BRPI0813553A2 - composições farmacêuticas e métodos para tratamento de distúrbios do olho seco - Google Patents
composições farmacêuticas e métodos para tratamento de distúrbios do olho secoInfo
- Publication number
- BRPI0813553A2 BRPI0813553A2 BRPI0813553A BRPI0813553A BRPI0813553A2 BR PI0813553 A2 BRPI0813553 A2 BR PI0813553A2 BR PI0813553 A BRPI0813553 A BR PI0813553A BR PI0813553 A BRPI0813553 A BR PI0813553A BR PI0813553 A2 BRPI0813553 A2 BR PI0813553A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- pharmaceutical compositions
- dry eye
- eye disorders
- treating dry
- Prior art date
Links
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- 206010013774 Dry eye Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94921607P | 2007-07-11 | 2007-07-11 | |
| US6003208P | 2008-06-09 | 2008-06-09 | |
| PCT/IB2008/001819 WO2009007839A1 (en) | 2007-07-11 | 2008-07-04 | Pharmaceutical compositions and methods of treating dry eye disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813553A2 true BRPI0813553A2 (pt) | 2017-05-09 |
Family
ID=39925011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813553A BRPI0813553A2 (pt) | 2007-07-11 | 2008-07-04 | composições farmacêuticas e métodos para tratamento de distúrbios do olho seco |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8541426B2 (pt) |
| EP (1) | EP2175858B1 (pt) |
| JP (2) | JP5649270B2 (pt) |
| KR (2) | KR101258316B1 (pt) |
| CN (1) | CN101743009A (pt) |
| AR (1) | AR067495A1 (pt) |
| AU (1) | AU2008273804B2 (pt) |
| BR (1) | BRPI0813553A2 (pt) |
| CA (1) | CA2691914C (pt) |
| ES (1) | ES2523303T3 (pt) |
| NZ (1) | NZ582188A (pt) |
| RU (1) | RU2445098C2 (pt) |
| TW (1) | TWI364281B (pt) |
| WO (1) | WO2009007839A1 (pt) |
| ZA (1) | ZA201000991B (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG137989A1 (en) | 2005-06-08 | 2008-01-28 | Rigel Pharmaceuticals Inc | Compositions and methods for inhibition of the JAK pathway |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP2343298B9 (en) | 2005-12-13 | 2020-05-06 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| RS53245B2 (sr) | 2007-06-13 | 2022-10-31 | Incyte Holdings Corp | Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila |
| NZ582188A (en) * | 2007-07-11 | 2012-03-30 | Pfizer | Pharmaceutical compositions and methods of treating dry eye disorders |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| CA2759026C (en) | 2009-04-20 | 2019-01-15 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of janus kinase 3 |
| WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| HRP20192203T1 (hr) | 2009-05-22 | 2020-03-06 | Incyte Holdings Corporation | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori |
| MX337849B (es) * | 2009-07-28 | 2016-03-09 | Rigel Pharmaceuticals Inc | Composiciones y metodos para inhibicion de la via jak. |
| SI3354652T1 (sl) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Derivati piperidin-4-il azetidina kot inhibitorji JAK1 |
| MY161078A (en) | 2010-05-21 | 2017-04-14 | Incyte Holdings Corp | Topical formulation for a jak inhibitor |
| JP5917545B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体 |
| SG193245A1 (en) * | 2011-04-08 | 2013-10-30 | Pfizer | Crystalline and non- crystalline forms of tofacitinib, and a pharmaceutical composition comprising tofacitinib and a penetration enhancer |
| PE20140832A1 (es) | 2011-06-20 | 2014-07-14 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US10973680B2 (en) | 2012-01-04 | 2021-04-13 | Sight Sciences, Inc. | Controller for dry eye treatment systems |
| US9510972B2 (en) | 2012-01-04 | 2016-12-06 | Sight Sciences, Inc. | Dry eye treatment systems |
| US9724230B2 (en) | 2012-01-04 | 2017-08-08 | Sight Sciences, Inc. | Dry eye treatment apparatus and methods |
| US11285040B2 (en) | 2012-01-04 | 2022-03-29 | Sight Sciences, Inc. | Combination treatment systems |
| TWI702057B (zh) | 2012-11-15 | 2020-08-21 | 美商英塞特控股公司 | 盧梭利替尼之緩釋性劑型 |
| CN103073552B (zh) * | 2013-02-05 | 2015-08-12 | 华润赛科药业有限责任公司 | 一种无定型枸橼酸托法替尼的制备方法 |
| ES2900492T3 (es) | 2013-03-06 | 2022-03-17 | Incyte Holdings Corp | Procesos y productos intermedios para elaborar un inhibidor de JAK |
| CN104341422A (zh) * | 2013-07-26 | 2015-02-11 | 重庆医药工业研究院有限责任公司 | 托菲替尼的中间体及其制备方法 |
| RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
| CN104447751A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种托法替尼化合物 |
| CN104447752A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种托法替尼水合物及其制备方法 |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| WO2016064078A1 (ko) * | 2014-10-22 | 2016-04-28 | 주식회사 지트리비앤티 | 티모신 베타 4를 함유하는 조성물 및 이를 포함하는 약학적 제형 |
| CN104857287B (zh) * | 2015-04-21 | 2021-05-11 | 湖南中医药大学 | 一种治疗干眼症的中药滴眼液及其制备方法 |
| US9867868B2 (en) * | 2015-08-18 | 2018-01-16 | G-Treebnt Co., Ltd. | Pharmaceutical composition for treating or preventing corneal wound comprising thymosin β4 and citric acid |
| US10851097B2 (en) | 2015-11-03 | 2020-12-01 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| PL3371185T3 (pl) | 2015-11-03 | 2021-04-06 | Topivert Pharma Limited | Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych |
| AU2017300268B2 (en) * | 2016-07-18 | 2024-06-13 | Regentree, Llc | Methods of treating dry eye syndrome |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| PT3746429T (pt) | 2018-01-30 | 2022-06-20 | Incyte Corp | Processos para a preparação de (1-(3-fluoro-2-(trifluorometil)isonicotinoíl)piperidin-4-ona) |
| CN111670036B (zh) | 2018-01-31 | 2024-08-09 | 安成生物科技股份有限公司 | 包含托法替尼的局部调配物 |
| EP4424328A3 (en) | 2018-03-30 | 2024-12-04 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| US12263115B2 (en) | 2018-09-11 | 2025-04-01 | Sight Sciences, Inc. | Forceps treatment systems |
| US20220280515A1 (en) * | 2019-08-07 | 2022-09-08 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic Composition for Promoting Tear Secretion |
| CN114845734A (zh) * | 2019-12-27 | 2022-08-02 | 乐敦制药株式会社 | 水性组合物 |
| CN119367282A (zh) * | 2019-12-27 | 2025-01-28 | 乐敦制药株式会社 | 水性组合物 |
| CN111467349B (zh) * | 2020-05-14 | 2021-06-01 | 华熙生物科技股份有限公司 | 人工泪液及其制备方法 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CN114948991A (zh) * | 2021-02-26 | 2022-08-30 | 复旦大学 | 氢化镁在制备防治干眼病相关眼表炎症药物中的应用 |
| JP2025014078A (ja) * | 2021-11-30 | 2025-01-29 | 興和株式会社 | 新規ニコチンアミド化合物及びその用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818537A (en) | 1986-10-21 | 1989-04-04 | Liposome Technology, Inc. | Liposome composition for treating dry eye |
| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| US5290572A (en) | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| WO1997020578A1 (en) | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| US5747474A (en) | 1996-07-29 | 1998-05-05 | Immune Modulation, Inc. | Immunosuppression by administration of N6,N6 -disubstituted cAMP's, analogues thereof, and related nucleosides |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6080747A (en) * | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| AU3630100A (en) * | 1999-03-19 | 2000-10-09 | Parker Hughes Institute | Quinazoline formulations and therapeutic use thereof |
| JP4078074B2 (ja) | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
| US20020132767A1 (en) * | 2000-01-31 | 2002-09-19 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| TWI324925B (en) * | 2001-08-23 | 2010-05-21 | Novartis Ag | Ophthalmic composition |
| GT200200234A (es) | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| RU2285511C2 (ru) * | 2004-10-13 | 2006-10-20 | НИИ ГБ им. Гельмгольца | Средство для лечения синдрома сухого глаза |
| RU2290923C2 (ru) * | 2005-03-04 | 2007-01-10 | Московский научно-исследовательский институт глазных болезней им. Гельмгольца | Способ лечения синдрома сухого глаза |
| MX2007012393A (es) * | 2005-04-05 | 2008-02-22 | Pharmacopeia Inc | Derivados de purina e imidazopiridina para la inmunosupresion. |
| EP1910358A2 (en) * | 2005-07-14 | 2008-04-16 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
| EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| RU2384583C2 (ru) | 2005-07-29 | 2010-03-20 | Пфайзер Продактс Инк. | ПИРРОЛО[2,3-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ И СИНТЕЗ |
| WO2007062459A1 (en) * | 2005-11-29 | 2007-06-07 | Cytopia Research Pty Ltd | Selective kinase inhibitors based on pyridine scaffold |
| JP2007314326A (ja) * | 2006-05-26 | 2007-12-06 | Mitsubishi Heavy Ind Ltd | チョッパ折り方法及び装置 |
| CL2007002867A1 (es) * | 2006-10-04 | 2008-06-27 | Pharmacopeia Inc | Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras. |
| JP2010523695A (ja) * | 2007-04-11 | 2010-07-15 | アルコン リサーチ, リミテッド | アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのTNFαのインヒビターおよび抗ヒスタミン薬の使用 |
| NZ582188A (en) * | 2007-07-11 | 2012-03-30 | Pfizer | Pharmaceutical compositions and methods of treating dry eye disorders |
-
2008
- 2008-07-04 NZ NZ582188A patent/NZ582188A/en not_active IP Right Cessation
- 2008-07-04 RU RU2009149687/15A patent/RU2445098C2/ru not_active IP Right Cessation
- 2008-07-04 US US12/668,604 patent/US8541426B2/en not_active Expired - Fee Related
- 2008-07-04 EP EP08776352.0A patent/EP2175858B1/en not_active Not-in-force
- 2008-07-04 CN CN200880024111A patent/CN101743009A/zh active Pending
- 2008-07-04 ES ES08776352.0T patent/ES2523303T3/es active Active
- 2008-07-04 KR KR1020107000362A patent/KR101258316B1/ko not_active Expired - Fee Related
- 2008-07-04 KR KR1020127022597A patent/KR20120115413A/ko not_active Abandoned
- 2008-07-04 CA CA2691914A patent/CA2691914C/en not_active Expired - Fee Related
- 2008-07-04 BR BRPI0813553A patent/BRPI0813553A2/pt not_active IP Right Cessation
- 2008-07-04 WO PCT/IB2008/001819 patent/WO2009007839A1/en not_active Ceased
- 2008-07-04 AU AU2008273804A patent/AU2008273804B2/en not_active Expired - Fee Related
- 2008-07-09 JP JP2008178868A patent/JP5649270B2/ja not_active Expired - Fee Related
- 2008-07-10 AR ARP080102963A patent/AR067495A1/es unknown
- 2008-07-10 TW TW097126126A patent/TWI364281B/zh not_active IP Right Cessation
-
2010
- 2010-02-10 ZA ZA2010/00991A patent/ZA201000991B/en unknown
-
2013
- 2013-05-10 JP JP2013100072A patent/JP2013147517A/ja not_active Withdrawn
- 2013-07-17 US US13/944,816 patent/US20130303557A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100029823A (ko) | 2010-03-17 |
| EP2175858A1 (en) | 2010-04-21 |
| TW200911265A (en) | 2009-03-16 |
| CA2691914C (en) | 2012-06-26 |
| JP5649270B2 (ja) | 2015-01-07 |
| KR101258316B1 (ko) | 2013-04-30 |
| RU2009149687A (ru) | 2011-07-10 |
| US20130303557A1 (en) | 2013-11-14 |
| AU2008273804A1 (en) | 2009-01-15 |
| AR067495A1 (es) | 2009-10-14 |
| ZA201000991B (en) | 2010-12-29 |
| AU2008273804B2 (en) | 2014-07-10 |
| ES2523303T3 (es) | 2014-11-24 |
| CN101743009A (zh) | 2010-06-16 |
| EP2175858B1 (en) | 2014-09-10 |
| US20100267751A1 (en) | 2010-10-21 |
| TWI364281B (en) | 2012-05-21 |
| US8541426B2 (en) | 2013-09-24 |
| KR20120115413A (ko) | 2012-10-17 |
| CA2691914A1 (en) | 2009-01-15 |
| NZ582188A (en) | 2012-03-30 |
| JP2009046470A (ja) | 2009-03-05 |
| RU2445098C2 (ru) | 2012-03-20 |
| WO2009007839A1 (en) | 2009-01-15 |
| JP2013147517A (ja) | 2013-08-01 |
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