mesmo
BRPI0908208A2 (pt)	2015-08-25	Composto derivado de oxazolidinona, medicamento, composição farmacêutica que o contém e uso desse composto.
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
BRPI0815079A2 (pt)	2015-02-03	Composto dericado de 1,2-diamido-etileno, composição farmacêutica que contém e uso desse composto
BRPI0821115A2 (pt)	2015-06-16	Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
BRPI0720124A2 (pt)	2014-03-04	Composições farmacêuticas e seus métodos de uso.
BRPI0917315A2 (pt)	2015-11-17	anticorpo, composicao farmaceutico, e, uso de uma composicao farmaceutica
BRPI0917661A2 (pt)	2015-12-01	produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan
BRPI0809977A2 (pt)	2014-10-07	Uso de um composto, compostos e composição farmacêutica que o contém
BRPI0810696A2 (pt)	2014-10-21	Composto, composição farmacêutica, e, uso de um composto
BRPI0809346A2 (pt)	2014-10-07	Compostos derivados substituídos de imidazopiridina e composição farmacêutica contendo os mesmos
BRPI0915120A2 (pt)	2016-07-26	composto derivado de oxima, uso do referido composto e composição farmacêutica
BRPI0819299A2 (pt)	2014-10-07	Uso de composição, e, composição contendo proteína
BRPI0919942A2 (pt)	2014-12-23	Composto, composição farmacêutica, e, uso de um composto
BRPI0907562A2 (pt)	2017-05-23	composto, composição farmacêutica, e, uso de um composto
BRPI0921375A2 (pt)	2015-12-29	composto, composição farmacêutica, e, uso de um composto
BRPI0809667A2 (pt)	2014-10-07	Composto, medicamento e composição farmacêutica que o contém e uso do composto
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