[go: up one dir, main page]

BRPI0816949B8 - Coluna cromatográfica incluindo uma unidade de vedação, e, método para sanitizar uma coluna cromatográfica - Google Patents

Coluna cromatográfica incluindo uma unidade de vedação, e, método para sanitizar uma coluna cromatográfica

Info

Publication number
BRPI0816949B8
BRPI0816949B8 BRPI0816949A BRPI0816949A BRPI0816949B8 BR PI0816949 B8 BRPI0816949 B8 BR PI0816949B8 BR PI0816949 A BRPI0816949 A BR PI0816949A BR PI0816949 A BRPI0816949 A BR PI0816949A BR PI0816949 B8 BRPI0816949 B8 BR PI0816949B8
Authority
BR
Brazil
Prior art keywords
chromatographic column
sealing unit
sanitizing
seal
sealing
Prior art date
Application number
BRPI0816949A
Other languages
English (en)
Inventor
Bielawski Jacek
Hammarstrand Erik
Agren Tomas
Original Assignee
Ge Healthcare Bio Sciences Ab
Cytiva Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences Ab, Cytiva Sweden Ab filed Critical Ge Healthcare Bio Sciences Ab
Publication of BRPI0816949A2 publication Critical patent/BRPI0816949A2/pt
Publication of BRPI0816949B1 publication Critical patent/BRPI0816949B1/pt
Publication of BRPI0816949B8 publication Critical patent/BRPI0816949B8/pt

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F16J15/3204—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip
    • F16J15/3208—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip provided with tension elements, e.g. elastic rings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/166—Sealings between relatively-moving surfaces with means to prevent the extrusion of the packing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F16J15/3204—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip
    • F16J15/3232—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip having two or more lips
    • F16J15/3236—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip having two or more lips with at least one lip for each surface, e.g. U-cup packings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/16—Sealings between relatively-moving surfaces
    • F16J15/32—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings
    • F16J15/3284—Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings characterised by their structure; Selection of materials
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16J—PISTONS; CYLINDERS; SEALINGS
    • F16J15/00—Sealings
    • F16J15/56—Other sealings for reciprocating rods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6026—Fluid seals

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sealing Devices (AREA)
  • Gasket Seals (AREA)
  • Sealing Material Composition (AREA)

Abstract

MÉTODO PARA FORMAÇÃO DE UMA VEDAÇÃO DENTRO DE UMA COLUNA CROMATOGRÁFICA, UNIDADE DE VEDAÇÃO PARA UMA COLUNA CROMATOGRÁFICA, COLUNA CROMATOGRÁFICA, E, MÉTODO PARA SANITIZAR UMA COLUNA CROMATOGRÁFICA A presente invenção refere-se a uma unidade de vedação para uso em colunas cromatográficas e métodos para formar uma vedação em tais colunas. A unidade compreende um elemento de vedação composto de um material tendo um baixo coeficiente de fricção e um membro resiliente separado cooperando com ele. A vedação provida é estável em uma faixa de temperatura de +2°Ca+30°C.
BRPI0816949A 2007-09-28 2008-09-26 Coluna cromatográfica incluindo uma unidade de vedação, e, método para sanitizar uma coluna cromatográfica BRPI0816949B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0718993.9A GB0718993D0 (en) 2007-09-28 2007-09-28 Sealing assembly for a chromatography column
GB0718993.9 2007-09-28
PCT/SE2008/000532 WO2009041877A1 (en) 2007-09-28 2008-09-26 Sealing assembly for a chromatography column

Publications (3)

Publication Number Publication Date
BRPI0816949A2 BRPI0816949A2 (pt) 2015-03-24
BRPI0816949B1 BRPI0816949B1 (pt) 2020-03-31
BRPI0816949B8 true BRPI0816949B8 (pt) 2022-07-05

Family

ID=38701861

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816949A BRPI0816949B8 (pt) 2007-09-28 2008-09-26 Coluna cromatográfica incluindo uma unidade de vedação, e, método para sanitizar uma coluna cromatográfica

Country Status (9)

Country Link
US (1) US8287737B2 (pt)
EP (1) EP2193295B1 (pt)
JP (1) JP5450422B2 (pt)
KR (1) KR101497743B1 (pt)
CN (1) CN101809342B (pt)
BR (1) BRPI0816949B8 (pt)
CA (1) CA2695699C (pt)
GB (1) GB0718993D0 (pt)
WO (1) WO2009041877A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1872839A1 (en) * 2006-06-30 2008-01-02 NV Bekaert SA A filter candle comprising an elongated mesh pack
US8465654B2 (en) * 2008-03-07 2013-06-18 Bekaert Advanced Filtration Sa Filter candle and mesh pack with a deformable seal, and method of filtering molten or dissolved polymers
SE534486C2 (sv) * 2010-03-12 2011-09-06 Ge Healthcare Bio Sciences Ab Fixtur för kromatografikolonner
US9457329B2 (en) * 2010-05-31 2016-10-04 Ge Healthcare Bio-Sciences Ab Adjustable volume mixer chamber and method of use
GB2485837A (en) 2010-11-29 2012-05-30 Ge Healthcare Bio Sciences Ab Securing a distributor plate of a chromatography column by generating a vacuum
GB2485838A (en) * 2010-11-29 2012-05-30 Ge Healthcare Bio Sciences Ab Chromatography column
AU2012212396B2 (en) * 2011-02-02 2016-11-03 Technofast Industries Pty Ltd High-pressure sealing ring
JP6159347B2 (ja) * 2012-02-22 2017-07-05 バイオ−ラッド ラボラトリーズ インコーポレーティッド 分取クロマトグラフィーカラム
GB2502329B (en) * 2012-05-24 2016-01-27 Agilent Technologies Inc Pressurizable injection seat
IN2014DN10304A (pt) 2012-06-21 2015-08-07 Ge Healthcare Bio Sciences Ab
JP6189078B2 (ja) * 2013-04-24 2017-08-30 三菱電線工業株式会社 シール材
US9357684B2 (en) 2013-09-24 2016-05-31 Bal Seal Engineering, Inc. Spring assemblies with spring energized seal members and related methods
KR102164128B1 (ko) * 2014-02-04 2020-10-12 가부시키가이샤 와이엠씨 가동 마개식 칼럼 및 그 사용방법
EP3325857A4 (en) * 2015-07-24 2019-06-12 Saint-Gobain Performance Plastics Corporation scraper
US10012313B2 (en) * 2015-09-30 2018-07-03 Deere & Company Asymmetrical energized seal arrangement
KR101759123B1 (ko) 2016-04-20 2017-07-19 주식회사빔스바이오 크로마토그래피 컬럼
US10690563B2 (en) * 2017-01-17 2020-06-23 Waters Technologies Corporation Systems, methods, and devices for detecting leaks in a chromatography system
CN107389525A (zh) * 2017-07-24 2017-11-24 绍兴文理学院 一种伺服控制的岩石裂隙剪切渗流试验密封装置
JP7054638B2 (ja) * 2018-03-16 2022-04-14 東京エレクトロン株式会社 シール構造およびシール方法
CN109781890B (zh) * 2019-02-14 2021-08-24 李素媛 一种茶叶单糖成分检测用液相色谱检测装置及其使用方法
GB201904125D0 (en) * 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP7400704B2 (ja) * 2020-11-26 2023-12-19 株式会社島津製作所 クロマトグラフ用接続アセンブリ
US11731062B2 (en) 2021-01-20 2023-08-22 Asahi Kasei Bioprocess America, Inc. Components that facilitate maintenance of chromatography and synthesis columns
DE102021102315A1 (de) * 2021-02-02 2022-08-04 Albert Handtmann Armaturenfabrik Gmbh & Co. Kg Radialflusssäule zum Durchleiten eines flüssigen Produkts durch ein Adsorbermaterial
ES2987289T3 (es) * 2021-09-08 2024-11-14 Robatech Ag Dispositivo de junta con una junta de varilla, dispositivo de distribución para la distribución de un medio fluido, así como junta de varilla
JP2024165833A (ja) * 2023-05-18 2024-11-28 三井・ケマーズ フロロプロダクツ株式会社 ゴム製シール部材用塗料組成物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2825590A (en) 1953-10-14 1958-03-04 Taylor Emmett Controls Inc Packing seal construction
US2814540A (en) * 1956-07-16 1957-11-26 Blackhawk Mfg Co Piston packing
CH410556A (de) 1964-03-16 1966-03-31 Contraves Ag Reibungsarme Kolbendichtung
DE2334023A1 (de) 1973-07-04 1975-01-30 Freudenberg Carl Fa Drehvakuumdichtring
US4861473A (en) 1984-02-29 1989-08-29 Rainin Instrument Co., Inc. Apparatus for facilitating compression of packing material in a liquid chromatography column
GB2177464B (en) * 1985-06-29 1988-06-02 Dowty Seals Ltd Sealing assembly
DE3729002A1 (de) * 1987-08-31 1989-04-20 Merck Patent Gmbh Chromatographiesaeulen-kartuschensystem
US4891133A (en) * 1987-09-15 1990-01-02 Cerex Corporation Chromatography apparatus
US4889351A (en) * 1988-05-12 1989-12-26 Frost Stanley A Hydraulic seal
US5169522A (en) * 1990-09-25 1992-12-08 Ht Chemicals, Inc. Column slurry packing compressor
SE468036B (sv) * 1991-05-08 1992-10-26 Peter Baeckstroem Kolonn foer separation av substansblandningar med ett vaetskemedium
JPH0512847U (ja) * 1991-07-31 1993-02-19 イーグル工業株式会社 フローテイングシール
CN2117508U (zh) * 1992-03-17 1992-09-30 车恒德 直角滑环式组合密封
JP2585992Y2 (ja) * 1992-04-17 1998-11-25 東洋電装株式会社 ダイヤフラム式スイッチ
CN2179492Y (zh) * 1992-09-24 1994-10-12 余毅钦 超高压往复杆复合动密封
US5423982A (en) * 1994-05-31 1995-06-13 Biosepra Inc. Liquid chromatography column adapted for in situ chemical sterilization
CN2195660Y (zh) * 1994-06-09 1995-04-26 车恒德 齿形滑环式组合密封
US5671928A (en) * 1995-12-29 1997-09-30 Millipore Investment Holdings Limited Seal for chromatography column having ridges
US6436284B1 (en) * 1997-11-12 2002-08-20 Biotage, Inc. Chromatography apparatus
US6932904B2 (en) * 2002-04-02 2005-08-23 Alltech Associates Inc. Chromatographic device and method of forming a chromatographic device
GB0230265D0 (en) * 2002-12-30 2003-02-05 Amersham Biosciences Ab Piston and scraper assembly
CN2641387Y (zh) 2003-09-19 2004-09-15 徐州车氏密封有限公司 L形滑环式组合密封
US7341258B2 (en) * 2004-09-24 2008-03-11 Greene, Tweed Of Delaware, Inc. Cammed seal assembly with sealing ring having an angled leg portion and foot portion with elastomeric energizer element

Also Published As

Publication number Publication date
CA2695699A1 (en) 2009-04-02
EP2193295B1 (en) 2019-08-14
JP5450422B2 (ja) 2014-03-26
EP2193295A4 (en) 2016-11-16
BRPI0816949B1 (pt) 2020-03-31
WO2009041877A1 (en) 2009-04-02
KR101497743B1 (ko) 2015-03-03
BRPI0816949A2 (pt) 2015-03-24
KR20100069657A (ko) 2010-06-24
US8287737B2 (en) 2012-10-16
EP2193295A1 (en) 2010-06-09
CA2695699C (en) 2016-03-29
GB0718993D0 (en) 2007-11-07
US20100230340A1 (en) 2010-09-16
JP2010540926A (ja) 2010-12-24
CN101809342A (zh) 2010-08-18
CN101809342B (zh) 2013-02-13

Similar Documents

Publication Publication Date Title
BRPI0816949B8 (pt) Coluna cromatográfica incluindo uma unidade de vedação, e, método para sanitizar uma coluna cromatográfica
BRPI0818672B8 (pt) composições, composições farmacêuticas e usos de 2'flúor-2'-desoxitetra-hidrouridinas
CL2008000873A1 (es) Compuestos derivados de pirrolidin amidas; composicion farmaceutica que comprende dichos compuestos; y su uso para tratar trombosis.
ECSP077316A (es) Compuestos imidazo-3-il-amina bicíclicos sustituidos
CL2008000197A1 (es) Compuestos derivados de 2,4-diamino pirimidina, inhibidores de antranilamida de cinasa aurora; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer.
CL2008002295A1 (es) Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
BRPI0815079A2 (pt) Composto dericado de 1,2-diamido-etileno, composição farmacêutica que contém e uso desse composto
GT201000047A (es) Mejoras en compuestos organicos o relacionadas con los mismos
CL2008003910A1 (es) Formulacion liquida, estable, conteniendo anticuerpo que comprende arginina y metionina; procedimiento para inhibir la deamidacion de moleculas de un anticuerpo que comprende agregar arginina a la formulacion liquida.
CL2008000825A1 (es) Compuestos heterociclicos derivados de quinolincarboxamidas utiles como antagonistas de p2x7; su metodo de preparacion; la composicion farmaceutica que lo contiene; el emtodo de preparacion de la composicion; y el uso de los mismos para preparar medicamentos utiles en artritis reumatoide.
CL2008000703A1 (es) Compuestos derivados de pirimidinas sustituidas; procedimiento para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar transtornos hematologicos.
CL2009000142A1 (es) Composicion liquida monocomponente con un contenido de fluor con respecto a la resina solida de 5 a 75% en peso para el tratamiento permanente de superficies de sustratos porosos y no porosos; procedimiento para la obtencion de composiciones que contienen fluor; y uso de dichas composiciones.
NZ710855A (en) Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto
CO6362020A2 (es) Mutantes fgf21 y uso de los mismos
AR066042A1 (es) Moleculas y metodos para modular la proteina convertasa-subtilisina /quexina tipo 9 (pcsk9)
CL2007003802A1 (es) Compuestos derivados de piperidina, inhibidores de la sintasa de acidos grasos; procedimiento de preparacion de dichos compuestos; y su uso para tratar la obesidad o el sobrepeso.
CL2008001951A1 (es) Compuestos derivados de imidazo[1,2-a]pirimidin-2-ilmetil sustituidos; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el trastorno del sueno, depresion, ansiedad, trastorno relacionado con el abuso de sustancias, entre otras.
CL2012001627A1 (es) Compuestos derivados de 1,3-tiazol-fenilaminopirimidinas, inhibidores de syk; composición farmacéutica; y su uso para el tratamiento de la artritis reumatoide y cancer.
CL2011000527A1 (es) Compuestos derivados de benzofurano; composicion farmaceutica que los comprende;y su uso en el tratamiento de la hepatitis c.
CL2007002617A1 (es) Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
CL2007003201A1 (es) Composicion farmaceutica liquida que comprende un derivado de ciclodextrina eterificada y un bencimidazol sustituido, donde el derivado de ciclodextrina se selecciona de eter de alfa, beta y gama-ciclodextrina; y uso para el tratamiento de insuficien
BRPI0818804A2 (pt) Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
CL2015003357A1 (es) Derivados de nucleósidos 4'-fluoro-2'-metil sustituidos
CL2008003712A1 (es) Compuestos derivados de tiadiazololoxifenilamidina o tiazoliloxifenilamidina; su procedimiento de preparacion; uso y procedimiento para combatir microorganismos no deseados; agente que comprende a dichos compuestos; compuestos intermediarios; y su procedimiento de preparacion.
CL2011000846A1 (es) Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/03/2020, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: CYTIVA SWEDEN AB (SE)