BRPI0812170A2 - SECRETASE RANGE MODULATORS - Google Patents

SECRETASE RANGE MODULATORS

Info

Publication number: BRPI0812170A2
Authority: BR; Brazil
Prior art keywords: secretase; range modulators; modulators; range; secretase range
Prior art date: 2007-06-01

Application number

BRPI0812170-2A2A

Other languages

Portuguese (pt)

Inventor

Zhaoning Zhu

William J Greenlee

Xianhai Huang

Brian A Mckittrick

John W Clader

Mark D Mcbriar

Anandan Palani

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-01

Filing date

2008-05-28

Publication date

2014-12-02

2008-05-28 Application filed by Schering Corp filed Critical Schering Corp

2014-12-02 Publication of BRPI0812170A2 publication Critical patent/BRPI0812170A2/en

2016-02-10 Publication of BRPI0812170A8 publication Critical patent/BRPI0812170A8/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0812170A 2007-06-01 2008-05-28 SECRETASE RANGE MODULATORS BRPI0812170A8 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US94140507P	2007-06-01	2007-06-01
US98448407P	2007-11-01	2007-11-01
PCT/US2008/006734 WO2008153793A2 (en)	2007-06-01	2008-05-28	Gamma secretase modulators

Publications (2)

Publication Number	Publication Date
BRPI0812170A2 true BRPI0812170A2 (en)	2014-12-02
BRPI0812170A8 BRPI0812170A8 (en)	2016-02-10

Family

ID=40084164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0812170A BRPI0812170A8 (en)	2007-06-01	2008-05-28	SECRETASE RANGE MODULATORS

Country Status (18)

Country	Link
US (1)	US8426403B2 (en)
EP (1)	EP2152695A2 (en)
JP (1)	JP5495331B2 (en)
KR (1)	KR20100037053A (en)
CN (1)	CN101809016A (en)
AR (1)	AR066152A1 (en)
AU (1)	AU2008263207B2 (en)
BR (1)	BRPI0812170A8 (en)
CA (1)	CA2689948A1 (en)
CL (1)	CL2008001560A1 (en)
CO (1)	CO6241123A2 (en)
EC (1)	ECSP099776A (en)
IL (1)	IL202315A0 (en)
MX (1)	MX2009013131A (en)
PE (1)	PE20090363A1 (en)
RU (1)	RU2009148866A (en)
TW (1)	TW200914459A (en)
WO (1)	WO2008153793A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8183276B2 (en) *	2007-02-08	2012-05-22	Christian Fischer	Therapeutic agents
CA2742317A1 (en) *	2008-11-06	2010-05-14	Schering Corporation	Gamma secretase modulators
AU2009314049B2 (en)	2008-11-13	2015-03-05	Merck Sharp & Dohme Corp.	Gamma secretase modulators
AU2009314205A1 (en) *	2008-11-13	2010-05-20	Merck Sharp & Dohme Corp.	Gamma secretase modulators
EP2379566A2 (en) *	2008-12-22	2011-10-26	Schering Corporation	Gamma secretase modulators
WO2010147975A1 (en) *	2009-06-16	2010-12-23	Schering Corporation	Gamma secretase modulators
US20120238546A1 (en) *	2009-06-16	2012-09-20	Zhaoning Zhu	Gamma secretase modulators
US20120232108A1 (en) *	2009-06-16	2012-09-13	Xianhai Huang	Gamma secretase modulators
JP2014001142A (en) *	2010-10-05	2014-01-09	Astellas Pharma Inc	Cycloalkane compound
JP5767393B2 (en)	2011-03-31	2015-08-19	ファイザー・インク	New bicyclic pyridinone
UA110688C2 (en)	2012-09-21	2016-01-25	Пфайзер Інк.	Bicyclic pirydynony
WO2015084752A1 (en) *	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Gamma secretase modulators
US10118890B2 (en)	2014-10-10	2018-11-06	The Research Foundation For The State University Of New York	Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
TN2017000342A1 (en)	2015-02-03	2019-01-16	Pfizer	Novel cyclopropabenzofuranyl pyridopyrazinediones
CN110997693A (en)	2017-06-07	2020-04-10	阿德克斯公司	Tau aggregation inhibitor
EP3668886A2 (en)	2017-08-18	2020-06-24	Adrx, Inc.	Tau aggregation peptide inhibitors
PE20210447A1 (en) *	2018-02-28	2021-03-08	Japan Tobacco Inc	DIHYDROPYRIMIDINONE OR DIHYDROTRIAZINONE COMPOUNDS FUSED WITH SATURATED RINGS AND THEIR PHARMACEUTICAL USE
WO2020113077A1 (en)	2018-11-29	2020-06-04	The Research Foundation For The State University Of New York	Compositions and methods for modular control of bioorthogonal ligation

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CA1065324A (en) *	1974-05-13	1979-10-30	E.R. Squibb And Sons	2-aminoalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(phenylmethylene)-2h-indazoles and related cyclohepta (c) pyrazoles and cyclopentapyrazoles
CH594667A5 (en) *	1974-05-31	1978-01-13	Squibb & Sons Inc	Hexahydro-2H-pyrazolo(4,3-C) pyridine derivs
US3979381A (en) *	1975-08-11	1976-09-07	E. R. Squibb & Sons, Inc.	Thiopyrano[4,3-c] pyrazoles
US4003890A (en) *	1976-05-27	1977-01-18	E. R. Squibb & Sons, Inc.	Benzylidene pyrano[4,3-c]pyrazoles
US4065617A (en) *	1977-02-04	1977-12-27	E. R. Squibb & Sons, Inc.	2-(2,2,2,-Trifluoroethyl)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridines
WO1999048873A1 (en) *	1998-03-25	1999-09-30	Bristol-Myers Squibb Company	Imidazolone anorectic agents: i. acyclic derivatives
SI1268407T1 (en) *	2000-03-20	2004-10-31	N-Gene Research Laboratories Inc.	Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
EP1603548A4 (en)	2003-02-05	2007-10-10	Myriad Genetics Inc	COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS
BRPI0410348A (en)	2003-05-14	2006-05-30	Torreypines Therapeutics Inc	compounds and uses thereof in amyloid-beta modulation
US20050042284A1 (en)	2003-07-11	2005-02-24	Myriad Genetics, Incorporated	Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
WO2006001877A2 (en)	2004-04-13	2006-01-05	Myriad Genetics, Inc.	Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
EP1750719A2 (en)	2004-05-19	2007-02-14	Boehringer Ingelheim International GmbH	Treatment of diseases associated with altered level of amyloid beta peptides
TWI335816B (en)	2004-05-26	2011-01-11	Eisai R&D Man Co Ltd	Cinnamide compound
EP1650183A1 (en)	2004-10-21	2006-04-26	Cellzome Ag	(Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
AU2006317457B2 (en)	2005-11-24	2011-09-08	Eisai R & D Management Co., Ltd.	Morpholine type cinnamide compound
TWI370130B (en) *	2005-11-24	2012-08-11	Eisai R&D Man Co Ltd	Two cyclic cinnamide compound
WO2007102580A1 (en) *	2006-03-09	2007-09-13	Eisai R & D Management Co., Ltd.	Polycyclic cinnamide derivative
CN101809019A (en)	2007-05-07	2010-08-18	先灵公司	Gamma secretase modulators
CA2689930A1 (en)	2007-06-01	2008-12-18	Schering Corporation	Gamma secretase modulators
AU2009314049B2 (en)	2008-11-13	2015-03-05	Merck Sharp & Dohme Corp.	Gamma secretase modulators

2008
- 2008-05-28 CN CN200880100987A patent/CN101809016A/en active Pending
- 2008-05-28 US US12/601,322 patent/US8426403B2/en active Active
- 2008-05-28 WO PCT/US2008/006734 patent/WO2008153793A2/en not_active Ceased
- 2008-05-28 AU AU2008263207A patent/AU2008263207B2/en not_active Ceased
- 2008-05-28 MX MX2009013131A patent/MX2009013131A/en not_active Application Discontinuation
- 2008-05-28 BR BRPI0812170A patent/BRPI0812170A8/en not_active IP Right Cessation
- 2008-05-28 JP JP2010510316A patent/JP5495331B2/en not_active Expired - Fee Related
- 2008-05-28 KR KR1020097027345A patent/KR20100037053A/en not_active Withdrawn
- 2008-05-28 RU RU2009148866/04A patent/RU2009148866A/en not_active Application Discontinuation
- 2008-05-28 CA CA2689948A patent/CA2689948A1/en not_active Abandoned
- 2008-05-28 EP EP08767902A patent/EP2152695A2/en not_active Withdrawn
- 2008-05-29 AR ARP080102261A patent/AR066152A1/en not_active Application Discontinuation
- 2008-05-29 TW TW097119930A patent/TW200914459A/en unknown
- 2008-05-29 PE PE2008000920A patent/PE20090363A1/en not_active Application Discontinuation
- 2008-05-29 CL CL2008001560A patent/CL2008001560A1/en unknown
2009
- 2009-11-24 IL IL202315A patent/IL202315A0/en unknown
- 2009-12-01 EC EC2009009776A patent/ECSP099776A/en unknown
- 2009-12-01 CO CO09137086A patent/CO6241123A2/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200914459A (en)	2009-04-01
CL2008001560A1 (en)	2009-05-22
WO2008153793A3 (en)	2009-03-19
AU2008263207A2 (en)	2010-01-28
EP2152695A2 (en)	2010-02-17
US8426403B2 (en)	2013-04-23
RU2009148866A (en)	2011-07-20
US20100256128A1 (en)	2010-10-07
AR066152A1 (en)	2009-07-29
IL202315A0 (en)	2010-06-30
PE20090363A1 (en)	2009-04-01
CA2689948A1 (en)	2008-12-18
ECSP099776A (en)	2010-01-29
JP2010529015A (en)	2010-08-26
JP5495331B2 (en)	2014-05-21
WO2008153793A2 (en)	2008-12-18
CO6241123A2 (en)	2011-01-20
KR20100037053A (en)	2010-04-08
AU2008263207A1 (en)	2008-12-18
BRPI0812170A8 (en)	2016-02-10
CN101809016A (en)	2010-08-18
AU2008263207B2 (en)	2013-10-03
MX2009013131A (en)	2010-01-15

Publication	Publication Date	Title
BRPI0812170A2 (en)	2014-12-02	SECRETASE RANGE MODULATORS
BRPI0814256A2 (en)	2015-02-03	TETRAHYDROPYROCHYROMENE RANGE INHIBITORS SECRETASE
BRPI0813653A2 (en)	2014-12-30	IMIDAZOTIZOLE COMPOUNDS SIRTUINE MODULATORS
BRPI0813651A2 (en)	2014-12-30	TIAZOLOPYRIDINE COMPOUNDS SIRTUINE MODULATORS
BRPI0921348A2 (en)	2019-09-24	heterocyclic gamma secretase modulators
BRPI0917394A2 (en)	2019-09-24	mif modulators
BRPI0815135A2 (en)	2015-02-03	AZEPINE DERIVATIVES AS RANGE INHIBITORS SECRETASE.
BRPI0818380A2 (en)	2014-10-07	HERBICIDE-PROTECTOR COMBINATION
BRPI0921327A2 (en)	2015-08-25	Herbicide-Protector Combination
IL201960A0 (en)	2010-06-16	Gamma secretase modulators
BRPI0813707A2 (en)	2014-12-30	PYRIMIDINYL-PYRIDAZINONE DERIVATIVES
BRPI0820112A2 (en)	2015-05-05	ISOXAZOL-PYRIDINE DERIVATIVES
EP2115519A4 (en)	2012-12-05	DYNAMIC OPHTHALMIC OPENING
BRPI0809992A2 (en)	2014-10-14	PYROLOPYRIMIDINE DERIVATIVES
BRPI0820113A2 (en)	2015-05-05	ISOXAZOLE-PYRIDAZINE DERIVATIVES
BRPI0812155A2 (en)	2019-09-24	spiroindolinone derivatives
BRPI0817935A2 (en)	2015-04-07	BIARILLE DERIVATIVES
BRPI0814236A2 (en)	2015-01-06	QUINAZOLINAMIDE DERIVATIVES
BRPI0813230A2 (en)	2014-12-23	CALICREIN MODULATORS 7
BRPI0812518A2 (en)	2015-03-31	INDAZOLAMIDE DERIVATIVES
BRPI0915991A2 (en)	2019-09-24	substituted sulfamide derivatives
BRPI0820649A2 (en)	2015-06-16	Isoxazalo-pyrazine derivatives
BRPI0822919A2 (en)	2015-06-23	Differential locking device
CU23870B1 (en)	2013-03-27	CYCLOPROPILAMIDE DERIVATIVES AS H3 MODULATORS
BRPI0914596A2 (en)	2015-12-15	crane combination

Legal Events

Date	Code	Title	Description
2015-08-25	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2016-02-10	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US)
2016-02-23	B25G	Requested change of headquarter approved	Owner name: MERCK SHARP AND DOHME CORP. (US)
2016-05-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.