BRPI0810082A2 - 3-imidazolil-indóis para o tratamento de doenças proliferativas - Google Patents

3-imidazolil-indóis para o tratamento de doenças proliferativas

Info

Publication number: BRPI0810082A2
Authority: BR; Brazil
Prior art keywords: indos; imidazolil; treatment; proliferative diseases; proliferative
Prior art date: 2007-03-29

Application number

BRPI0810082-9A2A

Other languages

English (en)

Inventor

Andreas Boettcher

Nicole Buschmann

Pascal Furet

Jean-Marc Groell

Joerg Kallen

Joanna Hergovich Lisztwan

Keiichi Mauya

Lorenz Mayr

Andrea Vaupel

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-29

Filing date

2008-03-27

Publication date

2014-10-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38328915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0810082(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-03-27 Application filed by Novartis Ag filed Critical Novartis Ag

2014-10-21 Publication of BRPI0810082A2 publication Critical patent/BRPI0810082A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0810082-9A2A 2007-03-29 2008-03-27 3-imidazolil-indóis para o tratamento de doenças proliferativas BRPI0810082A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07105269		2007-03-29
PCT/EP2008/053667 WO2008119741A2 (en)	2007-03-29	2008-03-27	3-imidazolyl-indoles for the treatment of proliferative diseases

Publications (1)

Publication Number	Publication Date
BRPI0810082A2 true BRPI0810082A2 (pt)	2014-10-21

Family

ID=38328915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0810082-9A2A BRPI0810082A2 (pt)	2007-03-29	2008-03-27	3-imidazolil-indóis para o tratamento de doenças proliferativas

Country Status (27)

Country	Link
US (1)	US8053457B2 (pt)
EP (1)	EP2142535A2 (pt)
JP (1)	JP2010522723A (pt)
KR (1)	KR20090122403A (pt)
CN (1)	CN101679382A (pt)
AR (1)	AR065860A1 (pt)
AU (1)	AU2008234954B9 (pt)
BR (1)	BRPI0810082A2 (pt)
CA (1)	CA2682483A1 (pt)
CL (1)	CL2008000899A1 (pt)
CR (1)	CR11019A (pt)
DO (1)	DOP2009000229A (pt)
EA (1)	EA200901212A1 (pt)
EC (1)	ECSP099660A (pt)
GT (1)	GT200900256A (pt)
IL (1)	IL200862A0 (pt)
MA (1)	MA31260B1 (pt)
MX (1)	MX2009010413A (pt)
NI (1)	NI200900177A (pt)
PA (1)	PA8774001A1 (pt)
PE (1)	PE20081897A1 (pt)
SM (1)	SMP200900085B (pt)
TN (1)	TN2009000388A1 (pt)
TW (1)	TW200843746A (pt)
UY (1)	UY30987A1 (pt)
WO (1)	WO2008119741A2 (pt)
ZA (1)	ZA200906210B (pt)

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ES2624808T3 (es)	2011-05-11	2017-07-17	The Regents Of The University Of Michigan	Antagonistas de MDM2 espirooxindólicos
WO2012177927A1 (en)	2011-06-21	2012-12-27	Mayo Foundation For Medical Education And Research	Transgenic animals capable of being induced to delete senescent cells
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WO2014179562A1 (en)	2013-05-01	2014-11-06	Massachusetts Institute Of Technology	1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
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WO2015116735A1 (en)	2014-01-28	2015-08-06	Mayo Foundation For Medical Education And Research	Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
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US9840479B2 (en)	2014-07-02	2017-12-12	Massachusetts Institute Of Technology	Polyamine-fatty acid derived lipidoids and uses thereof
JP6503386B2 (ja)	2014-07-03	2019-04-17	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
US10071087B2 (en)	2014-07-22	2018-09-11	Bioventures, Llc	Compositions and methods for selectively depleting senescent cells
KR20170042779A (ko)	2014-08-21	2017-04-19	베링거 인겔하임 인터내셔날 게엠베하	Mdm2-p53 억제제로서의 신규 스피로[3h-인돌-3,2'-피롤리딘]-2(1h)-온 화합물 및 유도체
US20180006236A1 (en)	2014-12-26	2018-01-04	Dow Global Technologies Llc	Organic compounds and electronic device comprising organic layer comprising organic compounds
CA2976752C (en)	2015-02-20	2019-12-17	Daiichi Sankyo Company, Limited	Method for treating cancer by combined use
TWI697329B (zh)	2015-04-13	2020-07-01	日商第一三共股份有限公司	血液癌症治療用之醫藥及其用途
WO2016207089A1 (de)	2015-06-22	2016-12-29	Bayer Pharma Aktiengesellschaft	Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen
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PL3359542T3 (pl)	2015-10-09	2021-09-20	Boehringer Ingelheim International Gmbh	Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53
US10759808B2 (en)	2016-04-06	2020-09-01	The Regents Of The University Of Michigan	Monofunctional intermediates for ligand-dependent target protein degradation
CN109415336B (zh)	2016-04-06	2023-08-29	密执安大学评议会	Mdm2蛋白质降解剂
JP6936498B2 (ja)	2016-04-21	2021-09-15	バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ，ＬＬＣ	抗アポトーシス性Ｂｃｌ−２ファミリータンパク質の分解を誘導する化合物及びその使用
CN105906610B (zh) *	2016-05-24	2018-10-23	绍兴文理学院	一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用
PT3272745T (pt) *	2016-07-21	2019-09-27	Inst Farmakologii Polskiej Akademii Nauk	Derivados de indol substituídos com imidazolilo que se ligam ao recetor de serotonina 5-ht7 e composições farmacêuticas dos mesmos
KR20190068544A (ko)	2016-10-17	2019-06-18	다이이찌 산쿄 가부시키가이샤	Mdm2 저해제와 dna 메틸트랜스페라아제 저해제의 병용 치료법
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JP2002114780A (ja) *	2000-10-11	2002-04-16	Taisho Pharmaceut Co Ltd	４−（３−インドリル）イミダゾール誘導体
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2008
- 2008-03-27 KR KR1020097022526A patent/KR20090122403A/ko not_active Withdrawn
- 2008-03-27 BR BRPI0810082-9A2A patent/BRPI0810082A2/pt not_active IP Right Cessation
- 2008-03-27 CA CA002682483A patent/CA2682483A1/en not_active Abandoned
- 2008-03-27 CN CN200880017611A patent/CN101679382A/zh active Pending
- 2008-03-27 MX MX2009010413A patent/MX2009010413A/es not_active Application Discontinuation
- 2008-03-27 JP JP2010500280A patent/JP2010522723A/ja active Pending
- 2008-03-27 EA EA200901212A patent/EA200901212A1/ru unknown
- 2008-03-27 US US12/593,721 patent/US8053457B2/en not_active Expired - Fee Related
- 2008-03-27 AU AU2008234954A patent/AU2008234954B9/en not_active Ceased
- 2008-03-27 AR ARP080101262A patent/AR065860A1/es unknown
- 2008-03-27 PE PE2008000554A patent/PE20081897A1/es not_active Application Discontinuation
- 2008-03-27 WO PCT/EP2008/053667 patent/WO2008119741A2/en not_active Ceased
- 2008-03-27 EP EP08735532A patent/EP2142535A2/en not_active Withdrawn
- 2008-03-28 UY UY30987A patent/UY30987A1/es not_active Application Discontinuation
- 2008-03-28 PA PA20088774001A patent/PA8774001A1/es unknown
- 2008-03-28 CL CL2008000899A patent/CL2008000899A1/es unknown
- 2008-03-28 TW TW097111568A patent/TW200843746A/zh unknown
2009
- 2009-09-08 ZA ZA200906210A patent/ZA200906210B/xx unknown
- 2009-09-09 CR CR11019A patent/CR11019A/es unknown
- 2009-09-10 IL IL200862A patent/IL200862A0/en unknown
- 2009-09-24 TN TNP2009000388A patent/TN2009000388A1/fr unknown
- 2009-09-24 MA MA32230A patent/MA31260B1/fr unknown
- 2009-09-28 DO DO2009000229A patent/DOP2009000229A/es unknown
- 2009-09-28 NI NI200900177A patent/NI200900177A/es unknown
- 2009-09-28 GT GT200900256A patent/GT200900256A/es unknown
- 2009-09-29 EC EC2009009660A patent/ECSP099660A/es unknown
- 2009-10-28 SM SM200900085T patent/SMP200900085B/it unknown

Also Published As

Publication number	Publication date
WO2008119741A3 (en)	2008-12-04
MA31260B1 (fr)	2010-03-01
CN101679382A (zh)	2010-03-24
US20100125064A1 (en)	2010-05-20
PA8774001A1 (es)	2008-11-19
DOP2009000229A (es)	2009-10-31
SMP200900085B (it)	2010-11-12
ZA200906210B (en)	2010-05-26
JP2010522723A (ja)	2010-07-08
MX2009010413A (es)	2009-10-20
TN2009000388A1 (en)	2010-12-31
KR20090122403A (ko)	2009-11-27
EP2142535A2 (en)	2010-01-13
TW200843746A (en)	2008-11-16
WO2008119741A2 (en)	2008-10-09
CA2682483A1 (en)	2008-10-09
CL2008000899A1 (es)	2009-02-20
AU2008234954B9 (en)	2012-02-02
AU2008234954B2 (en)	2011-10-27
ECSP099660A (es)	2009-10-30
US8053457B2 (en)	2011-11-08
UY30987A1 (es)	2008-10-31
AU2008234954A1 (en)	2008-10-09
AR065860A1 (es)	2009-07-08
CR11019A (es)	2009-10-20
EA200901212A1 (ru)	2010-04-30
GT200900256A (es)	2010-03-15
SMAP200900085A (it)	2010-01-19
PE20081897A1 (es)	2009-02-09
NI200900177A (es)	2010-09-09
IL200862A0 (en)	2010-05-17

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