BRPI0817562A2 - derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis - Google Patents

derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis

Info

Publication number: BRPI0817562A2
Authority: BR; Brazil
Prior art keywords: niltroxyl; donors; physiologically useful; new physiologically; hydroxylsulfonamide derivatives
Prior art date: 2007-09-26

Application number

BRPI0817562A

Other languages

English (en)

Inventor

D Cohen Andrew

Arthur Brookfield Frederick

p toscano John

Marie Frost Lisa

Martin Courtney Stephen

Jacob Kalish Vincent

Original Assignee

Cardioxyl Pharmaceuticals Inc

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-26

Filing date

2008-09-26

Publication date

2017-05-02

2008-09-26 Application filed by Cardioxyl Pharmaceuticals Inc, Univ Johns Hopkins filed Critical Cardioxyl Pharmaceuticals Inc

2017-05-02 Publication of BRPI0817562A2 publication Critical patent/BRPI0817562A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

BRPI0817562A 2007-09-26 2008-09-26 derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis BRPI0817562A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99563607P	2007-09-26	2007-09-26
PCT/US2008/078024 WO2009042970A1 (en)	2007-09-26	2008-09-26	N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

Publications (1)

Publication Number	Publication Date
BRPI0817562A2 true BRPI0817562A2 (pt)	2017-05-02

Family

ID=40140060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0817562A BRPI0817562A2 (pt)	2007-09-26	2008-09-26	derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis

Country Status (14)

Country	Link
US (4)	US8227639B2 (pt)
EP (1)	EP2190814B1 (pt)
JP (3)	JP2011502105A (pt)
KR (3)	KR101905004B1 (pt)
CN (2)	CN104119310B (pt)
AU (1)	AU2008304200B2 (pt)
BR (1)	BRPI0817562A2 (pt)
CA (1)	CA2699567C (pt)
IL (1)	IL204434B (pt)
MX (1)	MX2010003232A (pt)
NZ (1)	NZ584036A (pt)
RU (2)	RU2485097C2 (pt)
SG (2)	SG10201602375PA (pt)
WO (1)	WO2009042970A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL2489350T3 (pl)	2006-03-17	2014-08-29	Cardioxyl Pharmaceuticals Inc	Pochodne N-hydroksylosulfonamidu jako nowe, fizjologicznie użyteczne donory nitroksylu
SG10201602375PA (en) *	2007-09-26	2016-05-30	Univ Johns Hopkins	N-Hydroxylsulfonamide Derivatives As New Physiologically Useful Nitroxyl Donors
WO2011063339A1 (en)	2009-11-23	2011-05-26	Cardioxyl Pharmaceuticals, Inc.	Nitroxyl donors for the treatment of pulmonary hypertension
JP5826762B2 (ja)	2009-12-07	2015-12-02	ザジョンズホプキンスユニバーシティ	Ｎ−アシルオキシスルホンアミドおよびｎ−ヒドロキシ−ｎ−アシルスルホンアミド誘導体
IN2012DN05028A (pt)	2009-12-07	2015-10-23	Univ Johns Hopkins
CN104053647B (zh)	2011-10-17	2018-06-01	约翰斯霍普金斯大学	作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物
EP2914579A1 (en)	2012-11-01	2015-09-09	The Johns Hopkins University	Controlled hno release through intramolecular cyclization-elimination
PT2945621T (pt) *	2013-01-18	2019-01-21	Cardioxyl Pharmaceuticals Inc	Composições farmacêuticas compreendendo dadores de nitroxilo
EP2764868A1 (en)	2013-02-08	2014-08-13	Friedrich-Alexander-Universität Erlangen-Nürnberg	Combination of nitroprusside and a sulfide salt as an HNO-releasing therapeutic for the treatment or prevention of cardiovascular diseases
WO2015109210A1 (en)	2014-01-17	2015-07-23	Cardioxyl Pharmaceuticals, Inc.	N-hydroxymethanesulfonamide nitroxyl donors
ES2749682T3 (es)	2014-05-27	2020-03-23	Cardioxyl Pharmaceuticals Inc	Derivados de pirazolona como donadores de nitroxilo
WO2015183838A1 (en)	2014-05-27	2015-12-03	The Johns Hopkins University	N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
US9464061B2 (en)	2014-05-27	2016-10-11	The Johns Hopkins University	N-hydroxylamino-barbituric acid derivatives
US10723704B2 (en)	2015-10-19	2020-07-28	Cardioxyl Pharmaceuticals, Inc.	Pyrazolone derivatives as nitroxyl donors
CN108368038A (zh) *	2015-10-19	2018-08-03	卡尔迪奥克斯尔制药公司	作为硝酰基供体的n-羟基磺酰胺衍生物
US10913728B2 (en)	2016-07-28	2021-02-09	The Johns Hopkins University	O-substituted hydroxamic acids
CN110520116A (zh)	2017-01-03	2019-11-29	卡尔迪奥克斯尔制药公司	供硝酰化合物的给予方法
US11691971B2 (en)	2020-06-19	2023-07-04	Incyte Corporation	Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en)	2020-06-19	2021-12-23	Incyte Corporation	Pyrrolotriazine compounds as jak2 v617f inhibitors
US11767323B2 (en)	2020-07-02	2023-09-26	Incyte Corporation	Tricyclic pyridone compounds as JAK2 V617F inhibitors
MX2023000056A (es)	2020-07-02	2023-04-12	Incyte Corp	Compuestos tricíclicos de urea como inhibidores de la variante v617f de la cinasa de janus 2 (jak2 v617f).
WO2022046989A1 (en)	2020-08-27	2022-03-03	Incyte Corporation	Tricyclic urea compounds as jak2 v617f inhibitors
US11919908B2 (en)	2020-12-21	2024-03-05	Incyte Corporation	Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
TW202302589A (zh)	2021-02-25	2023-01-16	美商英塞特公司	作為ｊａｋ２ｖ６１７ｆ抑制劑之螺環內醯胺
CA3254582A1 (en)	2022-03-17	2023-09-21	Incyte Corporation	TRICYCLIC UREA COMPOUNDS AS JAK2 INHIBITORS V617F
WO2025043108A1 (en)	2023-08-23	2025-02-27	Bristol -Myers S Quibb Company	Co-crystals of nitroxyl donating compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3751255A (en) *	1972-03-24	1973-08-07	Eastman Kodak Co	Photosensitive and thermosensitive element, composition and process
JPS567710A (en) *	1979-06-28	1981-01-27	Sansho Seiyaku Kk	Whitening cosmetic
DE3583799D1 (de) *	1985-01-11	1991-09-19	Abbott Lab Ltd	Feste zubereitung mit langsamer freisetzung.
US4663351A (en) *	1985-08-23	1987-05-05	Berlex Laboratories, Inc.	Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent
US4798824A (en) *	1985-10-03	1989-01-17	Wisconsin Alumni Research Foundation	Perfusate for the preservation of organs
JPH0446169A (ja)	1990-06-14	1992-02-17	Mitsubishi Petrochem Co Ltd	新規なベンゾフラン誘導体及びそれを含有する除草剤
JP2773959B2 (ja) *	1990-07-10	1998-07-09	信越化学工業株式会社	大腸内放出性固形製剤
JPH04321671A (ja) *	1991-04-17	1992-11-11	Mitsubishi Petrochem Co Ltd	カルバモイルトリアゾール誘導体およびそれを有効成分とする除草剤
US6525081B1 (en) *	1997-10-24	2003-02-25	Shionogi & Co., Ltd.	Antirheumatic
UA73092C2 (uk) *	1998-07-17	2005-06-15	Брістол-Майерс Сквібб Компані	Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE69924735T2 (de) *	1998-07-28	2006-01-19	Tanabe Seiyaku Co., Ltd.	Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
GB9918684D0 (en)	1999-08-09	1999-10-13	Novartis Ag	Organic compounds
SK2682002A3 (en) *	1999-09-01	2002-07-02	Aventis Pharma Gmbh	Sulfonyl carboxamide derivatives, method for their production and their use as medicaments
JP4321671B2 (ja)	1999-10-12	2009-08-26	大阪瓦斯株式会社	フレキシブルチューブ用継手
JP2002072459A (ja) *	2000-08-28	2002-03-12	Toyo Gosei Kogyo Kk	光酸発生剤及びそれを含有する感光性樹脂組成物
GB0114223D0 (en)	2001-06-12	2001-08-01	Ici Plc	Catalytic oxidation process
US20040038947A1 (en)	2002-06-14	2004-02-26	The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services	Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en)	2002-08-21	2005-08-30	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Nitroxyl progenitors in the treatment of heart failure
US7572914B2 (en) *	2003-12-19	2009-08-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
WO2005074598A2 (en)	2004-01-30	2005-08-18	Johns Hopkins University	Nitroxyl progenitor compounds and methods of use
US8168771B2 (en)	2005-01-31	2012-05-01	The Johns Hopkins University	Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
US20090298795A1 (en)	2005-06-23	2009-12-03	The Johns Hopins University	Thiol-Sensitive Positive Inotropes
PL2489350T3 (pl)	2006-03-17	2014-08-29	Cardioxyl Pharmaceuticals Inc	Pochodne N-hydroksylosulfonamidu jako nowe, fizjologicznie użyteczne donory nitroksylu
SG10201602375PA (en)	2007-09-26	2016-05-30	Univ Johns Hopkins	N-Hydroxylsulfonamide Derivatives As New Physiologically Useful Nitroxyl Donors
JP5826762B2 (ja)	2009-12-07	2015-12-02	ザジョンズホプキンスユニバーシティ	Ｎ−アシルオキシスルホンアミドおよびｎ−ヒドロキシ−ｎ−アシルスルホンアミド誘導体
IN2012DN05028A (pt)	2009-12-07	2015-10-23	Univ Johns Hopkins

2008
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2012
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2013
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Also Published As

Publication number	Publication date
EP2190814A1 (en)	2010-06-02
KR20180002889A (ko)	2018-01-08
AU2008304200B2 (en)	2013-12-19
KR101813551B1 (ko)	2018-01-02
US8227639B2 (en)	2012-07-24
NZ584036A (en)	2012-06-29
AU2008304200A1 (en)	2009-04-02
US20140194416A1 (en)	2014-07-10
JP2014114316A (ja)	2014-06-26
US20120258965A1 (en)	2012-10-11
CN104119310A (zh)	2014-10-29
RU2013111317A (ru)	2014-09-20
CA2699567A1 (en)	2009-04-02
SG10201602375PA (en)	2016-05-30
EP2190814B1 (en)	2017-02-01
JP6122163B2 (ja)	2017-04-26
KR20100092928A (ko)	2010-08-23
RU2010116253A (ru)	2011-11-10
CA2699567C (en)	2018-01-09
JP2016138101A (ja)	2016-08-04
US20090163487A1 (en)	2009-06-25
US9617208B2 (en)	2017-04-11
KR101905004B1 (ko)	2018-10-08
CN104119310B (zh)	2017-04-12
CN101874018A (zh)	2010-10-27
MX2010003232A (es)	2010-08-23
WO2009042970A1 (en)	2009-04-02
JP2011502105A (ja)	2011-01-20
SG185255A1 (en)	2012-11-29
CN101874018B (zh)	2014-05-14
JP5878942B2 (ja)	2016-03-08
KR20160047598A (ko)	2016-05-02
IL204434B (en)	2018-05-31
US8674132B2 (en)	2014-03-18
US20150336880A1 (en)	2015-11-26
US9115064B2 (en)	2015-08-25
RU2485097C2 (ru)	2013-06-20

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