BRPI0814256A2 - Inibidores de tetrahidropiranocromeno gama secretase - Google Patents

Inibidores de tetrahidropiranocromeno gama secretase

Info

Publication number: BRPI0814256A2
Authority: BR; Brazil
Prior art keywords: tetrahydropyrochyromene; secretase; inhibitors; range; range inhibitors
Prior art date: 2007-07-05

Application number

BRPI0814256-4A2A

Other languages

English (en)

Inventor

Wen-Lian Wu

Thomas A Bara

Duane A Burnett

John W Clader

Martin S Domalski

Yan Jin

Hubert B Josien

Hongmei Li

Xian Liang

Dmitri A Pissarnitski

Thavalakulamgara K Sasikumar

Jesse K Wong

Ruo Xu

Zhiqiang Zhao

Paul Mcnamara

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-05

Filing date

2008-07-01

Publication date

2015-02-03

2008-07-01 Application filed by Schering Corp filed Critical Schering Corp

2015-02-03 Publication of BRPI0814256A2 publication Critical patent/BRPI0814256A2/pt

2016-02-10 Publication of BRPI0814256A8 publication Critical patent/BRPI0814256A8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

BRPI0814256A 2007-07-05 2008-07-01 Inibidores de tetrahidropiranocromeno gama secretase BRPI0814256A8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94803307P	2007-07-05	2007-07-05
PCT/US2008/008192 WO2009008980A2 (en)	2007-07-05	2008-07-01	Tetrahydropyranochromene gamma secretase inhibitors

Publications (2)

Publication Number	Publication Date
BRPI0814256A2 true BRPI0814256A2 (pt)	2015-02-03
BRPI0814256A8 BRPI0814256A8 (pt)	2016-02-10

Family

ID=39830164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0814256A BRPI0814256A8 (pt)	2007-07-05	2008-07-01	Inibidores de tetrahidropiranocromeno gama secretase

Country Status (16)

Country	Link
US (1)	US8664411B2 (pt)
EP (1)	EP2435416B1 (pt)
JP (1)	JP5240871B2 (pt)
KR (1)	KR20100044197A (pt)
CN (1)	CN101754960A (pt)
AR (1)	AR067445A1 (pt)
AU (1)	AU2008275735B2 (pt)
BR (1)	BRPI0814256A8 (pt)
CA (1)	CA2691542A1 (pt)
CL (1)	CL2008001960A1 (pt)
CO (1)	CO6270309A2 (pt)
EC (1)	ECSP109845A (pt)
PE (1)	PE20090435A1 (pt)
RU (1)	RU2483061C2 (pt)
TW (1)	TW200908959A (pt)
WO (1)	WO2009008980A2 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR059075A1 (es)	2006-01-20	2008-03-12	Schering Corp	Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
WO2009011851A1 (en)	2007-07-17	2009-01-22	Schering Corporation	Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
WO2011029920A1 (en)	2009-09-11	2011-03-17	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
WO2012040444A2 (en) *	2010-09-24	2012-03-29	Bristol-Myers Squibb Company	Treatment of patients with incipient alzheimer's disease
US8933116B2 (en)	2011-04-04	2015-01-13	Merck Sharp & Dohme Corp.	Gamma secretase inhibitors
US9226927B2 (en) *	2011-09-09	2016-01-05	Merck Sharp & Dohme Corp.	Gamma secretase inhibitors
WO2014085211A2 (en) *	2012-11-29	2014-06-05	Merck Sharp & Dohme Corp.	Spirocyclic sulfones as gamma secretase inhibitors
KR102209418B1 (ko) *	2012-12-20	2021-01-29	얀센 파마슈티카 엔.브이.	감마 세크레타제 조절 인자로서의 신규 삼환 3,4-디하이드로-2H-피리도[1,2-α]피라진-1,6-디온 유도체
CA2891755C (en)	2013-01-17	2021-10-26	Janssen Pharmaceutica Nv	Substituted pyrido-piperazinone derivatives as gamma secretase modulators
US10562897B2 (en)	2014-01-16	2020-02-18	Janssen Pharmaceutica Nv	Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CA3042877A1 (en) *	2016-11-09	2018-05-17	Bristol-Myers Squibb Company	Tricyclic sulfones as ror gamma modulators
US20230137562A1 (en)	2017-06-07	2023-05-04	Adrx, Inc.	Tau aggregation inhibitors
WO2019023247A1 (en)	2017-07-25	2019-01-31	Immutics, Inc.	TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND
AU2018318319A1 (en)	2017-08-18	2020-02-20	Adrx, Inc.	Tau aggregation peptide inhibitors
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase
CN116063505B (zh)	2019-01-30	2024-05-03	真和制药有限公司	抗gal3抗体及其用途
EP4157338A4 (en)	2020-05-26	2024-11-13	TrueBinding, Inc.	METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
AU2024265078A1 (en)	2023-05-04	2025-12-11	Revolution Medicines, Inc.	Combination therapy for a ras related disease or disorder
US20250049810A1 (en)	2023-08-07	2025-02-13	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
US20250154171A1 (en)	2023-10-12	2025-05-15	Revolution Medicines, Inc.	Ras inhibitors
WO2025171296A1 (en)	2024-02-09	2025-08-14	Revolution Medicines, Inc.	Ras inhibitors
WO2025240847A1 (en)	2024-05-17	2025-11-20	Revolution Medicines, Inc.	Ras inhibitors
WO2025255438A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en)	2024-06-21	2025-12-26	Revolution Medicines, Inc.	Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en)	2024-06-28	2026-01-02	Revolution Medicines, Inc.	Ras inhibitors
WO2026015801A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015825A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Use of ras inhibitor for treating pancreatic cancer
WO2026015796A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015790A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL349781A1 (en)	1999-02-26	2002-09-09	Merck & Co Inc	Novel sulfonamide compounds and uses thereof
FR2827590B1 (fr) *	2001-07-18	2003-10-24	Atuser	Transbordeur de liquides alimentaires usages
GB0108591D0 (en) *	2001-04-05	2001-05-23	Merck Sharp & Dohme	Therapeutic agents
WO2003014075A2 (en) *	2001-08-03	2003-02-20	Schering Corporation	Novel gamma secretase inhibitors
RU2202370C1 (ru) *	2001-12-26	2003-04-20	Эпштейн Олег Ильич	Нейропсихотропное лекарственное средство
GB0222833D0 (en)	2002-10-02	2002-11-06	Syngenta Ltd	Chemical process
GB0223039D0 (en) *	2002-10-04	2002-11-13	Merck Sharp & Dohme	Therapeutic compounds
EP1638951B1 (en) *	2003-05-16	2008-02-13	MERCK SHARP & DOHME LTD.	Cyclohexyl sulphones as gamma-secretase inhibitors
GB0317491D0 (en) *	2003-07-25	2003-08-27	Novartis Ag	Organic compounds
DE102005062098A1 (de) *	2005-12-22	2007-06-28	Merck Patent Gmbh	Oxaphenanthren-Derivate
AR059075A1 (es) *	2006-01-20	2008-03-12	Schering Corp	Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
TW200813054A (en)	2006-06-02	2008-03-16	Elan Pharm Inc	Fused, tricyclic sulfonamide inhibitors of gamma secretase
RU2011123862A (ru)	2008-11-13	2012-12-20	Шеринг Корпорейшн	Модуляторы гамма-секретазы

2008
- 2008-07-01 EP EP08768856.0A patent/EP2435416B1/en active Active
- 2008-07-01 CA CA002691542A patent/CA2691542A1/en not_active Abandoned
- 2008-07-01 RU RU2010103716/04A patent/RU2483061C2/ru not_active IP Right Cessation
- 2008-07-01 WO PCT/US2008/008192 patent/WO2009008980A2/en not_active Ceased
- 2008-07-01 JP JP2010514862A patent/JP5240871B2/ja not_active Expired - Fee Related
- 2008-07-01 KR KR1020107002496A patent/KR20100044197A/ko not_active Withdrawn
- 2008-07-01 CN CN200880023464A patent/CN101754960A/zh active Pending
- 2008-07-01 BR BRPI0814256A patent/BRPI0814256A8/pt not_active IP Right Cessation
- 2008-07-01 AU AU2008275735A patent/AU2008275735B2/en not_active Ceased
- 2008-07-01 US US12/665,580 patent/US8664411B2/en active Active
- 2008-07-02 TW TW097124900A patent/TW200908959A/zh unknown
- 2008-07-02 CL CL2008001960A patent/CL2008001960A1/es unknown
- 2008-07-02 PE PE2008001121A patent/PE20090435A1/es not_active Application Discontinuation
- 2008-07-02 AR ARP080102867A patent/AR067445A1/es not_active Application Discontinuation
2009
- 2009-12-30 CO CO09149364A patent/CO6270309A2/es not_active Application Discontinuation
2010
- 2010-01-05 EC EC2010009845A patent/ECSP109845A/es unknown

Also Published As

Publication number	Publication date
AU2008275735A1 (en)	2009-01-15
AR067445A1 (es)	2009-10-14
CL2008001960A1 (es)	2009-11-27
JP5240871B2 (ja)	2013-07-17
WO2009008980A3 (en)	2009-03-19
CA2691542A1 (en)	2009-01-15
CO6270309A2 (es)	2011-04-20
EP2435416B1 (en)	2016-03-30
RU2010103716A (ru)	2011-08-10
PE20090435A1 (es)	2009-04-18
US20110236400A1 (en)	2011-09-29
TW200908959A (en)	2009-03-01
EP2435416A2 (en)	2012-04-04
CN101754960A (zh)	2010-06-23
WO2009008980A2 (en)	2009-01-15
AU2008275735B2 (en)	2014-03-27
US8664411B2 (en)	2014-03-04
RU2483061C2 (ru)	2013-05-27
ECSP109845A (es)	2010-02-26
AU2008275735A2 (en)	2010-02-11
KR20100044197A (ko)	2010-04-29
JP2010532359A (ja)	2010-10-07
BRPI0814256A8 (pt)	2016-02-10

Publication	Publication Date	Title
BRPI0814256A2 (pt)	2015-02-03	Inibidores de tetrahidropiranocromeno gama secretase
FR20C1030I2 (fr)	2021-08-27	Inhibiteurs de beta-lactamase
BRPI0815135A2 (pt)	2015-02-03	Derivados de azepina como inibidores de gama secretase.
CY2017016I2 (el)	2017-07-12	Αναστολεις πρωτεασωματος
BRPI0812170A2 (pt)	2014-12-02	Moduladores de gama secretase
CR10831A (es)	2009-06-18	INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
EP2305306A4 (en)	2012-08-29	NEURO INVASION INHIBITOR
BRPI0810365A2 (pt)	2014-10-29	Inibidores de mlc-1 de indol 7-substituído
BRPI0810832A2 (pt)	2014-10-29	Ferramenta de nível
DK2041138T3 (da)	2014-08-11	Pyrroltriazinkinase-inhibitorer
BRPI1011129A2 (pt)	2016-11-01	métodos e compostos inibidores de janus cinase
DK2024375T3 (da)	2011-06-27	Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere
BRPI0918846A2 (pt)	2019-09-24	inibidores de cinase heterocíclica
BRPI0719499A2 (pt)	2015-06-16	Composições de poliolefina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
EP2192838A4 (en)	2011-07-27	HETEROCYCLIC NEKROPTOSIS HEMMER
BRPI0812825A2 (pt)	2014-12-09	Derivados ftalazinona como inibidores de parp-1
BRPI0922880A2 (pt)	2018-07-24	compostos inibidores de quinase
BRPI0918564A2 (pt)	2015-12-01	inibidores
CR10879A (es)	2009-08-05	Cyclized derivatives as eg-5 inhibitors
BRPI0720547A2 (pt)	2014-05-06	Inibidores de metaloprotease derivada de heterocíclico
BRPI0622049A2 (pt)	2014-06-10	Estimativa de estado dinâmico
DK2066662T3 (da)	2013-01-07	Serinhydrolaseinhibitorer
BRPI0716198A2 (pt)	2013-11-12	Pirrolo-isoquinolinas como inibidores de cinase
BRPI0806542A2 (pt)	2014-04-22	Derivados de sulfonamida como inibidores de quimase

Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2016-02-10	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US)
2016-02-23	B25G	Requested change of headquarter approved	Owner name: MERCK SHARP AND DOHME CORP. (US)
2016-03-29	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.