BRPI0817503A2 - Derivados de purina substituídos por pirimidina - Google Patents

Derivados de purina substituídos por pirimidina

Info

Publication number: BRPI0817503A2
Authority: BR; Brazil
Prior art keywords: pyrimidine; purine derivatives; substituted purine; substituted; derivatives
Prior art date: 2007-10-05

Application number

BRPI0817503-9A

Other languages

English (en)

Inventor

Harish Kumar Mysore Nagaraj

Meredith Williams

Original Assignee

S Bio Pte Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-05

Filing date

2008-10-03

Publication date

2015-05-05

2008-10-03 Application filed by S Bio Pte Ltd filed Critical S Bio Pte Ltd

2015-05-05 Publication of BRPI0817503A2 publication Critical patent/BRPI0817503A2/pt

2019-10-29 Publication of BRPI0817503B1 publication Critical patent/BRPI0817503B1/pt

2021-05-25 Publication of BRPI0817503B8 publication Critical patent/BRPI0817503B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BRPI0817503A 2007-10-05 2008-10-03 derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa BRPI0817503B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97772007P	2007-10-05	2007-10-05
US7553208P	2008-06-25	2008-06-25
PCT/SG2008/000379 WO2009045175A1 (en)	2007-10-05	2008-10-03	Pyrimidine substituted purine derivatives

Publications (3)

Publication Number	Publication Date
BRPI0817503A2 true BRPI0817503A2 (pt)	2015-05-05
BRPI0817503B1 BRPI0817503B1 (pt)	2019-10-29
BRPI0817503B8 BRPI0817503B8 (pt)	2021-05-25

Family

ID=40030252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0817503A BRPI0817503B8 (pt)	2007-10-05	2008-10-03	derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa

Country Status (16)

Country	Link
US (3)	US8247410B2 (pt)
EP (1)	EP2209786B1 (pt)
JP (2)	JP5479346B2 (pt)
KR (3)	KR101701109B1 (pt)
CN (2)	CN104119336B (pt)
AU (1)	AU2008307798B2 (pt)
BR (1)	BRPI0817503B8 (pt)
CA (1)	CA2701581C (pt)
DK (1)	DK2209786T3 (pt)
ES (1)	ES2406129T3 (pt)
IL (2)	IL204804A (pt)
MX (1)	MX2010003668A (pt)
MY (1)	MY150993A (pt)
RU (2)	RU2681081C2 (pt)
WO (1)	WO2009045175A1 (pt)
ZA (1)	ZA201003118B (pt)

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2008
- 2008-10-03 CN CN201410185174.XA patent/CN104119336B/zh not_active Expired - Fee Related
- 2008-10-03 WO PCT/SG2008/000379 patent/WO2009045175A1/en not_active Ceased
- 2008-10-03 ES ES08836404T patent/ES2406129T3/es active Active
- 2008-10-03 KR KR1020157013280A patent/KR101701109B1/ko not_active Expired - Fee Related
- 2008-10-03 BR BRPI0817503A patent/BRPI0817503B8/pt not_active IP Right Cessation
- 2008-10-03 US US12/681,584 patent/US8247410B2/en not_active Expired - Fee Related
- 2008-10-03 KR KR1020167026687A patent/KR20160116045A/ko not_active Withdrawn
- 2008-10-03 JP JP2010527915A patent/JP5479346B2/ja not_active Expired - Fee Related
- 2008-10-03 EP EP08836404A patent/EP2209786B1/en not_active Not-in-force
- 2008-10-03 KR KR1020107009977A patent/KR101643237B1/ko not_active Expired - Fee Related
- 2008-10-03 MY MYPI20101500 patent/MY150993A/en unknown
- 2008-10-03 MX MX2010003668A patent/MX2010003668A/es active IP Right Grant
- 2008-10-03 RU RU2014110894A patent/RU2681081C2/ru not_active IP Right Cessation
- 2008-10-03 RU RU2010117737/04A patent/RU2518098C2/ru not_active IP Right Cessation
- 2008-10-03 AU AU2008307798A patent/AU2008307798B2/en not_active Ceased
- 2008-10-03 DK DK08836404.7T patent/DK2209786T3/da active
- 2008-10-03 CN CN200880119649.8A patent/CN101889015B/zh not_active Expired - Fee Related
- 2008-10-03 CA CA2701581A patent/CA2701581C/en not_active Expired - Fee Related
2010
- 2010-03-28 IL IL204804A patent/IL204804A/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03118A patent/ZA201003118B/en unknown
2012
- 2012-07-20 US US13/554,491 patent/US8609838B2/en not_active Expired - Fee Related
2013
- 2013-11-11 US US14/076,810 patent/US20140066620A1/en not_active Abandoned
- 2013-12-06 JP JP2013253369A patent/JP5885729B2/ja not_active Expired - Fee Related
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Publication number	Publication date
IL204804A (en)	2014-11-30
AU2008307798B2 (en)	2013-10-03
HK1203488A1 (en)	2015-10-30
EP2209786B1 (en)	2013-02-27
US8609838B2 (en)	2013-12-17
CN104119336B (zh)	2016-08-24
RU2518098C2 (ru)	2014-06-10
MX2010003668A (es)	2010-07-02
IL204804A0 (en)	2010-11-30
US20100298319A1 (en)	2010-11-25
RU2014110894A (ru)	2015-07-10
US8247410B2 (en)	2012-08-21
CN101889015A (zh)	2010-11-17
JP5479346B2 (ja)	2014-04-23
KR20100075609A (ko)	2010-07-02
MY150993A (en)	2014-03-31
KR20160116045A (ko)	2016-10-06
HK1145832A1 (en)	2011-05-06
WO2009045175A1 (en)	2009-04-09
JP5885729B2 (ja)	2016-03-15
CN101889015B (zh)	2014-06-04
BRPI0817503B8 (pt)	2021-05-25
KR20150063171A (ko)	2015-06-08
IL235555B (en)	2019-08-29
US20140066620A1 (en)	2014-03-06
EP2209786A1 (en)	2010-07-28
US20130079512A1 (en)	2013-03-28
KR101643237B1 (ko)	2016-07-27
CN104119336A (zh)	2014-10-29
ZA201003118B (en)	2011-08-31
CA2701581A1 (en)	2009-04-09
CA2701581C (en)	2016-12-20
IL235555A0 (en)	2014-12-31
DK2209786T3 (da)	2013-06-03
JP2010540625A (ja)	2010-12-24
JP2014139159A (ja)	2014-07-31
AU2008307798A1 (en)	2009-04-09
ES2406129T3 (es)	2013-06-05
RU2681081C2 (ru)	2019-03-04
BRPI0817503B1 (pt)	2019-10-29
RU2010117737A (ru)	2011-11-10
KR101701109B1 (ko)	2017-02-13

Publication	Publication Date	Title
BRPI0817503A2 (pt)	2015-05-05	Derivados de purina substituídos por pirimidina
BRPI0923815A2 (pt)	2015-07-14	Síntese de nucleosídeos de purina
BRPI0923195A2 (pt)	2016-02-16	compostos purina
BRPI0819797A2 (pt)	2019-09-24	compostos de nucleosídeos antivirais
BRPI0813707A2 (pt)	2014-12-30	Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
SI2801580T1 (sl)	2024-01-31	Nukleozidna fosforamidatna predzdravila
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI0907435A2 (pt)	2015-07-14	Derivados de 5-flúor pirimidina
ES2465673T9 (es)	2014-11-14	Derivados de pirimidina
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
PT3133080T (pt)	2018-11-16	Nucleósidos de 7-deazapurina citostáticos inovadores
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
BRPI0812518A2 (pt)	2015-03-31	Derivados de indazolamida
BRPI0914544A2 (pt)	2015-12-15	derivados de pirimidona substituídos
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
BRPI0914301A2 (pt)	2015-10-13	derivados de pirimidin-4-ona substituída
GB0706632D0 (en)	2007-05-16	New purine derivatives
BRPI0920496A2 (pt)	2019-09-24	derivados substituídos de pirimidina etriazina
CR10520A (es)	2009-03-19	Derivados de purina como agonistas de a2a
BRPI0821258A2 (pt)	2015-06-16	Derivados de ciclopropilamina
BRPI0811115A2 (pt)	2014-12-23	Compostos de heteroarilamida pirimidona
DE602008000135D1 (de)	2009-10-22	Hintere Fahrzeugstruktur

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