BRPI0815673A2 - Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace. - Google Patents

Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace.

Info

Publication number: BRPI0815673A2
Authority: BR; Brazil
Prior art keywords: aminobenzile; sulphones; cycle; replaced; useful
Prior art date: 2007-08-23

Application number

BRPI0815673-5A2A

Other languages

English (en)

Inventor

Emmanuelle Briard

Rainer Martin Lueoend

Rainer Machauer

Henrik Moebitz

Olivier Rogel

Jean-Michel Rondeau

Heinrich Rueeger

Marina Tintelnot-Blomley

Siem Jacob Veenstra

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-23

Filing date

2008-08-22

Publication date

2015-02-18

2008-08-22 Application filed by Novartis Ag filed Critical Novartis Ag

2015-02-18 Publication of BRPI0815673A2 publication Critical patent/BRPI0815673A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0815673-5A2A 2007-08-23 2008-08-22 Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace. BRPI0815673A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07114881		2007-08-23
EP08160123		2008-07-10
PCT/EP2008/061030 WO2009024615A1 (en)	2007-08-23	2008-08-22	Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0815673A2 true BRPI0815673A2 (pt)	2015-02-18

Family

ID=39789883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0815673-5A2A BRPI0815673A2 (pt)	2007-08-23	2008-08-22	Sulfonas cíclicas substituídas por aminobenzila úteis como inibidores de bace.

Country Status (15)

Country	Link
US (1)	US20090054427A1 (pt)
EP (1)	EP2190833A1 (pt)
JP (1)	JP2010536831A (pt)
KR (1)	KR20100061805A (pt)
CN (1)	CN101835771A (pt)
AR (1)	AR068062A1 (pt)
AU (1)	AU2008290561A1 (pt)
BR (1)	BRPI0815673A2 (pt)
CA (1)	CA2697254A1 (pt)
CL (1)	CL2008002480A1 (pt)
EA (1)	EA201000340A1 (pt)
MX (1)	MX2010002007A (pt)
PE (1)	PE20090953A1 (pt)
TW (1)	TW200916097A (pt)
WO (1)	WO2009024615A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2011527311A (ja) *	2008-07-10	2011-10-27	ノバルティスアーゲー	Ｂａｃｅ阻害薬として有用なアミノベンジル置換環状スルホン誘導体
US9066948B2 (en)	2010-07-16	2015-06-30	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Oxadiazolo[3,2-a]pyrimidines and thiadiazolo[3,2-a]pyrimidines
US9242943B2 (en) *	2011-01-18	2016-01-26	Siena Biotech S.P.A.	1,4 oxazines as BACE1 and/or BACE2 inhibitors
EP2804610B1 (en)	2012-01-16	2018-10-31	The Rockefeller University	Organic compounds
US10202355B2 (en)	2013-02-12	2019-02-12	Buck Institute For Research On Aging	Hydantoins that modulate bace-mediated app processing
CN106674264A (zh) *	2016-12-20	2017-05-17	苏州汉德创宏生化科技有限公司	(2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法
EP3810134A4 (en)	2018-06-19	2022-03-30	Celecor Therapeutics, Inc.	DEUTERED RUC-4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0888325B1 (en) *	1996-02-07	2002-05-29	Warner-Lambert Company	Novel cyclic amino acids as pharmaceutical agents
AU759392B2 (en) *	1997-12-16	2003-04-10	Warner-Lambert Company	4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
GB0602951D0 (en) *	2006-02-14	2006-03-29	Novartis Ag	Organic Compounds

2008
- 2008-08-22 MX MX2010002007A patent/MX2010002007A/es not_active Application Discontinuation
- 2008-08-22 US US12/196,461 patent/US20090054427A1/en not_active Abandoned
- 2008-08-22 CA CA2697254A patent/CA2697254A1/en not_active Abandoned
- 2008-08-22 JP JP2010521442A patent/JP2010536831A/ja active Pending
- 2008-08-22 WO PCT/EP2008/061030 patent/WO2009024615A1/en not_active Ceased
- 2008-08-22 AU AU2008290561A patent/AU2008290561A1/en not_active Abandoned
- 2008-08-22 KR KR1020107006213A patent/KR20100061805A/ko not_active Withdrawn
- 2008-08-22 EP EP08787429A patent/EP2190833A1/en not_active Withdrawn
- 2008-08-22 EA EA201000340A patent/EA201000340A1/ru unknown
- 2008-08-22 BR BRPI0815673-5A2A patent/BRPI0815673A2/pt not_active Application Discontinuation
- 2008-08-22 CL CL2008002480A patent/CL2008002480A1/es unknown
- 2008-08-22 CN CN200880112386A patent/CN101835771A/zh active Pending
- 2008-08-25 AR ARP080103691A patent/AR068062A1/es unknown
- 2008-08-25 TW TW097132452A patent/TW200916097A/zh unknown
- 2008-08-25 PE PE2008001440A patent/PE20090953A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20090054427A1 (en)	2009-02-26
EA201000340A1 (ru)	2010-08-30
AU2008290561A1 (en)	2009-02-26
WO2009024615A1 (en)	2009-02-26
CN101835771A (zh)	2010-09-15
KR20100061805A (ko)	2010-06-09
CA2697254A1 (en)	2009-02-26
AR068062A1 (es)	2009-11-04
CL2008002480A1 (es)	2009-05-15
PE20090953A1 (es)	2009-08-10
JP2010536831A (ja)	2010-12-02
EP2190833A1 (en)	2010-06-02
TW200916097A (en)	2009-04-16
MX2010002007A (es)	2010-03-10

Publication	Publication Date	Title
NO2021006I1 (no)	2021-02-15	Quofenix, delafloksacin
BRPI1009415A2 (pt)	2016-03-01	escova de dentes.
BRPI1010301A2 (pt)	2016-03-15	composição.
BRPI1008939A2 (pt)	2016-03-15	2-mercaptoquinolina-3-carboxamidas substituídas como moduladores de kncq2/3.
BRPI1013614A2 (pt)	2019-09-24	compostos substituídos de espiro-amida
BRPI0906625A2 (pt)	2015-07-14	Derivados de tio-2-amino-quinolina-6-substituída úteis como inibidores da beta-secretase (bace)
UY3955Q (es)	2010-12-31	Carrocería
BRPI1007047A2 (pt)	2015-08-18	Biorrefino irganosolv de cana-de-açúcar inteira.
BRPI0811044A2 (pt)	2014-12-09	2-morfolin-4-il-pirimidinas como inibidores de p13k.
BRPI0806537A2 (pt)	2014-04-22	Indazóis substituídos por 5-piridinona
BRPI1005525A2 (pt)	2016-02-23	compostos de azaazuleno
BRPI0907925A2 (pt)	2015-07-28	Ativadores de glicoquinase.
BRPI0915524A2 (pt)	2016-01-26	conjunto de aerofólio
EP2344471A4 (en)	2012-05-30	7-PIPERIDINALKYL-3,4-dihydroquinolone DERIVATIVE
UY33125A (es)	2011-07-29	Diaza-espiro-[5,5]-undecanos
BRPI0912013A2 (pt)	2015-10-06	mecanismo de disposição de aerofólio
BRPI0919898A2 (pt)	2016-02-16	4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3
BRPI0917446A2 (pt)	2015-12-22	derivados de acilaminobenzamida.
BRPI0806506A2 (pt)	2014-04-22	Indazóis substituídos por 5-furopiridinona
BRPI0906714A2 (pt)	2015-06-30	Derivados de oxazepinopirimidona heteroarilamida substituídos.
BRPI1013157A2 (pt)	2016-04-05	meio de fixação.
BRPI1016192A2 (pt)	2016-04-19	derivados de soxazol.
EP2459573A4 (en)	2014-08-27	SUBSTITUTED 1,2-AZABORIN HETEROCYCLES
FR2947857B1 (fr)	2012-03-30	Agencement de deshuileur
ES1070267Y (es)	2009-10-26	Deposito de heces equino

Legal Events

Date	Code	Title	Description
2015-06-09	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2015-09-08	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]