BRPI0816807A2 - bortezomib e processo para a produção do mesmo - Google Patents
bortezomib e processo para a produção do mesmoInfo
- Publication number
- BRPI0816807A2 BRPI0816807A2 BRPI0816807A BRPI0816807A BRPI0816807A2 BR PI0816807 A2 BRPI0816807 A2 BR PI0816807A2 BR PI0816807 A BRPI0816807 A BR PI0816807A BR PI0816807 A BRPI0816807 A BR PI0816807A BR PI0816807 A2 BRPI0816807 A2 BR PI0816807A2
- Authority
- BR
- Brazil
- Prior art keywords
- bortezomib
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Light Receiving Elements (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2053CH2007 | 2007-09-12 | ||
| US5931808P | 2008-06-06 | 2008-06-06 | |
| IN1784CH2008 | 2008-07-24 | ||
| PCT/US2008/076178 WO2009036281A2 (en) | 2007-09-12 | 2008-09-12 | Bortezomib and process for producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816807A2 true BRPI0816807A2 (pt) | 2017-05-16 |
Family
ID=40452840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816807A BRPI0816807A2 (pt) | 2007-09-12 | 2008-09-12 | bortezomib e processo para a produção do mesmo |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100226597A1 (pt) |
| EP (1) | EP2185159A4 (pt) |
| JP (1) | JP2010539183A (pt) |
| KR (1) | KR20100051828A (pt) |
| AU (1) | AU2008298694A1 (pt) |
| BR (1) | BRPI0816807A2 (pt) |
| MX (1) | MX2010002836A (pt) |
| WO (1) | WO2009036281A2 (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2270019A1 (en) | 2009-06-19 | 2011-01-05 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters |
| EP2280016A1 (en) | 2009-07-27 | 2011-02-02 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters via substituted alk-1-ynes |
| WO2010146176A2 (en) | 2009-06-19 | 2010-12-23 | Lek Pharmaceuticals D.D. | Process for hydrogenation of halogenoalkenes without dehalogenation |
| AU2011214024A1 (en) | 2010-02-09 | 2012-08-30 | Ranbaxy Laboratories Limited | Process for the preparation of bortezomib |
| WO2011099018A1 (en) * | 2010-02-15 | 2011-08-18 | Hetero Research Foundation | Polymorphs of bortezomib |
| WO2011107912A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Polymorphic forms of bortezomib |
| EP2547333B1 (en) * | 2010-03-18 | 2017-08-23 | Innopharma, Inc. | Stable bortezomib formulations |
| US8263578B2 (en) | 2010-03-18 | 2012-09-11 | Innopharma, Inc. | Stable bortezomib formulations |
| EP2627636B1 (en) | 2010-10-14 | 2015-09-02 | Synthon BV | Process for making bortezomib and the intermediates for the process |
| WO2012131707A2 (en) * | 2011-03-28 | 2012-10-04 | Laurus Labs Private Limited | Novel crystalline form of bortezomib, process for the preparation and pharmaceutical composition thereof |
| CN102212036B (zh) * | 2011-04-08 | 2012-10-17 | 苏州二叶制药有限公司 | N-（吡嗪-2-基羰基）-l-苯丙氨酸的制备方法 |
| CN102206188B (zh) * | 2011-04-08 | 2013-02-27 | 苏州二叶制药有限公司 | N-(吡嗪-2-基羰基)-l-苯丙氨酸的制备方法 |
| US8497374B2 (en) | 2011-05-12 | 2013-07-30 | Scinopharm Taiwan, Ltd. | Process for preparing and purifying bortezomib |
| CN103030656B (zh) * | 2011-09-30 | 2015-08-26 | 北京大学 | 蛋白酶体抑制剂硼替佐米及其类似物的合成方法 |
| US9505787B2 (en) | 2012-09-11 | 2016-11-29 | Cipla Limited | Process for preparing of bortezomib |
| AU2013346322B2 (en) * | 2012-11-16 | 2016-11-10 | Shilpa Medicare Limited | Crystalline Bortezomib process |
| CN103044468B (zh) * | 2012-11-28 | 2015-05-13 | 深圳万乐药业有限公司 | N-(2-吡嗪羰基)-l-苯丙氨酸-l-亮氨酸硼酸的制备方法 |
| CN103012551B (zh) * | 2012-12-14 | 2014-11-12 | 江苏奥赛康药业股份有限公司 | 一种高纯度硼替佐米的合成方法及其中间体 |
| WO2014097306A1 (en) | 2012-12-21 | 2014-06-26 | Natco Pharma Limited | Stable and pure polymorphic form of bortezomib |
| WO2014102755A1 (en) * | 2012-12-31 | 2014-07-03 | Shilpa Medicare Limited | Bortezomib formulations |
| CN103059054A (zh) * | 2013-01-08 | 2013-04-24 | 杭州平和安康医药科技有限公司 | 硼替佐米合成方法 |
| CN103965231B (zh) * | 2013-01-31 | 2016-06-08 | 江苏奥赛康药业股份有限公司 | 用于检测硼替佐米中间体纯度的酰胺硼酸酯、制备方法及其应用 |
| IN2013MU01431A (pt) | 2013-04-16 | 2015-06-26 | Cipla Ltd | |
| CN103344733B (zh) * | 2013-07-08 | 2014-10-15 | 江苏奥赛康药业股份有限公司 | 一种硼替佐米对映异构体的高效液相色谱分离检测方法 |
| CN103408636B (zh) * | 2013-08-23 | 2015-02-04 | 南京正大天晴制药有限公司 | 一种26s蛋白酶体抑制剂的合成方法 |
| CN103604894A (zh) * | 2013-11-07 | 2014-02-26 | 深圳万乐药业有限公司 | 高效液相色谱法分离测定硼替佐米手性异构体的方法 |
| KR101691353B1 (ko) * | 2013-12-09 | 2016-12-30 | 주식회사 경보제약 | 보르테조밉의 제조방법 및 그의 신규 중간체 |
| WO2015122702A1 (en) * | 2014-02-14 | 2015-08-20 | Kyongbo Pharm. Co., Ltd. | Novel crystalline form of bortezomib and preparation method thereof |
| KR102303092B1 (ko) * | 2014-06-26 | 2021-09-15 | 마루이시세이야쿠가부시키가이샤 | 합성 펜타펩티드의 제조법 |
| CZ306322B6 (cs) | 2014-12-17 | 2016-11-30 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující |
| AU2018221670B2 (en) | 2017-02-17 | 2021-02-04 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of boronic acid esters |
| CN107827916B (zh) * | 2017-11-07 | 2020-02-07 | 宜昌人福药业有限责任公司 | 一种(r)-(1-氨基-3-甲基)丁基-1-硼酸蒎烷二醇酯的合成方法 |
| WO2019151133A1 (ja) * | 2018-02-01 | 2019-08-08 | 日本化薬株式会社 | ボルテゾミブ結晶の製造方法 |
| US10934315B2 (en) * | 2018-11-01 | 2021-03-02 | Pharmacore Biotech Co., Ltd. | Process for preparing bortezomib, intermediates, and crystalline forms thereof |
| US11964993B2 (en) | 2021-07-03 | 2024-04-23 | Shilpa Pharma Lifesciences Limited | Crystalline bortezomib process |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4525309A (en) * | 1983-03-15 | 1985-06-25 | Washington State University Research Foundation, Inc. | Lewis acid catalysis of the homologation of boronic esters with haloalkylmetal reagents |
| JPS6248656A (ja) * | 1985-08-28 | 1987-03-03 | Showa Denko Kk | Ｎ−フマリル−ｌ−フエニルアラニンメチルエステル及びその製法 |
| JP2973271B2 (ja) * | 1994-01-18 | 1999-11-08 | 参天製薬株式会社 | エンドペプチダーゼ２４．１５阻害剤 |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5698250A (en) * | 1996-04-03 | 1997-12-16 | Tenneco Packaging Inc. | Modifield atmosphere package for cut of raw meat |
| EP2251344B2 (en) * | 2001-01-25 | 2024-04-24 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Formulation of boronic acid compounds |
| US7223745B2 (en) * | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| WO2005097809A2 (en) * | 2004-03-30 | 2005-10-20 | Millennium Pharmaceuticals, Inc. | Synthesis of boronic ester and acid compounds |
| JP5108509B2 (ja) * | 2004-05-10 | 2012-12-26 | プロテオリックス， インコーポレイテッド | 酵素阻害のための化合物 |
| WO2008075376A1 (en) * | 2006-12-18 | 2008-06-26 | Natco Pharma Limited | Polymorphic forms of bortezomib and process for their preparation |
| WO2009004350A1 (en) * | 2007-07-03 | 2009-01-08 | Pliva Hrvatska D.O.O. | Methods for preparing bortezomib and intermediates used in its manufacture |
-
2008
- 2008-09-12 WO PCT/US2008/076178 patent/WO2009036281A2/en not_active Ceased
- 2008-09-12 KR KR1020107004208A patent/KR20100051828A/ko not_active Withdrawn
- 2008-09-12 US US12/677,872 patent/US20100226597A1/en not_active Abandoned
- 2008-09-12 MX MX2010002836A patent/MX2010002836A/es not_active Application Discontinuation
- 2008-09-12 AU AU2008298694A patent/AU2008298694A1/en not_active Abandoned
- 2008-09-12 JP JP2010525028A patent/JP2010539183A/ja active Pending
- 2008-09-12 EP EP08830326A patent/EP2185159A4/en not_active Withdrawn
- 2008-09-12 BR BRPI0816807A patent/BRPI0816807A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008298694A1 (en) | 2009-03-19 |
| WO2009036281A2 (en) | 2009-03-19 |
| KR20100051828A (ko) | 2010-05-18 |
| US20100226597A1 (en) | 2010-09-09 |
| EP2185159A4 (en) | 2012-02-08 |
| EP2185159A2 (en) | 2010-05-19 |
| WO2009036281A3 (en) | 2009-05-14 |
| MX2010002836A (es) | 2010-03-31 |
| JP2010539183A (ja) | 2010-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |