BRPI0816154A2 - Moduladores canabinóides de 5-vinilfenil-1-fenil-pirazol substituídos - Google Patents

Moduladores canabinóides de 5-vinilfenil-1-fenil-pirazol substituídos

Info

Publication number: BRPI0816154A2
Authority: BR; Brazil
Prior art keywords: vinylphenyl; phenyl; replaced; cannabinoid modulators; pyrazole cannabinoid
Prior art date: 2007-08-13

Application number

BRPI0816154-2A2A

Other languages

English (en)

Inventor

Mingde Xia

Meng Pan

Michael P Wachter

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-13

Filing date

2008-08-12

Publication date

2015-02-18

2008-08-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2015-02-18 Publication of BRPI0816154A2 publication Critical patent/BRPI0816154A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
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- A61P25/34—Tobacco-abuse
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- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)

BRPI0816154-2A2A 2007-08-13 2008-08-12 Moduladores canabinóides de 5-vinilfenil-1-fenil-pirazol substituídos BRPI0816154A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95541107P	2007-08-13	2007-08-13
PCT/US2008/072846 WO2009023653A2 (en)	2007-08-13	2008-08-12	Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators

Publications (1)

Publication Number	Publication Date
BRPI0816154A2 true BRPI0816154A2 (pt)	2015-02-18

Family

ID=40351436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0816154-2A2A BRPI0816154A2 (pt)	2007-08-13	2008-08-12	Moduladores canabinóides de 5-vinilfenil-1-fenil-pirazol substituídos

Country Status (12)

Country	Link
US (2)	US7943653B2 (pt)
EP (1)	EP2192900A4 (pt)
JP (1)	JP2011504167A (pt)
KR (1)	KR20100052532A (pt)
CN (1)	CN101969945A (pt)
AU (1)	AU2008286976A1 (pt)
BR (1)	BRPI0816154A2 (pt)
CA (1)	CA2696006A1 (pt)
MX (1)	MX2010001714A (pt)
NZ (1)	NZ583389A (pt)
RU (1)	RU2010109369A (pt)
WO (1)	WO2009023653A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7943653B2 (en) *	2007-08-13	2011-05-17	Janssen Pharmaceutica N.V.	Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
US8227461B2 (en) *	2009-04-30	2012-07-24	Hoffmann-La Roche Inc.	Isoxazoles
JP5460858B2 (ja) *	2009-05-05	2014-04-02	エフ．ホフマン−ラロシュアーゲー	イソオキサゾール−ピラゾール誘導体
US8859606B2 (en)	2010-07-01	2014-10-14	Allergan, Inc.	Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
US8652527B1 (en)	2013-03-13	2014-02-18	Upsher-Smith Laboratories, Inc	Extended-release topiramate capsules
US9101545B2 (en)	2013-03-15	2015-08-11	Upsher-Smith Laboratories, Inc.	Extended-release topiramate capsules
BR102017010169A2 (pt) *	2017-05-15	2019-02-26	Remer Consultores Assessoria Empresarial Ltda.	composto, intermediário de síntese, uso na preparação de anticonvulsivante, composição farmacêutica anticonvulsivante
WO2020123855A1 (en)	2018-12-12	2020-06-18	University Of Washington	Inhibitor compounds for male contraception

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2948718A (en) *		1960-08-09		New n-heterocyclic compounds
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPS5625169A (en) *	1979-06-01	1981-03-10	Wellcome Found	Triazine derivative
LU83729A1 (fr) *	1981-11-04	1983-09-01	Galephar	Sels d'acide valproique,leur preparation et leur utilisation
US4513006A (en) *	1983-09-26	1985-04-23	Mcneil Lab., Inc.	Anticonvulsant sulfamate derivatives
EP0330678B1 (en) *	1987-01-05	1990-10-24	E.I. Du Pont De Nemours And Company	Insecticidal pyrazolines
FR2665898B1 (fr) *	1990-08-20	1994-03-11	Sanofi	Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5242942A (en) *	1992-04-28	1993-09-07	Mcneilab, Inc.	Anticonvulsant fructopyranose cyclic sulfites and sulfates
US5384327A (en) *	1992-12-22	1995-01-24	Mcneilab, Inc.	Anticonvulsant sorbopyranose sulfamates
AU2096895A (en) *	1994-03-07	1995-09-25	Sugen, Incorporated	Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US6331555B1 (en) *	1995-06-01	2001-12-18	University Of California	Treatment of platelet derived growth factor related disorders such as cancers
EP1223929B1 (en) *	1999-10-18	2006-08-23	The University Of Connecticut	Cannabimimetic indole derivatives
US6900236B1 (en) *	1999-10-18	2005-05-31	University Of Connecticut	Cannabimimetic indole derivatives
US7452997B2 (en) *	2004-03-24	2008-11-18	Janssen Pharmaceutica, N.V.	Tetrahydro-indazole cannabinoid modulators
EP1937646A1 (en) *	2005-09-23	2008-07-02	Janssen Pharmaceutica N.V.	Tetrahydro-cyclopentyl pyrazole cannabinoid modulators
WO2007038045A1 (en) *	2005-09-23	2007-04-05	Janssen Pharmaceutica, N.V.	Tetrahydro-indazolyl cannabinoid modulators
US20070117858A1 (en) *	2005-11-23	2007-05-24	Mingde Xia	Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
US7943653B2 (en) *	2007-08-13	2011-05-17	Janssen Pharmaceutica N.V.	Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators

2008
- 2008-08-11 US US12/189,230 patent/US7943653B2/en not_active Expired - Fee Related
- 2008-08-12 BR BRPI0816154-2A2A patent/BRPI0816154A2/pt not_active IP Right Cessation
- 2008-08-12 NZ NZ583389A patent/NZ583389A/en not_active IP Right Cessation
- 2008-08-12 MX MX2010001714A patent/MX2010001714A/es active IP Right Grant
- 2008-08-12 JP JP2010521114A patent/JP2011504167A/ja active Pending
- 2008-08-12 AU AU2008286976A patent/AU2008286976A1/en not_active Abandoned
- 2008-08-12 WO PCT/US2008/072846 patent/WO2009023653A2/en not_active Ceased
- 2008-08-12 CN CN2008801056806A patent/CN101969945A/zh active Pending
- 2008-08-12 EP EP08797659.3A patent/EP2192900A4/en not_active Withdrawn
- 2008-08-12 RU RU2010109369/04A patent/RU2010109369A/ru not_active Application Discontinuation
- 2008-08-12 KR KR1020107005405A patent/KR20100052532A/ko not_active Withdrawn
- 2008-08-12 CA CA2696006A patent/CA2696006A1/en not_active Abandoned
2011
- 2011-04-04 US US13/079,114 patent/US20110178148A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MX2010001714A (es)	2010-03-10
RU2010109369A (ru)	2011-09-20
KR20100052532A (ko)	2010-05-19
US7943653B2 (en)	2011-05-17
US20110178148A1 (en)	2011-07-21
AU2008286976A1 (en)	2009-02-19
CN101969945A (zh)	2011-02-09
WO2009023653A3 (en)	2012-06-21
WO2009023653A2 (en)	2009-02-19
EP2192900A4 (en)	2013-04-10
NZ583389A (en)	2012-07-27
CA2696006A1 (en)	2009-02-19
US20090048235A1 (en)	2009-02-19
EP2192900A2 (en)	2010-06-09
JP2011504167A (ja)	2011-02-03

Publication	Publication Date	Title
BRPI0813653A2 (pt)	2014-12-30	Compostos de imidazotiazol moduladores de sirtuína
BRPI0813651A2 (pt)	2014-12-30	Compostos de tiazolopiridina moduladores de sirtuína
BR112012008159A2 (pt)	2016-03-01	moduladores de receptor canabinoide
BRPI0818380A2 (pt)	2014-10-07	Combinação de herbicida-protetor
EP2170350A4 (en)	2011-09-28	SUBSTITUTED IMIDAZOHETEROCYCLES
ATE542825T1 (de)	2012-02-15	Substituierte piperidino-dihydrothienopyrimidine
FI20075862A0 (fi)	2007-11-30	Jauhin
ATE501136T1 (de)	2011-03-15	Imidazopyridinone
BRPI0819093A2 (pt)	2017-05-02	compostos moduladores de sirtuína
ATE514696T1 (de)	2011-07-15	Diphenyl-dihydro-imidazopyridinone
BRPI0813230A2 (pt)	2014-12-23	Moduladores de calicreína 7
BRPI0811939A2 (pt)	2014-11-25	Tiazóis substituídos por heteroarila
BRPI0811451A2 (pt)	2014-11-04	Exopolissacarídeo
CU23870B1 (es)	2013-03-27	Derivados de ciclopropilamida como moduladores h3
EP1841794A4 (en)	2008-10-29	MODULATORS ADAM-9
AT505058A3 (de)	2008-12-15	Türschliesssystem
BRPI0822061A2 (pt)	2015-06-23	Moduladores do receptor canabinoide
BRPI0816154A2 (pt)	2015-02-18	Moduladores canabinóides de 5-vinilfenil-1-fenil-pirazol substituídos
BRPI0810195A2 (pt)	2014-12-30	Moduladores de gpbar1
EP2198082A4 (en)	2013-10-23	REFINER
ATE475602T1 (de)	2010-08-15	AUSGIEßER
DK2147106T3 (da)	2013-09-08	Expressionssystem
BRPI0819359A2 (pt)	2015-04-22	Unidade de embalagem
IL200957A0 (en)	2010-05-17	Hexahydro-cycloheptapyrazole cannabinoid modulators
EP1915162A4 (en)	2009-08-26	Modulators

Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application fees: application dismissed [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A E 7A ANUIDADES.
2016-03-29	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.