BRPI0812346A2 - Toxina netb clostridial - Google Patents
Toxina netb clostridialInfo
- Publication number
- BRPI0812346A2 BRPI0812346A2 BRPI0812346-2A2A BRPI0812346A BRPI0812346A2 BR PI0812346 A2 BRPI0812346 A2 BR PI0812346A2 BR PI0812346 A BRPI0812346 A BR PI0812346A BR PI0812346 A2 BRPI0812346 A2 BR PI0812346A2
- Authority
- BR
- Brazil
- Prior art keywords
- clostridial
- netb toxin
- netb
- toxin
- clostridial netb
- Prior art date
Links
- 241001112695 Clostridiales Species 0.000 title 1
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/517—Plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94285807P | 2007-06-08 | 2007-06-08 | |
| PCT/AU2008/000813 WO2008148166A1 (en) | 2007-06-08 | 2008-06-06 | Clostridial toxin netb |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0812346A2 true BRPI0812346A2 (pt) | 2015-01-27 |
| BRPI0812346B1 BRPI0812346B1 (pt) | 2019-01-22 |
Family
ID=40093085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0812346A BRPI0812346B1 (pt) | 2007-06-08 | 2008-06-06 | célula hospedeira, método para a produção de um polipeptídeo isolado, composição, vacinas, método de atenuação da virulência de uma bactéria, método para determinar se um indivíduo foi exposto a um patógeno e uso da célula hospedeira, das vacinas ou da bactéria |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8263088B2 (pt) |
| EP (2) | EP2980100A1 (pt) |
| JP (2) | JP5901115B2 (pt) |
| CN (1) | CN101903399B (pt) |
| AU (1) | AU2008258277B2 (pt) |
| BR (1) | BRPI0812346B1 (pt) |
| CA (1) | CA2689302C (pt) |
| ES (1) | ES2550685T3 (pt) |
| HU (1) | HUE025717T2 (pt) |
| MX (1) | MX2009012924A (pt) |
| PL (1) | PL2164862T3 (pt) |
| PT (1) | PT2164862E (pt) |
| RU (1) | RU2474587C2 (pt) |
| WO (1) | WO2008148166A1 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2391640B1 (en) * | 2009-01-30 | 2014-05-14 | Intervet International B.V. | A clostridium chauvoei polypeptide, dna encoding the polypeptide and a vaccine comprising the polypeptide |
| WO2011113801A1 (en) * | 2010-03-16 | 2011-09-22 | Universiteit Gent | Use of clostridium perfringens strain 23 to protect against necrotic enteritis |
| GB201118394D0 (en) | 2011-10-25 | 2011-12-07 | Univ Exeter | Vaccine |
| US10174086B2 (en) | 2011-10-25 | 2019-01-08 | University Of Exeter | Vaccine |
| KR101293667B1 (ko) | 2011-11-16 | 2013-08-07 | 대한민국 | 닭의 괴사성 장염을 예방하는 백신 조성물 |
| WO2013144636A1 (en) | 2012-03-29 | 2013-10-03 | University Of Exeter | Epsilon toxin epitopes from clostridium perfringens with reduced toxicity |
| US9493519B2 (en) * | 2012-05-23 | 2016-11-15 | University Of Guelph | Toxin in type A Clostridium perfringens |
| GB201322463D0 (en) * | 2013-12-18 | 2014-02-05 | Univ Exeter | Composition |
| US9505810B2 (en) | 2014-08-22 | 2016-11-29 | University Of Guelph | Toxins in type A Clostridium perfringens |
| EP3112474A1 (en) * | 2015-06-29 | 2017-01-04 | Evonik Degussa GmbH | Method of detecting avian necrotic enteritis |
| WO2018206690A1 (en) * | 2017-05-12 | 2018-11-15 | Evonik Degussa Gmbh | Method for detecting c. perfringens induced diseases in animals |
| KR20200006108A (ko) * | 2017-05-12 | 2020-01-17 | 에보니크 오퍼레이션즈 게엠베하 | 동물에서 씨. 퍼프린젠스 유발된 질환을 검출하는 방법 |
| EP3630800A4 (en) * | 2017-05-31 | 2021-03-24 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | VACCINE AGAINST NECROTIC ENTERITIS IN POULTRY |
| CA3092519A1 (en) | 2018-03-02 | 2019-09-06 | Evonik Operations Gmbh | In vitro method for detecting intestinal barrier failure in animals by determining ovotransferrin |
| MX2020012669A (es) * | 2018-05-29 | 2021-02-09 | Evonik Operations Gmbh | Procedimiento in vitro para monitorear la carga de patogenos en una poblacion animal. |
| CN112236533A (zh) * | 2018-06-15 | 2021-01-15 | 赢创运营有限公司 | 早期检测禽种群中坏死性肠炎爆发的方法 |
| WO2020035741A2 (en) * | 2018-07-05 | 2020-02-20 | Novobind Livestock Therapeutics Inc. | Antibodies against disease causing agents of poultry and uses thereof |
| EP3894863B1 (en) | 2018-12-14 | 2022-11-23 | Evonik Operations GmbH | In vitro method for detecting avian intestinal dysbiosis |
| KR102207354B1 (ko) * | 2019-09-02 | 2021-01-27 | (주)제이비바이오텍 | CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 닭의 괴사성장염 백신 |
| US11381146B2 (en) | 2019-09-04 | 2022-07-05 | Nti Ag | Drive device having a tubular linear motor and a stainless steel casing |
| CN113717292B (zh) * | 2021-09-27 | 2023-04-21 | 华中农业大学 | 一种针对鸡坏死性肠炎的融合蛋白疫苗及其制备方法 |
| CN116284281B (zh) * | 2023-03-07 | 2025-10-03 | 广东省农业科学院动物卫生研究所 | G型产气荚膜梭菌的重组蛋白、疫苗及应用 |
| WO2026017094A1 (zh) * | 2024-07-16 | 2026-01-22 | 成都今是科技有限公司 | 核酸测序系统 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| WO1987006614A1 (en) | 1986-04-30 | 1987-11-05 | Boyce Thompson Institute For Plant Research, Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| US4903635A (en) | 1986-07-02 | 1990-02-27 | Embrex, Inc. | High speed automated injection system for avian embryos |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| WO1991000360A1 (en) | 1989-06-29 | 1991-01-10 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5141131A (en) | 1989-06-30 | 1992-08-25 | Dowelanco | Method and apparatus for the acceleration of a propellable matter |
| US5056464A (en) | 1990-01-18 | 1991-10-15 | Embrex, Inc. | Automated injection system for avian embryos with advanced fluid delivery system |
| AU8914291A (en) | 1990-11-23 | 1992-06-25 | Plant Genetic Systems N.V. | Process for transforming monocotyledonous plants |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| EP0586505A1 (en) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| US5136979A (en) | 1991-09-25 | 1992-08-11 | Embrex, Inc. | Modular injection system for avian embryos |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5643578A (en) | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| WO1993021335A2 (en) | 1992-04-15 | 1993-10-28 | Plant Genetic Systems, N.V. | Transformation of monocot cells |
| DK0639640T3 (da) | 1993-07-30 | 2001-01-02 | Akzo Nobel Nv | Fjerkrævaccine indeholdende smitsomt bronchitis-virus serotype 4/91 |
| EP1170368B1 (en) | 1994-01-27 | 2010-07-28 | University Of Massachusetts Medical Center | Immunization by inoculation of dna transcription unit |
| ES2174027T3 (es) * | 1995-06-30 | 2002-11-01 | American Cyanamid Co | Composiciones estables que contienen macrolidos y macrolidos combinados con unas vacunas. |
| US5792294A (en) | 1995-11-16 | 1998-08-11 | Otis Elevator Company | Method of replacing sheave liner |
| US5939400A (en) | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| GB9605222D0 (en) * | 1996-03-12 | 1996-05-15 | Secr Defence | Clostridium perfringens epsilon toxin vaccines |
| AU3210997A (en) | 1996-05-24 | 1997-12-09 | University Of Maryland At Baltimore | Dna vaccines for eliciting a mucosal immune response |
| DE69836520T2 (de) * | 1997-06-20 | 2007-06-06 | Intervet International B.V. | Clostridium perfringens Impfstoff |
| EP1023442B1 (en) | 1997-10-16 | 2010-11-24 | University Of Georgia Research Foundation, Inc. | Transgenic birds and protein production |
| UA78486C2 (uk) * | 1999-12-10 | 2007-04-10 | Хемджен Корпорейшн | Композиція для перорального введення птахам та тваринам для лікування або зниження ризику інфекції травного тракту (варіанти), її застосування (варіанти) та спосіб лікування або зниження ризику інфекцій травного тракту (варіанти) |
| EP2380440B1 (en) * | 2002-04-15 | 2016-03-09 | Washington University | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
| US20040101531A1 (en) * | 2002-04-16 | 2004-05-27 | Roy Curtiss | Immunogenic compositions and vaccines comprising carrier bacteria that secrete antigens |
| EP1644492B1 (en) * | 2003-06-18 | 2009-01-07 | Genelux Corporation | Modified recombinant vaccinia viruses, uses thereof |
| US7617795B2 (en) | 2004-10-13 | 2009-11-17 | Embrex, Inc. | Methods and apparatus for injecting and sampling material through avian egg membranes |
| AU2006287110B2 (en) | 2005-08-30 | 2012-04-12 | Commonwealth Scientific And Industrial Research Organisation | Bacterial delivery of biologically active polypeptides |
| RU2409385C2 (ru) * | 2006-03-30 | 2011-01-20 | Эмбрекс, Инк. | Способ иммунизации птицы против инфекции, вызванной бактериями clostridium |
| US9040059B2 (en) * | 2007-10-05 | 2015-05-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting a protective immune response against C. perfringens |
-
2008
- 2008-06-06 BR BRPI0812346A patent/BRPI0812346B1/pt active IP Right Grant
- 2008-06-06 EP EP15177663.0A patent/EP2980100A1/en not_active Withdrawn
- 2008-06-06 CN CN200880019023.XA patent/CN101903399B/zh active Active
- 2008-06-06 HU HUE08756897A patent/HUE025717T2/en unknown
- 2008-06-06 WO PCT/AU2008/000813 patent/WO2008148166A1/en not_active Ceased
- 2008-06-06 RU RU2009149378/10A patent/RU2474587C2/ru active
- 2008-06-06 PL PL08756897T patent/PL2164862T3/pl unknown
- 2008-06-06 PT PT87568978T patent/PT2164862E/pt unknown
- 2008-06-06 ES ES08756897.8T patent/ES2550685T3/es active Active
- 2008-06-06 CA CA2689302A patent/CA2689302C/en active Active
- 2008-06-06 MX MX2009012924A patent/MX2009012924A/es active IP Right Grant
- 2008-06-06 JP JP2010510616A patent/JP5901115B2/ja active Active
- 2008-06-06 AU AU2008258277A patent/AU2008258277B2/en active Active
- 2008-06-06 US US12/663,215 patent/US8263088B2/en active Active
- 2008-06-06 EP EP08756897.8A patent/EP2164862B1/en active Active
-
2014
- 2014-06-12 JP JP2014121284A patent/JP2014221046A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2689302C (en) | 2015-08-25 |
| JP2010529838A (ja) | 2010-09-02 |
| EP2164862B1 (en) | 2015-07-22 |
| CN101903399A (zh) | 2010-12-01 |
| AU2008258277A1 (en) | 2008-12-11 |
| PL2164862T3 (pl) | 2015-12-31 |
| EP2164862A4 (en) | 2011-11-02 |
| ES2550685T3 (es) | 2015-11-11 |
| US8263088B2 (en) | 2012-09-11 |
| WO2008148166A1 (en) | 2008-12-11 |
| JP2014221046A (ja) | 2014-11-27 |
| US20100291131A1 (en) | 2010-11-18 |
| MX2009012924A (es) | 2010-03-25 |
| CA2689302A1 (en) | 2008-12-11 |
| RU2474587C2 (ru) | 2013-02-10 |
| JP5901115B2 (ja) | 2016-04-06 |
| RU2009149378A (ru) | 2011-07-20 |
| PT2164862E (pt) | 2015-10-29 |
| EP2164862A1 (en) | 2010-03-24 |
| BRPI0812346B1 (pt) | 2019-01-22 |
| EP2980100A1 (en) | 2016-02-03 |
| AU2008258277B2 (en) | 2012-07-12 |
| CN101903399B (zh) | 2014-09-10 |
| HUE025717T2 (en) | 2016-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0812346A2 (pt) | Toxina netb clostridial | |
| IL281675A (en) | Injectable botulinum toxin formulations | |
| BRPI0816771A2 (pt) | Espaçador interespinhal | |
| PL2419441T3 (pl) | Owadzie toksyny Cry obejmujące DIG-3 | |
| FI20085597L (fi) | Tiedon haku | |
| DE602008003603D1 (de) | Speicherplattensystem | |
| HRP20170963T1 (hr) | Modificirani saharidi | |
| EP2145362A4 (en) | DATA PROCESSING INFRASTRUCTURE | |
| DE602008002287D1 (de) | Aufzeichnungsgerät | |
| BRPI0819600A2 (pt) | Servoválvula. | |
| DE602008002037D1 (de) | Aufzeichnungsgerät | |
| FI7604U1 (fi) | Tuntoelin | |
| HK1142614A (en) | Clostridial toxin netb | |
| EP2202304A4 (en) | MODIFIED CREATININE AMIDOHYDROLASE | |
| FR2920806B1 (fr) | Cadenas. | |
| ES1065818Y (es) | Picaporte magnetico | |
| FI20075839A0 (fi) | Tietojärjestelmä | |
| ITCO20060012A1 (it) | Anti - urto | |
| SE0702505L (sv) | Smart dust | |
| FI20085818A0 (fi) | Informaatiojärjestelmä | |
| FI20085559A0 (fi) | Informaatiojärjestelmä | |
| FI20070088A0 (fi) | Haaviston luomu-arkku | |
| ES1066176Y (es) | Mueble publicitario | |
| UA17262S (uk) | Цінник | |
| UA16352S (uk) | Музичний автомат |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/01/2019, OBSERVADAS AS CONDICOES LEGAIS. |