[go: up one dir, main page]

BRPI0814582A2 - Dispositivo, método, e, usos de um método, e da quantidade de ácidos nucleicos virais totais. - Google Patents

Dispositivo, método, e, usos de um método, e da quantidade de ácidos nucleicos virais totais.

Info

Publication number
BRPI0814582A2
BRPI0814582A2 BRPI0814582-2A2A BRPI0814582A BRPI0814582A2 BR PI0814582 A2 BRPI0814582 A2 BR PI0814582A2 BR PI0814582 A BRPI0814582 A BR PI0814582A BR PI0814582 A2 BRPI0814582 A2 BR PI0814582A2
Authority
BR
Brazil
Prior art keywords
nucleic acids
viral nucleic
total viral
total
acids
Prior art date
Application number
BRPI0814582-2A2A
Other languages
English (en)
Inventor
Eugen Ermantraut
Thomas Kaiser
Torsten Schulz
Katrin Steinmetzer
Thomas Ullrich
Original Assignee
Clondiag Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clondiag Gmbh filed Critical Clondiag Gmbh
Publication of BRPI0814582A2 publication Critical patent/BRPI0814582A2/pt
Publication of BRPI0814582B1 publication Critical patent/BRPI0814582B1/pt

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/708Specific hybridization probes for papilloma
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • AIDS & HIV (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
BRPI0814582-2A 2007-07-23 2008-07-23 método, e, uso da carga viral total em uma amostra de sangue integral não tratada BRPI0814582B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95135807P 2007-07-23 2007-07-23
US60/951,358 2007-07-23
PCT/EP2008/059670 WO2009013321A2 (en) 2007-07-23 2008-07-23 Assays

Publications (2)

Publication Number Publication Date
BRPI0814582A2 true BRPI0814582A2 (pt) 2015-01-20
BRPI0814582B1 BRPI0814582B1 (pt) 2021-05-11

Family

ID=39885074

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814582-2A BRPI0814582B1 (pt) 2007-07-23 2008-07-23 método, e, uso da carga viral total em uma amostra de sangue integral não tratada

Country Status (11)

Country Link
US (2) US9925536B2 (pt)
EP (6) EP3527288B1 (pt)
JP (5) JP5859203B2 (pt)
CN (2) CN101848765B (pt)
AU (1) AU2008280121B2 (pt)
BR (1) BRPI0814582B1 (pt)
CA (2) CA2722242C (pt)
ES (2) ES2717940T3 (pt)
NZ (1) NZ582786A (pt)
WO (1) WO2009013321A2 (pt)
ZA (1) ZA201000845B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2717940T3 (es) 2007-07-23 2019-06-26 Alere Tech Gmbh Ensayos
KR101130698B1 (ko) * 2009-11-03 2012-04-02 삼성전자주식회사 밸브 유닛과 이를 구비한 미세유동장치 및 밸브 유닛의 구동방법
FR2967362B1 (fr) * 2010-11-16 2012-12-21 Genewave Cartouche microfluidique pour diagnostic moleculaire
US9952153B2 (en) 2010-12-03 2018-04-24 ALERE TECHNOLOGIES GmbH Transformation of material into an optically modulating state via laser radiation
JP2014525569A (ja) * 2011-08-30 2014-09-29 ザ・ロイヤル・インスティテューション・フォア・ザ・アドバンスメント・オブ・ラーニング/マクギル・ユニヴァーシティ 予めプログラムされた自己出力型マイクロ流体回路のための方法およびシステム
US9377475B2 (en) 2011-12-23 2016-06-28 Abbott Point Of Care Inc. Optical assay device with pneumatic sample actuation
CN104053992B (zh) * 2012-01-16 2016-12-14 皇家飞利浦有限公司 确定包括细胞的体液中的靶分子的存在
EP2809227A4 (en) * 2012-02-03 2015-08-26 L Livermore Nat Security Llc STARTER AMPLIFIED REINFORCEMENTS FLEXIBLE NEURALE PROBES AND METHOD FOR THE PRODUCTION THEREOF BY WICKING CHANNEL DISTRIBUTED FABRICS AND TISSUE SETTING AND EXTRACTION
US8804105B2 (en) * 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
US9617589B2 (en) 2012-05-25 2017-04-11 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
KR20150042283A (ko) * 2012-08-16 2015-04-20 엔브이에스 테크놀로지스 인코포레이티드 어세이 방법 및 시스템
EP3462172B1 (en) * 2012-12-17 2023-09-06 Accellix Ltd Systems and methods for detecting a biological condition
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
HK1218096A1 (zh) * 2013-03-15 2017-02-03 Nanobiosym, Inc. 用於移动设备分析核酸和蛋白质的系统和方法
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
SG10201707599WA (en) 2013-03-15 2017-10-30 Richard Harry Turner A System And Methods For The In Vitro Detection Of Particles And Soluble Chemical Entities In Body Fluids
CN105609507B (zh) * 2014-11-17 2018-09-07 华邦电子股份有限公司 软性微系统结构
CN106233818B (zh) * 2015-04-07 2020-10-27 源鉴定私人有限公司 一种直流加热器
WO2017065854A2 (en) 2015-07-22 2017-04-20 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
JP6619577B2 (ja) * 2015-08-05 2019-12-11 アルプスアルパイン株式会社 流路構造体、測定ユニット、測定対象液体の測定方法、および測定対象液体の測定装置
RU2018137800A (ru) * 2016-03-29 2020-04-29 Уильям Марш Райс Юниверсити Обнаружение нуклеиновых кислот на поверхности в устройствах с конвекционным потоком жидкости
WO2017184178A1 (en) * 2016-04-22 2017-10-26 Hewlett-Packard Development Company, L.P. Cell lysis
US20190240661A1 (en) * 2016-10-07 2019-08-08 Boehringer Ingelheim Vetmedica Gmbh Cartridge and analysis system for testing a sample
IT201600104601A1 (it) 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
JP6978255B2 (ja) * 2017-08-31 2021-12-08 日東電工株式会社 液体吐出装置及び測定用テープ
CN111182971B (zh) * 2017-10-03 2022-08-30 阿威尔斯医疗公司 用于基于氧化还原反应测定微生物的浓度和微生物对抗感染剂的敏感性的装置、系统和方法
KR102227029B1 (ko) * 2017-12-15 2021-03-16 프리시젼바이오 주식회사 진단 장치
WO2019193004A1 (en) * 2018-04-06 2019-10-10 Boehringer Ingelheim Vetmedica Gmbh Analysis device, cartridge, analysis system and method for testing a sample
EP3794080B1 (en) 2018-05-18 2024-04-10 The University of North Carolina at Chapel Hill Compositions, devices, and methods for improving a surface property of a substrate
FR3088340B1 (fr) * 2018-11-12 2021-01-22 Commissariat Energie Atomique Systeme automatise de preparation, de detection et d'analyse d'un echantillon fluidique
CN109884063B (zh) * 2019-04-24 2021-08-20 杭州翔毅科技有限公司 一种用于液体传感器的采集结构
EP3766578A1 (en) 2019-07-18 2021-01-20 Blink AG A liquid handling and processing tool for analyzing a biological sample
WO2021226475A1 (en) * 2020-05-08 2021-11-11 The Trustees Of The University Of Pennsylvania Methods for detection of pathogenic infections using red blood cell-containing patient samples
WO2022036323A1 (en) * 2020-08-14 2022-02-17 Ohio State Innovation Foundation Liquid crystal biosensor with ultrahigh sensitivity and selectivity
CN112169853B (zh) * 2020-12-01 2021-02-26 南京岚煜生物科技有限公司 一种多功能微流控检测芯片
WO2022182125A1 (ko) * 2021-02-23 2022-09-01 모던밸류 주식회사 열제어부가 통합된, turn-off 방식의 광신호 측정용 액적 로딩 카트리지
DE102021203409A1 (de) * 2021-04-07 2022-10-13 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zum Nachweis aktiver Viren
CN113101991B (zh) * 2021-04-20 2022-10-04 南方科技大学 一种病毒联合检测的微流控芯片及其应用
WO2024241780A1 (ja) * 2023-05-25 2024-11-28 国立大学法人大阪大学 第1の構造物の量および第2の構造物の量を検出する方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666866A (en) 1983-04-19 1987-05-19 Krauth Gary H Immunoassay for antigens employing supported binder
US5279538A (en) 1991-11-18 1994-01-18 E. I. Du Pont De Nemours And Company Centrifuge rotor having a predetermined region of failure
ATE140025T1 (de) 1992-05-01 1996-07-15 Univ Pennsylvania Mikrohergestellte vorrichtungen zum handhaben von sperma
EP0590327B1 (en) 1992-09-11 2003-04-09 F. Hoffmann-La Roche Ag Detection of nucleic acids in blood
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
FR2728687A1 (fr) * 1994-12-21 1996-06-28 Bio Merieux Procede de dosage d'un haptene selon une technique de competition
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
EP0862708A4 (en) 1995-12-18 1998-11-25 Armand P Neukermans MICROFLUIDIC VALVE AND INTEGRATED MICROFLUIDIC SYSTEM
ES2309022T3 (es) * 1997-12-24 2008-12-16 Cepheid Dispositivo y procedimiento para lisis.
US6235479B1 (en) * 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
JP4022069B2 (ja) 1999-05-28 2007-12-12 シーフィード 細胞破壊装置および方法
EP1192007B1 (de) 1999-07-02 2004-04-21 Clondiag Chip Technologies GmbH Microchip-matrix-vorrichtung zur vervielfältigung und charakterisierung von nukleinsäuren
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20060281112A1 (en) * 2000-03-24 2006-12-14 Jose Remacle Design of capture molecules for the detection of amplicons with high sensitivity
US6453928B1 (en) * 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
WO2003091407A2 (en) * 2002-04-24 2003-11-06 Hitachi Chemical Research Center, Inc. Device and method for high-throughput quantification of mrna from whole blood
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
EP1590669B1 (en) * 2003-02-05 2009-11-25 The General Hospital Corporation A microchip-based system for hiv diagnostics
WO2005093388A1 (en) 2004-03-26 2005-10-06 Infectio Recherche Inc. Removable microfluidic flow cell
CA3198754A1 (en) 2004-05-03 2005-11-17 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US8852862B2 (en) * 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
DE102004022263A1 (de) 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102005052752A1 (de) 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DK1778867T3 (da) * 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
JP4643277B2 (ja) * 2005-01-24 2011-03-02 株式会社島津製作所 反応容器、遺伝子多型検出方法及び装置
US20060275852A1 (en) * 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
EP1915467A2 (en) * 2005-08-19 2008-04-30 The Regents of the University of California Microfluidic methods for diagnostics and cellular analysis
KR20080044306A (ko) * 2005-09-02 2008-05-20 캘리포니아 인스티튜트 오브 테크놀로지 유동 장치들 내의 밸브들의 기계적 작동을 위한 방법 및장치
US20070051415A1 (en) 2005-09-07 2007-03-08 Honeywell International Inc. Microvalve switching array
US7851160B2 (en) * 2005-11-16 2010-12-14 Mitsubishi Gas Chemical Company, Inc. Method for determination of amount of double-stranded DNA and kit for the determination
WO2007076549A2 (en) 2005-12-29 2007-07-05 Honeywell International Inc. Assay implementation in a microfluidic format
DE102006005287B4 (de) * 2006-02-06 2012-12-27 Siemens Ag Verfahren zum Nachweis von Zielnukleinsäuren
US8137626B2 (en) * 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
CN103497991A (zh) * 2006-11-06 2014-01-08 科隆迪亚戈有限公司 使用结合元件用于分析的装置和方法
ES2717940T3 (es) 2007-07-23 2019-06-26 Alere Tech Gmbh Ensayos

Also Published As

Publication number Publication date
NZ582786A (en) 2012-09-28
EP2188054B1 (en) 2017-03-08
US20240226890A1 (en) 2024-07-11
EP2612708A1 (en) 2013-07-10
CA2722242A1 (en) 2009-01-29
ZA201000845B (en) 2021-09-29
ES2722874T3 (es) 2019-08-19
JP5859203B2 (ja) 2016-02-10
EP3527288B1 (en) 2021-05-12
JP2020202852A (ja) 2020-12-24
US9925536B2 (en) 2018-03-27
EP2626434A1 (en) 2013-08-14
JP5993397B2 (ja) 2016-09-14
CA2722242C (en) 2018-07-17
EP2188054A2 (en) 2010-05-26
JP2017029151A (ja) 2017-02-09
AU2008280121A1 (en) 2009-01-29
BRPI0814582B1 (pt) 2021-05-11
EP3527288A1 (en) 2019-08-21
JP2014195453A (ja) 2014-10-16
ES2717940T3 (es) 2019-06-26
CN101848765B (zh) 2016-03-09
CN105543084A (zh) 2016-05-04
EP2647432B1 (en) 2018-12-19
JP6755533B2 (ja) 2020-09-16
WO2009013321A3 (en) 2009-10-08
CN101848765A (zh) 2010-09-29
EP2612708B1 (en) 2018-12-19
AU2008280121B2 (en) 2015-02-26
JP2019054794A (ja) 2019-04-11
CA3006347A1 (en) 2009-01-29
EP2610007B1 (en) 2018-12-05
US20100255473A1 (en) 2010-10-07
EP2626434B1 (en) 2018-12-12
EP2647432A1 (en) 2013-10-09
WO2009013321A2 (en) 2009-01-29
CN105543084B (zh) 2019-09-06
EP2610007A1 (en) 2013-07-03
JP2010534328A (ja) 2010-11-04
AU2008280121A2 (en) 2010-03-11

Similar Documents

Publication Publication Date Title
BRPI0814582A2 (pt) Dispositivo, método, e, usos de um método, e da quantidade de ácidos nucleicos virais totais.
BRPI0915142A2 (pt) polipeptídeos, ácido nucleico e usos dos mesmos
BRPI0822078A2 (pt) Método, e, sistema.
BRPI0813914A2 (pt) Sistema, e, método.
FR2929502B1 (fr) Implant nucleique.
BRPI0821208A2 (pt) sistema de ablação.
BRPI0814085A2 (pt) Sistema, e, método
BRPI0815101A2 (pt) Método, e, sistema
BRPI0813757A2 (pt) Sistema de implante, e, método
BRPI0915433A2 (pt) método, e, dispositivo.
BRPI0910503A2 (pt) compostos, composições farmacêuticas e respectivos usos.
BRPI0811722A2 (pt) Método, e sistema
BRPI0810190A2 (pt) Sistema, e, método.
BRPI0916450A2 (pt) método, e sistema
BRPI1006885A2 (pt) sistema de completação utilizável com um poço, e método utilizável com um poço
BRPI0816151A2 (pt) válvula utilizável com um poço, sistema usável com um poço, e método usável com um poço
BRPI0821050A2 (pt) Método, e, sistema
NL2003118A1 (nl) Alignment system, lithographic system and method.
DK2200646T3 (da) RNA-Vacciner
BRPI0813525A2 (pt) Dispositivo de exibição, e, método de acionamento de um dispositivo de exibição.
BRPI0810963A2 (pt) sistema, e, método
BRPI0913112A2 (pt) fluxímetro, e, método.
BRPI0918084A2 (pt) método, e, sistema
BRPI0917784A2 (pt) sistema, e, método
BRPI0914131A2 (pt) sistema, e método

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/07/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF